surect cream - Lidocaine (4% w/w) + Metronidazole (1% w/w) medicine

Elfate-LM Rectal Cream: Complete Medicine Guide

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🏭 Nemus Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Seizures
  • Numbness or tingling in hands or feet
  • Severe rectal bleeding
  • Signs of liver problems (yellowing of skin or eyes, dark urine)
  • Persistent vomiting or severe headache

If experiencing severe symptoms, call emergency services immediately.

What is surect cream used for?

This medicine is a rectal cream containing lidocaine (a numbing agent) and metronidazole (an antibiotic). It is used to treat painful and infected conditions of the rectum and anus, such as hemorrhoids and anal fissures. Apply as directed by your doctor, usually 1-2 times daily.

  • Generic Name: Lidocaine (4% w/w) + Metronidazole (1% w/w)
  • Manufacturer: Nemus Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 surect cream के बारे में (Hindi Summary)

उपयोग: यह दवा मलाशय और गुदा के दर्द, खुजली और संक्रमण के इलाज के लिए उपयोग की जाती है। इसमें लिडोकेन और मेट्रोनिडाजोल होते हैं। लिडोकेन दर्द को सुन्न करता है और मेट्रोनिडाजोल संक्रमण को रोकता है। इसका उपयोग बवासीर, गुदा में दरार और प्रोक्टाइटिस जैसी समस्याओं में किया जाता है।

साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली या लालिमा शामिल है। कभी-कभी मुँह में धातु जैसा स्वाद आ सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, दौरे या हाथ-पैर में झुनझुनी हो सकती है। कोई भी असामान्य लक्षण दिखने पर डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा का उपयोग डॉक्टर के निर्देशानुसार ही करें। लगाने से पहले और बाद में हाथ धोएँ। आँखों, मुँह या नाक के संपर्क में न आने दें। उपचार के दौरान शराब न पिएँ। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। बच्चों की पहुँच से दूर रखें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 surect cream Uses & Benefits

[{"condition":"Hemorrhoids","description":"Provides relief from pain, itching, and inflammation associated with hemorrhoids.","evidence":"Well-established"},{"condition":"Anal fissures","description":"Helps reduce pain and promotes healing by preventing infection.","evidence":"Well-established"},{"condition":"Proctitis","description":"Treats inflammation and infection of the rectal lining.","evidence":"Moderate"},{"condition":"Pruritus ani","description":"Relieves itching around the anus, often due to infection or irritation.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Perianal abscess after drainage","description":"Sometimes used to prevent infection and relieve pain after surgical drainage.","evidence":"Limited"}]

Primary treatment for: Hemorrhoids

Also treats: Anal fissures, Proctitis, Pruritus ani

📋 Drug Information

Generic Name(s)Lidocaine (4% w/w) + Metronidazole (1% w/w)
Brand Namesurect cream
ManufacturerNemus Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationTopical (rectal)
StorageStore at room temperature (15-30°C). Protect from light and moisture.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply the cream after a bowel movement and after cleaning the area gently.
2
Use a finger cot or applicator to avoid contamination.
3
Avoid alcohol completely during treatment to prevent disulfiram-like reaction.
4
Do not use for more than 7 days without consulting your doctor.
5
If symptoms worsen or do not improve, seek medical advice.
6
Keep the area clean and dry to promote healing.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Rectal pain
This medicine is commonly prescribed for this.
Likely Use
✅
Anal itching
This medicine can help relieve itching.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionLidocaine is absorbed through mucous membranes; systemic absorption depends on the surface area and duration of application. Metronidazole is absorbed through the rectal mucosa, but systemic levels are generally low with topical use.
DistributionLidocaine distributes into tissues and crosses the placenta and blood-brain barrier. Metronidazole distributes widely into body tissues and fluids, including cerebrospinal fluid.
Protein BindingLidocaine is about 60-80% bound to plasma proteins. Metronidazole is less than 20% bound to plasma proteins.
MetabolismLidocaine is metabolized in the liver by cytochrome P450 enzymes (CYP3A4, CYP1A2). Metronidazole is metabolized in the liver by oxidation and glucuronidation.
Half-LifeLidocaine half-life is about 1.5-2 hours. Metronidazole half-life is about 6-8 hours.
ExcretionLidocaine metabolites are excreted in urine. Metronidazole and its metabolites are excreted mainly in urine, with some in feces.
BioavailabilityNot established from the available information for rectal cream.
Onset of ActionLidocaine provides local anesthesia within 2-5 minutes of application. Metronidazole's antimicrobial effect begins after absorption, but clinical improvement may take days.
Peak Plasma TimeNot established from the available information for rectal cream.
Duration of ActionLidocaine anesthesia lasts about 30-60 minutes. Metronidazole's effect persists as long as therapeutic levels are maintained.

