Acutrol C 400 Tablet (Sevelamer 400mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain with vomiting and inability to pass stool or gas
- Blood in vomit or black, tarry stools
- Difficulty swallowing or chest pain when swallowing
- Swelling of the face, lips, or throat, or difficulty breathing
- Unusual muscle weakness, bone pain, or confusion
- Rapid breathing or extreme tiredness
- Signs of dehydration such as very dark urine, dizziness, or fainting
If experiencing severe symptoms, call emergency services immediately.
What is acutrol c 400 tablet used for?
This medicine is a phosphate binder used to lower high phosphate levels in people with chronic kidney disease. It works by binding phosphate from food in the gut so it cannot be absorbed into the body. It is taken with meals and is not absorbed into the bloodstream.
- Generic Name: Sevelamer
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acutrol c 400 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से गुर्दे की बीमारी (किडनी डिजीज) वाले मरीजों में खून में फॉस्फेट का स्तर बढ़ने (हाइपरफॉस्फेटेमिया) के इलाज के लिए इस्तेमाल की जाती है। जब किडनी ठीक से काम नहीं करती, तो शरीर से अतिरिक्त फॉस्फेट बाहर नहीं निकल पाता, जिससे हड्डियों और दिल पर बुरा असर पड़ सकता है। यह दवा खाने के साथ लेने पर पेट और आंतों में फॉस्फेट को बांध लेती है, जिससे वह शरीर में अवशोषित नहीं हो पाता और मल के रास्ते बाहर निकल जाता है। यह दवा डायलिसिस कराने वाले मरीजों के लिए भी बहुत उपयोगी है। इसे डॉक्टर की सलाह के अनुसार ही लें और नियमित रूप से खून की जांच कराते रहें।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभाव पेट और आंतों से जुड़े होते हैं, जैसे जी मिचलाना, उल्टी होना, पेट में दर्द, कब्ज, दस्त या अपच। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कब्ज से बचने के लिए भरपूर पानी पिएं और फाइबर युक्त भोजन करें, जब तक डॉक्टर ने कुछ और न कहा हो। कभी-कभी यह दवा खून में फॉस्फेट को बहुत कम कर सकती है, जिससे मांसपेशियों में कमजोरी या हड्डियों में दर्द हो सकता है। बहुत कम मामलों में गंभीर कब्ज या आंतों में रुकावट हो सकती है। अगर पेट में तेज दर्द, उल्टी या मल त्याग में परेशानी हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन के साथ। गोली को पूरा निगलें, चबाएं या तोड़ें नहीं। यह दवा भोजन के साथ लेने पर ही अच्छी तरह काम करती है, क्योंकि यह भोजन से फॉस्फेट को बांधती है। अन्य दवाओं को इस दवा से कम से कम 1 घंटा पहले या 3 घंटे बाद लें, जब तक डॉक्टर ने कुछ और न कहा हो। अपनी सभी जांचें समय पर कराते रहें ताकि डॉक्टर फॉस्फेट, कैल्शियम और बाइकार्बोनेट के स्तर की निगरानी कर सकें। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। इस दवा को कमरे के तापमान पर, नमी और धूप से दूर, बच्चों की पहुंच से बाहर रखें।
💊 acutrol c 400 tablet Uses & Benefits
[{"condition":"Hyperphosphatemia in chronic kidney disease","description":"This medicine is used to lower high phosphate levels in patients with chronic kidney disease, including those on dialysis, by binding phosphate in the gut and preventing its absorption.","evidence":"Well-established"},{"condition":"Hyperphosphatemia in dialysis patients","description":"It is commonly prescribed for patients receiving hemodialysis or peritoneal dialysis who cannot control phosphate levels with diet alone.","evidence":"Well-established"},{"condition":"Adjunct to dietary phosphate restriction","description":"This medicine is used together with a low-phosphate diet to help achieve target phosphate levels.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Hyperphosphatemia in non-dialysis chronic kidney disease","description":"Sometimes used in earlier stages of chronic kidney disease to control phosphate, though the benefit in this group is still being studied.","evidence":"Limited"},{"condition":"Reduction of cardiovascular calcification","description":"Because it does not contain calcium, it has been studied for reducing calcium deposition in blood vessels, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Hyperphosphatemia in chronic kidney disease
Also treats: Chronic kidney disease, End-stage renal disease, Dialysis patients
📋 Drug Information
| Generic Name(s) | Sevelamer |
| Brand Name | Acutrol C 400 Tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTHERS |
| Action Class | Phosphorous binder |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in their original container, tightly closed, away from moisture and direct sunlight. Do not store in the bathroom. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works as a non-absorbed phosphate binder. After you swallow the tablet, the active ingredient, Sevelamer, travels through the stomach and intestines without being broken down or absorbed into the bloodstream. In the gut, it acts like a magnet for phosphate from your food. It binds phosphate molecules in the digestive tract and forms a large complex that cannot cross the intestinal wall. This bound phosphate then travels through the intestines and is eliminated in the stool. By preventing phosphate absorption, this medicine helps lower the amount of phosphate that reaches your blood. Over time, this reduces the risk of high phosphate damaging your bones, blood vessels, and heart. Because it does not contain calcium or aluminum, it avoids adding extra mineral load to your body. This medicine also has the ability to bind bile acids, which may help lower cholesterol, but this effect is secondary to its phosphate-binding action.
