Flodart Plus Capsule PR: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden fainting or severe dizziness
- Prolonged painful erection lasting more than 4 hours
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or rash
- Blood in urine or severe pain during urination
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain with nausea and vomiting
If experiencing severe symptoms, call emergency services immediately.
What is urisite d 0.4mg/0.5mg tablet used for?
This medicine is a combination of tamsulosin and dutasteride used to treat benign prostatic hyperplasia (BPH) in men. It works by relaxing prostate muscles and shrinking the prostate over time, improving urinary symptoms.
- Generic Name: Tamsulosin (0.4mg) + Dutasteride (0.5mg)
- Manufacturer: Zerdia Healthcare Pvt. Ltd.
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 urisite d 0.4mg/0.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टैम्सुलोसिन और ड्यूटास्टेराइड का संयोजन है, जिसका उपयोग पुरुषों में बेनाइन प्रोस्टेटिक हाइपरप्लासिया (बीपीएच) के इलाज के लिए किया जाता है। यह प्रोस्टेट की मांसपेशियों को आराम देकर और समय के साथ प्रोस्टेट के आकार को कम करके पेशाब की समस्याओं में सुधार करती है। यह दवा पेशाब की धारा को मजबूत बनाती है, बार-बार पेशाब आने और रात में उठने की समस्या को कम करती है। यह केवल पुरुषों के लिए है और डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, स्खलन में कमी, कामेच्छा में कमी, स्तनों में कोमलता या वृद्धि, और नाक बंद होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें बेहोशी, लंबे समय तक दर्दनाक इरेक्शन, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को रोजाना एक बार भोजन के 30 मिनट बाद लें। कैप्सूल को पूरा निगलें, चबाएं या तोड़ें नहीं। चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें। अचानक उठने-बैठने से बचें। यदि आपको लीवर या किडनी की बीमारी है तो डॉक्टर को बताएं। इस दवा को लेते समय और बंद करने के 6 महीने तक रक्तदान न करें। यदि आपकी पत्नी गर्भवती है या गर्भवती हो सकती है तो संभोग के दौरान कंडोम का उपयोग करें।
💊 urisite d 0.4mg/0.5mg tablet Uses & Benefits
[{"condition":"Benign prostatic hyperplasia (BPH) with enlarged prostate","description":"Improves lower urinary tract symptoms such as weak stream, hesitancy, frequency, and nocturia, and reduces the risk of acute urinary retention and need for surgery.","evidence":"Well-established"},{"condition":"Symptomatic BPH with moderate to severe symptoms","description":"Combination therapy provides greater symptom relief and flow improvement than either component alone, especially in men with prostate volume greater than 30 mL.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chronic prostatitis/chronic pelvic pain syndrome","description":"Sometimes used off-label for symptom relief in men with chronic pelvic pain, but evidence is limited and not routinely recommended.","evidence":"Limited"},{"condition":"Prevention of prostate cancer","description":"Dutasteride has been studied for prostate cancer risk reduction, but this is not an approved indication and remains controversial.","evidence":"Limited"}]
Primary treatment for: Benign prostatic hyperplasia (BPH)
Also treats: Lower urinary tract symptoms (LUTS), Acute urinary retention (risk reduction), Prostate enlargement
📋 Drug Information
| Generic Name(s) | Tamsulosin (0.4mg) + Dutasteride (0.5mg) |
| Brand Name | urisite d 0.4mg/0.5mg tablet |
| Manufacturer | Zerdia Healthcare Pvt. Ltd. |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed. Protect from light and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two complementary mechanisms. Tamsulosin selectively blocks alpha-1A and alpha-1D adrenergic receptors in the prostate and bladder neck, reducing smooth muscle tone and improving urine flow. Dutasteride inhibits both type 1 and type 2 isoforms of 5-alpha-reductase, preventing conversion of testosterone to dihydrotestosterone (DHT), which reduces prostate volume and slows disease progression. The combination addresses both the dynamic and static components of BPH.
Mechanism Steps
💡 How to Take urisite d 0.4mg/0.5mg tablet
Strength: Capsule containing tamsulosin 0.4 mg and dutasteride 0.5 mg.
Dosage Information
| Adult Dosage | The recommended dose for adult men is one capsule (tamsulosin 0.4 mg + dutasteride 0.5 mg) taken orally once daily, approximately 30 minutes after the same meal each day. The capsule should be swallowed whole and not crushed, chewed, or opened. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to the hypotensive effects of tamsulosin. Monitor blood pressure and advise caution with posture changes. |
| Renal Impairment | No dose adjustment is typically required for mild to moderate renal impairment. Use with caution in severe renal impairment (creatinine clearance <10 mL/min) as tamsulosin has not been studied in this population. |
| Hepatic Impairment | No dose adjustment is typically required for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment; dutasteride is extensively metabolized in the liver and may accumulate. |
| Maximum Daily Dose | One capsule (tamsulosin 0.4 mg + dutasteride 0.5 mg) once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of urisite d 0.4mg/0.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Sildenafil | Major | |
| Warfarin | Moderate | |
| Amlodipine | Moderate | |
| Rifampicin | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor | |
| Prazosin | Major | |
| Clarithromycin | Major | |
| Tadalafil | Major |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
- PDE5 inhibitors (e.g., sildenafil, tadalafil)
- Other alpha-blockers (e.g., prazosin, terazosin)
⚡ Moderate Interactions
- Warfarin
- Antihypertensives (e.g., amlodipine, lisinopril)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine)
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness and orthostatic hypotension. Limit or avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to tamsulosin, dutasteride, or any component of the formulation","History of orthostatic hypotension","Severe hepatic impairment","Women who are pregnant or may become pregnant","Pediatric patients","Concurrent use with strong CYP3A4 inhibitors (relative contraindication)"]
⚠️ Warnings & Precautions
["May cause orthostatic hypotension and dizziness; avoid driving or operating machinery until effects are known.","Do not donate blood while taking this medicine and for at least 6 months after stopping.","Use condoms during sexual intercourse if partner is pregnant or may become pregnant.","May increase risk of high-grade prostate cancer; regular monitoring is required.","Can affect PSA levels; inform your doctor before PSA testing.","Use with caution in patients with liver or kidney disease.","May cause priapism; seek immediate medical attention if erection lasts more than 4 hours.","Do not crush, chew, or open the capsule; swallow whole."]
