G Nac 1% Gel: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, or difficulty breathing.
- Severe skin reaction: painful rash with blistering or peeling.
- Signs of gastrointestinal bleeding: black or tarry stools, vomiting blood.
- Chest pain or shortness of breath.
- Sudden decrease in urine output.
- Yellowing of skin or eyes (jaundice).
- Severe abdominal pain.
If experiencing severe symptoms, call emergency services immediately.
What is profenac eye drop used for?
This medicine is a topical gel containing diclofenac 1% w/v, used to relieve pain and inflammation in conditions like osteoarthritis and soft tissue injuries. It works by blocking COX enzymes and reducing prostaglandins. Apply a thin layer to the affected area 3-4 times daily, up to a maximum of 16 grams per day. It is for external use only and should not be applied to broken skin or near the eyes.
- Generic Name: Diclofenac (1% w/v)
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 profenac eye drop के बारे में (Hindi Summary)
उपयोग: यह दवा डिक्लोफेनाक 1% w/v जेल है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह मुख्य रूप से घुटनों, हाथों और अन्य जोड़ों के ऑस्टियोआर्थराइटिस, मोच, और मांसपेशियों की चोटों में राहत के लिए इस्तेमाल की जाती है। यह जेल त्वचा पर लगाने से प्रभावित क्षेत्र में सूजन और दर्द को कम करती है। इसे दिन में 3 से 4 बार पतली परत में लगाएं। अधिकतम 16 ग्राम प्रतिदिन से अधिक न लगाएं। आंखों, मुंह, और घाव वाली त्वचा पर न लगाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा पर हल्की जलन, लालिमा, खुजली, या दाने शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। कभी-कभी त्वचा सूखी या पपड़ीदार हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया जैसे चेहरे, होंठ, या गले में सूजन, सांस लेने में कठिनाई, या गंभीर त्वचा दाने हो सकते हैं। यदि आपको कोई असामान्य लक्षण दिखे, तो दवा का उपयोग बंद करें और तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को केवल स्वस्थ त्वचा पर लगाएं और आंखों, होंठों, और अन्य श्लेष्मा झिल्ली से बचें। लगाने के बाद हाथ धो लें, जब तक कि हाथ इलाज वाला क्षेत्र न हो। इलाज वाले क्षेत्र को हवा बंद पट्टी से न ढकें। धूप और टैनिंग बेड से बचें। घाव, कट, या संक्रमित त्वचा पर न लगाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें। यदि दवा निगल ली जाए, तो तुरंत डॉक्टर से मिलें।
💊 profenac eye drop Uses & Benefits
[{"condition":"Osteoarthritis of the knee","description":"This medicine is applied to the affected knee to reduce pain and improve joint function in patients with knee osteoarthritis.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hand","description":"Topical diclofenac gel can relieve pain and stiffness in hand osteoarthritis when applied to the affected joints.","evidence":"Well-established"},{"condition":"Soft tissue injuries","description":"This medicine is used for localized pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling associated with sprains, strains, and sports injuries.","evidence":"Moderate"},{"condition":"Localized musculoskeletal pain","description":"It provides temporary relief of pain in muscles and joints due to minor injuries or overuse.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Actinic keratosis","description":"Topical diclofenac gel has been studied for treating actinic keratosis, a skin condition caused by sun damage, but this is not its primary approved use.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Soft tissue injuries, Localized musculoskeletal pain, Rheumatoid arthritis (adjunct), Ankylosing spondylitis (adjunct)
📋 Drug Information
| Generic Name(s) | Diclofenac (1% w/v) |
| Brand Name | profenac eye drop |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid) |
| Route of Administration | Topical |
| Storage | Store at room temperature, between 15°C and 30°C (59°F and 86°F). Keep away from direct sunlight and moisture. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the cyclooxygenase enzymes, specifically COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. By blocking these enzymes, diclofenac reduces the levels of prostaglandins at the site of application, thereby decreasing inflammation and pain. When applied to the skin, diclofenac penetrates the skin layers and reaches the underlying muscle and joint tissues, where it exerts its local effects. This topical route minimizes systemic absorption and reduces the risk of gastrointestinal side effects compared to oral NSAIDs.