Mechanism Steps
💡 How to Take acutrol c 400 tablet
Strength: Sevelamer 400 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for adults is 800 mg to 1600 mg taken with each meal, but the exact dose depends on your serum phosphate level and your diet. Your doctor will adjust the dose based on regular blood tests. The maximum daily dose should not exceed 2400 mg per meal or as directed by your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients can take this medicine at the same doses as younger adults, but they may be more prone to constipation and dehydration. Close monitoring of bowel habits and fluid intake is advised. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is required for renal impairment because this medicine is not absorbed and acts locally in the gut. However, it is specifically used in patients with kidney disease, and phosphate levels should guide dosing. |
| Hepatic Impairment | No dose adjustment is required for hepatic impairment because this medicine is not absorbed or metabolized by the liver. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the prescribed regimen. Typically, doses up to 2400 mg per meal have been used, but the total daily dose should not exceed what your doctor has prescribed. Always follow your doctor's instructions. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acutrol c 400 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Levothyroxine | Major | |
| Warfarin | Major | |
| Tacrolimus | Moderate | |
| Mycophenolate mofetil | Moderate | |
| Metformin | Moderate | |
| Amoxicillin | Minor | |
| Aspirin | Minor |
🚨 Major Interactions
- Ciprofloxacin
- Levothyroxine
- Warfarin
⚡ Moderate Interactions
- Tacrolimus
- Mycophenolate mofetil
- Metformin
🍷 Alcohol Interaction
There is no direct interaction between alcohol and this medicine. However, alcohol can irritate the stomach and worsen nausea or stomach pain. It is best to avoid or limit alcohol while taking this medicine, especially if you have kidney disease.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Bowel obstruction","Severe constipation or history of bowel obstruction","Known hypersensitivity to Sevelamer or any component of the tablet","Low phosphate levels (hypophosphatemia)"]
⚠️ Warnings & Precautions
["This medicine can cause constipation, which may rarely lead to bowel obstruction. Report severe constipation or abdominal pain immediately.","It may reduce the absorption of other medicines. Take other oral drugs at least 1 hour before or 3 hours after this medicine, unless instructed otherwise.","Patients with a history of gastrointestinal surgery or bowel problems should use this medicine with caution.","This medicine may lower bicarbonate levels. Your doctor may monitor this with blood tests.","Do not take this medicine if you have low phosphate levels.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep all follow-up appointments for blood tests to monitor phosphate and calcium levels."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Since it is not absorbed into the bloodstream, the amount in breast milk is expected to be negligible. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious harm because it is not absorbed. However, large amounts may cause severe constipation or bowel obstruction. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and may include measures to relieve constipation.
