alfagaba nt 300 mg/10 mg tablet - Uses, Price, Side Effects & Substitutes
What is alfagaba nt 300 mg/10 mg tablet used for?
Acegaba NT 400mg/10mg Tablet (Gabapentin + Nortriptyline) is used to treat NEURO CNS. It contains Gabapentin (300mg) + Nortriptyline (10mg), which Gabapentin: Binds to ฮฑ2ฮด subunit of voltage-gated calcium channels, reducing c. Always consult your doctor before use. Take as prescribed.
- Generic Name: Gabapentin + Nortriptyline
- Manufacturer: Med Manor Organics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ alfagaba nt 300 mg/10 mg tablet Uses & Benefits
Neuropathic pain, fibromyalgia, diabetic neuropathy, postherpetic neuralgia, depression with neuropathic pain.
Off-label uses: Migraine prophylaxis, restless legs syndrome, bipolar disorder, anxiety disorders.
๐ Drug Information
| Generic Name(s) | Gabapentin + Nortriptyline |
| Brand Name | Acegaba NT 400mg/10mg Tablet |
| Manufacturer | Med Manor Organics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Gabapentinoid + Tricyclic Antidepressant |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Gabapentin: Binds to ฮฑ2ฮด subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release. Nortriptyline: Inhibits reuptake of norepinephrine and serotonin, potentiating their effects.
Mechanism Steps
๐ก How to Take alfagaba nt 300 mg/10 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of alfagaba nt 300 mg/10 mg tablet
โ Common Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Constipation
- Blurred vision
- Weight gain
- Peripheral edema
๐จ Serious Side Effects
- Suicidal thoughts
- Seizures
- QTc prolongation
- Arrhythmias
- Serotonin syndrome
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Agranulocytosis
- Pancreatitis
- Rhabdomyolysis
- Angle-closure glaucoma
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CNS depressants | Major | Enhanced sedation and respiratory depression |
| Alcohol | Major | Increased CNS depression |
| Anticholinergics | Major | Additive anticholinergic effects |
| CYP2D6 inhibitors | Moderate | Increased nortriptyline levels |
| CYP3A4 inducers | Moderate | Decreased nortriptyline levels |
| Antihypertensives | Moderate | Additive hypotensive effect |
| QTc-prolonging drugs | Moderate | Increased risk of arrhythmias |
| Antacids | Minor | Reduced gabapentin absorption |
| Cimetidine | Minor | Increased nortriptyline levels |
| Oral contraceptives | Minor | Possible reduced contraceptive efficacy |
๐จ Major Interactions
- MAOIs
- CNS depressants
- Alcohol
- Anticholinergics
โก Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inducers
- Antihypertensives
- QTc-prolonging drugs
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
- Oral contraceptives
๐ฝ๏ธ Food Interactions
High-fat meals may reduce gabapentin absorption; avoid grapefruit juice with nortriptyline.
๐ท Alcohol Interaction
Increased CNS depression and sedation; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, concurrent MAOI use, severe renal impairment (CrCl <30 mL/min), narrow-angle glaucoma, urinary retention.
๐ Monitoring Parameters
Renal function, liver function, ECG (QTc), serum drug levels (nortriptyline), blood pressure, mental status.
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Supportive care; activated charcoal, gastric lavage; for nortriptyline, monitor ECG and treat arrhythmias; gabapentin overdose may require hemodialysis.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.