afoglip m 500 tablet er - Uses, Price, Side Effects & Substitutes
What is afoglip m 500 tablet er used for?
Afoglip M 500 Tablet ER (Metformin + Teneligliptin) is used to treat Type 2 diabetes mellitus as an adjunct to diet and exercise. It contains Metformin (500mg) + Teneligliptin (20mg), which Metformin: Decreases hepatic glucose production, increases insulin sensitivity; . Always consult your doctor before use. Take as prescribed.
- Generic Name: Metformin + Teneligliptin
- Manufacturer: Torrent Pharmaceuticals Ltd
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 afoglip m 500 tablet er के बारे में संक्षिप्त जानकारी (Hindi Summary)
afoglip m 500 tablet er का उपयोग मुख्य रूप से anti diabetic और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Metformin (500mg) + Teneligliptin (20mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
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📋 Drug Information
| Generic Name(s) | Metformin + Teneligliptin |
|---|---|
| Brand Name | Afoglip M 500 Tablet ER |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | Antidiabetic (Biguanide + DPP-4 inhibitor) |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25°C), protect from light and moisture. |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
💡 How and when to take afoglip m 500 tablet er?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at room temperature (20-25°C), protect from light and moisture.
⚙️ How afoglip m 500 tablet er Works
Metformin: Decreases hepatic glucose production, increases insulin sensitivity; Teneligliptin: Inhibits DPP-4, increasing incretin levels (GLP-1, GIP), enhancing insulin secretion and decreasing glucagon.
💊 afoglip m 500 tablet er Uses in Hindi (Ke Fayde), Benefits & Indications
Type 2 diabetes mellitus as an adjunct to diet and exercise, when monotherapy with metformin or teneligliptin is inadequate.
Off-label uses: Polycystic ovary syndrome (metformin), gestational diabetes (metformin), prevention of type 2 diabetes (metformin).
⚠️ What are the side effects of afoglip m 500 tablet er?
✅ Common Side Effects
- Nausea
- Diarrhea
- Abdominal discomfort
- Headache
- Nasopharyngitis
- Hypoglycemia (when combined with other agents)
🚨 Serious Side Effects
- Lactic acidosis
- Pancreatitis
- Severe hypersensitivity reactions
- Acute renal failure
- Hepatic injury
⚠️ Rare Side Effects
- Vitamin B12 deficiency
- Metallic taste
- Urticaria
- Angioedema
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Iodinated contrast agents | Major | Increased risk of lactic acidosis; discontinue metformin temporarily |
| Cimetidine | Major | Reduced renal clearance of metformin |
| Cationic drugs (e.g., amiloride, digoxin, procainamide) | Major | Competitive renal tubular secretion |
| Insulin | Moderate | Increased risk of hypoglycemia |
| Sulfonylureas | Moderate | Increased risk of hypoglycemia |
| Alcohol | Moderate | Increased risk of lactic acidosis |
| Furosemide | Minor | Increased metformin plasma concentration |
| Nifedipine | Minor | Increased metformin absorption |
| Topiramate | Minor | Possible decreased metformin efficacy |
🚨 Major Interactions
- Contrast agents (iodinated)
- Cimetidine
- Cationic drugs eliminated by renal tubular secretion
⚡ Moderate Interactions
- Insulin
- Sulfonylureas
- Thiazolidinediones
- Alcohol
ℹ️ Minor Interactions
- Furosemide
- Nifedipine
- Topiramate
🍽️ Food Interactions
Alcohol, High-fat meals may affect absorption
🍷 Alcohol Interaction
Increased risk of lactic acidosis with metformin
🛡️ Safety & Warnings
🚫 Contraindications
Severe renal impairment (eGFR <30 mL/min), metabolic acidosis, acute or chronic metabolic acidosis, diabetic ketoacidosis, hypersensitivity, hepatic impairment, acute myocardial infarction, sepsis.
📊 Monitoring Parameters
Blood glucose, HbA1c, renal function (eGFR), liver function, vitamin B12 levels (long-term metformin), signs of lactic acidosis.
🤱 Lactation Safety
Metformin excreted in milk; Teneligliptin unknown; avoid breastfeeding.
💊 Overdose Management
Supportive care; monitor blood glucose and lactate; hemodialysis may remove metformin.
⏰ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if next dose is due.
🛑 Myths vs. Facts about afoglip m 500 tablet er
- Myth: Generic substitutes of afoglip m 500 tablet er are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Metformin (500mg) + Teneligliptin (20mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of afoglip m 500 tablet er can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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