roxid m tablet - Roxithromycin (150mg) + Ambroxol (60mg) medicine

Roxid M Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Alembic Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Irregular heartbeat or palpitations

If experiencing severe symptoms, call emergency services immediately.

What is roxid m tablet used for?

This medicine is a combination of Roxithromycin (an antibiotic) and Ambroxol (a mucolytic) used to treat bacterial respiratory infections with thick mucus. It is taken twice daily with food for 5-10 days as prescribed.

  • Generic Name: Roxithromycin (150mg) + Ambroxol (60mg)
  • Manufacturer: Alembic Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 roxid m tablet के बारे में (Hindi Summary)

उपयोग: यह दवा रॉक्सिथ्रोमाइसिन और एम्ब्रोक्सोल का संयोजन है, जिसका उपयोग बैक्टीरियल श्वसन संक्रमण जैसे ब्रोंकाइटिस, निमोनिया और साइनसाइटिस के इलाज के लिए किया जाता है। यह बलगम को पतला करके खांसी को आसान बनाती है और संक्रमण को रोकती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, दस्त, पेट दर्द और स्वाद में बदलाव शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, लिवर की समस्या या दिल की धड़कन में गड़बड़ी हो सकती है। किसी भी असामान्य लक्षण पर डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब से बचें। पूरा कोर्स पूरा करें, बीच में न छोड़ें। अन्य दवाओं के बारे में डॉक्टर को बताएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 roxid m tablet Uses & Benefits

[{"condition":"Acute bacterial bronchitis","description":"Used to treat bacterial bronchitis when accompanied by thick mucus production.","evidence":"Well-established"},{"condition":"Bacterial pneumonia","description":"Effective against community-acquired pneumonia caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Acute sinusitis","description":"Helps resolve bacterial sinus infections and reduces mucus congestion.","evidence":"Moderate"},{"condition":"Pharyngitis and tonsillitis","description":"Used when caused by susceptible bacteria, particularly when mucus is a problem.","evidence":"Moderate"}]

Off-label uses: [{"condition":"COPD exacerbation with mucus","description":"Sometimes prescribed to reduce mucus viscosity in chronic obstructive pulmonary disease flare-ups, though not a standard first-line approach.","evidence":"Limited"}]

Primary treatment for: Bacterial respiratory tract infections

Also treats: Acute bronchitis, Bacterial pneumonia, Sinusitis, Pharyngitis

📋 Drug Information

Generic Name(s)Roxithromycin (150mg) + Ambroxol (60mg)
Brand Nameroxid m tablet
ManufacturerAlembic Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action Class
Route of AdministrationOral
StorageStore below 30°C in a dry place, protected from light. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Complete the full course even if you feel better after a few days.
3
Avoid alcohol while taking this medicine to prevent stomach irritation.
4
Do not use this medicine for viral infections like the common cold.
5
Inform your doctor if you have liver or heart problems before starting this medicine.
6
Report any unusual bleeding, bruising, or palpitations immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Sore throat
May be used if bacterial infection is confirmed.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRoxithromycin is rapidly absorbed from the gastrointestinal tract after oral administration, with a bioavailability of approximately 50%. Ambroxol is also well absorbed orally. Food may slightly delay absorption but does not significantly affect the extent.
DistributionRoxithromycin distributes widely into body tissues and fluids, including lung tissue, where it achieves concentrations higher than plasma. Ambroxol also penetrates lung tissue and bronchial secretions well.
Protein BindingRoxithromycin is about 86-91% bound to plasma proteins, primarily to alpha-1-acid glycoprotein and albumin. Ambroxol is approximately 90% protein-bound.
MetabolismRoxithromycin undergoes limited hepatic metabolism, mainly by CYP3A4, to inactive metabolites. Ambroxol is metabolized in the liver by conjugation to glucuronides and sulfates.
Half-LifeThe elimination half-life of Roxithromycin is approximately 10-12 hours. Ambroxol has a half-life of about 7-12 hours.
ExcretionRoxithromycin is excreted primarily in feces via bile, with a small portion in urine. Ambroxol metabolites are excreted mainly in urine.
BioavailabilityRoxithromycin oral bioavailability is about 50%. Ambroxol bioavailability is approximately 70-80%.
Onset of ActionAntibacterial effects begin within a few hours, but clinical improvement in symptoms may take 24-48 hours. Ambroxol's mucolytic effect starts within 30-60 minutes.
Peak Plasma TimeRoxithromycin reaches peak plasma concentration about 1.5-2 hours after oral intake. Ambroxol peaks at around 1-2 hours.
Duration of ActionThe antibacterial effect persists for about 12-24 hours, allowing twice-daily dosing. Ambroxol's mucolytic action lasts approximately 6-8 hours.

