Entocef 50mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe, persistent, or bloody diarrhea
- Widespread rash, blistering, or peeling skin
- Unusual bruising or bleeding
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- High fever with chills and worsening symptoms
If experiencing severe symptoms, call emergency services immediately.
What is xime 50mg tablet used for?
This medicine is a cephalosporin antibiotic injection used to treat serious bacterial infections. It works by killing bacteria and is given by a healthcare professional.
- Generic Name: Cefuroxime (50mg)
- Manufacturer: PCI Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 xime 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीबायोटिक इंजेक्शन है जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र पथ, त्वचा, हड्डियों और जोड़ों के संक्रमण में प्रभावी है। यह केवल डॉक्टर या नर्स द्वारा ही दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा या सूजन, दस्त, मतली, उल्टी, पेट में परेशानी और हल्के दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज एलर्जी, गंभीर त्वचा प्रतिक्रिया, और आंतों का गंभीर संक्रमण शामिल हो सकता है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी एलर्जी, अन्य दवाओं और चिकित्सीय स्थितियों के बारे में बताएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। निर्धारित कोर्स पूरा करें और बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 xime 50mg tablet Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used to treat bacterial pneumonia and acute exacerbations of chronic bronchitis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against many bacterial causes of uncomplicated and complicated urinary tract infections.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for infections such as cellulitis, wound infections, and abscesses caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used in the treatment of osteomyelitis and septic arthritis when caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used in the management of bloodstream infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Meningitis","description":"May be used in the treatment of bacterial meningitis, often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Surgical prophylaxis","description":"Given before certain surgical procedures to reduce the risk of postoperative infection.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Lyme disease","description":"Sometimes used off-label for early Lyme disease in patients who cannot take oral therapy.","evidence":"Limited"},{"condition":"Gonorrhea","description":"May be used off-label as an alternative treatment for uncomplicated gonorrhea, though resistance is a concern.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin infections, Bone and joint infections, Septicemia, Meningitis
📋 Drug Information
| Generic Name(s) | Cefuroxime (50mg) |
| Brand Name | xime 50mg tablet |
| Manufacturer | PCI Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 2nd generation |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unopened vial at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Once reconstituted, the solution should be used within the time specified by the manufacturer, typically within 1 hour if stored at room temperature, or up to 24 hours if refrigerated. Do not freeze. |
| Shelf Life | The shelf life of the unopened vial is typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to specific penicillin-binding proteins located inside the bacterial cell wall. This binding inhibits the final step of peptidoglycan synthesis, which is essential for the strength and rigidity of the bacterial cell wall. As a result, the cell wall becomes weak and the bacterium undergoes lysis and dies. This medicine is bactericidal, meaning it kills the bacteria directly. It is active against a wide range of gram-positive and gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, and Haemophilus influenzae. However, it is not effective against methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, or Enterococcus species.
Mechanism Steps
💡 How to Take xime 50mg tablet
Strength: Injection: 50 mg per vial (as cefuroxime sodium).
