Ampirok 500 mg/250 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing
- Swelling of the face, lips, or throat
- Severe rash or hives
- Severe or persistent diarrhea
- Seizures
- Unusual bleeding or bruising
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is sulbact 500 mg/250 mg injection used for?
This medicine is a combination antibiotic injection containing Ampicillin and Sulbactam. It is used to treat a wide range of bacterial infections by killing bacteria and preventing their growth. It is administered by a healthcare professional.
- Generic Name: Ampicillin (500mg) + Sulbactam (250mg)
- Manufacturer: Biochem Pharmaceutical Industries
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sulbact 500 mg/250 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एम्पीसिलिन और सल्बैक्टम का संयोजन है, जिसका उपयोग विभिन्न प्रकार के जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र पथ, त्वचा, पेट और स्त्री रोग संबंधी संक्रमणों में प्रभावी है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा दी जाती है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, उल्टी, दाने और खुजली शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी की प्रतिक्रिया, गंभीर दस्त, दौरे और रक्त विकार शामिल हो सकते हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों, विशेषकर गुर्दे या यकृत की बीमारी और एलर्जी के बारे में बताएं। अपनी सभी दवाओं की जानकारी दें। इंजेक्शन खुद न लगाएं। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दाने जैसे लक्षण दिखें तो तुरंत आपातकालीन चिकित्सा सहायता लें। दस्त होने पर बिना डॉक्टर की सलाह के दस्त रोकने की दवा न लें। संक्रमण को पूरी तरह ठीक करने के लिए दवा का पूरा कोर्स पूरा करें।
💊 sulbact 500 mg/250 mg injection Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat community-acquired pneumonia, acute exacerbations of chronic bronchitis, and other lower respiratory tract infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated urinary tract infections caused by susceptible strains of Escherichia coli, Klebsiella, and other organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for cellulitis, abscesses, and wound infections caused by susceptible Gram-positive and Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for peritonitis, appendicitis, and other intra-abdominal infections.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and postpartum endometritis caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible organisms.","evidence":"Moderate"},{"condition":"Surgical prophylaxis","description":"Administered before certain surgical procedures to prevent postoperative infections.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Listeria monocytogenes infections","description":"Ampicillin is a preferred agent for Listeria infections, and sulbactam may be added for broader coverage, though this combination is not specifically approved for this indication.","evidence":"Limited"},{"condition":"Enterococcal infections","description":"May be used off-label for serious enterococcal infections when combined with other antibiotics.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Intra-abdominal infections, Gynecological infections
📋 Drug Information
| Generic Name(s) | Ampicillin (500mg) + Sulbactam (250mg) |
| Brand Name | sulbact 500 mg/250 mg injection |
| Manufacturer | Biochem Pharmaceutical Industries |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store below 25°C. Protect from light. Do not freeze. Reconstituted solutions should be used immediately or stored as directed by the pharmacist. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ampicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) and blocking the cross-linking of peptidoglycan chains. This leads to bacterial cell lysis and death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, preventing them from hydrolyzing and inactivating ampicillin. This extends the spectrum of ampicillin to include beta-lactamase-producing strains of Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Klebsiella species, and Bacteroides species.
Mechanism Steps
💡 How to Take sulbact 500 mg/250 mg injection
Strength: Each vial contains Ampicillin 500 mg and Sulbactam 250 mg as a sterile powder for injection.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 g to 3 g (ampicillin 1 g to 2 g + sulbactam 0.5 g to 1 g) every 6 to 8 hours, administered intramuscularly or intravenously. The dose and frequency depend on the severity of the infection, the site of infection, and the patient's renal function. For severe infections, higher doses may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function, which may require dose adjustment. Monitor renal function and adjust dose accordingly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the dose and frequency should be adjusted based on creatinine clearance. For creatinine clearance 15-29 mL/min, the usual dose is every 12 hours. For creatinine clearance 5-14 mL/min, the usual dose is every 24 hours. For patients on hemodialysis, an additional dose should be given after dialysis. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dosage adjustment is established for hepatic impairment, but caution is advised. Monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 12 g (ampicillin 8 g + sulbactam 4 g) for adults with normal renal function. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sulbact 500 mg/250 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Aminoglycosides | Moderate | |
| Chloramphenicol | Moderate | |
| Tetracyclines | Minor | |
| Beta-blockers | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
- Probenecid
⚡ Moderate Interactions
- Oral contraceptives
- Aminoglycosides
- Chloramphenicol
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and gastrointestinal side effects. It is advisable to avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ampicillin, sulbactam, or any penicillin or beta-lactam antibiotic","History of severe allergic reaction to any beta-lactam antibiotic","Infectious mononucleosis (increased risk of rash)"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions have been reported. Before initiating therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, and other allergens.","Clostridioides difficile-associated diarrhea may occur. If diarrhea develops, evaluate for this condition.","Use with caution in patients with renal impairment. Dose adjustment may be necessary.","Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi.","Prescribing this medicine in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit and increases the risk of drug-resistant bacteria."]
