nicomend 10 tablet - Information coming soon medicine

Nicomend 10 Tablet: Complete Guide To Uses, Side Effects, And Safety

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🏭 Generic 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 29, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for chronic stable angina.
Reviewed by
SaathiMed Expert Panel | Oct 29, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe dizziness or fainting
  • Chest pain that does not go away with rest or usual angina medicine
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or wheezing
  • Black, tarry stools or vomiting blood
  • Severe abdominal pain
  • Yellowing of the skin or eyes
  • Decreased urine output
  • Irregular or very fast heartbeat

If experiencing severe symptoms, call emergency services immediately.

What is nicomend 10 tablet used for?

This medicine is an oral tablet containing nicorandil, used to prevent angina attacks in people with coronary artery disease. It works by relaxing blood vessels to improve blood flow to the heart. It is taken twice daily as prescribed by a doctor.

  • Generic Name: Information coming soon
  • Manufacturer: Multiple manufacturers
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nicomend 10 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एनजाइना (सीने में दर्द) को रोकने के लिए इस्तेमाल की जाती है। यह हृदय की धमनियों को फैलाकर हृदय तक रक्त का प्रवाह बढ़ाती है और हृदय पर दबाव कम करती है। यह आमतौर पर उन रोगियों को दी जाती है जिन्हें अन्य दवाओं से भी एनजाइना के दौरे पड़ते रहते हैं। यह दवा तीव्र एनजाइना के दौरे के इलाज के लिए नहीं है, बल्कि इससे बचाव के लिए है। इसे डॉक्टर के बताए अनुसार दिन में दो बार लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर गर्मी लगना, जी मिचलाना और मुँह में छाले हो सकते हैं। सिरदर्द आमतौर पर शुरुआत में होता है और कुछ दिनों में ठीक हो जाता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन बहुत कम रक्तचाप, बेहोशी, सांस लेने में कठिनाई, या चेहरे और गले में सूजन हो सकती है। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं। इसे भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। शराब न पिएं क्योंकि इससे रक्तचाप बहुत कम हो सकता है। अचानक उठने से बचें, धीरे-धीरे उठें। यदि आपको चक्कर आए या बेहोशी महसूस हो, तो तुरंत बैठ या लेट जाएं। नपुंसकता की दवाएं इस दवा के साथ न लें। अपने डॉक्टर को लीवर या किडनी की समस्या, कम रक्तचाप, या अल्सर की जानकारी दें। नियमित रूप से रक्तचाप की जांच कराएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 nicomend 10 tablet Uses & Benefits

  • [{"condition":"Chronic stable angina","description":"This medicine is used for the long-term prevention of angina attacks in patients with coronary artery disease.
  • It helps reduce the frequency and severity of chest pain episodes.","evidence":"Well-established"},{"condition":"Unstable angina","description":"In some cases, this medicine may be used as part of a treatment plan for unstable angina, but only under close medical supervision.","evidence":"Moderate"},{"condition":"Adjunctive therapy in heart failure","description":"This medicine has been studied as an add-on treatment in patients with chronic heart failure, but this is not a standard first-line use.","evidence":"Limited"}]

Off-label uses: [{"condition":"Prevention of contrast-induced nephropathy","description":"Some small studies suggest this medicine may help protect the kidneys from damage caused by contrast dyes used in imaging procedures, but this is not a standard use.","evidence":"Limited"},{"condition":"Raynaud's phenomenon","description":"Rarely, this medicine may be prescribed off-label to improve blood flow in fingers and toes in people with Raynaud's phenomenon.","evidence":"Limited"}]

Primary treatment for: Chronic stable angina

Also treats: Unstable angina, Coronary artery disease, Heart failure (adjunct)

