Emilast Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Seizures or convulsions
- Severe diarrhea with blood or mucus
- Yellowing of skin or eyes
- Decreased urine output
- Severe abdominal pain
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is zicerot 250mg/250mg injection used for?
This medicine is a combination antibiotic containing imipenem and cilastatin, used to treat serious bacterial infections. It works by killing bacteria and is administered by injection in a hospital setting.
- Generic Name: Imipenem (250mg) + Cilastatin (250mg)
- Manufacturer: Taj Pharma India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zicerot 250mg/250mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा इमिपेनम और सिलास्टेटिन का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में इंजेक्शन के रूप में दी जाती है और डॉक्टर की देखरेख में ही ली जानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, चकत्ते और इंजेक्शन स्थल पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, दौरे और आंतों का संक्रमण हो सकता है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जाती है। इसे स्वयं न लें। अपनी सभी एलर्जी और स्वास्थ्य समस्याओं के बारे में डॉक्टर को बताएं। शराब का सेवन न करें। उपचार का पूरा कोर्स करें।
💊 zicerot 250mg/250mg injection Uses & Benefits
[{"condition":"Complicated intra-abdominal infections","description":"Used to treat serious infections within the abdomen, such as peritonitis and abscesses, often caused by mixed bacteria.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"Effective against severe lung infections acquired during hospital stays, including ventilator-associated pneumonia.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Treats severe kidney and urinary tract infections that may be resistant to other antibiotics.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for serious skin infections, including those caused by multidrug-resistant bacteria.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Prescribed as empirical therapy for fever in patients with low white blood cell counts, often due to cancer treatment.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible organisms.","evidence":"Moderate"},{"condition":"Endocarditis","description":"Sometimes used for serious heart valve infections, often in combination with other antibiotics.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Melioidosis","description":"May be used off-label for this rare bacterial infection in some regions.","evidence":"Limited"},{"condition":"Nocardiosis","description":"Occasionally used off-label for infections caused by Nocardia species.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections
Also treats: Complicated intra-abdominal infections, Hospital-acquired pneumonia, Complicated urinary tract infections, Skin and soft tissue infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Imipenem (250mg) + Cilastatin (250mg) |
| Brand Name | zicerot 250mg/250mg injection |
| Manufacturer | Taj Pharma India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous infusion or intramuscular injection) |
| Storage | Store vials at controlled room temperature 20°C to 25°C (68°F to 77°F). Protect from light. Reconstituted solutions should be used immediately or stored as directed by the manufacturer. |
| Shelf Life | Typically 24 months from the date of manufacture. Refer to the product label for exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Imipenem, the active antibacterial component, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), particularly PBP-2 and PBP-1a/1b. This binding prevents the cross-linking of peptidoglycan chains, leading to weakened cell walls and bacterial lysis. Cilastatin is a renal dehydropeptidase inhibitor that blocks the enzyme responsible for metabolizing imipenem in the kidneys, thereby increasing imipenem's urinary concentration and reducing potential nephrotoxicity. This combination broadens the spectrum of activity against many Gram-positive, Gram-negative, and anaerobic bacteria.
Mechanism Steps
💡 How to Take zicerot 250mg/250mg injection
Strength: Injection: Imipenem 250 mg + Cilastatin 250 mg per vial.
