Alo NT 500mg/200mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Tendon pain or swelling
- Numbness or tingling in hands or feet
- Seizures or confusion
If experiencing severe symptoms, call emergency services immediately.
What is nixide o tablet used for?
This medicine is a combination of Nitazoxanide and Ofloxacin used to treat mixed bacterial and protozoal infections, especially infectious diarrhea, amoebiasis, and giardiasis. It works by killing both bacteria and protozoa. It should be taken with food and the full course must be completed.
- Generic Name: Nitazoxanide (500mg) + Ofloxacin (200mg)
- Manufacturer: Medley Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nixide o tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइटाज़ोक्सानाइड और ऑफ़लोक्सासिन का संयोजन है, जिसका उपयोग बैक्टीरिया और प्रोटोज़ोआ दोनों से होने वाले मिश्रित संक्रमणों के इलाज के लिए किया जाता है। यह आमतौर पर दस्त, अमीबियासिस, जियार्डियासिस और अन्य आंतों के संक्रमणों के लिए दी जाती है। यह दवा कीटाणुओं को मारकर संक्रमण को ठीक करती है। इसे डॉक्टर के निर्देशानुसार ही लें और पूरा कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, टेंडन टूटना, तंत्रिका समस्याएं और गंभीर दस्त हो सकते हैं। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। पर्याप्त पानी पिएं। दवा लेते समय शराब न पिएं। एंटासिड, आयरन या जिंक सप्लीमेंट्स को इस दवा से 2 घंटे पहले या बाद में लें। अगर आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको किडनी या लीवर की समस्या है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 nixide o tablet Uses & Benefits
[{"condition":"Infectious diarrhea","description":"Used to treat diarrhea caused by mixed bacterial and protozoal infections.","evidence":"Moderate"},{"condition":"Amoebiasis","description":"Effective against Entamoeba histolytica infections, including intestinal and hepatic amoebiasis.","evidence":"Moderate"},{"condition":"Giardiasis","description":"Used for Giardia lamblia infections, especially when bacterial co-infection is suspected.","evidence":"Moderate"},{"condition":"Bacterial gastroenteritis","description":"Covers susceptible bacteria causing gastroenteritis, such as Escherichia coli and Salmonella species.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Cryptosporidiosis","description":"Nitazoxanide component may be used off-label for cryptosporidiosis in immunocompetent patients.","evidence":"Limited"},{"condition":"Helicobacter pylori eradication","description":"Sometimes included in combination regimens for H. pylori, though not a standard first-line option.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhea
Also treats: Amoebiasis, Giardiasis, Bacterial gastroenteritis
📋 Drug Information
| Generic Name(s) | Nitazoxanide (500mg) + Ofloxacin (200mg) |
| Brand Name | nixide o tablet |
| Manufacturer | Medley Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Nitazoxanide is a thiazolide antiprotozoal that inhibits pyruvate:ferredoxin oxidoreductase (PFOR), an enzyme essential for anaerobic energy metabolism in protozoa and anaerobic bacteria. This disrupts their energy production and leads to cell death. Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination. This leads to inhibition of bacterial DNA synthesis and cell death. The combination provides broad coverage against both protozoal and bacterial pathogens.
Mechanism Steps
💡 How to Take nixide o tablet
Strength: Each tablet contains Nitazoxanide 500 mg and Ofloxacin 200 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, preferably with food. The exact dose and duration depend on the type and severity of the infection, your age, weight, kidney and liver function, and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Complete the full course as prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, tendon problems, and kidney-related effects. Dose adjustment may be necessary based on renal function. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, dose adjustment of ofloxacin is required. For creatinine clearance between 20-50 mL/min, the usual dose may be reduced or the dosing interval extended. For creatinine clearance less than 20 mL/min, further dose reduction is needed. Nitazoxanide does not require dose adjustment in renal impairment. Consult your doctor for personalized dosing. |
| Hepatic Impairment | No specific dose adjustment is established for nitazoxanide in hepatic impairment. Ofloxacin is minimally metabolized in the liver, so dose adjustment is generally not required for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily (total 1000 mg nitazoxanide and 400 mg ofloxacin). Do not exceed this dose unless specifically instructed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nixide o tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Antacids | Major | |
| Amiodarone | Major | |
| NSAIDs | Moderate | |
| Theophylline | Moderate | |
| Caffeine | Moderate | |
| Glibenclamide | Minor | |
| Probenecid | Minor |
🚨 Major Interactions
- Warfarin
- Antacids, sucralfate, iron, zinc
- QT-prolonging drugs (e.g., amiodarone, sotalol, quinidine)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Theophylline
- Caffeine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of dizziness, drowsiness, and liver stress. It may also worsen gastrointestinal side effects such as nausea and abdominal pain. Additionally, alcohol can interfere with the body's ability to fight infections and may reduce the effectiveness of the treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nitazoxanide, ofloxacin, or other fluoroquinolones","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis","Children under 18 years (unless specifically prescribed by a pediatrician)","Pregnancy and breastfeeding (unless clearly needed)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects. Reserve use for patients with no alternative treatment options.","May cause dizziness and lightheadedness. Avoid driving or operating machinery until you know how this medicine affects you.","May cause photosensitivity. Avoid excessive sun exposure and use sunscreen.","Do not use in patients with a history of tendon disorders.","Use with caution in patients with epilepsy or other seizure disorders.","May worsen muscle weakness in patients with myasthenia gravis.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Do not exceed the recommended dose or duration of treatment."]
