Succin Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden rise in body temperature with muscle rigidity during or after the procedure
- Severe difficulty in breathing or inability to breathe after the medicine should have worn off
- Irregular or very slow heart rate that does not improve
- Dark brown or cola-coloured urine after the procedure
- Severe muscle pain, weakness, or swelling that is unusual or worsening
- Swelling of the face, lips, tongue, or throat with difficulty swallowing
- Chest pain, severe dizziness, or loss of consciousness
- Signs of severe allergic reaction such as widespread rash, wheezing, or a sudden drop in blood pressure
If experiencing severe symptoms, call emergency services immediately.
What is Succin Injection used for?
This medicine is a short-acting depolarizing muscle relaxant given by injection in hospital settings. It is used mainly to help place a breathing tube, to provide brief muscle relaxation for short procedures, and to reduce muscle contractions during electroconvulsive therapy. It works within about one minute and wears off within about five to ten minutes in most patients. It must only be given by trained professionals with full monitoring and breathing support available.
- Generic Name: Suxamethonium (NA)
- Manufacturer: Harson Laboratories
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Succin Injection के बारे में (Hindi Summary)
उपयोग: यह दवा सक्सामेथोनियम सोडियम नामक सक्रिय तत्व वाली एक इंजेक्शन है, जिसका उपयोग अस्पताल में विशेष रूप से ऑपरेशन थियेटर, आईसीयू और आपातकालीन विभागों में किया जाता है। यह मांसपेशियों को अस्थायी रूप से ढीला करने वाली दवा है, जिससे डॉक्टर सांस की नली में ट्यूब डाल सकते हैं, छोटी प्रक्रियाओं के दौरान मांसपेशियों को आराम दे सकते हैं, और इलेक्ट्रोकन्वल्सिव थेरेपी के दौरान मांसपेशियों के झटकों को कम कर सकते हैं। यह दवा लगभग एक मिनट में असर करना शुरू कर देती है और आमतौर पर पांच से दस मिनट में इसका असर खत्म हो जाता है। यह दवा केवल प्रशिक्षित डॉक्टर या एनेस्थीसिया विशेषज्ञ द्वारा ही दी जानी चाहिए, और इसके दौरान मरीज की सांस, दिल की धड़कन और ऑक्सीजन के स्तर की लगातार निगरानी की जाती है। इसे घर पर कभी भी नहीं रखना या खुद से नहीं लगाना चाहिए।
साइड इफेक्ट्स: इस दवा का सबसे आम असर मांसपेशियों में फड़कन और ऑपरेशन के बाद मांसपेशियों में दर्द है। कुछ मरीजों में दिल की धड़कन धीमी हो सकती है या अनियमित हो सकती है। शरीर में पोटैशियम का स्तर अस्थायी रूप से बढ़ सकता है, जो कुछ मरीजों के लिए खतरनाक हो सकता है। बहुत कम मामलों में यह दवा मैलिग्नेंट हाइपरथर्मिया नामक गंभीर स्थिति पैदा कर सकती है, जिसमें शरीर का तापमान तेजी से बढ़ता है और मांसपेशियों में अकड़न होती है। कुछ मरीजों में एलर्जी की प्रतिक्रिया भी हो सकती है। चूंकि यह दवा अस्पताल में ही दी जाती है, इसलिए इन सभी प्रभावों की निगरानी डॉक्टर की टीम द्वारा की जाती है और जरूरत पड़ने पर तुरंत इलाज किया जाता है।
सुरक्षा सलाह: यह दवा केवल अस्पताल में ही दी जाती है और इसे घर पर कभी भी नहीं रखना चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी बीमारियों, दवाओं और एलर्जी के बारे में जरूर बताएं। अगर आपको या आपके परिवार में किसी को मैलिग्नेंट हाइपरथर्मिया, मांसपेशियों की बीमारी, जलने की गंभीर चोट, किडनी या लीवर की बीमारी, या दिल की धड़कन की समस्या है, तो डॉक्टर को पहले ही बता दें। इस दवा को लेने के बाद आपको सांस लेने में मदद के लिए मशीन पर रखा जा सकता है और पूरी तरह ठीक होने तक निगरानी की जाती है। अगर आपको मांसपेशियों में असामान्य दर्द, गहरे रंग का पेशाब, बुखार या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर को बताएं। गर्भवती महिलाओं को इस दवा के बारे में अपने डॉक्टर से सलाह लेनी चाहिए।
💊 Succin Injection Uses & Benefits
[{"condition":"Endotracheal intubation","description":"This medicine is used to produce rapid, brief paralysis of the vocal cords and airway muscles so that a breathing tube can be placed quickly in emergency and elective settings.","evidence":"Well-established"},{"condition":"Short surgical procedures","description":"This medicine provides brief muscle relaxation for procedures such as endoscopy, reduction of dislocations, and short orthopaedic manipulations where prolonged paralysis is not needed.","evidence":"Well-established"},{"condition":"Electroconvulsive therapy","description":"This medicine is used to soften or prevent the strong muscle contractions that occur during electroconvulsive therapy, reducing the risk of injury.","evidence":"Well-established"},{"condition":"Laryngospasm","description":"This medicine can be used to break severe laryngospasm when other measures have failed, because of its rapid onset and short duration.","evidence":"Established in clinical practice"},{"condition":"Rapid sequence induction","description":"This medicine is chosen when a patient is at risk of aspiration and the airway must be secured as quickly as possible.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Diagnostic muscle testing","description":"This medicine has been used in specialised settings to help assess abnormal muscle responses, but this is not a routine use.","evidence":"Limited"},{"condition":"Treatment of severe muscle spasm in selected critical care situations","description":"This medicine may be considered in rare critical care scenarios when other muscle relaxants are unsuitable, but this is not a standard indication.","evidence":"Limited"}]
Primary treatment for: Not applicable. This medicine is used for procedural muscle relaxation rather than for the treatment of a specific disease.
