Immithal 100mg Capsule (Thalidomide): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden shortness of breath or chest pain
- Swelling, redness, or pain in one leg
- Numbness, tingling, burning, or weakness in the hands or feet
- Fever, sore throat, or chills that may indicate infection
- Unusual bruising, nosebleeds, or bleeding gums
- Severe skin rash, blisters, or peeling skin
- Yellowing of the eyes or skin, or dark urine
- Fainting, confusion, or an unusually slow heartbeat
- Severe abdominal pain or persistent vomiting
- Swelling of the face, lips, or throat, or difficulty breathing
If experiencing severe symptoms, call emergency services immediately.
What is thaldo capsule used for?
This medicine contains thalidomide 100 mg and is used mainly to treat multiple myeloma and erythema nodosum leprosum. It works by reducing inflammation, blocking new blood vessel growth in tumours, and changing immune cell activity. It is strictly contraindicated in pregnancy because it causes severe birth defects, and it must only be used under specialist supervision with regular blood tests.
- Generic Name: Thalidomide (100mg)
- Manufacturer: Khandelwal Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 thaldo capsule के बारे में (Hindi Summary)
उपयोग: यह दवा थैलिडोमाइड 100 मिलीग्राम कैप्सूल के रूप में उपलब्ध है और मुख्य रूप से मल्टीपल मायलोमा नामक रक्त कैंसर तथा एरिथीमा नोडोसम लेप्रोसम नामक त्वचा और तंत्रिका संबंधी समस्या के इलाज में उपयोग की जाती है। यह शरीर की प्रतिरक्षा प्रणाली को नियंत्रित करके सूजन कम करती है, ट्यूमर में नई रक्त वाहिकाओं के बनने को रोकती है और असामान्य कोशिकाओं की वृद्धि को धीमा करती है। यह दवा केवल विशेषज्ञ डॉक्टर की देखरेख में ही लेनी चाहिए। गर्भवती महिलाओं या गर्भधारण कर सकने वाली महिलाओं के लिए यह दवा पूरी तरह वर्जित है क्योंकि इससे बच्चे में गंभीर जन्म दोष हो सकते हैं। पुरुषों को भी इस दवा के सेवन के दौरान और बंद करने के चार सप्ताह बाद तक कंडोम का उपयोग करना चाहिए।
साइड इफेक्ट्स: इस दवा से कई सामान्य और कुछ गंभीर दुष्प्रभाव हो सकते हैं। सबसे आम समस्याएँ हैं नींद आना, चक्कर आना, थकान, कब्ज, मुँह सूखना, त्वचा पर दाने और हाथ-पैरों में सूजन। कई लोगों को हाथ-पैरों में झनझनाहट, सुन्नपन या जलन महसूस होती है, जिसे पेरिफेरल न्यूरोपैथी कहते हैं और यह स्थायी हो सकती है। इस दवा से खून की कोशिकाएँ कम हो सकती हैं, जिससे संक्रमण, खून की कमी और आसानी से चोट लगने या खून बहने की समस्या हो सकती है। पैरों या फेफड़ों में खून के थक्के बनने का खतरा भी बढ़ जाता है। कोई भी नई झनझनाहट, कमजोरी, सीने में दर्द, साँस लेने में तकलीफ या असामान्य खून बहना तुरंत डॉक्टर को बताना चाहिए।
सुरक्षा सलाह: यह दवा केवल विशेषज्ञ डॉक्टर के बताए अनुसार ही लें और डोज़ में कोई बदलाव खुद न करें। चूँकि यह दवा गंभीर जन्म दोष पैदा कर सकती है, इसलिए गर्भधारण कर सकने वाली महिलाओं को इलाज शुरू करने से कम से कम चार सप्ताह पहले से, पूरे इलाज के दौरान और आखिरी खुराक के चार सप्ताह बाद तक दो विश्वसनीय गर्भनिरोधक तरीके अपनाने चाहिए। पुरुषों को इस दवा के सेवन के दौरान और बंद करने के चार सप्ताह बाद तक हर यौन संपर्क में कंडोम का उपयोग करना चाहिए। इलाज के दौरान खून की जाँच, लिवर और किडनी की जाँच नियमित रूप से करानी चाहिए। इस दवा के सेवन के दौरान और बंद करने के चार सप्ताह बाद तक खून या वीर्य दान न करें। जब तक पता न चले कि इस दवा से आपको कितनी नींद आती है, तब तक गाड़ी चलाने या भारी मशीन चलाने से बचें। शराब न पिएँ क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। कोई भी नई झनझनाहट, दाने, सूजन या साँस लेने में तकलीफ हो तो तुरंत डॉक्टर से मिलें।
💊 thaldo capsule Uses & Benefits
[{"condition":"Multiple myeloma","description":"This medicine is used, usually in combination with other anti-cancer medicines and steroids, to treat newly diagnosed or previously treated multiple myeloma.","evidence":"Well-established"},{"condition":"Erythema nodosum leprosum","description":"This medicine is used to control the painful skin nodules and systemic inflammation of erythema nodosum leprosum, a reaction that can occur in leprosy.","evidence":"Well-established"},{"condition":"Refractory Crohn's disease","description":"This medicine has been used in selected patients with Crohn's disease that has not responded to standard treatments, but it is not a first-line option.","evidence":"Limited"},{"condition":"Graft-versus-host disease","description":"This medicine has been used to treat chronic graft-versus-host disease after stem cell transplantation in some settings.","evidence":"Limited"}]
Off-label uses: [{"condition":"Behçet's disease","description":"This medicine has been used off-label to control mouth and genital ulcers and other inflammatory features of Behçet's disease.","evidence":"Limited"},{"condition":"Cutaneous lupus erythematosus","description":"This medicine has been used off-label for severe skin lupus that has not responded to standard treatments.","evidence":"Limited"},{"condition":"Prurigo nodularis","description":"This medicine has been used off-label to reduce severe itching and nodules in prurigo nodularis.","evidence":"Limited"},{"condition":"Myelofibrosis","description":"This medicine has been studied off-label for anaemia and spleen enlargement in myelofibrosis.","evidence":"Limited"}]
Primary treatment for: Multiple myeloma
Also treats: Erythema nodosum leprosum, Refractory Crohn's disease, Chronic graft-versus-host disease
📋 Drug Information
| Generic Name(s) | Thalidomide (100mg) |
| Brand Name | thaldo capsule |
| Manufacturer | Khandelwal Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Thalidomide & its Immunomodulatory derivatives (IMiDs) |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep it in the original container with the lid tightly closed. Do not store it in a bathroom cabinet. Keep it out of the reach of children and pets. |
