akme clobetacon-gm skin cream - Chlorhexidine Gluconate (0.2% w/w) + Clobetasol (0.05% w/w) medicine

Akme Clobetacon-GM Skin Cream - Uses, Price, Side Effects

4.7 (19 reviews)
๐Ÿญ Akme Biotec ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 23, 2026

What is akme clobetacon-gm skin cream used for?

Akme Clobetacon-GM Skin Cream is a combination medicine used to treat skin infections like eczema, dermatitis, and psoriasis. It contains Chlorhexidine Gluconate (an antiseptic) and Clobetasol (a potent corticosteroid) that work together to reduce inflammation, itching, and kill bacteria and fungi on the skin.

  • Generic Name: Chlorhexidine Gluconate + Clobetasol Propionate
  • Manufacturer: Akme Biotec
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š akme clobetacon-gm skin cream Uses & Benefits

Eczema, psoriasis, dermatitis, allergic reactions, bacterial skin infections

Off-label uses: Lichen planus, discoid lupus erythematosus

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorhexidine Gluconate + Clobetasol Propionate
Brand NameAkme Clobetacon-GM Skin Cream
ManufacturerAkme Biotec
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassCorticosteroid + Antiseptic
Route of AdministrationTopical
StorageStore at room temperature (20-25ยฐC), away from moisture and heat
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical; minimal systemic absorption through intact skin, increased with damaged skin or prolonged use
DistributionPrimarily local; systemic distribution minimal under normal use
Protein BindingClobetasol: 90-95% bound to plasma proteins
MetabolismClobetasol: Hepatic via CYP3A4; Chlorhexidine: Minimal systemic metabolism
Half-LifeClobetasol: Approximately 2-3 hours (systemic); Chlorhexidine: Not applicable topically
ExcretionClobetasol: Renal and biliary; Chlorhexidine: Primarily fecal (unabsorbed)
BioavailabilityLow systemic bioavailability due to topical application
Onset of ActionWithin a few days of regular application
Peak Plasma TimeNot applicable for topical use; systemic levels minimal
Duration of ActionDepends on application frequency; typically 12-24 hours

How It Works

Clobetasol: Binds to glucocorticoid receptors, inhibiting phospholipase A2, reducing prostaglandin and leukotriene synthesis; Chlorhexidine: Disrupts microbial cell membranes

Mechanism Steps

1Clobetasol binds to glucocorticoid receptors in target cells
2Receptor-ligand complex translocates to nucleus
3Inhibits phospholipase A2, reducing arachidonic acid release

๐Ÿ’ก How to Take akme clobetacon-gm skin cream

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of akme clobetacon-gm skin cream

โœ… Common Side Effects

  • Skin burning
  • itching
  • irritation
  • dryness
  • folliculitis

๐Ÿšจ Serious Side Effects

  • Adrenal suppression
  • Cushing's syndrome
  • skin atrophy
  • secondary infection

โš ๏ธ Rare Side Effects

  • Allergic contact dermatitis
  • hypertrichosis
  • pigmentation changes

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Corticosteroids (systemic) Moderate Increased risk of skin atrophy and systemic effects
Other topical antiseptics Minor Possible irritation or reduced efficacy

๐Ÿšจ Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
  • Other topical corticosteroids

โšก Moderate Interactions

  • Anticoagulants (e.g., warfarin) - systemic absorption may enhance effect
  • Antidiabetic agents - may increase blood glucose

โ„น๏ธ Minor Interactions

  • None significant

๐Ÿฝ๏ธ Food Interactions

None known

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity to components, untreated bacterial/fungal/viral infections, rosacea, perioral dermatitis

๐Ÿ“Š Monitoring Parameters

Skin condition, signs of infection, adrenal suppression with prolonged use

๐Ÿคฑ Lactation Safety

Use with caution; avoid application to breast area

๐Ÿ’Š Overdose Management

Excessive topical use may cause systemic corticosteroid effects; treat symptomatically

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

๐Ÿ”— View Profile

โญ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

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