Nitroace-sr Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe chest pain that does not respond to fast-acting nitrates
- Fainting or severe dizziness
- Bluish discoloration of lips, skin, or nails
- Shortness of breath or difficulty breathing
- Severe headache with visual changes
- Swelling of face, lips, or throat
- Irregular or very slow heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is nitroace-sr tablet used for?
This medicine is a sustained-release nitrate used to prevent angina attacks. It works by relaxing blood vessels to improve blood flow to the heart. It is not for immediate relief of acute angina. Take it exactly as prescribed, and avoid alcohol and erectile dysfunction drugs.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nitroace-sr tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एंजाइना पेक्टोरिस (सीने में दर्द) की रोकथाम और दीर्घकालिक प्रबंधन के लिए उपयोग की जाती है। यह रक्त वाहिकाओं को फैलाकर हृदय तक रक्त के प्रवाह को बेहतर बनाती है और हृदय पर दबाव कम करती है। यह दवा तीव्र एंजाइना हमले के तत्काल राहत के लिए नहीं है। इसका उपयोग डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, और चेहरे पर लालिमा शामिल हैं। ये आमतौर पर हल्के होते हैं और समय के साथ कम हो जाते हैं। गंभीर दुष्प्रभावों में गंभीर निम्न रक्तचाप, मेथेमोग्लोबिनेमिया, और एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको सांस लेने में कठिनाई, बेहोशी, या त्वचा का नीला पड़ना महसूस हो, तो तुरंत चिकित्सा सहायता लें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं। इरेक्टाइल डिसफंक्शन की दवाओं के साथ इसका सेवन न करें। शराब का सेवन न करें क्योंकि इससे रक्तचाप बहुत कम हो सकता है। दवा को अचानक बंद न करें। डॉक्टर के निर्देशों का पालन करें और नियमित जांच कराएं।
💊 nitroace-sr tablet Uses & Benefits
- [{"condition":"Chronic stable angina pectoris","description":"This medicine is used for the long-term prevention of angina attacks in patients with coronary artery disease.
- It helps reduce the frequency and severity of chest pain by improving blood flow to the heart.","evidence":"Well-established"},{"condition":"Vasospastic angina (Prinzmetal's angina)","description":"This medicine can be effective in preventing angina attacks caused by coronary artery spasm, as nitrates are potent vasodilators.","evidence":"Well-established"},{"condition":"Heart failure with reduced ejection fraction","description":"In combination with hydralazine, nitrates like nitroglycerin are used to reduce afterload and preload, improving symptoms and survival in certain heart failure patients.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Anal fissure","description":"Topical nitroglycerin is sometimes used off-label to relax the anal sphincter and promote healing of anal fissures, but this sustained-release oral form is not intended for this use.","evidence":"Limited"},{"condition":"Esophageal spasm","description":"Nitrates may be used off-label to relieve esophageal spasm, but evidence is limited and this is not a standard use for the oral sustained-release form.","evidence":"Limited"}]
Primary treatment for: Angina pectoris
Also treats: Coronary artery disease, Heart failure, Vasospastic angina
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nitroace-sr tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | Urinary Antiseptic-Nitrofurantoin |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate or freeze. |
| Shelf Life | Not established from the available information. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by releasing nitric oxide, which activates guanylate cyclase, leading to increased levels of cyclic guanosine monophosphate (cGMP). This results in the relaxation of vascular smooth muscle, causing vasodilation. The primary effect is on the venous system, leading to reduced preload and decreased cardiac workload. At higher doses, it also dilates coronary arteries and arterioles, improving blood flow to the ischemic myocardium. The sustained-release formulation provides a gradual release of nitroglycerin, maintaining therapeutic levels over an extended period.
