Actamase 1000 mg/125 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Seizures or confusion
- Decreased urine output or swelling in legs
- Severe skin rash with blisters or peeling
- Persistent high fever despite treatment
If experiencing severe symptoms, call emergency services immediately.
What is alfapime tz 1000mg/125mg injection used for?
This medicine is a combination antibiotic injection containing cefepime and tazobactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and preventing their growth.
- Generic Name: Cefepime + Tazobactam
- Manufacturer: Alniche Life Sciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alfapime tz 1000mg/125mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयोजन एंटीबायोटिक इंजेक्शन है जिसमें सेफेपाइम और टैज़ोबैक्टम शामिल हैं। इसका उपयोग अस्पताल में गंभीर बैक्टीरियल संक्रमणों जैसे कि जटिल मूत्र पथ संक्रमण, निमोनिया, त्वचा संक्रमण और पेट के संक्रमण के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया को मारती है और उनके विकास को रोकती है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, दाने और इंजेक्शन स्थल पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में तेज एलर्जी प्रतिक्रिया, गंभीर दस्त, दौरे और गुर्दे की समस्या शामिल हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल में दी जाती है। अपनी सभी एलर्जी और गुर्दे या लीवर की समस्याओं के बारे में डॉक्टर को बताएं। इलाज के दौरान शराब न पिएं। दवा का पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। गंभीर दस्त, दाने या सांस लेने में कठिनाई होने पर तुरंत डॉक्टर से संपर्क करें।
💊 alfapime tz 1000mg/125mg injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and bladder infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"Effective against many bacteria causing lung infections acquired in hospital settings.","evidence":"Well-established"},{"condition":"Complicated skin and soft tissue infections","description":"Treats deep skin infections, including those caused by mixed bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for abdominal infections.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in patients with low white blood cell counts.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Bone and joint infections","description":"Sometimes used for osteomyelitis or septic arthritis when susceptible organisms are involved.","evidence":"Limited"},{"condition":"Meningitis","description":"May be used for bacterial meningitis caused by susceptible organisms, but not first-line.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Complicated urinary tract infections, Hospital-acquired pneumonia, Complicated skin and soft tissue infections, Intra-abdominal infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Cefepime + Tazobactam |
| Brand Name | Actamase |
| Manufacturer | Alniche Life Sciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Beta-lactamase inhibitor) |
| Route of Administration | Intravenous (IV) infusion over 30 minutes to 2 hours, depending on the dose and clinical setting |
| Storage | Store the unreconstituted vial at room temperature (20-25°C). After reconstitution, the solution should be used immediately or stored as directed by the manufacturer. Protect from light and freezing. |
| Shelf Life | Refer to the expiration date on the vial. Typically 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting bacterial cell wall synthesis. Cefepime binds to penicillin-binding proteins, disrupting peptidoglycan cross-linking and causing bacterial cell death. Tazobactam irreversibly inhibits certain beta-lactamase enzymes, protecting cefepime from degradation and extending its spectrum against beta-lactamase-producing bacteria.
Mechanism Steps
💡 How to Take alfapime tz 1000mg/125mg injection
Strength: 1000 mg cefepime / 125 mg tazobactam per vial for intravenous injection.
Dosage Information
| Adult Dosage | The usual adult dose is 1 gram to 2 grams of cefepime every 8 to 12 hours, depending on the severity of infection and kidney function. Tazobactam is fixed at 125 mg per dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and may require dose adjustment. Monitor renal function closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 30-60 mL/min, the usual dose may be given every 12 hours. For creatinine clearance 11-29 mL/min, the dose may be given every 24 hours. For patients on hemodialysis, a dose after each dialysis session is recommended. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment alone. However, dose must be individualized by a qualified clinician based on overall clinical status. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 grams of cefepime (e.g., 2 grams every 8 hours) for adults with normal renal function. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of alfapime tz 1000mg/125mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Warfarin | Major | |
| Loop diuretics | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Warfarin
- Loop diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol may worsen side effects such as nausea, dizziness, and rapid heartbeat. It can also increase the risk of liver problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cefepime, tazobactam, or other beta-lactam antibiotics","Previous severe allergic reaction to penicillins or cephalosporins"]
⚠️ Warnings & Precautions
["Serious hypersensitivity reactions can occur. Discontinue immediately if allergic reaction suspected.","Clostridioides difficile-associated diarrhea may occur. Report severe diarrhea.","Use with caution in patients with renal impairment. Dose adjustment may be needed.","May cause seizures, especially in patients with renal impairment or CNS disorders.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Monitor for superinfections."]