How It Works

Roxithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing the translocation step and thus stopping bacterial growth. Ambroxol increases serous bronchial secretion, reduces mucus viscosity, and stimulates surfactant production, which improves mucociliary clearance. The combination targets both the infection and the associated mucus congestion.

Mechanism Steps

1
Roxithromycin binds to 50S ribosomal subunit: This binding blocks the translocation of peptidyl-tRNA, halting bacterial protein synthesis.
2
Inhibition of bacterial growth: As a result, susceptible bacteria cannot multiply and are eventually cleared by the immune system.
3
Ambroxol enhances mucus clearance: Ambroxol increases serous secretion and reduces mucus viscosity, making it easier to cough up.
4
Improved airway patency: The combined effect reduces mucus plugging and improves airflow in the respiratory tract.

💡 How to Take roxid m tablet

Strength: Tablet containing Roxithromycin 150 mg and Ambroxol 60 mg.

1Take the tablet with a full glass of water.
2Swallow it whole; do not crush or chew.
3Take it with food to reduce stomach upset.
4Take at evenly spaced times each day (e.g., morning and evening).
5Complete the full course as prescribed by your doctor.

Dosage Information

Adult DosageThe usual adult dose is one tablet twice daily, taken orally with food. The exact dose and duration depend on the type and severity of infection, your age, weight, kidney and liver function, and other medications you are taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require dose adjustment based on renal and hepatic function. Use with caution and monitor for side effects.
Renal ImpairmentDose adjustment may be needed in patients with severe renal impairment (creatinine clearance <30 mL/min). Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. Monitor liver function.
Maximum Daily DoseThe maximum recommended daily dose is 300 mg of Roxithromycin and 120 mg of Ambroxol (two tablets per day). Do not exceed without medical advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of roxid m tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food. If persists, consult your doctor.
Diarrhea (Common (5-10%))
Stay hydrated. Avoid fatty foods. Consult if severe.
Abdominal pain (Common (5-10%))
Take with meals. If severe, contact your doctor.
Altered taste (Uncommon (1-5%))
Usually temporary. Chew sugar-free gum or rinse mouth.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience swelling of face, lips, throat, or difficulty breathing.
Liver inflammation (hepatitis) (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain to your doctor immediately.
Irregular heartbeat (QT prolongation) (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, dizziness, or fainting.

⚠️ Rare Side Effects

Clostridioides difficile-associated diarrhea
Contact your doctor if you develop severe, persistent diarrhea, even weeks after finishing the antibiotic.
Stevens-Johnson syndrome
Seek emergency care if you develop a rash with blisters, peeling skin, or sores in the mouth.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ergotamine Major
Terfenadine Major
Digoxin Moderate
Theophylline Moderate
Carbamazepine Moderate
Antacids Minor
Oral contraceptives Minor

🚨 Major Interactions

  • Ergot alkaloids (e.g., ergotamine)
  • Terfenadine, astemizole, cisapride
  • Warfarin

⚡ Moderate Interactions

  • Digoxin
  • Theophylline
  • Carbamazepine

🍷 Alcohol Interaction

Alcohol may increase the risk of gastrointestinal side effects such as nausea and abdominal pain. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to Roxithromycin, other macrolides, or Ambroxol","Severe liver impairment","Concurrent use with ergot alkaloids, terfenadine, astemizole, or cisapride","History of QT prolongation or ventricular arrhythmias"]

⚠️ Warnings & Precautions

["Use with caution in patients with liver disease; monitor liver function.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use for viral infections; it is ineffective and promotes resistance.","Complete the full course as prescribed, even if symptoms improve.","Inform your doctor if you have myasthenia gravis; macrolides may worsen symptoms.","Avoid concurrent use with other QT-prolonging drugs."]

