allerfex m tablet - Uses, Price, Side Effects & Substitutes
What is allerfex m tablet used for?
Air-M Tablet (Montelukast + Fexofenadine) is used to treat RESPIRATORY. It contains Montelukast (10mg) + Fexofenadine (120mg), which Montelukast selectively antagonizes leukotriene D4 at the cysteinyl leukotriene . Always consult your doctor before use. Take as prescribed.
- Generic Name: Montelukast + Fexofenadine
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ allerfex m tablet Uses & Benefits
Seasonal allergic rhinitis, perennial allergic rhinitis, asthma prophylaxis, urticaria.
Off-label uses: Exercise-induced bronchoconstriction (montelukast), chronic urticaria.
๐ Drug Information
| Generic Name(s) | Montelukast + Fexofenadine |
| Brand Name | Air-M Tablet |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Leukotriene receptor antagonist + Antihistamine |
| Route of Administration | Oral. |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Montelukast selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor CysLT1, reducing airway edema, smooth muscle contraction, and inflammatory cell activity. Fexofenadine is a peripherally selective histamine H1 receptor antagonist, inhibiting histamine-mediated allergic responses.
Mechanism Steps
๐ก How to Take allerfex m tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of allerfex m tablet
โ Common Side Effects
- Headache
- Dizziness
- Nausea
- Diarrhea
- Fatigue
- Cough
- Pharyngitis
๐จ Serious Side Effects
- Anaphylaxis
- Angioedema
- Severe skin reactions (e.g., eosinophilic granulomatosis with polyangiitis)
- Hepatic dysfunction
โ ๏ธ Rare Side Effects
- Seizures
- Thrombocytopenia
- Hallucinations
- Churg-Strauss syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased montelukast levels |
| Rifampin | Major | Decreased montelukast efficacy |
| Erythromycin | Moderate | Increased fexofenadine levels |
| Warfarin | Moderate | Possible increased INR |
| Fruit juices | Minor | Reduced fexofenadine absorption |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2C9 inhibitors (e.g., fluconazole)
- Rifampin
- Phenobarbital
โก Moderate Interactions
- Erythromycin
- Gemfibrozil
- Warfarin
โน๏ธ Minor Interactions
- Theophylline
- Oral contraceptives
๐ฝ๏ธ Food Interactions
Fexofenadine absorption may be reduced by fruit juices (apple, orange, grapefruit). Montelukast absorption not significantly affected by food.
๐ท Alcohol Interaction
Alcohol may potentiate CNS depression; caution advised.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component.
๐ Monitoring Parameters
Liver function tests, renal function, asthma control, allergic symptom relief.
๐คฑ Lactation Safety
Montelukast: excreted in breast milk; Fexofenadine: excreted in breast milk; caution advised.
๐ Overdose Management
Symptomatic and supportive treatment; no specific antidote.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.