acez plus 100 mg/500 mg tablet - Aceclofenac (100mg) + Paracetamol (500mg) medicine

Axis Plus Tablet: Complete Guide to Uses, Dosage, and Safety

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🏭 Crest Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Use only if clearly needed and prescribed by a doctor. Avoid in third trimester due to risk of premature closure of ductus arteriosus. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for short-term pain relief.
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is acez plus 100 mg/500 mg tablet used for?

This medicine is a combination of Aceclofenac and Paracetamol used for short-term relief of pain and inflammation. It works by reducing prostaglandins that cause pain. Take it with food, avoid alcohol, and do not exceed the prescribed dose.

  • Generic Name: Aceclofenac (100mg) + Paracetamol (500mg)
  • Manufacturer: Crest Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 acez plus 100 mg/500 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एसिटोक्लोफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह मुख्य रूप से जोड़ों के दर्द, मांसपेशियों के दर्द, दांतों के दर्द, मासिक धर्म के दर्द और सर्जरी के बाद के दर्द में राहत के लिए दी जाती है। इसे भोजन के साथ लेना चाहिए और शराब का सेवन बिल्कुल नहीं करना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, आंखों या त्वचा का पीलापन, या पेशाब में कमी महसूस हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को भोजन या दूध के साथ लें ताकि पेट में जलन न हो। निर्धारित खुराक से अधिक न लें। शराब का सेवन बिल्कुल न करें क्योंकि इससे यकृत और पेट की समस्याएं बढ़ सकती हैं। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। पर्याप्त पानी पिएं। यदि आपको अल्सर, गुर्दे या यकृत की बीमारी है तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग बिना डॉक्टर की सलाह के न करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 acez plus 100 mg/500 mg tablet Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling in rheumatoid arthritis as an adjunct to disease-modifying therapy.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps relieve pain and stiffness in ankylosing spondylitis.","evidence":"Moderate"},{"condition":"Acute musculoskeletal pain","description":"Used for short-term relief of acute pain from sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from dental pain following extraction or other dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate post-operative pain.","evidence":"Moderate"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Fever","description":"Paracetamol component may reduce fever, but this combination is not primarily intended for fever alone.","evidence":"Limited"}]

Primary treatment for: Pain and inflammation associated with musculoskeletal conditions

Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal pain, Dental pain, Post-operative pain, Dysmenorrhea

📋 Drug Information

Generic Name(s)Aceclofenac (100mg) + Paracetamol (500mg)
Brand Nameacez plus 100 mg/500 mg tablet
ManufacturerCrest Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to minimize stomach irritation.
2
Do not exceed the prescribed dose or duration of treatment.
3
Avoid alcohol completely while taking this medicine.
4
Inform your doctor if you have a history of kidney, liver, or heart disease.
5
Do not take other NSAIDs or pain relievers without consulting your doctor.
6
Stay well hydrated throughout the day.
7
If pain persists beyond 7 days, consult your doctor for further evaluation.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Dental pain
This medicine is effective for short-term dental pain relief.
Likely Use
✅
Menstrual cramps
This medicine can relieve dysmenorrhea.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAceclofenac is rapidly absorbed after oral administration, with peak plasma concentrations reached in 1.5-2 hours. Paracetamol is also rapidly absorbed from the gastrointestinal tract, with peak plasma levels within 0.5-1 hour. Food may delay absorption slightly but does not significantly affect the extent of absorption.
DistributionAceclofenac is highly protein-bound (greater than 99%) and distributes into synovial fluid, achieving concentrations comparable to plasma. Paracetamol distributes widely into most body tissues, with a volume of distribution of approximately 0.9 L/kg.
Protein BindingAceclofenac: greater than 99% bound to plasma proteins, primarily albumin. Paracetamol: approximately 10-25% bound to plasma proteins.
MetabolismAceclofenac is metabolized in the liver primarily by cytochrome P450 2C9 to its major metabolite, 4'-hydroxyaceclofenac, and other metabolites. Paracetamol is metabolized in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione.
Half-LifeAceclofenac: approximately 4 hours. Paracetamol: 2-3 hours in adults with normal liver function.
ExcretionAceclofenac and its metabolites are excreted primarily in urine (approximately 70-80%) and feces (approximately 20%). Paracetamol metabolites are excreted mainly in urine.
BioavailabilityAceclofenac: approximately 100% due to rapid absorption. Paracetamol: approximately 80-90% after oral administration.
Onset of ActionPain relief typically begins within 30-60 minutes after oral intake.
Peak Plasma TimeAceclofenac: 1.5-2 hours. Paracetamol: 0.5-1 hour.
Duration of ActionPain relief lasts approximately 4-6 hours for Paracetamol and up to 12 hours for Aceclofenac, but the combination is usually dosed every 8-12 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts predominantly in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis. The combination provides enhanced pain relief through different pathways.

Mechanism Steps

1
Inhibition of cyclooxygenase enzymes: Aceclofenac inhibits both COX-1 and COX-2 enzymes, with greater selectivity for COX-2, reducing prostaglandin synthesis at sites of inflammation.
2
Reduction of prostaglandin production: Decreased prostaglandins lead to reduced vasodilation, edema, and sensitization of pain receptors.
3
Central analgesic action of Paracetamol: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis and modulate pain perception.
4
Antipyretic effect: Both agents act on the hypothalamus to reduce fever by promoting heat loss.

💡 How to Take acez plus 100 mg/500 mg tablet

Strength: Tablet containing Aceclofenac 100 mg and Paracetamol 500 mg.

