alkarate liquid - Disodium Hydrogen Citrate (1.37gm/5ml) medicine

Cital Oral Liquid Sugar Free: Complete Medicine Guide

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🏭 Macleods Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for symptomatic relief of UTI; Limited for other uses.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in your urine or stool
  • Severe abdominal or flank pain
  • High fever with chills and shaking
  • Persistent vomiting or inability to keep fluids down
  • Sudden swelling of your face, lips, or throat, or difficulty breathing
  • Irregular heartbeat or palpitations
  • Confusion or extreme weakness
  • Decreased urine output or no urination for several hours

If experiencing severe symptoms, call emergency services immediately.

What is alkarate liquid used for?

This medicine is a urinary alkalinizer containing disodium hydrogen citrate. It works by making urine less acidic, which helps relieve burning and discomfort during urinary tract infections. It is not an antibiotic and does not treat the infection itself.

  • Generic Name: Disodium Hydrogen Citrate
  • Manufacturer: Macleods Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 alkarate liquid के बारे में (Hindi Summary)

उपयोग: यह दवा मूत्र पथ के संक्रमण में जलन और दर्द को कम करने के लिए दी जाती है। यह पेशाब को कम अम्लीय बनाती है, जिससे पेशाब करते समय होने वाली जलन में आराम मिलता है। यह एंटीबायोटिक नहीं है, इसलिए यह संक्रमण को खत्म नहीं करती, बल्कि लक्षणों में राहत देती है। यह शुगर-फ्री है, इसलिए मधुमेह रोगी भी इसका उपयोग कर सकते हैं। इसका उपयोग यूरिक एसिड की पथरी को रोकने में भी मदद कर सकता है।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभाव हल्के होते हैं, जैसे पेट में हल्की परेशानी, जी मिचलाना, या दस्त। कुछ लोगों को पेशाब करने की इच्छा बार-बार हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन शरीर में सूजन, रक्तचाप बढ़ना, या एलर्जी की प्रतिक्रिया हो सकती है। अगर आपको चकत्ते, खुजली, चेहरे या गले में सूजन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को बताएं कि आपको दिल की बीमारी, उच्च रक्तचाप, गुर्दे की बीमारी, या नमक प्रतिबंधित आहार है या नहीं। यह दवा सोडियम युक्त है, इसलिए कम नमक वाले आहार पर रहने वाले लोगों को सावधानी बरतनी चाहिए। इस दवा को लेते समय खूब पानी पिएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बिना डॉक्टर की सलाह के लंबे समय तक इसका उपयोग न करें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 alkarate liquid Uses & Benefits

  • [{"condition":"Urinary tract infection (symptomatic relief)","description":"This medicine helps to reduce the burning and stinging sensation during urination by making the urine less acidic.
  • It does not treat the infection itself but provides comfort while antibiotics work.","evidence":"Well-established"},{"condition":"Metabolic acidosis (mild to moderate)","description":"In some cases, this medicine may be used to correct mild metabolic acidosis by providing citrate, which is converted to bicarbonate in the body.","evidence":"Limited"},{"condition":"Uric acid kidney stones (prevention)","description":"By alkalinizing the urine, this medicine can help prevent the formation of uric acid stones and may even help dissolve small existing ones.","evidence":"Moderate"},{"condition":"Cystitis (bladder inflammation)","description":"This medicine may be used to relieve discomfort associated with bladder inflammation by reducing urine acidity.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Chemotherapy-induced urinary discomfort","description":"Sometimes used to alkalinize urine and reduce bladder irritation from certain chemotherapy drugs.","evidence":"Limited"},{"condition":"Rhabdomyolysis prevention","description":"In some emergency settings, urinary alkalinization with citrate may be used to protect the kidneys, but this is not a standard use for this oral liquid.","evidence":"Limited"}]

