alkapil syrup - Disodium Hydrogen Citrate (1.53gm/5ml) medicine

Alkapil Syrup: Complete Medicine Guide

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🏭 Psychotropics India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for urinary alkalinization.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in urine
  • Severe abdominal pain
  • Swelling of hands, feet, or ankles
  • Muscle twitching or confusion
  • Difficulty breathing or rash
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is alkapil syrup used for?

This medicine is an oral syrup containing disodium hydrogen citrate, used to relieve burning during urination and to prevent certain kidney stones by making urine less acidic.

  • Generic Name: Disodium Hydrogen Citrate (1.53gm/5ml)
  • Manufacturer: Psychotropics India Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 alkapil syrup के बारे में (Hindi Summary)

उपयोग: यह दवा मूत्र पथ के संक्रमण में जलन और दर्द को कम करने, गुर्दे की पथरी को घोलने और शरीर में एसिड की मात्रा को संतुलित करने के लिए इस्तेमाल की जाती है। यह मूत्र को कम अम्लीय बनाकर काम करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, पेट में असुविधा और दस्त शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर हाथ-पैरों में सूजन, मांसपेशियों में ऐंठन या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी किडनी, हृदय या रक्तचाप की समस्या के बारे में बताएं। यह दवा सोडियम युक्त है, इसलिए कम नमक वाले आहार पर रहने वाले लोगों को सावधानी बरतनी चाहिए। इस दवा के साथ पर्याप्त पानी पिएं। एल्युमिनियम युक्त एंटासिड के साथ इसका सेवन न करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 alkapil syrup Uses & Benefits

[{"condition":"Urinary tract infections (UTIs)","description":"This medicine helps relieve burning and discomfort during urination by making the urine less acidic, which reduces irritation of the urinary tract lining.","evidence":"Well-established"},{"condition":"Uric acid kidney stones","description":"It helps dissolve and prevent the formation of uric acid stones by alkalinizing the urine.","evidence":"Well-established"},{"condition":"Metabolic acidosis","description":"It is used to correct mild to moderate metabolic acidosis by neutralizing excess acid in the body.","evidence":"Established"},{"condition":"Cystinuria","description":"It increases urine pH, which helps dissolve cystine stones and prevents their formation.","evidence":"Established"}]

Off-label uses: [{"condition":"Chemotherapy-induced nausea","description":"Sometimes used to alkalinize urine and prevent certain chemotherapy drugs from causing bladder irritation.","evidence":"Limited"},{"condition":"Rhabdomyolysis prevention","description":"May be used to alkalinize urine in patients with muscle breakdown to protect the kidneys.","evidence":"Limited"}]

Primary treatment for: Urinary tract infections

Also treats: Uric acid kidney stones, Metabolic acidosis, Cystinuria

📋 Drug Information

Generic Name(s)Disodium Hydrogen Citrate (1.53gm/5ml)
Brand Namealkapil syrup
ManufacturerPsychotropics India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassUROLOGY
Action ClassUricosuric agent-gout
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Drink plenty of water throughout the day to help flush your urinary system.
3
Avoid taking this medicine with aluminium-containing antacids.
4
Monitor your urine pH if advised by your doctor.
5
Do not exceed the prescribed dose.
6
Consult your doctor if symptoms persist beyond 7 days.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Burning during urination
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Kidney stone prevention
This medicine helps prevent uric acid stones.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDisodium hydrogen citrate is rapidly absorbed from the gastrointestinal tract after oral administration. The citrate is then metabolized to bicarbonate. The absorption is not significantly affected by food.
DistributionThe bicarbonate generated from this medicine distributes throughout the extracellular fluid and is used in various metabolic processes. It does not bind to plasma proteins significantly.
Protein BindingNot established from the available information.
MetabolismDisodium hydrogen citrate is metabolized in the liver to bicarbonate and other metabolites. This conversion is rapid and efficient.
Half-LifeNot established from the available information.
ExcretionThe bicarbonate and citrate are primarily excreted by the kidneys in the urine. Some may be excreted in the breath as carbon dioxide.
BioavailabilityNot established from the available information.
Onset of ActionThe alkalinizing effect on urine typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe effect on urine pH lasts for several hours, typically 4 to 6 hours, depending on the dose and individual factors.