🤱 Lactation Safety
Ampicillin and sulbactam are excreted in human milk in low concentrations. Caution should be exercised when administered to a nursing woman. Monitor the infant for diarrhea, thrush, or rash.
💊 Overdose Management
Overdose with this medicine may cause gastrointestinal symptoms, seizures, and electrolyte imbalances. Treatment is symptomatic and supportive. Ampicillin and sulbactam can be removed by hemodialysis. In case of overdose, seek immediate medical attention.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible to reschedule. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine should only be administered by a qualified healthcare professional. Before receiving this medicine, inform your doctor about all your medical conditions, especially kidney disease, liver disease, or any allergies. Also, tell your doctor about all other medicines you are taking, including prescription, over-the-counter, and herbal products. Do not self-administer this injection. If you experience any signs of a severe allergic reaction such as difficulty breathing, swelling of the face or throat, or a severe rash, seek emergency medical help immediately. Diarrhea that is severe or persists may be a sign of a serious bowel infection; do not treat it with over-the-counter antidiarrheal medicines without consulting your doctor. Complete the full course of treatment as prescribed, even if you feel better, to prevent the development of antibiotic resistance.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function, which may require dose adjustment. They may also be more susceptible to side effects like diarrhea and allergic reactions. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is classified as Pregnancy Category B and should be used only if clearly needed. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine is often used for surgical prophylaxis. If you have recently had surgery, inform your surgeon about any allergies and follow their instructions regarding antibiotic use.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with other medications used during dental procedures. It may also be used prophylactically before dental procedures in patients at risk of infective endocarditis.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue. Avoid strenuous exercise until you feel better. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, fatigue, or diarrhea, which can affect your ability to work or drive. Avoid operating heavy machinery until you know how it affects you. Inform your employer if you need time off for treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience severe side effects, contact your doctor immediately; they may adjust or stop the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of nonsusceptible organisms, including fungi, and may increase the risk of antibiotic resistance. Prolonged use may also cause blood dyscrasias, liver enzyme elevation, and renal impairment. Regular monitoring of blood counts, liver and kidney function is recommended during prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild infections, oral antibiotics like amoxicillin-clavulanate may be used instead of injections.
Evidence: Well-establishedCephalosporins or fluoroquinolones may be alternatives for patients allergic to penicillin.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Avoid vaccination with live organisms during treatment. Inactivated vaccines are generally safe.
📦 Storage Guide
✅ DO
Store below 25°C
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not expose to direct sunlight
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Use reconstituted solution immediately
❌ DON'T
Do not store reconstituted solution for later use
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of your prescription and a doctor's letter explaining the medical need. Keep it in your carry-on luggage to avoid temperature extremes. Store below 25°C and protect from light. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying injectable medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes after injection, but you may start feeling better within 24 to 48 hours. Complete the full course as prescribed.
A: This medicine is classified as Pregnancy Category B. It should be used during pregnancy only if clearly needed. Consult your doctor.
A: Common side effects include injection site pain, diarrhea, nausea, vomiting, rash, and itching. Most are mild and resolve on their own.
A: This medicine may cause dizziness. Avoid driving or operating machinery until you know how it affects you.
A: Pediatric dosing is not established from available information. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for sulbact 500 mg/250 mg injection
View AllAlternative brands with exact same active ingredient:
-
pre op 500 mg/250 mg injectionWanbury Ltd ₹43.86 45.3% COSTLIER
-
ampirok 500 mg/250 mg injectionAstrum Healthcare Pvt Ltd ₹48.57 60.9% COSTLIER
-
saltum 500 mg/250 mg injectionMorepen Laboratories Ltd ₹52.37 73.5% COSTLIER
-
ampirok 500 mg/250 mg tabletAstrum Healthcare Pvt Ltd ₹294.00 873.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent recurrence and antibiotic resistance. - Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for individuals allergic to penicillins or beta-lactam antibiotics. Always inform your doctor of any allergies.
🔄 Alternative Options
Generic Alternatives
- Ampicillin + Sulbactam generic injections
Brand Alternatives
- Ampirok 500 mg/250 mg injection