🤱 Lactation Safety
Not established from the available information. Ofloxacin is excreted in breast milk. Nitazoxanide is also likely to be excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, dizziness, and possibly seizures. There is no specific antidote. Treatment should be symptomatic and supportive. Gastric lavage may be considered if the overdose is recent. Maintain adequate hydration and monitor vital signs. In case of overdose, seek immediate medical attention or contact a poison control center.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not self-medicate or share it with others. Complete the full course even if you feel better after a few doses. Take it with food to reduce stomach upset. Drink plenty of water throughout the day. Avoid alcohol while taking this medicine as it may increase dizziness and liver stress. Do not take antacids, iron, or zinc supplements within 2 hours of this medicine as they can reduce absorption of ofloxacin. Inform your doctor if you have kidney or liver problems, heart rhythm disorders, diabetes, or a history of tendon problems. Avoid excessive sunlight and use sunscreen as this medicine may make your skin more sensitive to sunlight. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before taking this medicine. Do not stop the medicine without consulting your doctor, even if symptoms improve.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney problems, and central nervous system effects from ofloxacin. Dose adjustment may be needed based on renal function. Monitor for dizziness and falls. Consult your doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. This medicine should be used during pregnancy only if clearly needed. Discuss alternative treatments if you are trying to conceive.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with other medications used during surgery. Your doctor will decide if you need to stop it before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with other medications or affect healing. Your dentist may recommend postponing non-urgent procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from an infection. Rest is important. If you experience dizziness or fatigue, do not exercise. Consult your doctor before resuming your regular exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. You may need to take rest from work if you have severe diarrhea or weakness. Stay hydrated and take frequent breaks if you must work.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience serious side effects like tendon pain, severe allergic reaction, or seizures, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless specifically prescribed by your doctor. Prolonged use may lead to bacterial resistance, fungal overgrowth, and rare blood or liver abnormalities. Regular monitoring of kidney and liver function may be required if used for extended periods. Always consult your doctor before using this medicine for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration caused by diarrhea.
Evidence: Well-establishedMay help restore gut flora and reduce diarrhea duration.
Evidence: ModerateRecommended in children with diarrhea to reduce severity and duration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor as antibiotics may affect the vaccine's effectiveness. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust your dosing schedule to maintain approximately 12-hour intervals between doses. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 1-2 days, but it is important to complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset and improve absorption.
A: If you remember within 6 hours, take it. If more than 6 hours have passed, skip it and continue with your regular schedule. Do not double dose.
A: Consult your doctor. This medicine should be used during pregnancy only if clearly needed.
A: Avoid alcohol as it can increase dizziness and liver stress.
🤔 Common Patient Concerns
🔄 Substitutes for nixide o tablet
View AllAlternative brands with exact same active ingredient:
-
unin-nz 500mg/200mg tabletShinto Organics (P) Limited ₹46.56 14.4% CHEAPER
-
qurazine o 500mg/200mg tabletCure Quick Pharmaceuticals ₹46.88 13.8% CHEAPER
-
zstop o 500mg/200mg tabletManeesh Pharmaceuticals Ltd ₹54.85 0.9% COSTLIER
-
Nitazet O TabletGlenmark Pharmaceuticals Ltd ₹55.33 1.7% COSTLIER
-
nizanof tabletMolekule India Pvt Ltd ₹56.18 3.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine is effective only for specific bacterial and protozoal infections. It is not effective for viral diarrhea or diarrhea caused by other conditions. - Myth: I can stop taking this medicine once I feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance, even if symptoms improve. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription medicine. Self-medication can lead to resistance and serious side effects.