Eslo-AT Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Very slow heart rate (below 50 beats per minute) or fainting
- Severe dizziness or lightheadedness
- Sudden weight gain or swelling in legs and feet
- Difficulty breathing or wheezing
- Chest pain that worsens or is not relieved by rest
- Swelling of face, lips, tongue, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is samlodon at 2.5mg/50mg tablet used for?
This medicine is a combination of Amlodipine and Atenolol used to treat high blood pressure and prevent angina. It works by relaxing blood vessels and slowing the heart rate. It is taken once daily by mouth, usually with or without food. Do not stop it suddenly without medical advice.
- Generic Name: Amlodipine (2.5mg) + Atenolol (50mg)
- Manufacturer: Zydus Cadila
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 samlodon at 2.5mg/50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एम्लोडिपिन और एटेनोलोल का संयोजन है, जिसका उपयोग उच्च रक्तचाप (हाइपरटेंशन) और एनजाइना (सीने में दर्द) के इलाज के लिए किया जाता है। यह रक्त वाहिकाओं को आराम देकर और हृदय की गति को धीमा करके रक्तचाप को कम करती है। इसे आमतौर पर दिन में एक बार मुँह से लिया जाता है। इसे डॉक्टर की सलाह के बिना अचानक बंद न करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में थकान, चक्कर आना, सिरदर्द, टखनों में सूजन, धीमी हृदय गति और हाथ-पैर ठंडे होना शामिल हैं। गंभीर दुष्प्रभावों में बहुत धीमी हृदय गति, हृदय रुकावट, सांस लेने में कठिनाई और गंभीर निम्न रक्तचाप हो सकते हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर दिन में एक बार। इसे अचानक बंद न करें, क्योंकि इससे एनजाइना या हृदय की समस्या बढ़ सकती है। शराब से बचें क्योंकि इससे चक्कर आ सकते हैं। यदि आपको अस्थमा, मधुमेह, गुर्दे या यकृत की बीमारी है तो डॉक्टर को बताएं। गर्भावस्था की स्थिति में तुरंत डॉक्टर से मिलें। नियमित रूप से रक्तचाप और हृदय गति की जांच कराएं।
💊 samlodon at 2.5mg/50mg tablet Uses & Benefits
- [{"condition":"Hypertension","description":"Lowers blood pressure in adults whose hypertension is not controlled by a single agent.
- The combination provides both vasodilation and heart rate reduction.","evidence":"Well-established"},{"condition":"Chronic stable angina","description":"Reduces the frequency of angina attacks by decreasing cardiac workload and improving coronary blood flow.","evidence":"Well-established"},{"condition":"Angina prophylaxis","description":"Used to prevent exertional angina in patients who require both beta-blockade and calcium channel blockade.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Rate control in atrial fibrillation","description":"Atenolol component may help control heart rate in atrial fibrillation, but this combination is not a first-line choice and should be used only under specialist guidance.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Beta-blockers like atenolol are sometimes used off-label to prevent migraines, but the combination with amlodipine is not standard for this purpose.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Chronic stable angina, Angina prophylaxis
📋 Drug Information
| Generic Name(s) | Amlodipine (2.5mg) + Atenolol (50mg) |
| Brand Name | samlodon at 2.5mg/50mg tablet |
| Manufacturer | Zydus Cadila |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two complementary mechanisms. Amlodipine blocks L-type calcium channels in vascular smooth muscle, causing relaxation and vasodilation, which reduces peripheral resistance and lowers blood pressure. Atenolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, contractility, and cardiac output, thereby lowering blood pressure and myocardial oxygen demand. The combination addresses both vascular resistance and cardiac workload.
Mechanism Steps
💡 How to Take samlodon at 2.5mg/50mg tablet
Strength: Tablet containing Amlodipine 2.5 mg and Atenolol 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of Amlodipine 2.5 mg and Atenolol 50 mg once daily, preferably at the same time each day. The dose may be adjusted by your doctor based on your blood pressure response and tolerance. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and bradycardia. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Atenolol is excreted by the kidneys; dose reduction is recommended in patients with creatinine clearance below 35 mL/min. Amlodipine does not require renal dose adjustment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Amlodipine is metabolized in the liver; use with caution in hepatic impairment. Start with a lower dose and monitor closely. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is Amlodipine 10 mg and Atenolol 100 mg, but this fixed-dose combination should not exceed one tablet daily unless directed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of samlodon at 2.5mg/50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Clonidine | Major | |
| Ketoconazole | Major | |
| NSAIDs | Moderate | |
| Digoxin | Moderate | |
| Metformin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Verapamil or diltiazem
- Clonidine
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
⚡ Moderate Interactions
- NSAIDs
- Diabetes medications
- Digoxin
🍷 Alcohol Interaction
Alcohol can increase the blood pressure-lowering effect of this medicine and may cause dizziness, fainting, or drowsiness. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Severe asthma or COPD with bronchospasm","Known allergy to amlodipine or atenolol","Severe peripheral arterial disease"]
⚠️ Warnings & Precautions
["Do not stop abruptly; taper gradually to avoid rebound angina or hypertension.","Use with caution in asthma or COPD; may cause bronchospasm.","May mask symptoms of hypoglycemia in diabetics.","Use with caution in liver or kidney disease.","May cause dizziness; avoid driving until you know how it affects you.","Inform your doctor before any surgery or dental procedure.","Avoid alcohol while taking this medicine."]