⏰ Missed Dose
If you miss a dose, take it with your next meal if it is almost time for that meal. If you remember long after the meal, skip the missed dose and take the next dose with your next meal. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually with meals. Swallow the tablet whole with a glass of water; do not crush, chew, or break it unless your doctor or pharmacist says it is okay. Because this medicine binds phosphate from food, it works best when taken at the same time as your meals or within a short time after eating. Do not take other medicines at the same time as this medicine, because it can reduce the absorption of some drugs. As a general rule, take other oral medicines at least one hour before or three hours after this medicine, unless your doctor has given you different instructions. Keep all your laboratory appointments so your doctor can check your phosphate, calcium, and bicarbonate levels. Do not stop taking this medicine on your own, even if you feel well, because high phosphate often has no symptoms until complications develop. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also inform your doctor about all other medicines, vitamins, and supplements you take, especially thyroid medicines, antibiotics, and heart medicines. Store this medicine at room temperature, away from moisture and direct sunlight, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to constipation and dehydration while taking this medicine. Ensure adequate fluid intake and monitor bowel habits. Dose adjustments are not usually needed, but close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss this medicine with your doctor. It is not absorbed systemically, so it is unlikely to affect fertility or the developing baby, but your doctor may want to monitor your phosphate levels closely during pregnancy.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be paused briefly around the time of surgery, especially if you need to fast. Follow your doctor's instructions.
🦷 Dental Procedures
This medicine does not usually interfere with dental procedures. However, inform your dentist about all medicines you take. If you need to fast for a procedure, ask your doctor how to adjust your dose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine does not usually limit exercise. However, if you have bone pain or muscle weakness from kidney disease or low phosphate, avoid high-impact activities and consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is not expected to affect your ability to work or drive. However, if you experience dizziness or severe stomach upset, avoid driving or operating heavy machinery until you feel better. Take it with meals to minimize stomach side effects.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. It is usually continued long-term to control phosphate levels. Your doctor may adjust or stop it if your phosphate levels become too low or if you develop serious side effects such as bowel obstruction.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe because it is not absorbed. The main concern is the risk of constipation and, rarely, bowel obstruction. It may also lower bicarbonate levels, so periodic blood tests are needed. Long-term use helps control phosphate and may reduce the risk of bone disease and cardiovascular calcification. Regular monitoring of phosphate, calcium, and bicarbonate is essential. Do not stop the medicine without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Limiting high-phosphate foods can help control phosphate levels and may reduce the dose of medicine needed.
Evidence: Well-establishedThese are alternatives but may increase calcium load and are not suitable for all patients.
Evidence: Well-establishedAnother non-calcium phosphate binder that can be used if this medicine is not tolerated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, patients with chronic kidney disease should follow their doctor's recommendations for vaccinations, including hepatitis B, influenza, and pneumococcal vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription and a doctor's note explaining that you need this medicine for a chronic condition. Keep enough supply in your carry-on luggage in case of delays. Store at room temperature and avoid extreme heat or cold. If crossing time zones, continue taking the medicine with your meals as usual. Check customs regulations for carrying prescription medicines into your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working with the first dose taken with food, but it may take several days to weeks to see a significant drop in phosphate levels. Regular blood tests will show how well it is working.
A: No, this medicine must be taken with meals to bind phosphate effectively. Taking it without food reduces its effectiveness.
A: If you miss a dose, take it with your next meal if it is mealtime. If you remember after the meal, skip the missed dose and take the next dose with your next meal. Do not double dose.
A: Yes, it can reduce the absorption of some medicines, including thyroid medicines, certain antibiotics, and blood thinners. Take other medicines at least 1 hour before or 3 hours after this medicine, unless your doctor says otherwise.
A: Data on use in pregnancy are limited. Since it is not absorbed into the bloodstream, it is unlikely to harm the fetus, but you should consult your doctor before using it during pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for acutrol c 400 tablet
View AllAlternative brands with exact same active ingredient:
-
sevcar sachetEmcure Pharmaceuticals Ltd ₹31.31 82.8% CHEAPER
-
davaindia sevelamer 400mg tablet dtDavaindia Generic Pharmacy ₹55.00 69.8% CHEAPER
-
sevgia 400mg tabletHygeia Pharmaceuticals ₹89.06 51% CHEAPER
-
forsemer 400mg tabletMicro Labs Ltd ₹92.81 49% CHEAPER
-
phoslam 400mg tabletLividus Pharmaceuticals Pvt Ltd ₹92.81 49% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without food.
Fact: This medicine must be taken with meals to bind phosphate effectively. Taking it without food reduces its effectiveness. - Myth: This medicine contains calcium.
Fact: This medicine does not contain calcium or aluminum. It is a non-calcium-based phosphate binder. - Myth: This medicine can be stopped once phosphate levels are normal.
Fact: High phosphate often has no symptoms, and stopping the medicine can cause levels to rise again. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Sevelamer 400 mg tablet
Brand Alternatives
- Acutrol C 400 Tablet