actorise 200 injection - Uses, Price, Side Effects & Substitutes
What is actorise 200 injection used for?
Actorise 25 Injection (Darbepoetin alfa) is used to treat BLOOD RELATED. It contains Darbepoetin alfa (200mcg), which Stimulates erythropoiesis by binding to erythropoietin receptors on erythroid pr. Always consult your doctor before use. Take as prescribed.
- Generic Name: Darbepoetin alfa
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ actorise 200 injection Uses & Benefits
Treatment of anemia associated with chronic kidney disease (CKD) in patients on dialysis and not on dialysis; treatment of anemia in patients with non-myeloid malignancies receiving chemotherapy.
Off-label uses: Anemia in myelodysplastic syndromes, anemia in HIV patients on zidovudine, anemia of prematurity.
๐ Drug Information
| Generic Name(s) | Darbepoetin alfa |
| Brand Name | Actorise 25 Injection |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Erythropoiesis-stimulating agent (ESA) |
| Route of Administration | Subcutaneous or intravenous injection. |
| Storage | Store at 2ยฐC to 8ยฐC (refrigerate). Do not freeze. Protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Stimulates erythropoiesis by binding to erythropoietin receptors on erythroid progenitor cells, promoting their survival, proliferation, and differentiation.
Mechanism Steps
๐ก How to Take actorise 200 injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of actorise 200 injection
โ Common Side Effects
- Hypertension
- Headache
- Arthralgia
- Fatigue
- Diarrhea
- Nausea
- Vomiting
- Injection site pain
๐จ Serious Side Effects
- Thrombotic events (stroke, MI, DVT)
- Hypertensive encephalopathy
- Pure red cell aplasia
- Seizures
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Hyperkalemia
- Hyperphosphatemia
- Myalgia
- Rash
- Urticaria
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk due to enhanced red cell mass and potential for thrombosis. |
| Heparin | Major | Increased risk of thrombosis. |
| ACE inhibitors | Moderate | May attenuate erythropoietic response. |
| Angiotensin II receptor blockers | Moderate | May attenuate erythropoietic response. |
| Iron supplements | Minor | Concomitant use may enhance erythropoiesis. |
| Folic acid | Minor | Concomitant use may enhance erythropoiesis. |
๐จ Major Interactions
- Warfarin
- Heparin
โก Moderate Interactions
- ACE inhibitors
- Angiotensin II receptor blockers
โน๏ธ Minor Interactions
- Iron supplements
- Folic acid
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Uncontrolled hypertension, known hypersensitivity to darbepoetin alfa or any component, pure red cell aplasia (PRCA) with prior erythropoietin therapy.
๐ Monitoring Parameters
Hemoglobin (weekly until stable, then monthly), blood pressure, iron stores (ferritin, transferrin saturation), CBC with differential.
๐คฑ Lactation Safety
Unknown if excreted in human milk; caution advised.
๐ Overdose Management
Monitor hemoglobin and blood pressure; phlebotomy may be considered if hemoglobin exceeds target. Supportive care for hypertension.
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose and resume regular schedule. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for actorise 200 injection
View AllAlternative brands with exact same active ingredient (Darbepoetin alfa (200mcg)):
-
ibidarb 200mcg injectionIndiabulls pharmaceutical ltd โน9,285.71 38.1% CHEAPER
-
derise 200 injectionHetero Drugs Ltd โน9,600.00 36% CHEAPER
-
zynesp 200 injectionZydus Cadila โน10,500.00 30% CHEAPER
-
cresp onco 200mcg injectionDr Reddy's Laboratories Ltd โน10,570.00 29.6% CHEAPER
-
darbelife 200 injectionHetero Drugs Ltd โน10,771.00 28.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.