Nicomend 10 Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Chest pain that does not go away with rest or usual angina medicine
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or wheezing
- Black, tarry stools or vomiting blood
- Severe abdominal pain
- Yellowing of the skin or eyes
- Decreased urine output
- Irregular or very fast heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is nicomend 10 tablet used for?
This medicine is an oral tablet containing nicorandil, used to prevent angina attacks in people with coronary artery disease. It works by relaxing blood vessels to improve blood flow to the heart. It is taken twice daily as prescribed by a doctor.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nicomend 10 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एनजाइना (सीने में दर्द) को रोकने के लिए इस्तेमाल की जाती है। यह हृदय की धमनियों को फैलाकर हृदय तक रक्त का प्रवाह बढ़ाती है और हृदय पर दबाव कम करती है। यह आमतौर पर उन रोगियों को दी जाती है जिन्हें अन्य दवाओं से भी एनजाइना के दौरे पड़ते रहते हैं। यह दवा तीव्र एनजाइना के दौरे के इलाज के लिए नहीं है, बल्कि इससे बचाव के लिए है। इसे डॉक्टर के बताए अनुसार दिन में दो बार लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर गर्मी लगना, जी मिचलाना और मुँह में छाले हो सकते हैं। सिरदर्द आमतौर पर शुरुआत में होता है और कुछ दिनों में ठीक हो जाता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन बहुत कम रक्तचाप, बेहोशी, सांस लेने में कठिनाई, या चेहरे और गले में सूजन हो सकती है। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं। इसे भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। शराब न पिएं क्योंकि इससे रक्तचाप बहुत कम हो सकता है। अचानक उठने से बचें, धीरे-धीरे उठें। यदि आपको चक्कर आए या बेहोशी महसूस हो, तो तुरंत बैठ या लेट जाएं। नपुंसकता की दवाएं इस दवा के साथ न लें। अपने डॉक्टर को लीवर या किडनी की समस्या, कम रक्तचाप, या अल्सर की जानकारी दें। नियमित रूप से रक्तचाप की जांच कराएं।
💊 nicomend 10 tablet Uses & Benefits
- [{"condition":"Chronic stable angina","description":"This medicine is used for the long-term prevention of angina attacks in patients with coronary artery disease.
- It helps reduce the frequency and severity of chest pain episodes.","evidence":"Well-established"},{"condition":"Unstable angina","description":"In some cases, this medicine may be used as part of a treatment plan for unstable angina, but only under close medical supervision.","evidence":"Moderate"},{"condition":"Adjunctive therapy in heart failure","description":"This medicine has been studied as an add-on treatment in patients with chronic heart failure, but this is not a standard first-line use.","evidence":"Limited"}]
Off-label uses: [{"condition":"Prevention of contrast-induced nephropathy","description":"Some small studies suggest this medicine may help protect the kidneys from damage caused by contrast dyes used in imaging procedures, but this is not a standard use.","evidence":"Limited"},{"condition":"Raynaud's phenomenon","description":"Rarely, this medicine may be prescribed off-label to improve blood flow in fingers and toes in people with Raynaud's phenomenon.","evidence":"Limited"}]
Primary treatment for: Chronic stable angina
Also treats: Unstable angina, Coronary artery disease, Heart failure (adjunct)
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nicomend 10 tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Potassium channel opener |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. First, it acts as a potassium channel activator, opening ATP-sensitive potassium channels in the smooth muscle cells of blood vessels. This leads to an efflux of potassium ions, which causes the cell membrane to hyperpolarize, reducing calcium entry and leading to relaxation of the blood vessel wall. Second, it has a nitrate-like effect, donating nitric oxide, which activates guanylate cyclase and increases cyclic GMP levels. This further relaxes vascular smooth muscle. The combined effect is dilation of both arteries and veins, with a particularly strong effect on coronary arteries. This improves blood supply to the heart muscle and reduces the heart's workload, helping to prevent angina.