📋 Drug Information

Generic Name(s)Information coming soon
Brand Namenicomend 10 tablet
ManufacturerMultiple manufacturers
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassPotassium channel opener
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same times each day, preferably with meals, to maintain consistent blood levels and reduce stomach upset.
2
Rise slowly from sitting or lying positions to prevent dizziness caused by low blood pressure.
3
Avoid alcohol completely while on this medicine, as it can cause a dangerous drop in blood pressure.
4
Do not take erectile dysfunction medicines like sildenafil while on this medicine, as the combination can be life-threatening.
5
Report any new mouth ulcers or persistent stomach pain to your doctor, as this may require a change in treatment.
6
Keep a record of your angina attacks and inform your doctor if they become more frequent or severe.
7
Do not stop this medicine abruptly without consulting your doctor, even if you feel better.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chest pain on exertion
This medicine is commonly prescribed to prevent angina chest pain.
Likely Use
❌
Acute angina attack
This medicine is not for immediate relief of an ongoing attack. Use fast-acting nitrates.
Not Primary
❌
High blood pressure
This medicine is not a primary blood pressure medicine, though it can lower blood pressure.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 75% to 80% due to some first-pass metabolism. Food does not significantly affect the extent of absorption, but taking it with food may reduce the risk of stomach upset.
DistributionThis medicine is widely distributed throughout the body. It is not highly bound to plasma proteins. The volume of distribution is approximately 1.5 liters per kilogram. It crosses the placenta and is excreted in breast milk in small amounts.
Protein BindingLess than 25% bound to plasma proteins.
MetabolismThis medicine is extensively metabolized in the liver, primarily by denitration and glucuronidation. The main metabolites are inactive or have minimal activity. One metabolite, N-(2-hydroxyethyl)nicotinamide, is pharmacologically active but less potent than the parent drug.
Half-LifeThe elimination half-life is approximately 1 to 1.5 hours, but the duration of action is longer due to the formation of active metabolites and the nature of its mechanism.
ExcretionThis medicine and its metabolites are primarily excreted in the urine. About 70% of a dose is excreted in urine, and a smaller amount in feces.
BioavailabilityApproximately 75% to 80% after oral administration.
Onset of ActionThe onset of action is usually within 30 to 60 minutes after oral administration, but the full anti-anginal effect may take several days to develop with regular use.
Peak Plasma TimePeak plasma concentrations are reached approximately 30 to 60 minutes after oral administration.
Duration of ActionThe duration of action is approximately 12 hours, which supports twice-daily dosing for angina prevention.

How It Works

This medicine works through two complementary mechanisms. First, it acts as a potassium channel activator, opening ATP-sensitive potassium channels in the smooth muscle cells of blood vessels. This leads to an efflux of potassium ions, which causes the cell membrane to hyperpolarize, reducing calcium entry and leading to relaxation of the blood vessel wall. Second, it has a nitrate-like effect, donating nitric oxide, which activates guanylate cyclase and increases cyclic GMP levels. This further relaxes vascular smooth muscle. The combined effect is dilation of both arteries and veins, with a particularly strong effect on coronary arteries. This improves blood supply to the heart muscle and reduces the heart's workload, helping to prevent angina.

Mechanism Steps

1
Potassium channel activation: This medicine opens ATP-sensitive potassium channels in vascular smooth muscle cells, causing potassium to leave the cell and hyperpolarize the membrane.
2
Reduced calcium entry: Hyperpolarization closes voltage-gated calcium channels, reducing calcium entry into the cell, which leads to muscle relaxation.
3
Nitric oxide donation: The nitrate group in this medicine releases nitric oxide, which activates guanylate cyclase and increases cyclic GMP.
4
Vasodilation: Increased cyclic GMP and reduced calcium cause relaxation of smooth muscle in blood vessel walls, widening both arteries and veins.
5
Improved oxygen balance: Coronary arteries dilate to increase oxygen supply to the heart, while peripheral dilation reduces the heart's workload, preventing angina.

💡 How to Take nicomend 10 tablet

Strength: 10 mg immediate-release tablet

1Swallow the tablet whole with a glass of water.
2Do not crush, chew, or break the tablet.
3Take it with or without food, but with food if it upsets your stomach.
4Take it at the same times each day to maintain consistent blood levels.
5If you feel dizzy after taking it, sit or lie down until the feeling passes.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 mg to 20 mg taken twice daily, depending on the severity of angina and the patient's response. The dose may be increased gradually under medical supervision. The maximum recommended daily dose is 40 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentIn patients with mild to moderate renal impairment, no dose adjustment is usually needed. In severe renal impairment, use with caution and consider dose reduction. Dose must be individualized by a qualified clinician.
Hepatic ImpairmentIn patients with mild to moderate hepatic impairment, no dose adjustment is usually needed. In severe hepatic impairment, use is contraindicated. Dose must be individualized by a qualified clinician.
Maximum Daily Dose40 mg per day in divided doses.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Grapefruit
Avoid or limit
May increase drug levels and side effects.
Alcohol
Avoid
Increases risk of low blood pressure and dizziness.

⏰ What to Do If You Miss a Dose

📌 Less than 6 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than 6 hours since missed dose
→ Skip the missed dose and take the next dose at the regular time.
💡 Do not double dose to catch up.