🤱 Lactation Safety
Not applicable. This medicine is not indicated for use in women. It is not known whether tamsulosin or dutasteride are excreted in human breast milk.
💊 Overdose Management
Overdose may cause severe hypotension, dizziness, and fainting. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if less than half the dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed, once daily, approximately 30 minutes after the same meal each day. Swallow the capsule whole; do not crush, chew, or open it. Do not drive or operate heavy machinery until you know how this medicine affects you, as it may cause dizziness. Avoid sudden changes in posture to reduce the risk of falls. Inform your doctor if you have liver disease, kidney disease, or low blood pressure. Do not donate blood while taking this medicine and for at least 6 months after stopping, because the dutasteride component can harm a developing male fetus if transfused to a pregnant woman. Use condoms during sexual intercourse if your partner is pregnant or may become pregnant, as dutasteride can be present in semen. Do not share this medicine with anyone else. Keep all follow-up appointments for prostate checks and PSA monitoring.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of tamsulosin. Monitor for dizziness and falls. No dose adjustment is required based on age alone, but regular monitoring of renal and hepatic function is advised.
🤰 Pregnancy Planning (TTC)
This medicine is not for use in women. Women who are pregnant or planning pregnancy should avoid handling crushed or broken capsules, as dutasteride can be absorbed through the skin and harm a male fetus. If a woman accidentally contacts the capsule contents, wash the area immediately with soap and water.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery, especially cataract surgery, as tamsulosin can cause intraoperative floppy iris syndrome (IFIS). Your doctor may advise stopping the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, especially if you have a history of orthostatic hypotension or are taking blood thinners. No specific precautions are typically required for routine dental work, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting immediately after starting this medicine, as it may increase the risk of dizziness and falls. Gradually resume activities as tolerated. If you experience dizziness during exercise, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or orthostatic hypotension, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause retrograde ejaculation, which can affect sexual function but is usually not harmful. Discuss any concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe dizziness, fainting, priapism, or allergic reactions, seek immediate medical attention. Your doctor may adjust or discontinue the medicine based on your response and side effects.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well-tolerated. Dutasteride may reduce prostate volume and lower the risk of acute urinary retention and surgery. However, it may increase the risk of high-grade prostate cancer, so regular PSA monitoring and prostate checks are essential. Tamsulosin may cause persistent retrograde ejaculation or dizziness. Liver function should be monitored in patients with hepatic impairment. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Weight loss, dietary changes, and pelvic floor exercises can help manage BPH symptoms.
Evidence: Well-establishedProcedures like TURP or laser therapy may be considered for severe symptoms not controlled by medication.
Evidence: Well-establishedSaw palmetto and other supplements are sometimes used, but evidence is limited and they may interact with medications.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any live vaccines while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, continue taking it approximately 30 minutes after your main meal at your usual local time. Do not pack it in checked luggage; keep it in your carry-on. Check customs regulations for carrying prescription medicines. Do not donate blood during travel or for 6 months after stopping this medicine.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Tamsulosin may provide some symptom relief within days, but dutasteride takes 3–6 months for maximum effect on prostate size.
A: Yes, take it approximately 30 minutes after the same meal each day to reduce side effects like dizziness.
A: If less than half the dosing interval has passed, take it as soon as you remember. If more than half has passed, skip it and continue your regular schedule. Do not double dose.
A: Yes, it is generally safe for long-term use under medical supervision. Regular monitoring of PSA and prostate health is recommended.
A: Do not stop without consulting your doctor. Stopping may cause symptoms to return or worsen.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken by women for hair loss.
Fact: This medicine is not for women. Dutasteride can cause serious harm to a male fetus and is contraindicated in women of childbearing potential. - Myth: This medicine works immediately.
Fact: Tamsulosin may provide some relief within days, but dutasteride takes 3–6 months for maximum effect on prostate size. - Myth: You can stop taking this medicine once symptoms improve.
Fact: BPH is a chronic condition. Stopping without medical advice may cause symptoms to return.
🔄 Alternative Options
Generic Alternatives
- Tamsulosin + Dutasteride combination capsules (various manufacturers)
Brand Alternatives
- Flodart Plus Capsule PR