agrogesic plus gel - Uses, Price, Side Effects & Substitutes
What is agrogesic plus gel used for?
Arofen Plus Gel (Diclofenac diethylamine + Linseed Oil) is used to treat PAIN ANALGESICS. It contains Diclofenac diethylamine (1.16% w/w) + Linseed Oil (3% w/w), which Diclofenac inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin syn. Always consult your doctor before use. Take as prescribed.
- Generic Name: Diclofenac diethylamine + Linseed Oil
- Manufacturer: Agresco Pharma
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ agrogesic plus gel Uses & Benefits
Local relief of pain and inflammation in musculoskeletal conditions such as sprains, strains, arthritis, and soft tissue injuries
Off-label uses: Tendinopathy, bursitis, local inflammatory conditions not approved in label
๐ Drug Information
| Generic Name(s) | Diclofenac diethylamine + Linseed Oil |
| Brand Name | Arofen Plus Gel |
| Manufacturer | Agresco Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Herbal Emollient |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30ยฐC); keep tube tightly closed; avoid freezing |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis; Linseed oil provides emollient and anti-inflammatory effects via omega-3 fatty acids
Mechanism Steps
๐ก How to Take agrogesic plus gel
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of agrogesic plus gel
โ Common Side Effects
- Application site reactions (rash, itching, redness, burning)
- Dry skin
- Contact dermatitis
๐จ Serious Side Effects
- Severe allergic reactions (anaphylaxis)
- Angioedema
- Stevens-Johnson syndrome
- Gastrointestinal bleeding (rare with topical)
- Renal impairment (with extensive use)
โ ๏ธ Rare Side Effects
- Photosensitivity
- Exfoliative dermatitis
- Hepatitis
- Nephrotic syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk due to additive anticoagulant effect |
| Oral NSAIDs | Major | Increased risk of gastrointestinal ulceration and bleeding |
| Lithium | Major | Increased lithium levels and toxicity |
| Methotrexate | Major | Increased methotrexate toxicity |
| Anticoagulants | Major | Enhanced anticoagulant effect |
| Aspirin | Moderate | Increased risk of gastrointestinal side effects |
| Corticosteroids | Moderate | Increased risk of gastrointestinal ulceration |
| SSRIs | Moderate | Increased bleeding risk |
| Diuretics | Moderate | Reduced diuretic efficacy |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Antacids | Minor | May slightly reduce absorption of oral diclofenac (not relevant for topical) |
| Cholestyramine | Minor | May delay absorption of oral diclofenac |
| Digoxin | Minor | Possible increase in digoxin levels |
๐จ Major Interactions
- Warfarin
- Other NSAIDs (oral)
- Lithium
- Methotrexate
- Anticoagulants
โก Moderate Interactions
- Aspirin
- Corticosteroids
- SSRIs
- Diuretics
- ACE inhibitors
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
- Digoxin
๐ฝ๏ธ Food Interactions
No significant food interactions for topical use
๐ท Alcohol Interaction
No significant interaction with topical use
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to diclofenac, aspirin, or other NSAIDs; history of asthma, urticaria, or allergic reactions after NSAIDs; active peptic ulcer; severe renal or hepatic impairment; third trimester of pregnancy; application to open wounds or broken skin
๐ Monitoring Parameters
Monitor for local skin reactions (rash, itching, irritation); assess pain relief; in long-term use, monitor renal function and liver enzymes if extensive application
๐คฑ Lactation Safety
Use with caution; minimal systemic absorption, but avoid application to breast area
๐ Overdose Management
Topical overdose unlikely; if ingested accidentally, treat symptomatically; for systemic toxicity, consider activated charcoal and supportive care
โฐ Missed Dose
Apply as soon as remembered; if near next dose, skip missed dose and resume regular schedule; do not double dose