Mechanism Steps
💡 How to Take profenac eye drop
Strength: This medicine is a gel containing diclofenac at 1% w/v, which means 10 milligrams of diclofenac per gram of gel.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is to apply a thin layer of the gel to the affected area 3 to 4 times daily. The amount needed depends on the size of the area being treated. For example, for knee osteoarthritis, a typical dose is 2 to 4 grams of gel per application, which is about 4 to 8 centimeters of gel. The maximum daily dose should not exceed 16 grams of gel per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Wash hands after application unless the hands are the treated area. Do not exceed the recommended dose or duration of use without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may use this medicine at the same dosage as adults, but they should be monitored for signs of skin irritation or systemic side effects. No specific dose adjustment is required, but caution is advised due to potential increased sensitivity. |
| Renal Impairment | No dose adjustment is typically required for topical diclofenac in patients with renal impairment, as systemic absorption is low. However, caution is advised in patients with severe renal impairment, and they should be monitored for any signs of worsening renal function. |
| Hepatic Impairment | No dose adjustment is typically required for topical diclofenac in patients with hepatic impairment. However, in patients with severe hepatic impairment, caution is advised, and they should be monitored for any signs of systemic toxicity. |
| Maximum Daily Dose | The maximum recommended daily dose is 16 grams of gel per day, which corresponds to 160 milligrams of diclofenac. Do not exceed this dose without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of profenac eye drop
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Aspirin | Major | |
| Methotrexate | Moderate | |
| Cyclosporine | Moderate | |
| Furosemide | Moderate | |
| Lisinopril | Moderate | |
| Lithium | Moderate | |
| Topical corticosteroids | Minor | |
| Other topical products | Minor |
🚨 Major Interactions
- Oral NSAIDs (e.g., ibuprofen, naproxen)
- Anticoagulants (e.g., warfarin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
⚡ Moderate Interactions
- Methotrexate
- Cyclosporine
- Diuretics (e.g., furosemide)
🍷 Alcohol Interaction
No specific interaction between alcohol and topically applied diclofenac has been established. However, alcohol may increase the risk of gastrointestinal bleeding if diclofenac is absorbed systemically. It is advisable to limit alcohol consumption while using this medicine, especially if you have a history of stomach ulcers or bleeding.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to diclofenac or any other component of the gel.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Application on broken, infected, or inflamed skin.","Use in the eyes or on mucous membranes.","Third trimester of pregnancy.","Severe heart failure, as NSAIDs may worsen the condition."]
⚠️ Warnings & Precautions
["For external use only. Do not ingest.","Avoid contact with eyes, lips, and mucous membranes.","Do not apply to large areas of skin or use for prolonged periods without medical advice.","Do not use with occlusive dressings unless directed by a doctor.","Avoid exposure of treated skin to sunlight or tanning beds.","Consult a doctor if symptoms persist or worsen after 7 days of use.","Use with caution in patients with a history of gastrointestinal ulcers or bleeding.","Use with caution in elderly patients who may be more susceptible to side effects.","Do not use in children under 12 years of age without medical advice."]
🤱 Lactation Safety
It is not known whether diclofenac applied topically is excreted in human breast milk. However, systemic absorption is low. To minimize potential exposure to the infant, avoid applying the gel to the breast area and wash hands thoroughly before breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose with topical diclofenac is unlikely due to the limited amount that can be absorbed through the skin. If accidental ingestion occurs, seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, abdominal pain, dizziness, and drowsiness. Treatment is supportive and symptomatic. In case of excessive topical application, wash the area with water and soap to remove the gel.
⏰ Missed Dose
If you miss a dose of this medicine, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Apply this medicine only to intact skin and avoid contact with eyes, lips, and other mucous membranes. Wash your hands thoroughly after applying the gel, unless your hands are the treated area. Do not cover the treated area with airtight dressings or bandages unless instructed by your doctor. Avoid exposing the treated area to sunlight or tanning beds, as this may increase the risk of skin reactions. Do not use this medicine on wounds, cuts, or infected skin. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Do not use this medicine for more than the recommended duration without medical advice. Keep this medicine out of reach of children. If you accidentally swallow this medicine, seek medical attention immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of NSAIDs, including topical diclofenac. They should use the lowest effective dose for the shortest duration and monitor for skin irritation or systemic symptoms. Kidney and liver function should be monitored if used long-term.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. Oral NSAIDs may affect ovulation and are generally avoided during pregnancy, especially in the third trimester. Topical use has lower systemic absorption, but caution is still advised.