Primary treatment for: Urinary tract infection

Also treats: Cystitis, Uric acid kidney stones, Metabolic acidosis

📋 Drug Information

Generic Name(s)Disodium Hydrogen Citrate
Brand NameAlkasol Oral Solution
ManufacturerMacleods Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassUROLOGY
Action ClassUricosuric agent-gout
Route of AdministrationOral
StorageStore at room temperature, below 30°C, in a cool, dry place. Protect from direct sunlight. Do not freeze. Keep the bottle tightly closed when not in use.
Shelf Life24 months from the date of manufacture, or as indicated on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with a full glass of water to help flush your urinary system.
2
Shake the bottle well before each use to ensure the medicine is evenly mixed.
3
Do not take aluminum-containing antacids within 2 hours of this medicine, as they can reduce its effectiveness.
4
If you have high blood pressure or heart disease, monitor for signs of fluid retention such as swelling in the legs or sudden weight gain.
5
Complete the full course as prescribed by your doctor, even if you feel better, to prevent complications.
6
If your symptoms do not improve within 2 to 3 days, contact your doctor; you may need additional treatment.
7
Keep a record of your doses to avoid missing or doubling up.
8
Inform your doctor if you are taking lithium or methenamine, as this medicine can interact with them.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Burning sensation during urination
This medicine is commonly prescribed for this symptom.
Likely Use
✅
Frequent urination
This medicine may help reduce urgency and frequency by alkalinizing urine.
Likely Use
❌
Fever
This medicine is not a fever reducer. Fever with UTI may indicate a more serious infection requiring antibiotics.
Not Primary
❌
Flank pain
Flank pain may indicate kidney involvement and requires immediate medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDisodium hydrogen citrate is rapidly absorbed from the gastrointestinal tract after oral administration. The citrate component is absorbed and then metabolized. The sugar-free liquid formulation is designed for easy swallowing and quick absorption, especially in patients who have difficulty taking tablets.
DistributionAfter absorption, citrate is distributed throughout the body's extracellular fluid. It does not bind significantly to plasma proteins. It is taken up by tissues, particularly the liver and kidneys, where it participates in metabolic processes.
Protein BindingNot established from the available information.
MetabolismCitrate is metabolized in the body, primarily in the liver and kidneys, through the tricarboxylic acid cycle (Krebs cycle) to produce bicarbonate and carbon dioxide. This metabolic conversion is essential for its alkalinizing effect.
Half-LifeNot established from the available information.
ExcretionThe metabolites of disodium hydrogen citrate, mainly bicarbonate, are excreted primarily by the kidneys into the urine. Some citrate may also be excreted unchanged in the urine. The excretion of bicarbonate helps to alkalinize the urine.
BioavailabilityNot established from the available information.
Onset of ActionThe alkalinizing effect on urine typically begins within 1 to 2 hours after oral administration, but symptomatic relief may take a few doses to become noticeable.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe effect on urinary pH lasts for several hours, generally requiring dosing every 4 to 6 hours or as directed by a physician to maintain alkaline urine.

How It Works

This medicine works by providing citrate ions, which are metabolized in the body to bicarbonate. Bicarbonate is an alkali that neutralizes excess acid. When taken orally, it increases the pH of the urine, making it less acidic. This alkalinization helps to relieve the burning sensation during urination because acidic urine irritates the inflamed bladder and urethra. Additionally, by making the urine less acidic, it creates an environment that is less favorable for the formation of certain types of kidney stones, particularly uric acid stones. It does not have antibacterial properties, so it does not treat the infection itself.

Mechanism Steps

1
Ingestion and absorption: Disodium hydrogen citrate is swallowed and absorbed from the gastrointestinal tract.
2
Metabolism to bicarbonate: In the body, citrate is metabolized, primarily in the liver and kidneys, to produce bicarbonate, which is an alkali.
3
Systemic alkalinization: The bicarbonate enters the bloodstream and helps to buffer excess acid, raising blood pH slightly.
4
Urinary excretion: The kidneys filter the bicarbonate and other citrate metabolites into the urine, raising its pH.
5
Symptom relief: The less acidic urine causes less irritation to the inflamed bladder and urethra, reducing burning and pain during urination.

💡 How to Take alkarate liquid

Strength: Oral liquid, sugar-free, containing disodium hydrogen citrate 1.37 g per 5 ml.

1Shake the bottle well before each use.
2Use a measuring cup or spoon to measure the exact dose prescribed.
3Take the medicine orally, with or without food.
4Drink a full glass of water after taking the dose.
5Follow your doctor's instructions regarding frequency and duration.
6Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5 to 10 ml (one to two teaspoons) taken orally every 4 to 6 hours, or as directed by your physician. The dose may be adjusted based on your condition and response. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the sodium content of this medicine and are at higher risk of fluid retention and electrolyte imbalances. Use with caution and under medical supervision. Dose adjustment may be necessary based on kidney function.
Renal ImpairmentIn patients with renal impairment, this medicine should be used with caution. Dose reduction may be required, and monitoring of kidney function and electrolytes is recommended. Consult your doctor for specific dosing.
Hepatic ImpairmentNo specific dose adjustment is established for hepatic impairment. Use with caution and consult your doctor.
Maximum Daily DoseThe maximum daily dose should not exceed 60 ml in adults, or as directed by a physician. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
High-sodium foods
Limit
This medicine contains sodium; excess sodium can worsen fluid retention.
Cranberry juice
Consult doctor
May acidify urine and counteract the alkalinizing effect.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of alkarate liquid

✅ Common Side Effects

Mild stomach discomfort (Common (5-10%))
Take with food or milk to reduce stomach upset. If it persists, consult your doctor.
Nausea (Common (5-10%))
Try taking the medicine with a small snack. If nausea continues, speak to your doctor.
Loose stools (Uncommon (1-5%))
Stay hydrated. If diarrhea becomes severe or persistent, contact your doctor.
Increased urination (Common (5-10%))
This is expected as the medicine helps flush the urinary tract. Drink plenty of water.

