Abipime T 250mg/31.25mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Seizures or confusion
- Decreased urine output or swelling
- Severe rash or blistering skin
- Persistent high fever despite treatment
If experiencing severe symptoms, call emergency services immediately.
What is abipime t 250mg/31.25mg injection used for?
This medicine is a combination antibiotic injection containing cefepime and tazobactum, used to treat serious bacterial infections. It works by killing bacteria and is administered intravenously by a healthcare professional.
- Generic Name: Cefepime + Tazobactam
- Manufacturer: Abiz Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 abipime t 250mg/31.25mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीबायोटिक इंजेक्शन है जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि मूत्र मार्ग संक्रमण, पेट के अंदर संक्रमण, त्वचा संक्रमण, और निमोनिया। यह सेफेपाइम और टैज़ोबैक्टम का संयोजन है, जो बैक्टीरिया को मारता है और संक्रमण को फैलने से रोकता है। यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा, दस्त, जी मिचलाना, उल्टी, दाने और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त, दौरे और रक्त विकार हो सकते हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल में दी जानी चाहिए। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों, विशेषकर गुर्दे की बीमारी, कोलाइटिस, या एंटीबायोटिक एलर्जी के बारे में बताएं। यदि आपको सेफेपाइम, टैज़ोबैक्टम या अन्य बीटा-लैक्टम एंटीबायोटिक्स से एलर्जी है तो इसका उपयोग न करें। उपचार के दौरान शराब से बचें। गंभीर दस्त, दाने या सांस लेने में कठिनाई होने पर तुरंत चिकित्सा सहायता लें।
💊 abipime t 250mg/31.25mg injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and bladder infections caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Effective against mixed aerobic and anaerobic bacteria in conditions like peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Pneumonia","description":"Used for moderate to severe community-acquired or hospital-acquired pneumonia.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in patients with low white blood cell counts.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are unsuitable.","evidence":"Limited"},{"condition":"Bone and joint infections","description":"May be used off-label for osteomyelitis or septic arthritis based on culture results.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Complicated urinary tract infections, Intra-abdominal infections, Skin and soft tissue infections, Pneumonia, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Cefepime + Tazobactam |
| Brand Name | Actamase |
| Manufacturer | Abiz Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Beta-lactamase inhibitor) |
| Route of Administration | Intravenous (IV) infusion over 30 minutes |
| Storage | Store vials at room temperature (20-25°C). After reconstitution, use immediately or store as directed by the manufacturer. Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefepime, a fourth-generation cephalosporin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. Tazobactum is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes, protecting cefepime from hydrolysis and extending its spectrum against beta-lactamase-producing bacteria.
Mechanism Steps
💡 How to Take abipime t 250mg/31.25mg injection
Strength: 250 mg cefepime + 31.25 mg tazobactum per vial for intravenous injection.
Dosage Information
| Adult Dosage | The usual adult dose is 1-2 grams of cefepime every 8-12 hours, depending on the severity of infection and renal function. The tazobactum component is fixed at 31.25 mg per 250 mg cefepime. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function. Monitor renal function closely. |
| Renal Impairment | Dose adjustment is required in patients with creatinine clearance less than 60 mL/min. Refer to prescribing information for specific guidelines. |
| Hepatic Impairment | No specific dosage adjustment is recommended for hepatic impairment alone, but monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 grams of cefepime (as 2 grams every 8 hours) for adults with normal renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of abipime t 250mg/31.25mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Warfarin | Major | |
| Furosemide | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Warfarin
- Loop diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine as it may worsen side effects such as nausea, dizziness, and increase the risk of seizures.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to cefepime, tazobactum, or other beta-lactam antibiotics","History of anaphylactic reaction to penicillins or cephalosporins","Not for intrathecal or intraocular use"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment required.","May cause Clostridioides difficile-associated diarrhea; monitor for severe diarrhea.","Serious allergic reactions can occur; discontinue immediately if suspected.","May cause seizures, especially in patients with renal impairment.","Prolonged use may lead to bacterial or fungal superinfections.","Not recommended for routine prophylaxis unless indicated."]
🤱 Lactation Safety
Cefepime is excreted in human milk in low amounts. Tazobactum excretion is unknown. Consult your doctor before breastfeeding; may need to pump and discard milk during treatment.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, seizures, and renal impairment. Treatment is symptomatic and supportive. Hemodialysis may be considered to remove cefepime from the blood in severe cases. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional in a hospital or clinic setting. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a clinical setting. Inform your doctor about all your medical conditions, especially kidney disease, colitis, or allergies to antibiotics. Do not use this medicine if you are allergic to cefepime, tazobactum, or other beta-lactam antibiotics. Your doctor will monitor your kidney function, blood counts, and signs of superinfection during treatment. Avoid alcohol while receiving this medicine. If you experience severe diarrhea, rash, or difficulty breathing, seek immediate medical attention. Do not stop the injection course early without consulting your doctor, as this may lead to resistance.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney toxicity and seizures. Dose adjustment based on renal function is essential.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. Use effective contraception during treatment if appropriate.
🏥 Post-Surgery Considerations
This medicine is often used to prevent or treat surgical site infections. Follow your surgeon's instructions for dosing and monitoring.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used prophylactically for dental procedures in certain heart conditions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during acute infection. Rest is important for recovery. Gradually resume activities as you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work during treatment, especially if hospitalized. Avoid operating machinery or driving if you feel dizzy or weak.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed to prevent resistance and relapse.
📅 Long-Term Use Effects
Long-term use may lead to antibiotic resistance, superinfections, and rarely, blood disorders or kidney issues. Regular monitoring of renal function and blood counts is advised during prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used for milder infections once stabilized.
Evidence: Well-establishedAlternatives based on culture and sensitivity results.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, inform your doctor about recent vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting and is not for self-administration during travel. If you are traveling and need this medicine, ensure you have a prescription and arrange for administration at a clinic or hospital. Carry the original packaging and prescription copy. Store at room temperature and protect from light. Check customs regulations for carrying injectable antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours after the first dose, but full recovery depends on the type and severity of infection.
A: This medicine may cause dizziness; avoid driving until you know how it affects you.
A: It is Pregnancy Category B. Use only if clearly needed and under medical supervision.
🤔 Common Patient Concerns
🔄 Substitutes for abipime t 250mg/31.25mg injection
View AllAlternative brands with exact same active ingredient:
-
atracef t 250mg/31.25mg injectionAshlife Healthcare ₹80.00 5.9% CHEAPER
-
Forthcef TZ 250mg/31.25mg InjectionRidhima Biocare ₹80.00 5.9% CHEAPER
-
cefe well t 250mg/31.25mg injectionEverwell Pharma Pvt Ltd ₹82.50 2.9% CHEAPER
-
dxpime tz 250mg/31.25mg injectionDoux Healthcare Pvt Ltd ₹83.44 1.8% CHEAPER
-
genpime 250mg/31.25mg injectionPlus India ₹84.37 0.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: It is effective only against susceptible bacteria and should be used as prescribed. - Myth: You can stop the injection once you feel better.
Fact: You must complete the full course to prevent resistance and relapse.
🔄 Alternative Options
Generic Alternatives
- Cefepime + Tazobactum injection (generic)
Brand Alternatives
- Abipime T 250mg/31.25mg injection