Nitrofirst 60mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Fainting or severe dizziness
- Bluish lips, skin, or nails
- Chest pain that is more frequent or severe than usual
- Shortness of breath or difficulty breathing
- Sudden swelling of face, lips, or throat
- Very slow or very fast heartbeat
- Confusion or unusual weakness
If experiencing severe symptoms, call emergency services immediately.
What is nitrofirst 60mg tablet used for?
This medicine is a prescription nitrate tablet used to prevent angina attacks in people with coronary artery disease. It works by relaxing blood vessels to improve blood flow to the heart. It is not for immediate relief of an ongoing angina attack.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nitrofirst 60mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से एंजाइना (सीने में दर्द) को रोकने के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को फैलाकर दिल तक रक्त का प्रवाह बढ़ाती है और दिल पर दबाव कम करती है। यह दवा तीव्र एंजाइना के दौरे के इलाज के लिए नहीं है, बल्कि भविष्य में होने वाले दौरों को रोकने के लिए है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर लालिमा और धड़कन तेज होना शामिल हैं। गंभीर दुष्प्रभावों में बहुत कम रक्तचाप, बेहोशी और मेथेमोग्लोबिनेमिया (खून में ऑक्सीजन की कमी) हो सकते हैं। अगर आपको बहुत ज्यादा चक्कर आए, बेहोशी हो, या होठों और त्वचा का रंग नीला पड़े, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को सिल्डेनाफिल, टैडालाफिल या वार्डेनाफिल जैसी दवाओं के साथ कभी न लें, क्योंकि इससे खतरनाक रूप से रक्तचाप गिर सकता है। शराब से बचें। उठते-बैठते समय धीरे-धीरे उठें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक गाड़ी न चलाएं। डॉक्टर की सलाह के बिना यह दवा अचानक बंद न करें।
💊 nitrofirst 60mg tablet Uses & Benefits
[{"condition":"Chronic stable angina prophylaxis","description":"This medicine is used to reduce the frequency and severity of angina attacks in people with coronary artery disease when taken regularly as prescribed.","evidence":"Well-established"},{"condition":"Angina pectoris due to coronary artery spasm","description":"It can help prevent chest pain caused by temporary narrowing of the coronary arteries.","evidence":"Moderate"},{"condition":"Heart failure with reduced ejection fraction (adjunct)","description":"In some cases, long-acting nitrates are added to standard therapy to relieve symptoms and improve exercise tolerance, but this is not a first-line treatment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Esophageal spasm","description":"Sometimes used to relieve chest pain caused by esophageal spasm when other treatments fail.","evidence":"Limited"},{"condition":"Anal fissure","description":"Topical nitroglycerin is used for anal fissures, but this oral form is not standard for that purpose.","evidence":"Not established from the available information."}]
Primary treatment for: Chronic stable angina
Also treats: Coronary artery disease, Heart failure (adjunct), Esophageal spasm (off-label)
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nitrofirst 60mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | NO Donors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | Not established from the available information. Check the expiry date on the package. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by entering the smooth muscle cells of blood vessels and being converted into nitric oxide. Nitric oxide then activates an enzyme called guanylate cyclase, which increases the production of cyclic guanosine monophosphate (cGMP). The rise in cGMP causes the smooth muscle to relax, leading to widening of both arteries and veins. This reduces the workload on the heart and improves the supply of oxygen-rich blood to the heart muscle. The 60 mg immediate-release tablet provides a large amount of nitroglycerin at once, so it must be used only under close medical supervision.
