aclomov p 100mg/325mg tablet - Aceclofenac (100mg) + Paracetamol (325mg) medicine

Aceclofenac + Paracetamol: Comprehensive Medical Guide

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🏭 Alexa Medicare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is aclomov p 100mg/325mg tablet used for?

Aceclofenac + Paracetamol is a combination medicine used for pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis. Aceclofenac is an NSAID that reduces inflammation, while paracetamol provides additional pain relief and fever reduction. It is taken twice daily with food. Common side effects include nausea and dizziness. Avoid alcohol and do not exceed the recommended dose.

  • Generic Name: Aceclofenac + Paracetamol
  • Manufacturer: Alexa Medicare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 aclomov p 100mg/325mg tablet Uses & Benefits

  • This combination is primarily used for the symptomatic treatment of acute and chronic pain associated with musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
  • It is also effective for dental pain, postoperative pain, and dysmenorrhea.
  • The antipyretic property of paracetamol makes it useful for fever associated with pain conditions.

Off-label uses: Off-label uses include management of migraine headaches, low back pain, and soft tissue injuries. However, evidence for these uses is limited and should be guided by clinical judgment.

Primary treatment for: Osteoarthritis

Also treats: Rheumatoid arthritis, Ankylosing spondylitis, Musculoskeletal pain, Dental pain, Postoperative pain, Dysmenorrhea

📋 Drug Information

Generic Name(s)Aceclofenac + Paracetamol
Brand NameAldigesic P
ManufacturerAlexa Medicare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNonsteroidal Anti-inflammatory Drugs (NSAIDs) + Analgesic/Antipyretic
Action ClassCyclooxygenase (COX) inhibitor + Central analgesic
Route of AdministrationOral
StorageStore at room temperature (15-30°C), protected from light and moisture. Keep out of reach of children.
Shelf Life3 years
WHO GuidelineWHO Model List of Essential Medicines: Paracetamol is included; aceclofenac is not specifically listed.
ICMR GuidelineICMR guidelines for management of osteoarthritis recommend NSAIDs like aceclofenac with paracetamol for pain relief.

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAceclofenac is rapidly and completely absorbed after oral administration, with peak plasma concentrations reached in 1-3 hours. Paracetamol is rapidly absorbed from the gastrointestinal tract, with peak levels in 30-60 minutes.
DistributionAceclofenac is highly protein-bound (>99%) and distributes into synovial fluid. Paracetamol is widely distributed throughout body fluids, with low protein binding (10-25%).
Protein BindingAceclofenac: >99%; Paracetamol: 10-25%
MetabolismAceclofenac is metabolized in the liver primarily via CYP2C9 to 4-hydroxyaceclofenac. Paracetamol is metabolized mainly by glucuronidation and sulfation; a minor pathway via CYP2E1 produces a toxic metabolite (NAPQI) that is normally detoxified by glutathione.
Half-LifeAceclofenac: 4-5 hours; Paracetamol: 2-3 hours
ExcretionAceclofenac is excreted mainly in urine as metabolites (about 70-80%) and feces. Paracetamol is excreted in urine as metabolites (glucuronide and sulfate conjugates) and a small amount unchanged.
BioavailabilityAceclofenac: ~100%; Paracetamol: ~88%
Onset of ActionAceclofenac: 30-60 minutes; Paracetamol: 30 minutes
Peak Plasma TimeAceclofenac: 1-3 hours; Paracetamol: 30-60 minutes
Duration of ActionAceclofenac: 12 hours; Paracetamol: 4-6 hours

How It Works

Aceclofenac is a potent NSAID that selectively inhibits COX-2 more than COX-1, reducing the production of prostaglandins involved in inflammation and pain. Paracetamol acts centrally by inhibiting COX-3 (a variant of COX-1) in the hypothalamus, reducing prostaglandin synthesis and modulating the endogenous cannabinoid system. The combination provides enhanced analgesia through complementary mechanisms.

Mechanism Steps

1Inhibition of cyclooxygenase enzymes (COX-1 and COX-2) by aceclofenac
2Reduction of prostaglandin synthesis in peripheral tissues
3Central inhibition of COX-3 by paracetamol in the hypothalamus
4Modulation of pain perception and fever response

💡 How to Take aclomov p 100mg/325mg tablet

1Take the tablet with a full glass of water.
2Preferably take after meals to reduce stomach upset.
3Do not crush or chew the tablet; swallow whole.
4Follow the prescribed dosage and timing exactly.