How It Works

This medicine works by providing citrate ions that are metabolized in the body to bicarbonate. Bicarbonate is a base that neutralizes excess acid, thereby increasing the pH of the urine. This alkalinization makes the urine less acidic, which helps relieve the burning sensation associated with acidic urine in urinary tract infections. It also increases the solubility of certain substances like uric acid and cystine, preventing them from forming stones in the kidneys. Additionally, by correcting acidosis, it helps maintain the body's normal acid-base balance.

Mechanism Steps

1
Absorption and metabolism: After oral administration, disodium hydrogen citrate is absorbed from the gastrointestinal tract and rapidly metabolized in the liver to bicarbonate.
2
Bicarbonate generation: The bicarbonate produced acts as a buffer, neutralizing excess hydrogen ions in the blood and urine.
3
Urine alkalinization: The increased bicarbonate is excreted in the urine, raising its pH and making it less acidic.
4
Clinical effects: The less acidic urine reduces bladder irritation and increases the solubility of uric acid and cystine, preventing stone formation.

💡 How to Take alkapil syrup

Strength: Each 5 ml contains Disodium Hydrogen Citrate 1.53 gm.

1Shake the bottle well before use.
2Measure the dose accurately using the measuring cup or spoon provided.
3Take the medicine orally with a glass of water.
4Take it with or after meals to reduce stomach upset.
5Drink plenty of water throughout the day.
6Do not take with citrus juices or aluminium-containing antacids.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5 to 10 ml taken 3 to 4 times daily, depending on the condition being treated. For urinary tract infections, it is often taken with plenty of water. For kidney stones, the dose may be adjusted based on urine pH. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially regarding fluid retention and electrolyte imbalance. Dose should be adjusted cautiously by a clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor.
Hepatic ImpairmentNo specific dose adjustment is established for hepatic impairment. Consult a doctor.
Maximum Daily DoseThe maximum daily dose should not exceed 30 ml per day unless directed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Citrus fruits and juices
Avoid
May reduce the medicine's effectiveness by acidifying urine.
High-sodium foods
Limit
May increase fluid retention and blood pressure.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of alkapil syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take the medicine with food or after meals to reduce nausea. If it persists, consult your doctor.
Stomach discomfort (Common (5-10%))
Taking with food may help. Avoid taking on an empty stomach.
Loose stools (Common (5-10%))
Usually resolves on its own. Stay hydrated. If diarrhea is severe or persistent, consult your doctor.
Increased thirst (Common (5-10%))
Drink plenty of water throughout the day. This is usually not a cause for concern.

🚨 Serious Side Effects

Fluid retention (edema) (Rare (<0.1%))
Seek medical attention if you notice swelling of your hands, feet, or ankles.
Electrolyte imbalance (Rare (<0.1%))
Report symptoms like muscle twitching, confusion, or irregular heartbeat to your doctor immediately.
Allergic reaction (Rare (<0.1%))
Stop the medicine and seek emergency care if you experience rash, itching, swelling of the face or throat, or difficulty breathing.

⚠️ Rare Side Effects

Hypernatremia (high sodium levels)
Seek medical attention if you experience excessive thirst, confusion, or seizures.
Metabolic alkalosis
Report symptoms like muscle cramps, dizziness, or tingling to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Aluminium-containing antacids Major
Lithium Major
Methenamine Major
Amphetamines Moderate
Quinidine Moderate
Salicylates Moderate
Citrus fruits Minor
High-sodium foods Minor

🚨 Major Interactions

  • Aluminium-containing antacids
  • Lithium
  • Methenamine

⚡ Moderate Interactions

  • Amphetamines
  • Quinidine
  • Salicylates

🍷 Alcohol Interaction

Alcohol can increase stomach irritation and may worsen the side effects of this medicine. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe kidney disease","Heart failure","High blood pressure (uncontrolled)","Salt-restricted diet","Active peptic ulcer","Allergy to any ingredient"]