🏥 Post-Surgery Considerations
After surgery, consult your surgeon before using this medicine on the surgical site. It should not be applied to healing wounds or incisions. It may be used on other areas for pain relief if approved by your doctor.
🦷 Dental Procedures
This medicine is not typically used for dental pain. If you have a dental procedure and experience pain, consult your dentist for appropriate pain relief. Do not apply this gel inside the mouth.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While using this medicine, you can continue with your regular exercise routine, but avoid putting excessive strain on the treated area. If you experience increased pain or discomfort, stop the activity and consult your doctor. Low-impact exercises are generally safe and can help improve joint mobility.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness (which is rare), avoid driving or operating heavy machinery until you know how the medicine affects you. You can continue your daily activities as usual, but avoid exposing the treated area to excessive sunlight.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if your symptoms do not improve after 7 days, if they worsen, or if you experience any severe side effects such as skin rash, swelling, or difficulty breathing. Do not stop abruptly if you have been using it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine over large areas or for extended periods may increase the risk of systemic side effects similar to oral NSAIDs, including gastrointestinal, cardiovascular, and renal effects. It is advisable to use the lowest effective dose for the shortest duration necessary. Regular monitoring by a healthcare provider is recommended if prolonged use is required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedMay help reduce pain in some individuals with osteoarthritis.
Evidence: ModerateApplying heat or cold packs can help reduce pain and inflammation.
Evidence: Well-establishedLosing excess weight can reduce stress on weight-bearing joints.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations while using this medicine. However, if you are scheduled for a vaccine, inform your healthcare provider about all medications you are using.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, keep it in its original packaging with the prescription label. Carry a copy of your prescription in case you need to show it at customs. Store the gel at room temperature and protect it from extreme heat or cold. If you are flying, pack it in your carry-on luggage if you need it during the flight, but ensure it complies with liquid restrictions. There are no specific time zone adjustments needed for topical application, but try to maintain your regular schedule as much as possible.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling pain relief within 30 minutes to 1 hour after application, but full anti-inflammatory effects may take several days of regular use.
A: No, this medicine is for topical use on joints and muscles and is not intended for headaches.
A: It can be used for short periods, but long-term use should be under medical supervision. Consult your doctor if you need to use it for more than 7 days.
A: Using topical diclofenac with oral NSAIDs may increase the risk of side effects. Consult your doctor before combining them.
A: Apply the missed dose as soon as you remember, unless it is almost time for your next dose. Do not apply a double dose.
A: Consult your doctor before using this medicine during pregnancy, especially in the third trimester.
A: Yes, topical diclofenac can increase the risk of bleeding when used with blood thinners like warfarin. Monitor closely and consult your doctor.
A: No, this medicine is not recommended for use on the face unless specifically directed by a doctor.
A: Consult a pediatrician before using this medicine in children, as dosing and safety are not established.
A: Yes, it can be used for sprains, but avoid applying it on broken skin and follow the recommended dosage.
🤔 Common Patient Concerns
🔄 Substitutes for profenac eye drop
View AllAlternative brands with exact same active ingredient:
-
g nac 1% gelGujarat Pharma Lab Pvt Ltd ₹70.00 352.2% COSTLIER
-
powerflam sprayAlkem Laboratories Ltd ₹83.75 441% COSTLIER
-
dp gesic sprayCadila Pharmaceuticals Ltd ₹156.56 911.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine works instantly.
Fact: It may take 30 minutes to an hour for pain relief to begin, and several days for full anti-inflammatory effects. - Myth: More gel means faster relief.
Fact: Using more than the recommended amount does not speed up relief and may increase the risk of side effects. - Myth: This medicine is safe to use on any skin condition.
Fact: It should not be applied to broken, infected, or irritated skin, as this can worsen the condition and increase absorption. - Myth: This medicine has no side effects because it is topical.
Fact: While side effects are usually mild and local, systemic side effects can occur if absorbed in significant amounts. - Myth: You can use this medicine indefinitely without consulting a doctor.
Fact: Prolonged use without medical supervision is not recommended; consult a doctor if symptoms persist beyond 7 days.
🔄 Alternative Options
Generic Alternatives
- Diclofenac 1% w/v gel
- Diclofenac sodium 1% gel
- Diclofenac diethylamine 1.16% gel (equivalent to diclofenac sodium 1%)
Brand Alternatives
- Voltaren
- Voveran
- Diclomol
- Dynapar
- Nac
- Reactin