Mechanism Steps
💡 How to Take nitrofirst 60mg tablet
Strength: Immediate-release tablet, 60 mg
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. The 60 mg immediate-release tablet is not a typical starting dose for acute angina. It is usually prescribed for chronic prevention of angina, often with a nitrate-free interval to prevent tolerance. Never adjust the dose without your doctor's advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor closely for dizziness and falls. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Not established from the available information. No specific dose adjustment is provided in the labeling, but use with caution in patients with severe kidney disease. |
| Hepatic Impairment | Not established from the available information. Use with caution in patients with severe liver disease. |
| Maximum Daily Dose | Not established from the available information. The maximum daily dose must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nitrofirst 60mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Tadalafil | Major | |
| Riociguat | Major | |
| Alcohol | Major | |
| Beta-blockers | Moderate | |
| Calcium channel blockers | Moderate | |
| Diuretics | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Aspirin | Minor | |
| Heparin | Minor |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)
- Riociguat
- Alcohol
⚡ Moderate Interactions
- Beta-blockers
- Calcium channel blockers
- Diuretics
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol can greatly increase the blood pressure-lowering effect of this medicine, leading to severe dizziness, fainting, and falls. It is best to avoid alcohol completely while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nitroglycerin or other nitrates","Concurrent use of phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)","Concurrent use of riociguat","Severe hypotension (systolic blood pressure less than 90 mmHg)","Severe anemia","Increased intracranial pressure","Constrictive pericarditis","Hypertrophic obstructive cardiomyopathy","Aortic stenosis"]
⚠️ Warnings & Precautions
["This medicine can cause severe low blood pressure, especially when standing up. Rise slowly from sitting or lying positions.","Do not use this medicine to treat an acute angina attack. It is for prevention only.","Tolerance can develop with continuous use. Your doctor may recommend a nitrate-free interval.","Avoid alcohol while taking this medicine.","Do not drive or operate machinery until you know how this medicine affects you.","Tell your doctor if you have kidney or liver problems.","Do not stop this medicine suddenly without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. It is not known whether nitroglycerin passes into breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
An overdose of this medicine can cause severe low blood pressure, fainting, headache, confusion, and methemoglobinemia. If you suspect an overdose, seek emergency medical help immediately. Treatment may include supportive care, intravenous fluids, and medications to raise blood pressure. Methylene blue may be used for methemoglobinemia.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
Additional Safety Advice
Never take this medicine with erectile dysfunction medicines such as sildenafil, tadalafil, or vardenafil, because the combination can cause a life-threatening drop in blood pressure. Avoid alcohol, as it can worsen dizziness and low blood pressure. Stand up slowly from sitting or lying positions to prevent falls. Do not drive or operate heavy machinery until you know how this medicine affects you. If you feel faint or have blurred vision, sit or lie down immediately and call for help. Do not stop this medicine suddenly without talking to your doctor, because sudden withdrawal can trigger angina or a heart attack. Keep this medicine in its original container, away from light and moisture, and never store it in a bathroom. Tell all your healthcare providers that you take this medicine, especially before any surgery or dental procedure. If you are pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the blood pressure-lowering effects of this medicine. They should start with a lower dose and be monitored closely for dizziness and falls. Dose must be individualized by a qualified clinician.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before using this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with medications used during surgery and affect blood pressure. Your doctor may adjust or temporarily stop it before surgery.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine. It can cause low blood pressure, and dental procedures may need to be modified. Your dentist may consult your doctor before proceeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can trigger angina. Start slowly and gradually increase intensity. Always carry your fast-acting angina medicine if prescribed. Stop exercising and rest if you feel chest pain, dizziness, or shortness of breath.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness and low blood pressure, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Inform your employer if your job involves heavy machinery or driving.
🛑 When to Stop This Medicine
Do not stop this medicine suddenly without consulting your doctor, as it can worsen angina or trigger a heart attack. Your doctor will decide if and when to stop based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, meaning it may become less effective over time. Your doctor may recommend a nitrate-free interval to prevent this. Regular monitoring of blood pressure and heart rate is important. Report any new or worsening symptoms to your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, regular exercise, and smoking cessation can complement medicine for angina.
Evidence: Well-establishedAnother class of medicines used for angina prevention.
Evidence: Well-establishedUsed for angina prevention, especially when beta-blockers are not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Discuss with your doctor about vaccinations, especially flu and pneumonia, as they are recommended for people with heart disease.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from light and moisture. If traveling across time zones, consult your doctor about dose timing. Keep it in your carry-on luggage, not in checked baggage. Be aware of customs regulations regarding prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action for this specific 60 mg immediate-release tablet is not established from available information. Your doctor will monitor your response.
A: No, this medicine is for prevention of angina attacks. For acute attacks, your doctor will prescribe a fast-acting form of nitroglycerin.
A: Avoid alcohol, erectile dysfunction drugs, and driving until you know how this medicine affects you.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken for immediate relief of chest pain.
Fact: This medicine is for prevention of angina, not for immediate relief. A different fast-acting form is used for acute attacks. - Myth: It is safe to take this medicine with erectile dysfunction drugs.
Fact: Combining this medicine with erectile dysfunction drugs can cause a life-threatening drop in blood pressure. - Myth: You can stop this medicine suddenly without any problem.
Fact: Sudden withdrawal can worsen angina or trigger a heart attack. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Nitroglycerin 60 mg immediate-release tablet
Brand Alternatives
- Nitrofirst 60mg tablet