🚨 Serious Side Effects

Fluid retention and swelling (Rare (<0.1%))
Seek medical attention if you notice swelling in your legs, ankles, or face, or sudden weight gain.
High blood pressure (Rare (<0.1%))
Monitor your blood pressure if you have hypertension. Report any significant increase to your doctor.
Electrolyte imbalance (e.g., low potassium) (Rare (<0.1%))
Your doctor may order blood tests if you are on long-term therapy. Report muscle weakness, cramps, or irregular heartbeat.
Allergic reaction (Rare (<0.1%))
Stop the medicine and seek emergency help if you experience rash, itching, swelling of the face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Metabolic alkalosis
Seek medical attention if you experience confusion, muscle twitching, or irregular heartbeat.
Hypernatremia (high sodium levels)
Report excessive thirst, confusion, or seizures to a doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Aluminum antacids Major
Lithium Major
Methenamine Major
Diuretics Moderate
Corticosteroids Moderate
ACE inhibitors Moderate
Aspirin Minor
Amphetamines Minor

🚨 Major Interactions

  • Antacids containing aluminum
  • Lithium
  • Methenamine

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide, hydrochlorothiazide)
  • Corticosteroids
  • ACE inhibitors or ARBs

🍷 Alcohol Interaction

Alcohol may worsen dehydration and irritate the bladder, which can counteract the benefits of this medicine in urinary tract infections. It is advisable to avoid alcohol while taking this medicine, especially if you have a urinary tract infection, as alcohol can increase the frequency of urination and worsen discomfort.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe kidney disease or kidney failure","Uncontrolled high blood pressure","Heart failure or conditions requiring sodium restriction","Metabolic alkalosis","Hypernatremia (high blood sodium)","Known hypersensitivity to disodium hydrogen citrate or any component of the formulation"]

⚠️ Warnings & Precautions

["This medicine contains sodium; use with caution if you are on a low-sodium diet or have heart or kidney problems.","Do not use for prolonged periods without medical supervision.","Drink plenty of water to help flush the urinary system and prevent stone formation.","If you have diabetes, this sugar-free formulation is suitable, but monitor your blood sugar as usual.","Do not take aluminum-containing antacids within 2 hours of this medicine.","Consult your doctor if symptoms do not improve within a few days or worsen.","Keep out of reach of children.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]

🤱 Lactation Safety

It is not known whether disodium hydrogen citrate passes into breast milk in significant amounts. It is generally considered safe for use during breastfeeding, but consult your doctor before taking this medicine while nursing.

💊 Overdose Management

Overdose of this medicine can lead to metabolic alkalosis, hypernatremia, and fluid overload. Symptoms may include nausea, vomiting, confusion, muscle twitching, and irregular heartbeat. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and may include intravenous fluids and correction of electrolyte imbalances. In severe cases, dialysis may be required.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Before you start taking this medicine, tell your doctor if you have any heart problems, high blood pressure, kidney disease, or if you are on a low-salt diet. This medicine contains sodium, so it may not be suitable for you if you need to restrict salt. Do not take more than the recommended dose, as it can upset your body's acid-base balance. Drink plenty of water while taking this medicine to help flush your urinary system. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not use this medicine for more than the recommended duration without medical advice. Keep it out of reach of children. If you experience severe stomach pain, persistent vomiting, or any signs of an allergic reaction, stop taking it and seek medical attention right away.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the sodium content of this medicine and are at higher risk of fluid retention, high blood pressure, and electrolyte imbalances. Use with caution and monitor kidney function and electrolytes regularly. Dose adjustment may be needed based on renal function.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally considered safe during pregnancy when used as directed, but medical supervision is essential. Your doctor may adjust the dose or recommend alternatives based on your condition.

🏥 Post-Surgery Considerations

After surgery, this medicine may be used to alkalinize urine, especially if you have a urinary catheter or are at risk of uric acid stones. Follow your surgeon's instructions regarding dosing and monitoring. Inform your surgical team about all medicines you are taking.

🦷 Dental Procedures

There are no specific precautions for dental procedures while taking this medicine. However, inform your dentist about all medications you are taking. Maintain good oral hygiene as usual.

💚 Lifestyle Tips for Better Results

🏃
Drink plenty of water throughout the day to help flush your urinary system.
🥗
Maintain good personal hygiene to prevent urinary tract infections.
😴
Urinate frequently and completely; do not hold urine for long periods.
💧
Include foods rich in vitamin C and antioxidants to support urinary health.
🧘
Avoid excessive caffeine and alcohol, which can irritate the bladder.
🌞
Wear loose-fitting cotton underwear to reduce moisture and bacterial growth.
🚭
Practice pelvic floor exercises to strengthen bladder muscles.