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach irritation.
3Swallow the tablet whole; do not crush or chew.
4Follow the prescribed dose and duration exactly.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally every 8 to 12 hours as needed for pain, not exceeding three tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Take with food or milk to reduce stomach upset.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction may be necessary. Avoid in severe renal impairment (creatinine clearance <30 mL/min). Consult your doctor for dose adjustment.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. Consult your doctor for dose adjustment.
Maximum Daily DoseMaximum daily dose: Aceclofenac 200 mg and Paracetamol 1500 mg (i.e., two tablets of 100 mg + 500 mg per day). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and gastrointestinal bleeding.
Caffeine
Limit
May increase restlessness and insomnia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of acez plus 100 mg/500 mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Stomach pain or indigestion (Common (5-10%))
Take with food. Avoid alcohol. If severe, contact your doctor.
Headache (Common (5-10%))
Usually resolves on its own. Stay hydrated. Consult if persistent.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how it affects you.
Diarrhea or constipation (Uncommon (1-5%))
Maintain hydration. Consult if severe or persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding or ulcer (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Liver damage (hepatotoxicity) (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue immediately.
Kidney impairment (Rare (<0.1%))
Report decreased urine output, swelling, or confusion to your doctor.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Seek emergency care if you experience swelling of face, lips, throat, or difficulty breathing.
Cardiovascular events (heart attack, stroke) (Rare (<0.1%))
Seek immediate medical help if you experience chest pain, shortness of breath, or sudden weakness.

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Seek emergency care if you develop rash, blisters, or peeling skin.
Agranulocytosis
Report sudden fever, sore throat, or mouth ulcers.
Aseptic meningitis
Seek medical attention for severe headache, stiff neck, or sensitivity to light.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Methotrexate Major
ACE inhibitors Major
Corticosteroids Major
Diuretics Moderate
Lithium Moderate
SSRIs Moderate
Antacids Minor
Cholestyramine Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Corticosteroids
  • Methotrexate
  • ACE inhibitors and ARBs

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide, hydrochlorothiazide)
  • Lithium
  • SSRIs (e.g., fluoxetine, sertraline)
  • Antihypertensives (beta-blockers, calcium channel blockers)
  • Zidovudine

🍷 Alcohol Interaction

Avoid alcohol completely while taking this medicine. Alcohol increases the risk of liver damage, especially from Paracetamol, and increases the risk of gastrointestinal bleeding from Aceclofenac.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Aceclofenac, Paracetamol, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure","Severe hepatic impairment","Severe renal impairment (creatinine clearance

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration.","Use with caution in elderly patients.","Inform your doctor if you have a history of kidney or liver disease.","Do not use concurrently with other NSAIDs.","May cause dizziness; avoid driving if affected.","Consult your doctor if pain persists beyond 7 days."]

🤱 Lactation Safety

Aceclofenac and Paracetamol are excreted in breast milk in small amounts. Consult your doctor before use. Generally considered compatible with breastfeeding but use with caution.

💊 Overdose Management

Overdose can cause severe liver damage from Paracetamol and gastrointestinal bleeding from Aceclofenac. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for Paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Take this medicine with food or milk to reduce stomach irritation. Do not exceed the prescribed dose or duration. Avoid alcohol completely while taking this medicine as it increases the risk of liver damage and gastrointestinal bleeding. Do not take other pain relievers or NSAIDs without consulting your doctor. Stay well hydrated. If you have a history of ulcers, kidney disease, liver disease, or heart problems, inform your doctor before taking this medicine. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are planning pregnancy. Avoid use, especially in the third trimester, due to risk of premature closure of ductus arteriosus.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain, but consult your surgeon before taking it, especially if you are on other medications or have bleeding risks.

🦷 Dental Procedures

This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, especially if bleeding is a concern.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Stay hydrated.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may worsen pain while taking this medicine. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Avoid alcohol

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects, if pain persists beyond 7 days, or if you develop signs of gastrointestinal bleeding, liver problems, or allergic reactions.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal ulcers, bleeding, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of renal and hepatic function is advised. Use the lowest effective dose for the shortest duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot and cold therapy

May help reduce pain and inflammation.

Evidence: Moderate
Acupuncture

May provide pain relief for some conditions.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. Consult your doctor before vaccination if you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep enough supply for your trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 30-year-old woman with acute dental pain
Took this medicine after a tooth extraction. Experienced good pain relief within 45 minutes. Was advised to avoid alcohol and take with food. No side effects reported.
💡 Lesson: This medicine provides effective short-term relief for dental pain when taken as directed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe for long-term use?

A: Long-term use should be under medical supervision due to potential kidney, liver, and gastrointestinal risks.

Q: Can I take it with other painkillers?

A: Do not take other NSAIDs or pain relievers without consulting your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for acez plus 100 mg/500 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food to reduce stomach upset.
  • Myth: This medicine is safe to take with other pain relievers.
    Fact: Combining with other NSAIDs increases the risk of side effects.
  • Myth: This medicine can be used for fever alone.
    Fact: It is primarily for pain and inflammation, not just fever.

🔄 Alternative Options

Generic Alternatives

  • Aceclofenac 100 mg + Paracetamol 500 mg tablet (generic)

Brand Alternatives

  • Aceclo-P
  • Aceclofenac-Paracetamol
  • Hifenac-P
  • Zerodol-P
  • Aceproxyvon-P

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Aceclofenac + Paracetamol)","composition":"Aceclofenac 100 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, headache"},{"medicine":"Ibuprofen + Paracetamol","composition":"Ibuprofen 400 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, dizziness"},{"medicine":"Diclofenac + Paracetamol","composition":"Diclofenac 50 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, headache"}]

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