Dosage Information
| Adult Dosage | The usual adult dose ranges from 250 mg to 1000 mg of imipenem/cilastatin every 6 to 8 hours, depending on the severity and type of infection. For moderate infections, 500 mg every 6 to 8 hours may be used; for severe infections, 1000 mg every 6 to 8 hours may be required. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. Use with caution and monitor renal function. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 20-40 mL/min, reduce dose; for less than 20 mL/min, further reduce or avoid unless dialysis is available. Consult a clinician for specific dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but monitor liver function closely. |
| Maximum Daily Dose | The maximum daily dose is typically 4000 mg (4 grams) of imipenem/cilastatin, but this must be individualized by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zicerot 250mg/250mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ganciclovir | Major | |
| Valproic acid | Major | |
| Probenecid | Moderate | |
| Cyclosporine | Moderate | |
| Aminoglycosides | Moderate | |
| Warfarin | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Ganciclovir
- Valproic acid
- Probenecid
⚡ Moderate Interactions
- Cyclosporine
- Aminoglycosides
- Warfarin
🍷 Alcohol Interaction
Avoid alcohol consumption while receiving this medicine, as it may increase the risk of seizures and gastrointestinal side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to imipenem, cilastatin, or other carbapenems","Severe allergic reaction to penicillins or cephalosporins","History of seizures (relative contraindication)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, have been reported.","Seizures may occur, especially in patients with renal impairment or CNS disorders.","Clostridium difficile-associated diarrhea may occur; monitor for severe diarrhea.","Prolonged use may lead to superinfection with resistant organisms.","Use with caution in patients with renal impairment; dose adjustment may be needed.","May interact with valproic acid, reducing its efficacy."]
🤱 Lactation Safety
Imipenem and cilastatin are excreted in breast milk in small amounts. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause nausea, vomiting, seizures, and electrolyte imbalances. Treatment is symptomatic and supportive. Hemodialysis may be considered to remove imipenem and cilastatin from the blood in severe cases.
⏰ Missed Dose
Since this medicine is administered by healthcare professionals, missed doses are unlikely. If a dose is missed, contact your healthcare provider for guidance. Do not attempt to self-administer.
Additional Safety Advice
This medicine should only be administered by a healthcare professional in a hospital or clinic setting. Inform your doctor about any allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems, seizures, or gastrointestinal issues. Do not self-administer. Use exactly as prescribed and complete the full course. Avoid alcohol during treatment. Report any signs of allergic reaction, severe diarrhea, or seizures immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of seizures and renal impairment. Dose adjustment based on renal function is essential.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy. This medicine is Category C and should be used only if clearly needed.
🏥 Post-Surgery Considerations
May be used to prevent or treat surgical site infections. Monitor for signs of infection.
🦷 Dental Procedures
Not typically used for dental infections unless severe and resistant. Consult your dentist and doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment, especially if you feel weak or dizzy. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital, so you will need to take time off work. Driving may be unsafe if you experience dizziness or seizures.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better.
📅 Long-Term Use Effects
Long-term use may lead to antibiotic resistance and superinfections. Prolonged use requires monitoring of kidney and liver function. Use only for as long as prescribed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection, other antibiotics like meropenem or piperacillin-tazobactam may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, live vaccines should be avoided during antibiotic treatment.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. Consult your doctor before travel if you have ongoing treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement is usually seen within 24-48 hours, but the full course must be completed.
A: No, it must be administered by a healthcare professional in a hospital or clinic.
A: Report any side effects to your doctor immediately, especially severe ones like seizures or difficulty breathing.
🤔 Common Patient Concerns
🔄 Substitutes for zicerot 250mg/250mg injection
View AllAlternative brands with exact same active ingredient:
-
v penum injectionIntas Pharmaceuticals Ltd ₹446.42 62% CHEAPER
-
primapen 250 mg/250 mg injectionNeon Laboratories Ltd ₹587.50 50% CHEAPER
-
imi cila 250 mg/250 mg injectionAbbott ₹600.00 49% CHEAPER
-
rolnem 250mg injectionMylan Pharmaceuticals Pvt Ltd ₹609.38 48.2% CHEAPER
-
imituf injectionTorrent Pharmaceuticals Ltd ₹626.25 46.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is only available as an injection and must be given by a healthcare professional. - Myth: This medicine is safe for mild infections.
Fact: It is reserved for serious infections to prevent antibiotic resistance. - Myth: You can stop the medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance.
🔄 Alternative Options
Generic Alternatives
- Imipenem and Cilastatin Injection
Brand Alternatives
- Emilast Injection