🏋️ Exercise Considerations

There are no specific exercise restrictions while taking this medicine. However, if you have a urinary tract infection, strenuous exercise may worsen discomfort. Listen to your body and rest if needed. Stay hydrated during exercise.

🥗 Diet Recommendations

Drink at least 8-10 glasses of water daily.
Include fresh fruits and vegetables rich in vitamin C.
Limit processed foods and high-sodium snacks.
Avoid excessive caffeine and alcohol.
Include probiotics like yogurt to support gut and urinary health.

💼 Impact on Daily Work & Life

This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness (rare), avoid these activities until you know how the medicine affects you. It may increase urination frequency, so plan bathroom breaks accordingly during work or travel.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms worsen or do not improve within 2-3 days, or if you experience any serious side effects such as swelling, irregular heartbeat, or allergic reactions. Do not stop abruptly if you are on long-term therapy without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine without medical supervision can lead to electrolyte imbalances, metabolic alkalosis, and fluid retention due to its sodium content. It may also increase the risk of kidney stones if not adequately hydrated. Regular monitoring of kidney function, electrolytes, and blood pressure is recommended for prolonged use. Always follow your doctor's guidance and do not exceed the recommended duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Increased water intake

Drinking plenty of water helps dilute urine and flush out bacteria, reducing irritation.

Evidence: Well-established
Cranberry products

Some studies suggest cranberry may help prevent UTIs, but evidence is mixed.

Evidence: Limited
Probiotics

Probiotics may help maintain a healthy urinary tract flora.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. You can receive vaccinations as scheduled. Consult your doctor if you have any concerns.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, adjust your dosing schedule gradually to maintain consistent intervals, but consult your doctor for specific advice. Keep the bottle tightly closed and upright to prevent leakage. Check customs regulations for carrying liquids and medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with a urinary tract infection
She was prescribed this medicine along with an antibiotic for her UTI. She took the liquid as directed every 6 hours and drank plenty of water. Within a day, the burning sensation during urination reduced significantly. She completed the full course and her symptoms resolved completely.
💡 Lesson: Taking this medicine as prescribed along with adequate hydration helps relieve UTI symptoms effectively while the antibiotic treats the infection.
👤 A 55-year-old man with a history of uric acid kidney stones
He was advised to take this sugar-free liquid to alkalinize his urine and prevent stone formation. He incorporated it into his daily routine, took it regularly, and stayed well hydrated. Over several months, his follow-up scans showed no new stones, and his urinary pH was maintained in the target range.
💡 Lesson: Long-term use of this medicine under medical supervision can help prevent uric acid stones when combined with good hydration and dietary changes.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts alkalinizing your urine within 1 to 2 hours, but you may notice relief from burning within a few doses. If symptoms persist beyond 2-3 days, consult your doctor.

Q: Is this medicine an antibiotic?

A: No, this medicine is not an antibiotic. It is a urinary alkalinizer that helps relieve symptoms by making urine less acidic. It does not kill bacteria.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.

Q: Is this medicine safe for diabetics?

A: Yes, this sugar-free formulation is suitable for people with diabetes. However, always monitor your blood sugar as usual and consult your doctor.

Q: Can I take this medicine during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. It is generally considered safe when used as directed, but medical supervision is required.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for diabetics?
  • Can I take it with antibiotics?

🔄 Substitutes for alkarate liquid

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure urinary tract infections.
    Fact: This medicine only relieves symptoms by alkalinizing urine. It does not kill bacteria, so antibiotics are needed to treat the infection.
  • Myth: It is safe to take this medicine for as long as you want.
    Fact: Prolonged use without medical supervision can lead to electrolyte imbalances and other complications. Follow your doctor's advice.
  • Myth: This medicine is safe for everyone.
    Fact: It is not suitable for people with severe kidney disease, uncontrolled high blood pressure, or heart failure. Always consult a doctor.

🔄 Alternative Options

Generic Alternatives

  • Disodium hydrogen citrate oral liquid (various manufacturers)

Brand Alternatives

  • Cital Oral Liquid Sugar Free

📊 Comparison with Similar Medicines

[{"medicine":"Disodium hydrogen citrate","class":"Urinary alkalinizer","main_use":"Symptomatic relief of UTI","route":"Oral"},{"medicine":"Potassium citrate","class":"Urinary alkalinizer","main_use":"Prevention of kidney stones","route":"Oral"},{"medicine":"Sodium citrate","class":"Urinary alkalinizer","main_use":"Metabolic acidosis","route":"Oral"}]

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