acigesic mr tablet - Chlorzoxazone (250mg) + Diclofenac (50mg) medicine

Acigesic MR Tablet - Uses, Price, Side Effects

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๐Ÿญ Acichem Laboratories ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 30, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 30, 2026

What is acigesic mr tablet used for?

Acigesic MR Tablet is a combination medicine containing Chlorzoxazone (250mg) and Diclofenac (50mg). It is used to relieve muscle spasms and pain associated with musculoskeletal conditions. Chlorzoxazone acts as a muscle relaxant, while Diclofenac reduces inflammation and pain. It is typically taken twice daily after meals.

  • Generic Name: Chlorzoxazone + Diclofenac
  • Manufacturer: Acichem Laboratories
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š acigesic mr tablet Uses & Benefits

Acute musculoskeletal pain, muscle spasms

Off-label uses: Chronic pain (not recommended)

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorzoxazone + Diclofenac
Brand NameAche X Tablet
ManufacturerAcichem Laboratories
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassMuscle Relaxant + NSAID
Route of AdministrationOral
StorageStore at 20-25ยฐC, protect from moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributes widely; crosses placenta
Protein BindingChlorzoxazone: 13-18%; Diclofenac: >99%
MetabolismChlorzoxazone: Hepatic (CYP2E1); Diclofenac: Hepatic (CYP2C9)
Half-LifeChlorzoxazone: 1-2 hrs; Diclofenac: 2 hrs
ExcretionUrine (metabolites)
BioavailabilityChlorzoxazone: ~100%; Diclofenac: ~50%
Onset of Action30-60 minutes
Peak Plasma Time1-2 hours
Duration of Action4-6 hours

How It Works

Chlorzoxazone: Depresses CNS; Diclofenac: Inhibits COX-1/2

Mechanism Steps

1Chlorzoxazone acts on CNS to depress reflexes and relax muscles
2Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes
3COX inhibition reduces prostaglandin synthesis

๐Ÿ’ก How to Take acigesic mr tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of acigesic mr tablet

โœ… Common Side Effects

  • Drowsiness
  • Dizziness
  • Nausea
  • Dyspepsia
  • Headache

๐Ÿšจ Serious Side Effects

  • GI bleeding
  • Hepatotoxicity
  • Renal failure
  • Anaphylaxis

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Stevens-Johnson syndrome
  • Pancreatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Aspirin Moderate Increased risk of gastrointestinal bleeding
Methotrexate Major Increased methotrexate toxicity
Lithium Moderate Increased lithium levels
ACE inhibitors Moderate Reduced antihypertensive effect

๐Ÿšจ Major Interactions

  • Warfarin
  • Aspirin
  • Lithium
  • Methotrexate
  • CYP2C9 inhibitors

โšก Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Anticoagulants
  • Corticosteroids

โ„น๏ธ Minor Interactions

  • Antacids
  • Caffeine

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption

๐Ÿท Alcohol Interaction

Increased hepatotoxicity risk

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Moderate
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity, active GI bleeding, severe hepatic/renal impairment, history of asthma with NSAIDs, third trimester pregnancy

๐Ÿ“Š Monitoring Parameters

Liver function, renal function, CBC, signs of GI bleeding

๐Ÿคฑ Lactation Safety

Not recommended; excreted in milk

๐Ÿ’Š Overdose Management

Symptomatic and supportive; gastric lavage, activated charcoal

โฐ Missed Dose

Take as soon as remembered; skip if near next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 30, 2026

๐Ÿ”— View Profile

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