⚠️ Side Effects of nicomend 10 tablet

✅ Common Side Effects

Headache (Common (10-30%))
This often improves after the first few days. If it persists or is severe, consult your doctor. Do not stop the medicine on your own.
Dizziness (Common (5-10%))
Stand up slowly and avoid driving if you feel dizzy. If dizziness is severe or persistent, contact your doctor.
Flushing (Common (5-10%))
This usually goes away with continued use. If it bothers you, talk to your doctor.
Nausea (Common (5-10%))
Take the tablet with food to reduce nausea. If it continues, consult your doctor.
Mouth ulcers (Uncommon (1-5%))
Report to your doctor if you develop painful mouth ulcers. They may need to adjust your treatment.

🚨 Serious Side Effects

Severe hypotension (Rare (<0.1%))
Seek immediate medical attention if you feel faint, have blurred vision, or collapse.
Angioedema (Rare (<0.1%))
Seek emergency care if you develop swelling of the face, lips, tongue, or throat, or difficulty breathing.
Gastrointestinal ulcers (Rare (<0.1%))
Report persistent stomach pain, black stools, or vomiting blood to your doctor immediately.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you develop a rash, itching, or difficulty breathing.

⚠️ Rare Side Effects

Thrombocytopenia
Report unusual bruising or bleeding to your doctor.
Hepatic dysfunction
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Sildenafil Major
Nitroglycerin Major
Alcohol Major
Beta-blockers Moderate
Calcium channel blockers Moderate
Diuretics Moderate
Tricyclic antidepressants Moderate
Grapefruit juice Minor

🚨 Major Interactions

  • Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
  • Nitrates (e.g., nitroglycerin, isosorbide mononitrate)
  • Alcohol

⚡ Moderate Interactions

  • Antihypertensives (e.g., beta-blockers, calcium channel blockers)
  • Diuretics
  • Tricyclic antidepressants

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can enhance the blood pressure-lowering effect and increase the risk of dizziness, fainting, and falls.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to nicorandil or any component of the tablet","Cardiogenic shock","Severe hypotension (low blood pressure)","Acute myocardial infarction with low filling pressures","Concomitant use of phosphodiesterase-5 inhibitors (e.g., sildenafil)","Severe dehydration","Severe liver disease","Severe kidney disease"]

⚠️ Warnings & Precautions

["This medicine can cause severe low blood pressure, especially when standing up. Rise slowly from sitting or lying positions.","Avoid alcohol while taking this medicine as it can worsen hypotension.","Do not take medicines for erectile dysfunction while on this medicine.","Report any mouth ulcers or persistent stomach pain to your doctor.","Use with caution in elderly patients and those with liver or kidney disease.","Do not stop this medicine abruptly without consulting your doctor, as it may worsen angina.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep all follow-up appointments and monitor your blood pressure regularly."]

🤱 Lactation Safety

This medicine is excreted in breast milk in small amounts. It is not known whether it is safe during breastfeeding. Consult your doctor before breastfeeding while on this medicine.

💊 Overdose Management

Overdose of this medicine can cause severe hypotension, dizziness, fainting, and reflex tachycardia. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids, vasopressors, and monitoring of vital signs. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor, as sudden discontinuation may worsen your angina. Swallow the tablet whole with a glass of water; do not crush or chew it. You may take it with or without food, but taking it with food may reduce stomach upset. Avoid alcohol while taking this medicine because it can increase the risk of low blood pressure and dizziness. Stand up slowly from a sitting or lying position to prevent dizziness. If you feel faint or lightheaded, sit or lie down immediately and inform your doctor. Do not take medicines for erectile dysfunction while on this medicine, as the combination can cause a dangerous drop in blood pressure. Inform your doctor if you have liver or kidney problems, low blood pressure, or a history of ulcers. Keep all follow-up appointments and get regular blood pressure checks. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Falls due to dizziness are a concern, so advise slow position changes. Regular review of kidney and liver function is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before conceiving. This medicine should be used during pregnancy only if clearly needed. Your doctor will weigh the benefits and risks. Effective contraception is advised while on this medicine unless otherwise directed.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery to avoid interactions with anesthetic agents. Do not stop it without medical advice.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It can cause low blood pressure, so dental procedures should be performed with caution. Your dentist may take precautions to monitor your blood pressure during the procedure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce the workload on your heart.
🥗
Engage in regular low-impact exercise like walking or swimming, as advised by your doctor.
😴
Follow a heart-healthy diet rich in fruits, vegetables, and whole grains.
💧
Avoid smoking and limit alcohol intake.
🧘
Manage stress through relaxation techniques like deep breathing or meditation.
🌞
Get adequate sleep and rest.
🚭
Monitor your blood pressure regularly at home if advised.