Dosage Information

Adult DosageOne tablet twice daily (morning and evening) or as directed by a physician.
Pediatric DosageNot recommended for children under 12 years of age. For children above 12 years, same as adult dosage.
Elderly DosageUse with caution; consider lower doses or increased dosing interval due to increased risk of side effects.
Renal ImpairmentContraindicated in severe renal impairment (CrCl <30 mL/min). Use with caution in mild to moderate impairment; adjust dose if necessary.
Hepatic ImpairmentContraindicated in severe hepatic impairment. Use with caution in mild to moderate impairment; maximum daily dose of paracetamol should not exceed 2 g.
Maximum Daily Dose2 tablets (200 mg aceclofenac + 650 mg paracetamol) per day, unless otherwise directed by a physicia

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of aclomov p 100mg/325mg tablet

✅ Common Side Effects

Nausea
Vomiting
Abdominal pain
Dyspepsia
Diarrhea
Constipation
Dizziness
Headache
Rash
Pruritus

🚨 Serious Side Effects

Gastrointestinal bleeding
Peptic ulcer
Stevens-Johnson syndrome
Acute liver failure
Renal impairment
Anaphylaxis

⚠️ Rare Side Effects

Pancreatitis
Agranulocytosis
Thrombocytopenia
Aplastic anemia
Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased risk of bleeding
Methotrexate Major Increased methotrexate toxicity
Lithium Major Increased lithium levels
Aspirin Major Increased risk of gastrointestinal ulceration and bleeding
Other NSAIDs Major Additive gastrointestinal toxicity
ACE inhibitors Moderate Reduced antihypertensive effect
Diuretics Moderate Reduced diuretic effect and increased risk of renal impairment
Anticoagulants Moderate Increased bleeding risk
Corticosteroids Moderate Increased risk of gastrointestinal ulceration
SSRIs Moderate Increased bleeding risk
Antacids Minor Reduced absorption of aceclofenac
Cholestyramine Minor Reduced absorption of paracetamol
Metoclopramide Minor Increased absorption of paracetamol

🚨 Major Interactions

  • Warfarin
  • Methotrexate
  • Lithium
  • Aspirin
  • Other NSAIDs

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Anticoagulants
  • Corticosteroids
  • Selective serotonin reuptake inhibitors (SSRIs)

🍷 Alcohol Interaction

Chronic alcohol consumption increases the risk of paracetamol hepatotoxicity. Alcohol may also increase the risk of gastrointestinal bleeding with aceclofenac.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to aceclofenac, paracetamol, or any excipients. Active peptic ulcer or gastrointestinal bleeding. Severe hepatic impairment. Severe renal impairment (CrCl

⚠️ Warnings & Precautions

Use with caution in patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease), renal impairment, hepatic impairment, cardiovascular disease, hypertension, asthma, or bleeding disorders. Avoid concomitant use with other NSAIDs or paracetamol-containing products. Monitor liver function tests during prolonged use. Paracetamol overdose can cause severe liver damage; maximum daily dose should not exceed 4 g in adults. Elderly patients are at increased risk of side effects.

🤱 Lactation Safety

Aceclofenac is excreted in breast milk in small amounts; paracetamol is also excreted. Use with caut

💊 Overdose Management

Paracetamol overdose: Administer N-acetylcysteine as soon as possible if serum paracetamol levels are toxic. Aceclofenac overdose: Symptomatic and supportive care; no specific antidote. Gastric lavage and activated charcoal may be considered if ingestion is recent.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.

🔄 Substitutes for aclomov p 100mg/325mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Paracetamol is a strong anti-inflammatory drug.
    Fact: Paracetamol has minimal anti-inflammatory effects; it is primarily an analgesic and antipyretic.
  • Myth: Aceclofenac is safe for long-term use without monitoring.
    Fact: Long-term use requires monitoring of liver, kidney, and gastrointestinal function due to potential side effects.

🔄 Alternative Options

Generic Alternatives

  • Aceclofenac + Paracetamol tablets

Brand Alternatives

  • Dolokind-AP
  • Aceclo-Plus
  • Zerodol-P
  • Acepar

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