| Shelf Life | Not established from the available information. Check the expiry date printed on the pack and do not use the medicine after that date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Thalidomide works through several connected actions rather than a single target. It reduces the production of tumour necrosis factor alpha by immune cells, which lowers inflammation. It also interferes with the formation of new blood vessels inside tumours, which slows their growth. In addition, it changes the activity of T cells and natural killer cells, and it affects a protein complex called cereblon, which leads to the breakdown of certain proteins that are important for cancer cell survival. These combined effects help control cancer cells and inflammatory reactions.
Mechanism Steps
💡 How to Take thaldo capsule
Strength: Thalidomide 100 mg immediate-release capsule for oral use.
Dosage Information
| Adult Dosage | The dose of this medicine depends on the condition being treated, your body weight, your blood counts, your kidney and liver function, and how well you tolerate the medicine. For multiple myeloma, it is usually given together with other anti-cancer medicines and steroids, and the dose is often taken once daily at bedtime because it can cause drowsiness. For erythema nodosum leprosum, the dose is usually started higher and then reduced gradually as the reaction comes under control. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never change the dose on your own. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults may be more sensitive to the drowsiness, dizziness, and nerve-related side effects of this medicine. Blood counts, kidney function, and liver function should be checked carefully, and the dose must be individualized by a qualified clinician. Falls and confusion should be watched for closely. |
| Renal Impairment | This medicine is removed from the body mainly through the kidneys, so people with kidney disease may need a lower dose or extra monitoring. The exact adjustment is not established from the available information, and the dose must be individualized by a qualified clinician based on kidney function. |
| Hepatic Impairment | People with liver disease may need extra monitoring because this medicine can rarely cause liver injury. The exact dose adjustment is not established from the available information, and the dose must be individualized by a qualified clinician based on liver function. |
| Maximum Daily Dose | The maximum daily dose depends on the condition being treated and must be determined by a qualified clinician. Do not exceed the dose prescribed for you. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of thaldo capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioid painkillers | Major | |
| Benzodiazepines | Major | |
| Hormonal contraceptives | Major | |
| Bortezomib | Major | |
| Live vaccines | Major | |
| Beta blockers | Moderate | |
| Liver-affecting medicines | Moderate | |
| Kidney-affecting medicines | Moderate | |
| Antacids | Minor | |
| Laxatives | Minor |
🚨 Major Interactions
- Other medicines that cause drowsiness, such as opioids, benzodiazepines, and sedating antihistamines
- Medicines that increase the risk of blood clots, such as hormonal contraceptives and hormone replacement therapy
- Bortezomib and other myeloma medicines
- Live vaccines
⚡ Moderate Interactions
- Medicines that slow the heart rate, such as beta blockers and some calcium channel blockers
- Medicines that affect the liver
- Medicines that affect the kidneys
🍷 Alcohol Interaction
Alcohol must be avoided while taking this medicine because it increases drowsiness, dizziness, and the risk of falls and accidents. Alcohol can also add to the sedative effect and may worsen liver strain. If you drink alcohol regularly, discuss this with your doctor before starting treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy or the possibility of becoming pregnant","Breastfeeding","Known severe allergic reaction to thalidomide or any ingredient of this medicine","Women who can become pregnant and are not able or willing to use two reliable forms of contraception","Men who are not able or willing to use condoms during sexual contact","Severe existing peripheral neuropathy","Severe bone marrow suppression with very low blood counts","Use of live vaccines during treatment"]
⚠️ Warnings & Precautions
["This medicine can cause severe birth defects and must never be taken during pregnancy.","Two reliable forms of contraception are required for women who can become pregnant, starting at least four weeks before treatment and continuing for at least four weeks after the last dose.","Men must use condoms during all sexual contact while taking this medicine and for at least four weeks after stopping it.","Do not donate blood or semen while taking this medicine and for at least four weeks after stopping it.","This medicine can cause drowsiness and dizziness, so avoid driving or operating machinery until you know how it affects you.","Report numbness, tingling, burning, or weakness in the hands or feet immediately, because peripheral neuropathy can become permanent.","Regular blood tests are needed to check blood counts, liver function, kidney function, and thyroid function.","This medicine increases the risk of blood clots, so report leg swelling, chest pain, or shortness of breath immediately.","Avoid alcohol while taking this medicine.","Do not stop or change the dose without talking to your specialist first."]
