Acromus 0.1% Eye Ointment - Uses, Price, Side Effects
What is acromus 0.1% eye ointment used for?
Acromus 0.1% Eye Ointment contains Tacrolimus, an immunosuppressant used to treat inflammatory eye conditions like vernal keratoconjunctivitis and uveitis. It works by suppressing the immune response that causes inflammation, reducing redness, swelling, and discomfort. Apply a thin layer to the affected eye as directed by your doctor.
- Generic Name: Tacrolimus
- Manufacturer: Pharmatak Opthalmics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ acromus 0.1% eye ointment Uses & Benefits
Prophylaxis of organ rejection in kidney, liver, and heart transplant recipients.
Off-label uses: Autoimmune hepatitis, Ulcerative colitis, Atopic dermatitis, Nephrotic syndrome
๐ Drug Information
| Generic Name(s) | Tacrolimus |
| Brand Name | Advagraf |
| Manufacturer | Pharmatak Opthalmics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunosuppressant- Calcineurin inhibitors |
| Route of Administration | Oral |
| Storage | Store at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines.
Mechanism Steps
๐ก How to Take acromus 0.1% eye ointment
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of acromus 0.1% eye ointment
โ Common Side Effects
- Tremor
- Headache
- Diarrhea
- Hypertension
- Nausea
- Renal impairment
- Hyperglycemia
- Hyperkalemia
- Insomnia
- Paresthesia
๐จ Serious Side Effects
- Nephrotoxicity
- Neurotoxicity (e.g., seizures, encephalopathy)
- Posterior reversible encephalopathy syndrome (PRES)
- Thrombotic microangiopathy
- Anaphylaxis
- Lymphoma
- Skin malignancies
โ ๏ธ Rare Side Effects
- Hemolytic uremic syndrome
- Cardiomyopathy
- Leukoencephalopathy
- Pure red cell aplasia
- Interstitial lung disease
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Cyclosporine | Major | Increased risk of nephrotoxicity |
| Corticosteroids | Moderate | Increased immunosuppression |
| Live vaccines | Major | Risk of disseminated infection |
๐จ Major Interactions
- Ciclosporin
- Sirolimus
- Potassium-sparing diuretics
- ACE inhibitors
- NSAIDs
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- Antacids
โน๏ธ Minor Interactions
- Grapefruit juice
- Magnesium-containing antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice increases tacrolimus levels, High-fat meals decrease absorption
๐ท Alcohol Interaction
Alcohol may increase hepatotoxicity risk; avoid excessive consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to tacrolimus or any excipients; concomitant use with cyclosporine.
๐ Monitoring Parameters
Tacrolimus trough levels, renal function, liver function, blood pressure, blood glucose, electrolytes (especially potassium), and signs of infection.
๐คฑ Lactation Safety
Not recommended; excreted in breast milk.
๐ Overdose Management
Supportive care; no specific antidote. Hemodialysis not effective.
โฐ Missed Dose
Take as soon as remembered unless close to next dose; skip missed dose if near next dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for acromus 0.1% eye ointment
View AllAlternative brands with exact same active ingredient (Tacrolimus (0.1%)):
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taclix 0.1% ointmentBiochemix Health Care Pvt. Ltd. โน80.63 57% CHEAPER
-
tacrosze 0.1% ointmentZeelab Pharmacy Pvt Ltd โน100.00 46.7% CHEAPER
-
tacronid creamNidus Pharma Pvt Ltd โน101.25 46% CHEAPER
-
tacsus 0.1% ointmentBiovalence Skin Care โน196.88 5% COSTLIER
-
Tactis 0.1% OintmentJabs Biotech Pvt Ltd โน225.00 20% COSTLIER
-
acroli forte ointmentPsycormedies โน233.44 24.5% COSTLIER
-
cossrim forte 0.1% ointmentCosmoderm India โน234.38 25% COSTLIER
-
tic tac 0.1% ointmentCutis Biologicals โน234.38 25% COSTLIER
-
Tacrostar 0.1% OintmentUnimarck Healthcare Ltd โน234.38 25% COSTLIER
-
Tarmus OintmentParidhi Remedies โน234.38 25% COSTLIER
Medical Note: Always consult your doctor before switching medications.