📋 Drug Information
| Generic Name(s) | Suxamethonium (NA) |
| Brand Name | Succin Injection |
| Manufacturer | Harson Laboratories |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral, usually by intravenous injection. It may also be given by intramuscular injection in some situations, but the intravenous route is preferred because of its rapid onset |
| Storage | This medicine should be stored in its original container in a refrigerator at 2 to 8 degrees Celsius, as directed by the manufacturer. It should not be frozen. Once removed from the refrigerator, it should be used within the time specified by the manufacturer. It should be kept out of reach of children and away from direct sunlight. |
| Shelf Life | The shelf life is usually 24 to 36 months from the date of manufacture when stored under the recommended conditions. The expiry date on the label should always be checked before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine acts as a depolarizing neuromuscular blocker at the nicotinic acetylcholine receptor of the motor endplate. It binds to the receptor and mimics acetylcholine, but it is not broken down quickly by acetylcholinesterase at the synapse. This causes persistent depolarization of the muscle fibre membrane, which first produces fasciculations and then prevents further excitation, resulting in flaccid paralysis. Because the block is depolarizing in nature, it cannot be reversed by acetylcholinesterase inhibitors such as neostigmine. Recovery depends on the gradual diffusion of the medicine away from the receptor and its breakdown by plasma pseudocholinesterase.
Mechanism Steps
💡 How to Take Succin Injection
Strength: This medicine is supplied as an injection containing suxamethonium sodium. The exact strength and concentration should be confirmed from the product label. It is available as a sterile solution for injection.
Dosage Information
| Adult Dosage | The dose of this medicine is determined by the anaesthesia or critical care team based on the patient's weight, age, clinical condition, and the procedure being performed. A typical intravenous dose for adults is in the range of 1 to 1.5 mg per kilogram of body weight, but this is only a general guide. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and the presence of any interacting medicines. Repeated doses may be needed for longer procedures, but the total dose should be kept as low as possible to reduce the risk of prolonged blockade and cardiac effects. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anaesthetist. This medicine should only be used in children by trained professionals in a hospital setting with full monitoring and resuscitation equipment. |
| Elderly Dosage | Elderly patients may be more sensitive to the cardiac and neuromuscular effects of this medicine. The dose should be individualised by the clinical team, and heart rhythm, blood pressure, and neuromuscular function should be monitored closely. |
| Renal Impairment | Kidney disease can increase the risk of hyperkalaemia and may prolong the effect of this medicine. The dose should be individualised by the clinical team, and potassium levels and neuromuscular function should be monitored closely. |
| Hepatic Impairment | Severe liver disease can reduce pseudocholinesterase activity and prolong the effect of this medicine. The dose should be individualised by the clinical team, and prolonged paralysis should be anticipated. |
| Maximum Daily Dose | The maximum dose must be determined by the clinical team based on the patient's weight, condition, and the procedure. There is no fixed maximum daily dose that applies to all patients. Doses should be kept as low as possible to reduce the risk of prolonged blockade and cardiac effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Succin Injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Volatile inhalational anaesthetics | Major | |
| Aminoglycoside antibiotics | Major | |
| Magnesium sulfate | Major | |
| Ester local anaesthetics | Major | |
| Anticholinesterases | Major | |
| Beta-blockers | Moderate | |
| Calcium channel blockers | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| Metoclopramide | Moderate |
🚨 Major Interactions
- Volatile inhalational anaesthetics
- Aminoglycoside antibiotics
- Magnesium sulfate
- Local anaesthetics of the ester type
- Anticholinesterases such as neostigmine
⚡ Moderate Interactions
- Beta-blockers
- Calcium channel blockers
- Diuretics
- Lithium
- Metoclopramide
🍷 Alcohol Interaction
Alcohol is not directly relevant to this medicine because it is given in a hospital setting by injection. However, alcohol can affect liver function and general anaesthesia, so patients should inform the clinical team about any recent alcohol use.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known or suspected malignant hyperthermia","Personal or family history of malignant hyperthermia","Severe hyperkalaemia","Major burns or crush injuries beyond the safe window","Pre-existing pseudocholinesterase deficiency","Known allergy to suxamethonium or related muscle relaxants","Severe muscle disease such as Duchenne muscular dystrophy","Prolonged immobilisation with muscle wasting"]