🤱 Lactation Safety
This medicine must not be used during breastfeeding because thalidomide passes into breast milk and can cause serious harm to the baby. Women who need this medicine should not breastfeed. Discuss safe feeding alternatives with your doctor.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. If an overdose is suspected, seek emergency medical care immediately. Treatment is supportive and may include monitoring of breathing, heart rate, blood pressure, and blood counts. Do not try to make yourself vomit unless a healthcare professional tells you to do so.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
This medicine must only be taken exactly as prescribed by a specialist, and the dose must never be changed without medical advice. Because thalidomide causes severe birth defects, women who can become pregnant must use two effective methods of contraception for at least four weeks before starting, during the entire treatment, and for at least four weeks after the last dose. Men taking this medicine must use condoms during all sexual contact, even after a vasectomy, because the medicine can pass into semen. Regular blood tests are essential to check blood counts, liver function, kidney function, and thyroid function. Do not donate blood or semen while taking this medicine and for at least four weeks after stopping it. Avoid driving or operating heavy machinery until you know how drowsiness affects you. Do not drink alcohol, because it increases drowsiness and dizziness. Keep all appointments with your doctor and report any numbness, tingling, rash, swelling, or breathing difficulty immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the drowsiness, dizziness, and nerve-related side effects of this medicine. They may also have reduced kidney and liver function, which can affect how the medicine is handled. Blood counts, kidney function, and liver function should be checked carefully, and the dose must be individualized by a qualified clinician. Falls and confusion should be watched for closely.
🤰 Pregnancy Planning (TTC)
This medicine must not be used if you are pregnant or planning to become pregnant. Women who can become pregnant must use two reliable forms of contraception for at least four weeks before starting treatment, during the entire treatment, and for at least four weeks after the last dose. Men taking this medicine must use condoms during all sexual contact and for at least four weeks after stopping. If you are planning a pregnancy, discuss it with your specialist well in advance so that safe alternatives can be considered.
🏥 Post-Surgery Considerations
This medicine increases the risk of blood clots, which is especially important after surgery. Tell your surgeon and anaesthetist that you are taking this medicine before any operation. Your doctor may advise temporary interruption or extra clot prevention measures. Do not stop the medicine on your own; follow your specialist's instructions.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. Because this medicine can lower blood counts and increase bleeding risk, your dentist may need to check your blood counts or take extra precautions. Good oral hygiene and regular dental check-ups are important during treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and nerve damage, so avoid driving, cycling, or using heavy gym equipment until you know how it affects you. If you have peripheral neuropathy, avoid exercises that require fine balance or that could cause falls. Low-impact activities such as walking or swimming may be suitable if you feel well, but check with your doctor before starting any new exercise programme.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine commonly causes drowsiness, dizziness, and tiredness, which can affect your ability to drive, operate machinery, or perform tasks that need concentration. You may need to adjust your work schedule or take time off during the first few weeks of treatment. Peripheral neuropathy can affect your grip, balance, and ability to do fine tasks. Discuss your job with your doctor so that appropriate precautions can be taken.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor may stop it or change the dose if you develop serious side effects such as peripheral neuropathy, blood clots, low blood counts, severe skin reactions, or liver problems. If you experience any red-flag symptom, contact your doctor immediately. Always discuss with your specialist before stopping treatment.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to persistent peripheral neuropathy, which may not improve after stopping the medicine. It can also cause ongoing bone marrow suppression, increasing the risk of infections and bleeding. Regular monitoring of blood counts, liver function, kidney function, and thyroid function is needed throughout treatment. Some people may develop blood clots or heart rate changes. Your doctor will review the benefits and risks regularly and may stop or change the medicine if serious side effects occur.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Related immunomodulatory medicines that may be used in multiple myeloma, depending on your condition and treatment history.
