Aziliv 250mg/250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Sudden joint pain or swelling
- Numbness or tingling in hands or feet
- Irregular heartbeat or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is zisan lv 250mg/250mg tablet used for?
This medicine is a combination antibiotic containing levofloxacin and azithromycin. It is used to treat certain bacterial infections, especially respiratory tract infections like pneumonia. It works by killing bacteria through two different mechanisms. It should only be taken when prescribed by a doctor.
- Generic Name: Levofloxacin (250mg) + Azithromycin (250mg)
- Manufacturer: Arvincare Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zisan lv 250mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लेवोफ्लोक्सासिन और एज़िथ्रोमाइसिन का संयोजन है, जिसका उपयोग कुछ जीवाणु संक्रमणों, विशेष रूप से निमोनिया और श्वसन पथ के संक्रमणों के इलाज के लिए किया जाता है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, दस्त, पेट में परेशानी, सिरदर्द, चक्कर आना और स्वाद में बदलाव शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें टेंडन टूटना, तंत्रिका क्षति, गंभीर एलर्जी और दिल की धड़कन में अनियमितता शामिल हो सकती है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। शराब न पिएं। एंटासिड, आयरन या जिंक सप्लीमेंट के साथ इस दवा को लेने से 2 घंटे पहले या बाद में लें। यदि आपको टेंडन में दर्द या सूजन हो, तो दवा बंद करें और डॉक्टर से मिलें। धूप से बचें और सनस्क्रीन का उपयोग करें।
💊 zisan lv 250mg/250mg tablet Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat bacterial pneumonia caused by susceptible organisms when combination therapy is considered appropriate.","evidence":"Well-established"},{"condition":"Acute bacterial exacerbation of chronic bronchitis","description":"May be used to treat flare-ups of chronic bronchitis caused by bacteria.","evidence":"Moderate"},{"condition":"Acute bacterial sinusitis","description":"Can be used for bacterial sinus infections when other options are not suitable.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Atypical mycobacterial infections","description":"Sometimes used in combination regimens for certain nontuberculous mycobacterial infections.","evidence":"Limited"}]
Primary treatment for: Community-acquired pneumonia
Also treats: Acute bacterial exacerbation of chronic bronchitis, Acute bacterial sinusitis
📋 Drug Information
| Generic Name(s) | Levofloxacin (250mg) + Azithromycin (250mg) |
| Brand Name | zisan lv 250mg/250mg tablet |
| Manufacturer | Arvincare Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with different mechanisms. Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. Azithromycin binds to the 50S ribosomal subunit and inhibits bacterial protein synthesis by blocking translocation of peptidyl-tRNA. The combination provides broad-spectrum activity against many Gram-positive, Gram-negative, and atypical respiratory pathogens.
Mechanism Steps
💡 How to Take zisan lv 250mg/250mg tablet
Strength: Tablet containing levofloxacin 250 mg and azithromycin 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, but the exact dose and duration depend on the type and severity of the infection, your kidney and liver function, and other factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Complete the full course as prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially tendon rupture, kidney problems, and QT prolongation. Dose adjustment may be necessary based on renal function. Use with caution. |
| Renal Impairment | Levofloxacin requires dose adjustment in patients with renal impairment. Azithromycin does not require renal dose adjustment. Consult your doctor for appropriate dosing if you have kidney disease. |
| Hepatic Impairment | No specific dose adjustment is provided for hepatic impairment, but use with caution in patients with severe liver disease. Monitor liver function. |
| Maximum Daily Dose | The maximum daily dose of this medicine is one tablet (levofloxacin 250 mg + azithromycin 250 mg) once daily, unless otherwise prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zisan lv 250mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Amiodarone | Major | |
| Antacids | Major | |
| Corticosteroids | Moderate | |
| NSAIDs | Moderate | |
| Theophylline | Moderate | |
| Cyclosporine | Minor | |
| Caffeine | Minor | |
| Digoxin | Moderate | |
| Insulin | Moderate |
🚨 Major Interactions
- QT-prolonging drugs (e.g., amiodarone, sotalol, quinidine)
- Warfarin
- Antacids, sucralfate, iron, zinc
⚡ Moderate Interactions
- Corticosteroids
- NSAIDs
- Theophylline
🍷 Alcohol Interaction
Alcohol may increase the risk of central nervous system side effects such as dizziness, drowsiness, and confusion. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to levofloxacin, azithromycin, or any other quinolone or macrolide antibiotic","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis","Severe hepatic impairment","Concurrent use with QT-prolonging drugs that cannot be avoided"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including levofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects. Reserve use for patients with no alternative treatment options.","Azithromycin can cause serious allergic reactions, including angioedema and anaphylaxis. Discontinue if allergic reaction occurs.","Both drugs can cause QT interval prolongation. Use with caution in patients with risk factors.","Clostridioides difficile-associated diarrhea has been reported with nearly all antibacterial agents. Consider this diagnosis in patients who present with diarrhea following antibiotic use.","Avoid excessive sunlight and use sunscreen, as levofloxacin can cause photosensitivity.","Do not use in patients with myasthenia gravis, as it may exacerbate muscle weakness."]