🤱 Lactation Safety
Amlodipine is present in breast milk in small amounts. Atenolol is also excreted in breast milk and may cause bradycardia in the infant. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose can cause severe hypotension, bradycardia, heart failure, and bronchospasm. Seek emergency medical care immediately. Treatment is supportive and may include intravenous fluids, atropine, glucagon, or vasopressors as needed. Do not induce vomiting.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed, usually once daily, with or without food. Do not stop abruptly, especially if you have angina or heart disease, as sudden withdrawal can worsen chest pain or precipitate a heart attack. Avoid alcohol because it can amplify blood pressure-lowering effects and increase dizziness. Inform your doctor if you have asthma, diabetes, kidney or liver disease, or thyroid disorders. Do not use potassium supplements or salt substitutes without medical advice. Monitor your pulse and blood pressure as directed. If you become pregnant or plan to become pregnant, contact your doctor immediately. Keep all follow-up appointments for blood pressure and heart rate monitoring.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to blood pressure-lowering effects and bradycardia. Start with a lower dose and monitor closely for dizziness, falls, and heart rate changes.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the first trimester. If you are planning pregnancy, consult your doctor to switch to a safer alternative before conception.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthesia and affect heart rate and blood pressure during surgery. Do not stop unless instructed.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or interact with local anesthetics containing epinephrine. Monitor blood pressure during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise initially as it may cause dizziness or excessive heart rate reduction. Gradually increase activity as tolerated. If you experience chest pain, shortness of breath, or severe dizziness during exercise, stop and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work routine with dose adjustment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects like severe bradycardia, heart block, or allergic reactions, seek immediate medical attention. Your doctor may gradually taper the dose to prevent rebound effects.
📅 Long-Term Use Effects
Long-term use requires regular monitoring of blood pressure, heart rate, and kidney function. Atenolol may mask hypoglycemia in diabetics. Amlodipine can cause persistent ankle swelling. Do not stop abruptly. Your doctor may adjust the dose over time.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress reduction can help control blood pressure and may reduce medication needs.
Evidence: Well-establishedARBs, ACE inhibitors, or diuretics may be alternatives if this combination is not tolerated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, inform your doctor before any vaccination, especially if you have heart or lung disease.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Carry enough supply for the entire trip plus extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Amlodipine starts lowering blood pressure within 24-48 hours, with full effect in 1-2 weeks. Atenolol reduces heart rate within 1 hour. You may notice improvement in angina within a few days.
A: No, do not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause dangerous rebound hypertension or angina.
A: If you remember within 12 hours, take it. If more than 12 hours have passed, skip it and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for samlodon at 2.5mg/50mg tablet
View AllAlternative brands with exact same active ingredient:
-
samloday a 2.5 mg/50 mg tabletShrinivas Gujarat Laboratories Pvt Ltd ₹30.77 19.8% CHEAPER
-
amlomed at 2.5 mg/50 mg tabletZydus Healthcare Limited ₹32.85 14.4% CHEAPER
-
esdil at 2.5mg/50mg tabletMedley Pharmaceuticals ₹35.90 6.4% CHEAPER
-
esamlo at 2.5 mg/50 mg tabletOrchid Chemicals & Pharmaceuticals Ltd ₹41.78 8.9% COSTLIER
-
samlokind-at tabletMankind Pharma Ltd ₹44.90 17% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often has no symptoms and requires long-term treatment. Stopping suddenly can cause dangerous rebound hypertension or angina. - Myth: This medicine damages the kidneys.
Fact: Untreated high blood pressure damages the kidneys. This medicine helps protect them by controlling blood pressure. Atenolol may require dose adjustment in kidney disease. - Myth: You can skip doses if you feel fine.
Fact: Skipping doses can lead to uncontrolled blood pressure and increased risk of heart attack or stroke.
🔄 Alternative Options
Generic Alternatives
- Amlodipine 2.5 mg + Atenolol 50 mg tablet (generic)
Brand Alternatives
- Emlo-AT
- Amlokind-AT
- Aten-A
- Amlopres-AT