acticuf cd 2mg/10mg syrup - Chlorpheniramine Maleate (2mg) + Codeine (10mg) medicine

Acticuf CD 2mg/10mg Syrup - Uses, Price, Side Effects

4.6 (14 reviews)
๐Ÿญ Pharmed Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is acticuf cd 2mg/10mg syrup used for?

Acticuf CD 2mg/10mg Syrup is a combination medicine used for the symptomatic relief of dry cough and allergic conditions. It contains Chlorpheniramine Maleate, an antihistamine that reduces allergy symptoms, and Codeine, an opioid cough suppressant that acts on the cough center in the brain to reduce the urge to cough.

  • Generic Name: Chlorpheniramine Maleate + Codeine
  • Manufacturer: Pharmed Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š acticuf cd 2mg/10mg syrup Uses & Benefits

Symptomatic relief of cough associated with allergies or cold

Off-label uses: Not commonly used off-label

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorpheniramine Maleate + Codeine
Brand NameAscoril C Syrup
ManufacturerPharmed Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntitussive and Antihistamine Combination
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract
DistributionWidely distributed; crosses blood-brain barrier and placenta
Protein BindingChlorpheniramine: ~72%; Codeine: ~7-25%
MetabolismChlorpheniramine: Hepatic via CYP450; Codeine: Hepatic via CYP2D6 to morphine
Half-LifeChlorpheniramine: 14-24 hours; Codeine: 2.5-4 hours
ExcretionRenal (primarily as metabolites)
BioavailabilityChlorpheniramine: ~25-50%; Codeine: ~90%
Onset of ActionChlorpheniramine: 30-60 minutes; Codeine: 30-60 minutes
Peak Plasma TimeChlorpheniramine: 2-6 hours; Codeine: 1-2 hours
Duration of ActionChlorpheniramine: 4-6 hours; Codeine: 4-6 hours

How It Works

Chlorpheniramine: H1-receptor antagonist; Codeine: mu-opioid receptor agonist

Mechanism Steps

1Chlorpheniramine blocks H1 receptors, reducing histamine-mediated cough reflex and allergic symptoms
2Codeine binds to mu-opioid receptors in the cough center of the medulla oblongata, suppressing cough reflex
3Codeine is metabolized by CYP2D6 to morphine, which contributes to analgesic and antitussive effects

๐Ÿ’ก How to Take acticuf cd 2mg/10mg syrup

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of acticuf cd 2mg/10mg syrup

โœ… Common Side Effects

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Nausea
  • Constipation

๐Ÿšจ Serious Side Effects

  • Respiratory depression
  • Hypotension
  • Seizures
  • Serotonin syndrome

โš ๏ธ Rare Side Effects

  • QT prolongation
  • Urinary retention
  • Blurred vision
  • Allergic dermatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Alcohol Major Increased CNS depression and sedation
MAOIs Major Risk of hypertensive crisis
CNS Depressants Moderate Additive sedation and respiratory depression

๐Ÿšจ Major Interactions

  • MAOIs
  • CNS depressants
  • Alcohol
  • Opioid analgesics

โšก Moderate Interactions

  • Anticholinergics
  • Antihypertensives
  • CYP2D6 inhibitors

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Ritonavir

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase codeine levels

๐Ÿท Alcohol Interaction

Enhanced CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Low
Heart
Moderate
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity, respiratory depression, asthma, MAOI use, children <12 years (codeine risk)

๐Ÿ“Š Monitoring Parameters

Respiratory rate, sedation level, cough frequency, allergic reactions

๐Ÿคฑ Lactation Safety

Not recommended; codeine excreted in breast milk

๐Ÿ’Š Overdose Management

Supportive care, naloxone for codeine overdose, antihistamine toxicity management

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

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