⚠️ Warnings & Precautions

["This medicine contains sodium; use with caution in patients on a low-sodium diet.","Do not take with aluminium-containing antacids.","Monitor urine pH to ensure adequate alkalinization.","Use with caution in patients with kidney or heart disease.","Consult your doctor before use if pregnant or breastfeeding.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether this medicine passes into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of this medicine may cause metabolic alkalosis, hypernatremia, or fluid retention. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and may include intravenous fluids and electrolyte correction.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Before starting this medicine, tell your doctor if you have kidney problems, heart failure, high blood pressure, or any condition that requires you to limit your salt intake. This medicine contains sodium, so it may not be suitable if you are on a low-sodium diet. Do not take this medicine with antacids that contain aluminium, as they can reduce its effect. Drink plenty of water while taking this medicine to help flush your urinary system. Avoid taking it with large amounts of citrus fruits or juices, as they can make your urine more acidic and reduce the medicine's benefit. Do not change the dose or stop taking this medicine without consulting your doctor. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor before use. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more prone to fluid retention and electrolyte imbalances. Close monitoring is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before using this medicine. The safety profile is not well established.

🏥 Post-Surgery Considerations

This medicine may be used after surgery to alkalinize urine, but only under medical supervision.

🦷 Dental Procedures

No specific considerations for dental procedures. Inform your dentist about all medicines you are taking.

💚 Lifestyle Tips for Better Results

🏃
Drink plenty of water to help flush your urinary system.
🥗
Limit intake of citrus fruits and juices.
😴
Maintain a balanced diet low in sodium.
💧
Follow good hygiene practices to prevent UTIs.
🧘
Exercise regularly to maintain overall health.

🏋️ Exercise Considerations

No specific exercise restrictions are associated with this medicine. However, if you experience dizziness or muscle weakness, avoid strenuous activities until you feel better.

🥗 Diet Recommendations

Stay well hydrated.
Reduce intake of citrus fruits and juices.
Limit high-sodium foods.
Include plenty of fresh vegetables and whole grains.

💼 Impact on Daily Work & Life

This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid these activities until you know how the medicine affects you.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to electrolyte imbalances, fluid retention, or metabolic alkalosis. Regular monitoring of kidney function and electrolytes is advised. It should be used only under medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Increased water intake

Drinking plenty of water can help dilute urine and reduce irritation.

Evidence: Well-established
Dietary changes

Reducing purine-rich foods can help prevent uric acid stones.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. Continue routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, continue your regular dosing schedule as closely as possible. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with recurrent urinary tract infections
She was prescribed this medicine for burning during urination. After taking it regularly with plenty of water, her symptoms improved within two days. She also learned to avoid citrus juices while on this medicine.
💡 Lesson: Taking the medicine as directed and staying hydrated can significantly relieve UTI symptoms.
👤 A 50-year-old man with a history of uric acid kidney stones
He was started on this medicine to prevent stone formation. His doctor monitored his urine pH regularly. He remained stone-free for over a year by following the prescribed dose and dietary advice.
💡 Lesson: Regular monitoring and adherence to the prescribed regimen are key to preventing kidney stones.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 30 to 60 minutes after taking a dose, but symptom relief may take a few days.

Q: Can I take this medicine with other medications?

A: It can interact with certain medicines like antacids and lithium. Always inform your doctor about all medicines you are taking.

Q: Is it safe to take during pregnancy?

A: Consult your doctor before use during pregnancy. The safety is not well established.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for alkapil syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any urinary infection without antibiotics.
    Fact: This medicine only relieves symptoms by alkalinizing urine; it does not kill bacteria. Antibiotics may be needed for bacterial infections.
  • Myth: It is safe to take this medicine with antacids.
    Fact: Aluminium-containing antacids can interact and cause toxicity. Always check with your doctor.

🔄 Alternative Options

Generic Alternatives

  • Disodium hydrogen citrate syrup

Brand Alternatives

  • Alkapil Syrup

📊 Comparison with Similar Medicines

[{"medicine":"Disodium hydrogen citrate","composition":"Disodium hydrogen citrate","uses":"Urinary alkalinizer","notes":"Contains sodium; caution in hypertension."},{"medicine":"Potassium citrate","composition":"Potassium citrate","uses":"Urinary alkalinizer","notes":"Contains potassium; caution in kidney disease."}]

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