🤱 Lactation Safety
Cefepime and tazobactam are excreted in human milk in low amounts. Consult your doctor before breastfeeding. Monitor infant for diarrhea or thrush.
💊 Overdose Management
Overdose may cause nausea, vomiting, and seizures. Treatment is supportive. Hemodialysis may be considered to remove cefepime from the blood in severe cases. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a clinical setting. Inform your doctor about all your allergies, especially to antibiotics, and about any kidney or liver problems. Do not self-administer this injection. Complete the full course as prescribed, even if you feel better. Report any signs of severe diarrhea, rash, or difficulty breathing immediately. Avoid alcohol during treatment as it may worsen side effects. Your doctor may monitor your kidney function, liver function, and blood counts during therapy.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary. They may also be more susceptible to side effects such as confusion or seizures. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is generally considered safe in pregnancy when clearly needed, but the benefits and risks should be weighed. Use effective contraception during treatment if you are of childbearing age.
🏥 Post-Surgery Considerations
This medicine is often used to prevent or treat infections after surgery. It is important to complete the prescribed course to prevent surgical site infections. Follow your surgeon's instructions for wound care and follow-up.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used to prevent infection during dental procedures in certain high-risk patients. Your dentist may consult with your doctor before proceeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered. Light activity such as walking is encouraged if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work during treatment. You may feel tired or experience side effects that affect your ability to drive or operate machinery. It is best to rest and avoid driving until you feel fully recovered.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early may allow the infection to return and contribute to antibiotic resistance. Your doctor will determine when it is safe to stop based on your clinical response and test results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rarely, kidney or liver problems. It is important to use this medicine only as prescribed and for the recommended duration. Regular monitoring of kidney and liver function may be needed during prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the bacteria causing the infection, other antibiotics may be used.
Evidence: Well-establishedRest, hydration, and fever control can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, it is always good to keep your vaccinations up to date. Consult your doctor about timing of vaccines if you are on antibiotics.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel is not applicable. If you are discharged with a prescription for home infusion, carry the medicine in its original packaging with the prescription copy. Store it as directed and keep it away from extreme temperatures. Inform airport security about your medical condition and carry a doctor's letter. Check customs regulations for carrying injectable antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working immediately after infusion, but you may not feel better for 24-48 hours. Complete the full course as prescribed.
A: This medicine is usually given in a hospital or clinic. In some cases, home infusion may be arranged by your doctor with proper training.
A: If you miss a dose, contact your healthcare provider immediately. Do not try to self-administer a double dose.
🤔 Common Patient Concerns
🔄 Substitutes for alfapime tz 1000mg/125mg injection
View AllAlternative brands with exact same active ingredient:
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impeno tz 1000mg/125mg injectionTNT Lifesciences ₹136.00 84.7% CHEAPER
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nexpime xp 1000mg/125mg injectionProtech Telelinks ₹178.13 80% CHEAPER
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megapime xp 1000 mg/125 mg injectionAlkem Laboratories Ltd ₹204.38 77.1% CHEAPER
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qpime injectionQuick Heal Life Sciences ₹205.31 76.9% CHEAPER
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Tazowok 1000 mg/125 mg InjectionWockhardt Ltd ₹206.25 76.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance.
🔄 Alternative Options
Generic Alternatives
- Cefepime and Tazobactam injection
Brand Alternatives
- Actamase 1000 mg/125 mg injection