abivela 1000mg tablet - Valacyclovir (1000mg) medicine

Abivela 1000mg Tablet - Uses, Price, Side Effects

4.5 (17 reviews)

Valacyclovir (1000mg)

🏭 Abigail Care Pharmaceutical 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is abivela 1000mg tablet used for?

Abivela 1000mg Tablet contains Valacyclovir, an antiviral medication used to treat infections caused by herpes viruses, including genital herpes, cold sores, shingles, and chickenpox. It works by stopping the virus from multiplying, helping to reduce symptoms and speed up healing.

Generic Name: Valacyclovir
Manufacturer: Abigail Care Pharmaceutical
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 abivela 1000mg tablet Uses & Benefits

Herpes zoster (shingles), genital herpes (initial and recurrent), herpes labialis (cold sores), varicella (chickenpox)

Off-label uses: Prevention of CMV infection in transplant patients; treatment of EBV infection

📋 Drug Information

Generic Name(s)	Valacyclovir
Brand Name	Abivela
Manufacturer	Abigail Care Pharmaceutical
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Antiviral (Non-HIV) drugs
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; prodrug rapidly converted to acyclovir

DistributionWidely distributed; crosses blood-brain barrier

Protein Binding13-18% (acyclovir)

MetabolismHepatic; valacyclovir hydrolyzed to acyclovir by first-pass metabolism

Half-Life2.5-3.3 hours (acyclovir); prolonged in renal impairment

ExcretionRenal (primarily as acyclovir via glomerular filtration and tubular secretion)

Bioavailability54-70% (valacyclovir)

Onset of ActionRapid; within 1-2 hours

Peak Plasma Time1-2 hours (valacyclovir); 2-4 hours (acyclovir)

Duration of Action8-12 hours

How It Works

Inhibits viral DNA polymerase after phosphorylation to acyclovir triphosphate

Mechanism Steps

1Valacyclovir is absorbed and rapidly converted to acyclovir by first-pass metabolism

2Acyclovir enters virus-infected cells and is phosphorylated to acyclovir monophosphate by viral thymidine kinase

3Cellular kinases convert acyclovir monophosphate to acyclovir triphosphate

💡 How to Take abivela 1000mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of abivela 1000mg tablet

✅ Common Side Effects

Headache
Nausea
Diarrhea
Dizziness
Abdominal pain

🚨 Serious Side Effects

Acute renal failure
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS)
Neurotoxicity (confusion, hallucinations, seizures)
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Hepatitis
Neutropenia
Anaphylaxis
Angioedema

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Probenecid	Moderate	Increased valacyclovir concentration
Nephrotoxic drugs	Major	Increased risk of kidney toxicity
Cimetidine	Moderate	Reduced valacyclovir clearance

🚨 Major Interactions

Probenecid
Cimetidine
Mycophenolate mofetil
Tenofovir
Nephrotoxic drugs (e.g., aminoglycosides, cyclosporine)

⚡ Moderate Interactions

NSAIDs
ACE inhibitors
Loop diuretics

ℹ️ Minor Interactions

Digoxin
Phenytoin

🍽️ Food Interactions

No significant food interaction; may be taken with or without food

🍷 Alcohol Interaction

No direct interaction; alcohol may worsen side effects like dizziness

🛡️ Safety & Warnings

Liver

Low

Kidney

Moderate

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Hypersensitivity to valacyclovir or acyclovir

📊 Monitoring Parameters

Renal function (especially in elderly or renal impairment); signs of neurotoxicity (confusion, hallucinations)

🤱 Lactation Safety

Excreted in breast milk; caution advised

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination; monitor renal function

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for abivela 1000mg tablet

View All

Alternative brands with exact same active ingredient (Valacyclovir (1000mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026