acroli ointment - Tacrolimus (0.03% w/w) medicine

Acroli Ointment (Tacrolimus 0.03% w/w) - Uses, Price, Side Effects

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Tacrolimus (0.03% w/w)
🏭 Psycormedies 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

What is acroli ointment used for?

Acroli Ointment contains Tacrolimus 0.03% w/w, a topical calcineurin inhibitor used to treat moderate to severe eczema (atopic dermatitis) and psoriasis. It works by suppressing the immune response that causes skin inflammation and itching. Apply a thin layer to affected areas twice daily as directed by your doctor.

  • Generic Name: Tacrolimus
  • Manufacturer: Psycormedies
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 acroli ointment Uses & Benefits

Prophylaxis of organ rejection in kidney, liver, and heart transplant recipients.

Off-label uses: Autoimmune hepatitis, Ulcerative colitis, Atopic dermatitis, Nephrotic syndrome

📋 Drug Information

Generic Name(s)Tacrolimus
Brand NameAdvagraf
ManufacturerPsycormedies
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassImmunosuppressant- Calcineurin inhibitors
Route of AdministrationOral
StorageStore at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAbsorbed from the gastrointestinal tract; absorption is variable and incomplete.
DistributionExtensively distributed; high concentration in erythrocytes.
Protein BindingApproximately 99% bound to plasma proteins, mainly albumin and alpha-1-acid glycoprotein.
MetabolismMetabolized primarily in the liver via CYP3A4 and CYP3A5.
Half-LifeApproximately 8.7 hours in healthy volunteers; longer in patients with hepatic impairment.
ExcretionPrimarily excreted in bile and feces; less than 1% excreted unchanged in urine.
BioavailabilityVariable; approximately 17-23% after oral administration.
Onset of ActionRapid; immunosuppressive effects occur within hours.
Peak Plasma Time1-3 hours for immediate-release; prolonged for extended-release (Advagraf).
Duration of Action12-24 hours; dosing interval depends on formulation.

How It Works

Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines.

Mechanism Steps

1Tacrolimus binds to FKBP12 in T-cells.
2Tacrolimus-FKBP12 complex binds to calcineurin.
3Inhibits calcineurin's phosphatase activity.
4Prevents dephosphorylation of NF-AT.
5NF-AT cannot translocate to nucleus.
6Reduced transcription of IL-2 and other cytokines.
7Suppresses T-cell activation and proliferation.

💡 How to Take acroli ointment

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of acroli ointment

✅ Common Side Effects

Tremor
Headache
Diarrhea
Hypertension
Nausea
Renal impairment
Hyperglycemia
Hyperkalemia
Insomnia
Paresthesia

🚨 Serious Side Effects

Nephrotoxicity
Neurotoxicity (e.g., seizures, encephalopathy)
Posterior reversible encephalopathy syndrome (PRES)
Thrombotic microangiopathy
Anaphylaxis
Lymphoma
Skin malignancies

⚠️ Rare Side Effects

Hemolytic uremic syndrome
Cardiomyopathy
Leukoencephalopathy
Pure red cell aplasia
Interstitial lung disease

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Cyclosporine Major Increased risk of nephrotoxicity
Live vaccines Major Risk of disseminated infection
Potassium-sparing diuretics Moderate Increased risk of hyperkalemia

🚨 Major Interactions

  • Ciclosporin
  • Sirolimus
  • Potassium-sparing diuretics
  • ACE inhibitors
  • NSAIDs

⚡ Moderate Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
  • CYP3A4 inducers (e.g., rifampin, phenytoin)
  • Antacids

🍷 Alcohol Interaction

Alcohol may increase hepatotoxicity risk; avoid excessive consumption.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to tacrolimus or any excipients; concomitant use with cyclosporine.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Supportive care; no specific antidote. Hemodialysis not effective.

⏰ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose. Do not double dose.

🔄 Substitutes for acroli ointment

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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