🤱 Lactation Safety

Roxithromycin and Ambroxol are excreted in breast milk in small amounts. Consult your doctor before breastfeeding while on this medicine. Monitoring the infant for diarrhea or thrush is advised.

💊 Overdose Management

Overdose may cause severe nausea, vomiting, diarrhea, and hearing loss. Seek immediate medical attention. Treatment is symptomatic and supportive. There is no specific antidote. Gastric lavage may be considered if taken recently.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Take it with food to reduce stomach upset. Avoid alcohol while on this medicine. Inform your doctor about all other medicines you are taking, especially blood thinners, ergot derivatives, and antiarrhythmics. Do not use this medicine for viral infections like the common cold. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to side effects like dizziness and QT prolongation. Dose adjustment may be needed based on kidney and liver function. Monitor closely.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy or are pregnant, consult your doctor before taking this medicine. Roxithromycin is generally acceptable if clearly needed, but Ambroxol is avoided in the first trimester.

🏥 Post-Surgery Considerations

Inform your surgeon if you are on this medicine before any surgery. It may interact with anesthetics and other medications used during surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with certain antibiotics or anesthetics used in dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Use a humidifier to ease breathing.
😴
Avoid smoking and secondhand smoke.
💧
Get plenty of rest to support recovery.
🧘
Wash hands frequently to prevent spread of infection.

🏋️ Exercise Considerations

Rest during the acute phase of infection. Gradually resume light activities as you feel better. Avoid strenuous exercise until fully recovered.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas.
Include vitamin C-rich fruits and vegetables.
Avoid cold, sugary, and processed foods.
Eat light, easily digestible meals.

💼 Impact on Daily Work & Life

You may feel tired or dizzy; avoid driving or operating heavy machinery until you know how this medicine affects you. Take rest as needed.

🛑 When to Stop This Medicine

Stop only if your doctor advises or if you experience a severe allergic reaction. Do not stop early even if symptoms improve, to prevent relapse and resistance.

📅 Long-Term Use Effects

Long-term use of antibiotics can lead to bacterial resistance and disruption of normal flora. Roxithromycin may rarely cause liver enzyme changes. Ambroxol is generally safe for short-term use. Prolonged use should be monitored by a doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and ease breathing.

Evidence: Well-established
Saline nasal irrigation

Can reduce nasal congestion and mucus.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Antibiotics do not interact with vaccines. However, if you are acutely ill, your doctor may postpone non-urgent vaccinations until you recover.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute bronchitis and thick mucus
Started this medicine as prescribed. Within 3 days, cough and mucus production reduced significantly. Emphasized taking with food to prevent nausea.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old with sinusitis and post-nasal drip
Took this medicine for 7 days. Symptoms improved by day 4. Completed the full course to prevent relapse. Advised to avoid alcohol.
💡 Lesson: Completing the full antibiotic course is crucial to prevent bacterial resistance.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 24-48 hours, but complete the full course as prescribed.

Q: Can I take it with other medicines?

A: Inform your doctor about all medicines you take, as Roxithromycin can interact with several drugs.

Q: Is it safe during pregnancy?

A: Consult your doctor. It is generally avoided in the first trimester.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for roxid m tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: It can cure the common cold.
    Fact: It is an antibiotic and does not work against viral infections like the common cold.
  • Myth: You can stop taking it once you feel better.
    Fact: You must complete the full course to prevent bacterial resistance and relapse.

🔄 Alternative Options

Generic Alternatives

  • Roxithromycin + Ambroxol combination generics available

Brand Alternatives

  • Roxid M
  • Roximac M
  • Roxifree M

📊 Comparison with Similar Medicines

[{"medicine":"Roxithromycin + Ambroxol","composition":"Roxithromycin 150mg + Ambroxol 60mg","class":"Macrolide antibiotic + mucolytic","usual_dose":"One tablet twice daily","notes":"Good lung penetration, twice-daily dosing."},{"medicine":"Azithromycin + Ambroxol","composition":"Azithromycin 250mg + Ambroxol 60mg","class":"Macrolide antibiotic + mucolytic","usual_dose":"One tablet once daily","notes":"Once-daily dosing, broader spectrum."}]

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