Mechanism Steps
💡 How to Take nicomend 10 tablet
Strength: 10 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mg to 20 mg taken twice daily, depending on the severity of angina and the patient's response. The dose may be increased gradually under medical supervision. The maximum recommended daily dose is 40 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually needed. In severe renal impairment, use with caution and consider dose reduction. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is usually needed. In severe hepatic impairment, use is contraindicated. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | 40 mg per day in divided doses. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nicomend 10 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Nitroglycerin | Major | |
| Alcohol | Major | |
| Beta-blockers | Moderate | |
| Calcium channel blockers | Moderate | |
| Diuretics | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
- Nitrates (e.g., nitroglycerin, isosorbide mononitrate)
- Alcohol
⚡ Moderate Interactions
- Antihypertensives (e.g., beta-blockers, calcium channel blockers)
- Diuretics
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can enhance the blood pressure-lowering effect and increase the risk of dizziness, fainting, and falls.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nicorandil or any component of the tablet","Cardiogenic shock","Severe hypotension (low blood pressure)","Acute myocardial infarction with low filling pressures","Concomitant use of phosphodiesterase-5 inhibitors (e.g., sildenafil)","Severe dehydration","Severe liver disease","Severe kidney disease"]
⚠️ Warnings & Precautions
["This medicine can cause severe low blood pressure, especially when standing up. Rise slowly from sitting or lying positions.","Avoid alcohol while taking this medicine as it can worsen hypotension.","Do not take medicines for erectile dysfunction while on this medicine.","Report any mouth ulcers or persistent stomach pain to your doctor.","Use with caution in elderly patients and those with liver or kidney disease.","Do not stop this medicine abruptly without consulting your doctor, as it may worsen angina.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep all follow-up appointments and monitor your blood pressure regularly."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. It is not known whether it is safe during breastfeeding. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe hypotension, dizziness, fainting, and reflex tachycardia. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids, vasopressors, and monitoring of vital signs. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor, as sudden discontinuation may worsen your angina. Swallow the tablet whole with a glass of water; do not crush or chew it. You may take it with or without food, but taking it with food may reduce stomach upset. Avoid alcohol while taking this medicine because it can increase the risk of low blood pressure and dizziness. Stand up slowly from a sitting or lying position to prevent dizziness. If you feel faint or lightheaded, sit or lie down immediately and inform your doctor. Do not take medicines for erectile dysfunction while on this medicine, as the combination can cause a dangerous drop in blood pressure. Inform your doctor if you have liver or kidney problems, low blood pressure, or a history of ulcers. Keep all follow-up appointments and get regular blood pressure checks. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Falls due to dizziness are a concern, so advise slow position changes. Regular review of kidney and liver function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conceiving. This medicine should be used during pregnancy only if clearly needed. Your doctor will weigh the benefits and risks. Effective contraception is advised while on this medicine unless otherwise directed.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery to avoid interactions with anesthetic agents. Do not stop it without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause low blood pressure, so dental procedures should be performed with caution. Your dentist may take precautions to monitor your blood pressure during the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is beneficial for heart health, but avoid strenuous activities that trigger angina. Always warm up and cool down. If you experience chest pain, dizziness, or shortness of breath during exercise, stop immediately and rest. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or lightheadedness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how this medicine affects you. Most people can continue their normal daily activities, but take precautions to prevent falls.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as severe hypotension, allergic reactions, or persistent mouth ulcers, contact your doctor immediately. Your doctor may adjust the dose or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well-tolerated, but it may be associated with the development of ulcers in the mouth, intestines, or other areas. Regular monitoring by your doctor is important. If you develop persistent mouth ulcers or stomach pain, inform your doctor. Periodic blood pressure checks and assessment of angina control are recommended. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, regular exercise, smoking cessation, and stress management can complement medicine for angina.
Evidence: Well-establishedAngioplasty or bypass surgery may be considered for severe coronary artery disease.
Evidence: Well-establishedSupervised exercise and education programs can improve heart health and reduce angina.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, annual influenza vaccination is recommended for patients with heart disease. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store it at room temperature and protect it from direct sunlight. If crossing time zones, continue taking your doses at approximately 12-hour intervals, but consult your doctor for specific advice. Check local customs regulations regarding prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 to 60 minutes, but its full preventive effect may take several days to develop with regular use.
A: Yes, but inform your doctor. This medicine does not usually affect blood sugar, but monitoring is advised.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop without consulting your doctor. Stopping suddenly can worsen your angina.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken to relieve an ongoing angina attack.
Fact: This medicine is for prevention of angina attacks, not for immediate relief. For acute attacks, use a fast-acting nitrate as prescribed. - Myth: Once you feel better, you can stop taking this medicine.
Fact: Stopping suddenly can worsen angina. Always consult your doctor before stopping. - Myth: This medicine is safe to take with erectile dysfunction drugs.
Fact: Combining this medicine with erectile dysfunction drugs can cause a dangerous drop in blood pressure and is contraindicated.
🔄 Alternative Options
Generic Alternatives
- Nicorandil 10 mg tablet
Brand Alternatives
- Nicomend 10 tablet