Adidase Tablet - Uses, Price, Side Effects
What is adidase tablet used for?
Adidase Tablet is a combination of Diclofenac and Paracetamol used to relieve pain and inflammation in conditions like arthritis, muscle pain, and dental pain. Diclofenac works by blocking prostaglandin synthesis, while Paracetamol reduces fever and pain. It is typically taken twice daily with food.
- Generic Name: Diclofenac + Paracetamol
- Manufacturer: Adips Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ adidase tablet Uses & Benefits
Management of mild to moderate pain, fever, and inflammation (e.g., headache, dental pain, menstrual cramps, musculoskeletal pain).
Off-label uses: Diclofenac: Topical for actinic keratosis; Paracetamol: None commonly.
๐ Drug Information
| Generic Name(s) | Diclofenac + Paracetamol |
| Brand Name | At Sp Tablet |
| Manufacturer | Adips Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Diclofenac: Inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis; Paracetamol: Central COX inhibition and activation of descending serotonergic pathways.
Mechanism Steps
๐ก How to Take adidase tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of adidase tablet
โ Common Side Effects
- Nausea
- Vomiting
- Dyspepsia
- Abdominal pain
- Diarrhea
- Constipation
- Headache
- Dizziness
- Rash
๐จ Serious Side Effects
- GI bleeding
- Peptic ulcer
- Hepatotoxicity
- Renal failure
- Cardiovascular thrombotic events
- Stevens-Johnson syndrome
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Pancreatitis
- Hematologic disorders (agranulocytosis, thrombocytopenia)
- Interstitial nephritis
- Hepatic necrosis
- Aseptic meningitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Lithium | Moderate | Increased lithium toxicity |
| Methotrexate | Moderate | Increased methotrexate toxicity |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- ACE inhibitors
- Diuretics
- Aspirin
- Other NSAIDs
- Anticoagulants
โก Moderate Interactions
- Corticosteroids
- SSRIs
- Alcohol
- Cyclosporine
- Tacrolimus
- Quinolone antibiotics
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
- Digoxin
- Phenytoin
๐ฝ๏ธ Food Interactions
Food may delay absorption of diclofenac; paracetamol absorption unaffected.
๐ท Alcohol Interaction
Increased risk of hepatotoxicity with chronic alcohol use (paracetamol) and GI bleeding (diclofenac).
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to diclofenac, paracetamol, or any component; Active peptic ulcer; History of GI bleeding; Severe hepatic or renal impairment; Third trimester of pregnancy; Asthma with NSAID sensitivity; Coronary artery bypass graft surgery.
๐ Monitoring Parameters
Liver function tests, renal function, blood pressure, signs of GI bleeding, CBC (if prolonged use).
๐คฑ Lactation Safety
Diclofenac: Excreted in breast milk in low amounts, generally considered safe; Paracetamol: Excreted
๐ Overdose Management
Paracetamol overdose: Administer N-acetylcysteine; Diclofenac overdose: Supportive care, activated charcoal if recent ingestion.
โฐ Missed Dose
Take as soon as remembered unless near time of next dose; do not double dose.