⚠️ Warnings & Precautions
["This medicine must only be given by trained anaesthesia or critical care professionals.","Immediate access to intubation equipment, oxygen, and mechanical ventilation is essential.","Use with caution in patients with heart disease, electrolyte imbalance, or kidney disease.","Use with caution in patients with liver disease because pseudocholinesterase activity may be reduced.","Use with caution in children and elderly patients, who may be more sensitive to cardiac effects.","Repeated doses can cause a shift from depolarizing block to a non-depolarizing block, prolonging paralysis.","This medicine can raise intraocular pressure, so caution is needed in patients with glaucoma or eye injuries.","This medicine can raise intragastric pressure, so precautions against aspiration are needed.","Patients with low pseudocholinesterase activity may experience prolonged paralysis and require extended ventilation."]
🤱 Lactation Safety
Not established from the available information. Because this medicine is given in a hospital setting and has a very short duration of action, it is unlikely to affect a breastfed infant, but breastfeeding mothers should discuss this with their clinical team.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. Management is supportive and includes maintaining a clear airway, providing mechanical ventilation, and monitoring heart rhythm, blood pressure, oxygen levels, and temperature. If malignant hyperthermia occurs, dantrolene must be given immediately along with aggressive cooling and supportive care. If hyperkalaemia occurs, treatment with calcium, insulin and glucose, and other measures may be needed. Prolonged paralysis should be managed with continued ventilation until muscle function returns. Patients should be monitored closely until all effects of the medicine have worn off.
⏰ Missed Dose
This medicine is given only in a hospital or clinic setting by a trained professional, so a missed dose is not applicable in the usual sense. If a planned dose is delayed or omitted, the clinical team will decide whether it is still needed based on the procedure and the patient's condition. Patients should not attempt to take or store this medicine at home.
Additional Safety Advice
This medicine is a hospital-only medicine and must never be self-administered, stored at home, or used without continuous monitoring of breathing, heart rhythm, and oxygen levels. Before receiving this medicine, tell the anaesthesia team about any personal or family history of malignant hyperthermia, any muscle disease, any recent burn or crush injury, any kidney problem, any liver problem, any heart rhythm disorder, and any known allergy to muscle relaxants. Inform the team about all medicines you take, especially antibiotics, heart medicines, antidepressants, and seizure medicines, because some of these can prolong the effect of this medicine. Do not eat or drink before a planned procedure unless the clinical team gives specific instructions. After receiving this medicine, you will remain on a breathing machine until the drug wears off and your muscles recover fully. Report any unusual muscle pain, dark urine, fever, or difficulty breathing to the medical team immediately. Pregnant women should inform the clinical team so that the risks and benefits can be weighed carefully. This medicine is not for children outside a supervised hospital setting, and it is not for elderly patients without individualised assessment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the cardiac effects of this medicine, including bradycardia and other rhythm disturbances. They may also have reduced pseudocholinesterase activity, which can prolong the effect of the medicine. The dose should be individualised, and heart rhythm, blood pressure, and neuromuscular function should be monitored closely.
🤰 Pregnancy Planning (TTC)
If you are planning a pregnancy or are pregnant, inform your clinical team before receiving this medicine. This medicine can cross the placenta and may affect the fetus. It should be used during pregnancy only when the clinical benefit clearly outweighs the potential risk, and only under the supervision of an experienced anaesthesia team.
🏥 Post-Surgery Considerations
After surgery in which this medicine was used, you will be monitored until your muscle function and breathing have fully recovered. You may experience muscle pain, fatigue, or a sore throat from the breathing tube. Follow your clinical team's instructions about when to eat, drink, and resume normal activities. Report any unusual muscle weakness, dark urine, fever, or difficulty breathing immediately.