Mechanism Steps
💡 How to Take nitroace-sr tablet
Strength: Sustained-release tablet. Available strengths may vary; consult your pharmacist for details.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and response to therapy. Typically, sustained-release nitroglycerin tablets are prescribed at a dose of 2.5 mg to 9 mg taken two to three times daily. The dose may be titrated to achieve optimal symptom control while minimizing side effects. A nitrate-free interval of 10 to 12 hours is often recommended to prevent tolerance. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor closely for dizziness, falls, and hypotension. Dose adjustments should be made cautiously by a clinician. |
| Renal Impairment | Not established from the available information. Use with caution in patients with renal impairment and consult a clinician for dose adjustments. |
| Hepatic Impairment | Not established from the available information. Use with caution in patients with hepatic impairment and consult a clinician for dose adjustments. |
| Maximum Daily Dose | The maximum daily dose should be determined by a qualified clinician. Typically, doses above 9 mg per day are not recommended due to increased risk of tolerance and side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nitroace-sr tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Tadalafil | Major | |
| Riociguat | Major | |
| Alcohol | Moderate | |
| Beta-blockers | Moderate | |
| Calcium channel blockers | Moderate | |
| Ergotamine | Moderate | |
| NSAIDs | Minor |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
- Riociguat
⚡ Moderate Interactions
- Alcohol
- Antihypertensives (e.g., beta-blockers, calcium channel blockers)
- Ergot alkaloids (e.g., ergotamine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can intensify the blood pressure-lowering effects of nitroglycerin, leading to severe dizziness, fainting, and potentially dangerous drops in blood pressure. If you choose to drink alcohol, do so in moderation and monitor for symptoms of low blood pressure such as lightheadedness or rapid heartbeat. Consult your doctor for personalized advice.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to nitrates","Concomitant use with phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)","Concomitant use with riociguat","Severe hypotension (systolic blood pressure
⚠️ Warnings & Precautions
["This medicine may cause severe hypotension, especially when standing up quickly. Rise slowly from sitting or lying positions.","Tolerance to the effects of this medicine can develop with continuous use. A nitrate-free interval of 10-12 hours is often recommended.","Avoid alcohol while taking this medicine as it can enhance the blood pressure-lowering effect.","Use with caution in patients with glaucoma or increased intraocular pressure.","This medicine may impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you.","Do not use this medicine for acute angina attacks. A fast-acting nitrate should be used for immediate relief.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether nitroglycerin is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of this medicine can cause severe hypotension, throbbing headache, dizziness, palpitations, visual disturbances, and methemoglobinemia. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. If methemoglobinemia is present, methylene blue may be administered. Maintain blood pressure with intravenous fluids and vasopressors if necessary. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Before starting this medicine, inform your doctor about all your medical conditions, especially low blood pressure, heart conditions, kidney or liver disease, and any allergies. Do not use this medicine if you are taking medications for erectile dysfunction, as this can cause a dangerous drop in blood pressure. Avoid alcohol while taking this medicine, as it can intensify the blood pressure-lowering effect and increase the risk of dizziness or fainting. Do not stop taking this medicine abruptly without consulting your doctor, as this can lead to withdrawal symptoms or worsening of angina. Follow your doctor's instructions exactly regarding dosage and timing. If you experience severe headache, blurred vision, or fainting, seek medical help immediately. Keep this medicine out of reach of children and store it as directed. Regular monitoring of blood pressure and heart rate may be necessary during treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of this medicine in these conditions is not fully established.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the blood pressure-lowering effects. Start with a lower dose and monitor closely for dizziness, falls, and hypotension. Regular check-ups are important.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor. The safety of this medicine during pregnancy is not fully established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure during surgery. Your doctor may advise temporary discontinuation.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dizziness or hypotension during dental procedures. Take precautions to avoid sudden position changes.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can trigger angina, so start slowly and gradually increase intensity. Always carry your fast-acting nitrate during exercise. If you experience chest pain, stop immediately and take your fast-acting nitrate. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how it affects you. Take precautions to prevent falls. Inform your employer about your condition and medicine if necessary.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Abrupt discontinuation can cause worsening of angina or a heart attack. Your doctor may adjust the dose or switch to another medicine if needed.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, where the medicine becomes less effective. To prevent this, a nitrate-free interval of 10-12 hours is often recommended. Regular monitoring of blood pressure and heart rate is advised. Long-term use may also cause headaches and dizziness. Consult your doctor for periodic evaluation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress management can complement medicine.
Evidence: Well-establishedAlternative class of anti-anginal medicines.
Evidence: Well-establishedMay be used if nitrates are not tolerated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid extreme temperatures. If crossing time zones, consult your doctor about adjusting the dosing schedule. Store at room temperature and protect from light and moisture. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is for prevention and works over time to reduce the frequency of angina attacks. It is not for immediate relief. The full effect may take several days to weeks.
A: No, this medicine is not for immediate relief of an acute attack. You should use a fast-acting nitrate as prescribed for acute attacks.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol can intensify the blood pressure-lowering effect and cause severe dizziness or fainting. Avoid alcohol while taking this medicine.
A: No, stopping suddenly can worsen angina. Always consult your doctor before stopping.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be used to relieve an acute angina attack.
Fact: This medicine is for prevention and long-term management. For acute attacks, a fast-acting nitrate is needed. - Myth: It is safe to take this medicine with erectile dysfunction drugs.
Fact: Combining nitrates with erectile dysfunction drugs can cause a dangerous drop in blood pressure and is contraindicated. - Myth: You can stop taking this medicine abruptly without any issues.
Fact: Abrupt discontinuation can worsen angina. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Nitroglycerin sustained-release tablets
Brand Alternatives
- Nitroace-SR Tablet