🤱 Lactation Safety
Levofloxacin and azithromycin are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, discontinue the medicine and seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor vital signs, ECG, and fluid and electrolyte balance. Hemodialysis does not effectively remove levofloxacin or azithromycin from the body.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not share it with others or use it for a condition for which it was not prescribed. Complete the full course even if you feel better. Avoid alcohol while taking this medicine. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially antacids, blood thinners, and diabetes medicines. Do not take antacids, sucralfate, or iron or zinc supplements within 2 hours before or after this medicine. If you have kidney or liver problems, your doctor may need to adjust the dose. Avoid excessive sunlight and use sunscreen, as this medicine can make your skin more sensitive to sunlight. If you develop tendon pain, stop the medicine and contact your doctor. Do not drive or operate machinery if you feel dizzy or confused.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney problems, and QT prolongation. Dose adjustment may be needed based on kidney function. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed. Discuss alternative antibiotics with your doctor.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and doctor before taking this medicine. It may interact with other medications and affect wound healing. Follow your doctor's advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications used during dental work. Your dentist may recommend postponing elective procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon rupture. Gentle walking is usually fine, but listen to your body and stop if you feel pain.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, confusion, or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest and avoid strenuous activities during the course of treatment.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to incomplete treatment and antibiotic resistance. If you experience serious side effects such as tendon pain, severe diarrhea, or allergic reactions, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance, fungal infections, and rare but serious side effects such as tendon damage, nerve damage, and liver problems. It should only be used for the prescribed duration. Regular monitoring of kidney and liver function may be needed if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Rest, fluids, and fever control can help manage symptoms while the antibiotic works.
Evidence: Well-establishedMay help prevent antibiotic-associated diarrhea.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interfere with vaccines. However, if you are due for a vaccine, inform your doctor. Live vaccines should be avoided if you are immunocompromised, but this medicine does not typically require postponing vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations regarding prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full prescribed course.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended during pregnancy unless your doctor determines it is clearly needed. Consult your doctor for alternative options.
A: No, you must complete the full prescribed course to prevent the infection from returning and to reduce the risk of antibiotic resistance.
🤔 Common Patient Concerns
🔄 Substitutes for zisan lv 250mg/250mg tablet
View AllAlternative brands with exact same active ingredient:
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qulef z 250 mg/250 mg tabletHetero Drugs Ltd ₹57.66 73.7% CHEAPER
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xuv 250 mg/250 mg tabletMedley Pharmaceuticals ₹72.19 67% CHEAPER
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levomac az 250 tabletMacleods Pharmaceuticals Pvt Ltd ₹79.41 63.7% CHEAPER
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zithrox lx 250 mg/250 mg tabletMacleods Pharmaceuticals Pvt Ltd ₹79.41 63.7% CHEAPER
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ertycin l 250mg/250mg tabletAbbott ₹84.90 61.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full prescribed course to prevent the infection from returning and to reduce the risk of antibiotic resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription-only medicine. It should only be taken under the supervision of a qualified doctor.
🔄 Alternative Options
Generic Alternatives
- Levofloxacin 250 mg + Azithromycin 250 mg tablet (generic)
Brand Alternatives
- Aziliv 250mg/250mg tablet