🏋️ Exercise Considerations

Moderate exercise is beneficial for heart health, but avoid strenuous activities that trigger angina. Always warm up and cool down. If you experience chest pain, dizziness, or shortness of breath during exercise, stop immediately and rest. Consult your doctor before starting any new exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Limit salt to control blood pressure.
Eat plenty of fruits and vegetables.
Stay well hydrated unless advised otherwise.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or lightheadedness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how this medicine affects you. Most people can continue their normal daily activities, but take precautions to prevent falls.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as severe hypotension, allergic reactions, or persistent mouth ulcers, contact your doctor immediately. Your doctor may adjust the dose or switch to another medicine.

📅 Long-Term Use Effects

Long-term use of this medicine is generally well-tolerated, but it may be associated with the development of ulcers in the mouth, intestines, or other areas. Regular monitoring by your doctor is important. If you develop persistent mouth ulcers or stomach pain, inform your doctor. Periodic blood pressure checks and assessment of angina control are recommended. Do not stop the medicine without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Heart-healthy diet, regular exercise, smoking cessation, and stress management can complement medicine for angina.

Evidence: Well-established
Revascularization procedures

Angioplasty or bypass surgery may be considered for severe coronary artery disease.

Evidence: Well-established
Cardiac rehabilitation

Supervised exercise and education programs can improve heart health and reduce angina.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions with this medicine. However, annual influenza vaccination is recommended for patients with heart disease. Consult your doctor for personalized advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store it at room temperature and protect it from direct sunlight. If crossing time zones, continue taking your doses at approximately 12-hour intervals, but consult your doctor for specific advice. Check local customs regulations regarding prescription medicines before you travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with a history of coronary artery disease and frequent angina attacks despite taking beta-blockers.
He was prescribed this medicine twice daily. After two weeks, he noticed that his angina attacks became less frequent and less severe. He experienced mild headache initially, which improved after a few days. He was advised to avoid alcohol and to take the tablet with food.
💡 Lesson: This medicine can significantly reduce angina frequency when taken regularly. Initial headaches are common but usually transient.
👤 A 65-year-old woman with chronic stable angina and mild kidney impairment.
She started this medicine and was monitored closely. Her blood pressure was checked regularly, and the dose was adjusted. She was advised to rise slowly from bed to avoid dizziness. She reported no major side effects and her exercise tolerance improved.
💡 Lesson: Elderly patients and those with kidney issues need careful monitoring and dose adjustment. Lifestyle modifications like slow rising help prevent falls.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 30 to 60 minutes, but its full preventive effect may take several days to develop with regular use.

Q: Can I take this medicine if I have diabetes?

A: Yes, but inform your doctor. This medicine does not usually affect blood sugar, but monitoring is advised.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop without consulting your doctor. Stopping suddenly can worsen your angina.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe to take with sildenafil?
  • What should I do if I develop mouth ulcers?

🛑 Myths vs. Facts

  • Myth: This medicine can be taken to relieve an ongoing angina attack.
    Fact: This medicine is for prevention of angina attacks, not for immediate relief. For acute attacks, use a fast-acting nitrate as prescribed.
  • Myth: Once you feel better, you can stop taking this medicine.
    Fact: Stopping suddenly can worsen angina. Always consult your doctor before stopping.
  • Myth: This medicine is safe to take with erectile dysfunction drugs.
    Fact: Combining this medicine with erectile dysfunction drugs can cause a dangerous drop in blood pressure and is contraindicated.

🔄 Alternative Options

Generic Alternatives

  • Nicorandil 10 mg tablet

Brand Alternatives

  • Nicomend 10 tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nicorandil","class":"Potassium channel activator","main_use":"Chronic stable angina","route":"Oral","common_side_effects":"Headache, dizziness, flushing"},{"medicine":"Isosorbide mononitrate","class":"Nitrate","main_use":"Angina prevention","route":"Oral","common_side_effects":"Headache, hypotension, tolerance"},{"medicine":"Ranolazine","class":"Late sodium current inhibitor","main_use":"Chronic angina","route":"Oral","common_side_effects":"Dizziness, constipation, nausea"}]

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