Oxetacaine (10mg/5ml) + Aluminium Hydroxide (300mg/5ml) + Magnesium Trisilicate (150mg/5ml) + Milk Of Magnesia (100mg/5ml) + Simethicone (25mg/5ml) (Medical Monograph)

Overview

A comprehensive, multi-ingredient antacid and anti-flatulent suspension indicated for the symptomatic relief of hyperacidity, gastroesophageal reflux disease (GERD), and associated dyspepsia. It combines fast-acting and long-acting antacids with a potent topical anesthetic and a defoaming agent for rapid and sustained relief from pain, burning, and bloating.

Uses

  • Symptomatic relief of hyperacidity
  • Gastroesophageal Reflux Disease (GERD)
  • Heartburn
  • Acid indigestion
  • Dyspepsia
  • Flatulence and bloating associated with above conditions

Side Effects

  • Chalky taste
  • Mild constipation or diarrhea (depending on individual sensitivity to aluminium/magnesium balance)
  • White or speckled stools

Detailed Pharmacology

1. **Antacids (Aluminium Hydroxide, Magnesium Trisilicate, Magnesium Hydroxide)**: Neutralize gastric hydrochloric acid, raising the intragastric pH. This reduces pepsin activity and provides a physical protective coating (especially Magnesium Trisilicate). 2. **Oxetacaine**: A potent surface anesthetic that blocks sodium channels in neuronal membranes, inhibiting the initiation and conduction of nerve impulses, thereby providing rapid relief from pain and burning sensations in the esophagus and stomach. 3. **Simethicone**: A physiologically inert defoaming agent that reduces the surface tension of gas bubbles, causing them to coalesce and be more easily expelled by belching or passing flatus, relieving bloating and discomfort.

Available Brands in India

BrandManufacturerPrice
Mucaine Pfizer Limited (formerly Parke-Davis) ₹180 - ₹250 for 200 ml bottle
Acigon-S Cipla Ltd ₹120 - ₹170 for 170 ml bottle
Acigone Sun Pharmaceutical Industries Ltd. ₹110 - ₹160 for 170 ml bottle
Oxe-Spaz Mankind Pharma Ltd. ₹100 - ₹150 for 170 ml bottle
Acigut-S Lupin Ltd ₹115 - ₹165 for 170 ml bottle