How It Works

This medicine combines a local anesthetic and an antimicrobial. Lidocaine blocks sodium channels in nerve cell membranes, preventing the generation and conduction of pain signals. Metronidazole enters susceptible microorganisms and disrupts DNA structure, leading to cell death. Together, they provide symptomatic relief and treat underlying infection.

Mechanism Steps

1
Sodium channel blockade: Lidocaine binds to voltage-gated sodium channels on nerve endings, blocking the influx of sodium ions and preventing depolarization.
2
Pain signal inhibition: This blockade stops the transmission of pain impulses from the rectum to the brain, providing rapid relief.
3
Metronidazole uptake: Metronidazole diffuses into anaerobic bacteria and protozoa, where its nitro group is reduced.
4
DNA disruption: The reduced metronidazole forms reactive intermediates that damage microbial DNA, leading to cell death.

💡 How to Take surect cream

Strength: Rectal cream containing lidocaine 4% w/w and metronidazole 1% w/w.

1Wash your hands thoroughly before and after application.
2Clean and dry the affected area gently.
3Apply a thin layer of the cream to the affected area using your finger or an applicator.
4Avoid contact with the eyes, mouth, or nose.
5Do not cover the area with an airtight dressing unless instructed by your doctor.

Dosage Information

Adult DosageApply a thin layer to the affected area 1-2 times daily, or as directed by your doctor. The dose and duration depend on the condition being treated. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients, but use with caution due to potential for increased sensitivity.
Renal ImpairmentNo dose adjustment is typically needed for topical use, but consult your doctor if you have severe kidney disease.
Hepatic ImpairmentUse with caution in patients with severe liver disease. Consult your doctor for dose adjustment.
Maximum Daily DoseNot established from the available information. Follow your doctor's prescription.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Alcohol
Avoid
Can cause disulfiram-like reaction.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of surect cream

✅ Common Side Effects

Application site burning (Common (1-10%))
Usually resolves on its own. If persistent, consult your doctor.
Application site itching (Common (1-10%))
Avoid scratching. Consult your doctor if severe.
Metallic taste (Uncommon (0.1-1%))
Usually temporary. Drink plenty of water.

🚨 Serious Side Effects

Severe allergic reaction (Rare (<0.1%))
Seek immediate medical attention if you experience rash, swelling, or difficulty breathing.
Seizures (Rare (<0.1%))
Stop use and get emergency help if seizures occur.
Peripheral neuropathy (Rare (<0.1%))
Report numbness or tingling in hands or feet to your doctor.

⚠️ Rare Side Effects

Contact dermatitis
Discontinue use and consult a doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Cimetidine Moderate
Lithium Moderate
Antacids Minor

🚨 Major Interactions

  • Alcohol
  • Warfarin

⚡ Moderate Interactions

  • Cimetidine
  • Lithium

🍷 Alcohol Interaction

Avoid alcohol completely while using this medicine and for at least 48 hours after stopping, as metronidazole can cause a disulfiram-like reaction with symptoms like severe nausea, vomiting, flushing, and rapid heartbeat.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Allergy to lidocaine or metronidazole","Use in the eye","Severe liver disease"]

⚠️ Warnings & Precautions

["For rectal use only.","Avoid contact with eyes and mucous membranes.","Do not use on large areas of broken skin.","Avoid alcohol during treatment.","Consult doctor if symptoms persist beyond 7 days."]