Evidence: Well-establishedAnother class of medicines used in multiple myeloma, often in combination with immunomodulatory agents.
Evidence: Well-establishedUsed to control inflammation in erythema nodosum leprosum and as part of myeloma treatment.
Evidence: Well-establishedCan help manage nerve symptoms, weakness, and general fitness during treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines must not be given while you are taking this medicine because it suppresses the immune system and may increase the risk of infection from the vaccine. Inactivated vaccines may be given, but they may not work as well. Discuss the timing of any vaccination with your doctor before receiving it.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless the label says so
✅ DO
Keep the capsule in its original container with the lid tightly closed
❌ DON'T
Do not transfer it to an unmarked container
✅ DO
Keep it away from direct sunlight and moisture
❌ DON'T
Do not store it in a bathroom cabinet
✅ DO
Keep it out of the reach of children and pets
❌ DON'T
Do not leave it where children can see or reach it
✅ DO
Check the expiry date before use
❌ DON'T
Do not use the medicine after the expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the pharmacy label clearly visible. Keep a copy of your prescription and a letter from your doctor explaining that you need this medicine, especially for international travel. Carry enough medicine for the entire trip and a little extra in case of delays. Store it in a cool, dry place away from direct sunlight, and do not leave it in a hot car or checked luggage. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Because this medicine is a controlled risk-management product, check the customs rules of your destination before travelling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The time to work depends on the condition being treated. In erythema nodosum leprosum, improvement may be seen within days to weeks. In multiple myeloma, the effect builds up over weeks of continuous treatment, and your doctor will check your response with regular tests.
A: You may take this medicine with a light meal or snack if it upsets your stomach. Otherwise, it can be taken with water. Follow your doctor's instructions about timing.
A: No. This medicine is absolutely contraindicated in pregnancy because it causes severe, life-threatening birth defects. Pregnancy must be prevented with two reliable forms of contraception, and men must use condoms during sexual contact.
A: If you remember within half the dosing interval, take the missed dose. If more than half the interval has passed, skip it and continue with your regular schedule. Do not double dose.
A: No. Do not stop this medicine without talking to your specialist, because stopping suddenly can cause the disease to come back or worsen.
A: Yes, this medicine can cause peripheral neuropathy, which means numbness, tingling, burning, or weakness in the hands and feet. Report these symptoms immediately, because early detection is important.
A: No. Alcohol increases drowsiness, dizziness, and the risk of falls, and it may add to liver strain. Avoid alcohol completely during treatment.
A: You will need regular blood tests to check your blood counts, liver function, kidney function, and thyroid function. Women who can become pregnant will also need regular pregnancy tests.
🤔 Common Patient Concerns
🔄 Substitutes for thaldo capsule
View AllAlternative brands with exact same active ingredient:
-
mythal 100mg capsuleAureate Healthcare Pvt Ltd ₹525.00 17.9% CHEAPER
-
Thaliglob 100mg CapsuleGlobela Pharma Pvt Ltd ₹525.00 17.9% CHEAPER
-
thycad 100mg capsuleCadila Pharmaceuticals Ltd ₹596.93 6.6% CHEAPER
-
Thalimax 100mg CapsuleGetwell Pharmaceutical Pvt Ltd ₹620.00 3% CHEAPER
-
adthal 100mg capsuleAdley Formulations ₹624.30 2.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a general painkiller.
Fact: This medicine is not a general painkiller. It is a specialised immunomodulatory medicine used for specific cancers and inflammatory conditions under specialist supervision. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine is absolutely contraindicated in pregnancy because it causes severe, life-threatening birth defects. - Myth: Once I feel better, I can stop this medicine on my own.
Fact: You must not stop this medicine without talking to your specialist, because stopping suddenly can cause the disease to come back or worsen. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious side effects including nerve damage, blood clots, low blood counts, and severe skin reactions. - Myth: Men taking this medicine do not need to worry about pregnancy.
Fact: Men taking this medicine must use condoms during all sexual contact because the medicine can pass into semen and harm a developing baby.
🔄 Alternative Options
Generic Alternatives
- Thalidomide 100 mg capsule
Brand Alternatives
- Immithal 100 mg capsule