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of the infection, the patient's age, weight, renal and hepatic function, and the susceptibility of the infecting organism. For adults with normal kidney function, typical doses range from 750 mg to 1.5 g every 6 to 8 hours for severe infections, or 750 mg to 1.5 g every 8 hours for less severe infections. For surgical prophylaxis, a single dose of 1.5 g is often given 30 to 60 minutes before the procedure. This 50 mg strength is not typically used for systemic infections in adults; it may be used for specialized purposes or in specific preparations. Always follow the prescribed dose and duration exactly as directed by your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific 50 mg strength. In general, cefuroxime dosing in children is weight-based and must be determined by a pediatrician. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can increase the risk of side effects. Dose adjustment may be necessary based on renal function. Your doctor will determine the appropriate dose. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For adults with a creatinine clearance (CrCl) of 10-20 mL/min, the usual dose may be given every 12 hours. For CrCl less than 10 mL/min, the usual dose may be given every 24 hours. Patients on hemodialysis should receive an additional dose after dialysis. Consult your doctor for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment alone, as cefuroxime is not significantly metabolized by the liver. However, caution is advised in patients with both hepatic and renal impairment. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information for this 50 mg strength. For systemic infections, the maximum daily dose of cefuroxime is typically 6 g per day in adults with normal renal function, but this must be individualized by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of xime 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol does not directly interact with cefuroxime, but it can worsen dehydration and gastrointestinal side effects such as nausea and diarrhea. It is advisable to avoid alcohol while you are being treated for an infection and while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to cefuroxime or any other cephalosporin","Previous severe allergic reaction to penicillins (cross-reactivity possible)","Use in patients with a history of anaphylaxis to beta-lactam antibiotics"]
⚠️ Warnings & Precautions
["Before starting this medicine, tell your doctor if you are allergic to penicillin or other antibiotics.","Use with caution in patients with kidney disease; dose adjustment may be necessary.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","If severe diarrhea occurs, consider Clostridium difficile-associated diarrhea and manage appropriately.","This medicine may interfere with certain laboratory tests, such as urine glucose tests and Coombs test.","Do not use this medicine for viral infections; it is ineffective against viruses.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
Cefuroxime is excreted in human breast milk in low concentrations. It is generally considered safe during breastfeeding, but monitor the infant for diarrhea, thrush, or rash. Consult your doctor before use.
💊 Overdose Management
Overdose with this medicine can cause severe gastrointestinal symptoms, seizures, and kidney damage. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, seek immediate medical attention. Hemodialysis may help remove cefuroxime from the blood in patients with renal failure.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible to reschedule. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must only be administered by a trained healthcare professional. Before receiving this medicine, inform your doctor if you are allergic to cefuroxime, other cephalosporins, or penicillins, or if you have ever had a severe allergic reaction to any antibiotic. Tell your doctor about all your medical conditions, especially kidney disease, liver disease, gastrointestinal problems such as colitis, or a history of bleeding disorders. Also, inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, as some may interact with this medicine. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor before receiving this medicine. Do not drive or operate heavy machinery if you feel dizzy or unwell after the injection. Complete the full course as prescribed by your doctor, even if you start feeling better, to prevent the infection from returning and to reduce the risk of antibiotic resistance. Do not self-administer this medicine at home; it is for hospital or clinic use only.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. Your doctor will adjust the dose based on your kidney function and monitor you closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is generally considered safe in pregnancy when clearly needed, but always consult your doctor.
🏥 Post-Surgery Considerations
This medicine is often used to prevent infections after surgery. If you have recently had surgery, your doctor will determine the appropriate dose and duration. Follow their instructions carefully.
🦷 Dental Procedures
If you are scheduled for a dental procedure, inform your dentist that you are receiving this medicine. In some cases, your dentist may prescribe antibiotics before dental work to prevent infection, but this medicine is not typically used for that purpose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You may feel tired or dizzy after receiving this medicine. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work or school while receiving this medicine, especially if you are hospitalized. Do not drive or operate machinery if you feel dizzy or unwell. Follow your doctor's advice regarding return to normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience severe side effects, contact your doctor immediately; they will decide whether to stop the medicine or change the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfections. It is generally not used for long periods. If prolonged therapy is necessary, your doctor will monitor your kidney and liver function, as well as your blood counts. Report any new symptoms promptly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
If your condition improves, your doctor may switch you to oral antibiotics to complete the course.
Evidence: Well-establishedDepending on the bacteria and your allergies, other antibiotics may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics may affect the vaccine's effectiveness. Generally, antibiotics do not interfere with most vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, it must be administered by a healthcare professional at your destination. Carry a copy of your prescription and a letter from your doctor explaining the medical need. Keep the medicine in its original packaging and store it at the recommended temperature. If traveling by air, check with the airline about carrying injectable medications. For time zone changes, consult your doctor about adjusting the dosing schedule.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours after starting this medicine, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: This medicine is in pregnancy category B. It should be used during pregnancy only if clearly needed. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for xime 50mg tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance.
🔄 Alternative Options
Generic Alternatives
- Cefuroxime injection (generic)
Brand Alternatives
- Not applicable; this is the only brand name referenced.