🤱 Lactation Safety

Lidocaine and metronidazole may pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose is unlikely with topical use. If accidental ingestion occurs, seek emergency medical attention. Symptoms of lidocaine overdose include dizziness, seizures, and irregular heartbeat. Metronidazole overdose may cause nausea, vomiting, and neurological symptoms.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Use this medicine only as prescribed by your doctor. Wash your hands before and after application. Apply a thin layer to the affected area and avoid contact with the eyes, mouth, or nose. Do not use it for longer than recommended. Avoid alcohol while using this medicine because metronidazole can cause a disulfiram-like reaction (severe nausea, vomiting, flushing). Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine if you have a history of allergy to lidocaine or metronidazole. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of lidocaine. Use with caution and monitor for side effects.

🤰 Pregnancy Planning (TTC)

Consult your doctor before using this medicine if you are planning pregnancy. It is generally considered safe for topical use but use only if clearly needed.

🏥 Post-Surgery Considerations

This medicine may be used after rectal surgery to relieve pain and prevent infection. Follow your surgeon's instructions.

🦷 Dental Procedures

No specific considerations for dental procedures, as this medicine is for rectal use.

💚 Lifestyle Tips for Better Results

🏃
Eat a high-fiber diet to prevent constipation.
🥗
Drink plenty of water throughout the day.
😴
Avoid straining during bowel movements.
💧
Exercise regularly to improve circulation.
🧘
Maintain good anal hygiene.

🏋️ Exercise Considerations

Avoid strenuous exercise that increases pressure on the rectal area until symptoms improve.

🥗 Diet Recommendations

Include plenty of fruits and vegetables.
Choose whole grains over refined grains.
Stay well hydrated.
Avoid spicy and processed foods that can irritate.

💼 Impact on Daily Work & Life

This medicine may cause mild dizziness or numbness; avoid driving or operating machinery if affected. It should not interfere with most work activities.

🛑 When to Stop This Medicine

Stop using this medicine if you experience severe side effects or if your symptoms do not improve within 7 days. Consult your doctor before stopping if you are unsure.

📅 Long-Term Use Effects

Prolonged use may increase the risk of systemic absorption and side effects such as peripheral neuropathy. Use only for the prescribed duration and consult your doctor if symptoms persist.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Sitz baths

Warm water baths can help relieve pain and itching.

Evidence: Well-established
Stool softeners

Help prevent straining during bowel movements.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. Continue routine vaccinations as scheduled.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, continue your regular dosing schedule. Declare it at customs if required.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 40-year-old man with painful hemorrhoids
He was prescribed this medicine for hemorrhoid pain and swelling. After applying it twice daily for 5 days, he noticed significant pain relief and reduced itching. He avoided alcohol and followed a high-fiber diet.
💡 Lesson: Consistent use and lifestyle modifications improve outcomes.
👤 A 35-year-old woman with an anal fissure
She used this cream as directed and experienced relief within 3 days. She also increased her water intake and used stool softeners to prevent straining.
💡 Lesson: Combining medicine with proper hydration and diet helps healing.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Lidocaine provides numbness within minutes, while metronidazole starts working against infection over a few days.

Q: Can I use it for other skin conditions?

A: No, it is specifically for rectal use. Consult your doctor for other conditions.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine long-term?
  • Will it affect my liver?
  • Can I drive after applying this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while using this?

🔄 Substitutes for surect cream

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This cream can cure hemorrhoids permanently.
    Fact: It provides symptomatic relief and treats infection but does not cure the underlying condition. Lifestyle changes and medical procedures may be needed.
  • Myth: You can use it for any skin problem.
    Fact: It is specifically for rectal use and should not be applied to other areas unless directed by a doctor.

🔄 Alternative Options

Generic Alternatives

  • Lidocaine 4% + Metronidazole 1% rectal cream

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Lidocaine + Metronidazole","primary_use":"Pain and infection","route":"Rectal"},{"medicine":"Hydrocortisone rectal cream","active_ingredients":"Hydrocortisone","primary_use":"Inflammation and itching","route":"Rectal"}]

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