🦷 Dental Procedures
If you are having a dental procedure that requires general anaesthesia or muscle relaxation, inform the dental team and the anaesthesia team about any history of malignant hyperthermia, muscle disease, or reactions to anaesthesia. This medicine may be used in some dental procedures that require intubation, but the decision will be made by the anaesthesia team based on your individual needs.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
After receiving this medicine, you should not drive, operate machinery, or perform any activity that requires full muscle control until the clinical team confirms that you have fully recovered. Muscle weakness and fatigue may persist for a short time after the procedure. Follow the advice of your clinical team regarding when it is safe to resume normal activities and exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic setting, and its effects wear off within a short time. However, you may feel tired, weak, or have muscle pain for a day or two after the procedure. You should not drive, operate heavy machinery, or make important decisions until you feel fully recovered and your clinical team confirms it is safe. Most people can return to their normal activities within a day or two, but this depends on the procedure and your overall health.
🛑 When to Stop This Medicine
This medicine is given as a single dose or a few doses during a procedure, so there is no long-term course to stop. If you experience any serious side effect during or after receiving this medicine, the clinical team will stop it immediately and provide appropriate treatment. Do not attempt to stop or adjust this medicine on your own, as it is only given by trained professionals.
📅 Long-Term Use Effects
This medicine is used for short periods and is not intended for long-term use. Most patients recover fully once the medicine wears off. In rare cases, prolonged paralysis may occur, especially in patients with pseudocholinesterase deficiency or those who receive repeated doses. Patients who experience malignant hyperthermia may need long-term follow-up and should avoid triggering medicines in the future. Anyone who has received this medicine and develops unusual muscle weakness, dark urine, or persistent breathing problems should seek medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
These medicines provide muscle relaxation for longer procedures and can be reversed with specific agents.
Evidence: Well-establishedIn some patients, the airway can be secured without muscle relaxants using a flexible scope.
Evidence: Well-establishedFor some procedures, regional blocks can provide surgical conditions without general muscle relaxation.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There is no known interaction between this medicine and vaccines. If you have a planned procedure, inform your clinical team about any recent vaccinations.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2 to 8 degrees Celsius as directed by the manufacturer
❌ DON'T
Do not freeze the product
✅ DO
Keep in the original container with the label intact
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not store at room temperature for long periods unless the manufacturer allows it
✅ DO
Check the expiry date before use
❌ DON'T
Do not use if the solution is discoloured or contains particles
✈️ Traveling with This Medicine
This medicine is a hospital-only injection and is not carried by patients during travel. If you are travelling after a procedure in which this medicine was used, carry a copy of your discharge summary and any relevant medical records. Inform your travel insurance provider about any recent anaesthesia or hospital treatment. If you have a history of malignant hyperthermia or a related family history, carry a medical alert card and inform any new clinical team before future procedures. Do not carry this medicine in personal luggage, and do not attempt to store it outside a hospital or clinic.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within about 30 to 60 seconds after it is injected into a vein.
A: The effect usually lasts about 5 to 10 minutes in most patients, but it can last longer in some situations.
A: This medicine does not put you to sleep. You will usually receive anaesthesia or sedation along with it, depending on the procedure.
A: No. This medicine must only be given in a hospital or clinic by trained professionals with full monitoring and breathing support.
A: The most serious side effects include malignant hyperthermia, severe hyperkalaemia with heart problems, anaphylaxis, and prolonged paralysis. These are rare but require immediate medical attention.
A: This medicine should not be given to patients with malignant hyperthermia, severe hyperkalaemia, major burns or crush injuries, certain muscle diseases, or a known allergy to the medicine.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be used as a painkiller.
Fact: This medicine is a muscle relaxant and has no pain-relieving effect. It must be used with appropriate anaesthesia or sedation when needed. - Myth: This medicine can be stored and used at home.
Fact: This medicine is a hospital-only medicine and must never be stored or used at home. It requires continuous monitoring and breathing support. - Myth: This medicine can be reversed with neostigmine.
Fact: This medicine causes a depolarizing block, which cannot be reversed by anticholinesterases such as neostigmine. Recovery depends on the medicine being broken down in the body. - Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for everyone. It should be avoided in patients with malignant hyperthermia, severe hyperkalaemia, major burns, crush injuries, and certain muscle diseases.
🔄 Alternative Options
Generic Alternatives
- Suxamethonium sodium injection
Brand Alternatives
- Succin Injection