Nusulta 375 Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Difficulty breathing or swelling of face, lips, or throat
- Severe skin rash with blisters or peeling
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is nusulta 375 tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins and acting centrally to relieve pain and fever.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nusulta 375 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, जोड़ों के दर्द, दांत दर्द और सर्जरी के बाद के दर्द में राहत देती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें यकृत की क्षति, गुर्दे की समस्या, गंभीर त्वचा प्रतिक्रियाएं और जठरांत्र रक्तस्राव शामिल हो सकते हैं।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें। निर्धारित खुराक से अधिक न लें। शराब का सेवन न करें। यकृत या गुर्दे की बीमारी, पेट के अल्सर या हृदय रोग होने पर डॉक्टर को बताएं। 5-7 दिनों से अधिक उपयोग न करें।
💊 nusulta 375 tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Reduces joint pain and stiffness in osteoarthritis, improving mobility.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Manages mild to moderate pain after surgery.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used for menstrual cramps, but not a first-line option.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Osteoarthritis, Dental pain, Post-operative pain, Musculoskeletal injuries
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nusulta 375 tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Ampicillin & Sulbactam ester compound |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a selective inhibitor of the cyclooxygenase-2 (COX-2) enzyme, which reduces the synthesis of prostaglandins, thereby decreasing inflammation, pain, and fever. Paracetamol acts primarily in the central nervous system to produce analgesia and antipyresis, though its exact mechanism remains unclear; it may inhibit prostaglandin synthesis in the brain and interfere with pain signal transmission.
Mechanism Steps
💡 How to Take nusulta 375 tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (nimesulide 100 mg + paracetamol 325 mg) taken orally every 8 hours as needed for pain, not exceeding three tablets in 24 hours. The lowest effective dose for the shortest duration is recommended. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use with caution, starting at the lowest effective dose and monitoring for side effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Avoid in patients with severe hepatic impairment. In mild to moderate impairment, use with caution and consider dose reduction. Consult a doctor. |
| Maximum Daily Dose | Maximum daily dose is 3 tablets (nimesulide 300 mg + paracetamol 975 mg) in 24 hours. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nusulta 375 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Carbamazepine | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Methotrexate
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Lithium
- Phenytoin
- Carbamazepine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage, especially with paracetamol, and may worsen gastrointestinal irritation caused by nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to nimesulide, paracetamol, or any component","Active peptic ulcer or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment","History of NSAID-induced asthma, urticaria, or allergic reactions","Children under 12 years of age","Third trimester of pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["Take with food to reduce gastrointestinal irritation.","Do not exceed the recommended dose or duration.","Avoid alcohol during treatment.","Use with caution in elderly patients.","Monitor liver and kidney function with prolonged use.","Discontinue if signs of liver damage or severe skin reaction occur.","Not recommended for patients with cardiovascular disease.","May impair ability to drive or operate machinery."]
🤱 Lactation Safety
Not recommended during breastfeeding as nimesulide may pass into breast milk and could harm the infant. Consult your doctor for alternative pain relief.
💊 Overdose Management
Overdose can cause severe liver damage, especially due to paracetamol. Symptoms include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Always take this medicine with food or milk to reduce stomach upset. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Inform your doctor if you have a history of liver or kidney disease, stomach ulcers, or heart problems. Do not use this medicine for more than 5-7 days without consulting a doctor. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for safer alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but it should be prescribed by a surgeon or doctor who is aware of your medical history. It may increase bleeding risk, so inform your surgeon if you are taking it before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. It can be used for dental pain, but follow your dentist's advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may worsen pain while taking this medicine. Gentle stretching and low-impact exercises are generally safe. Consult your doctor before starting any exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any serious side effects such as severe abdominal pain, blood in stool, yellowing of eyes, or skin rash. Do not stop abruptly if you are on a prescribed course without consulting your doctor. For short-term use, stop after the prescribed duration.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If prolonged use is necessary, regular monitoring of liver and kidney function is advised. Consult your doctor for alternative treatments if pain persists.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce localized pain and inflammation.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it with food.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: Do not take with other NSAIDs or paracetamol-containing products without consulting your doctor, as it may increase the risk of side effects.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use. Prolonged use can cause liver and kidney damage. - Myth: It can be taken without food.
Fact: It should be taken with food to reduce stomach upset. - Myth: It is safe for children.
Fact: It is not recommended for children under 12 years.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination generics
Brand Alternatives
- Nusulta 375 Tablet