Nicef Oz Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing.
- Bloody diarrhea or severe abdominal pain.
- Seizures or convulsions.
- Yellowing of skin or eyes, dark urine.
- Unusual bleeding or bruising.
- Severe headache with visual changes.
- Decreased urine output.
If experiencing severe symptoms, call emergency services immediately.
What is nicef oz tablet used for?
This medicine is a combination antibiotic containing cefixime and ornidazole. It is used to treat bacterial and protozoal infections such as typhoid fever, amoebic dysentery, and giardiasis. It works by killing bacteria and protozoa. It should be taken with food and alcohol must be avoided.
- Generic Name: Cefixime (NA) + Ornidazole (NA)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nicef oz tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्सिम और ओर्निडाजोल का संयोजन है, जिसका उपयोग बैक्टीरियल और प्रोटोज़ोअल संक्रमणों के इलाज के लिए किया जाता है। यह टाइफाइड बुखार, अमीबिक पेचिश, गियार्डिया और पेट के मिश्रित संक्रमणों में प्रभावी है। यह दवा कीटाणुओं को मारकर संक्रमण को ठीक करती है। इसे डॉक्टर के निर्देशानुसार ही लें और पूरा कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, रक्त विकार, दौरे और यकृत की समस्या हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन बिल्कुल न करें क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। यदि आपको गुर्दे या यकृत की बीमारी है तो डॉक्टर को बताएं। पूरा कोर्स पूरा करें, बीच में दवा न छोड़ें।
💊 nicef oz tablet Uses & Benefits
[{"condition":"Typhoid fever","description":"Used to treat enteric fever caused by Salmonella typhi, especially when caused by susceptible strains.","evidence":"Well-established"},{"condition":"Amoebic dysentery","description":"Effective against Entamoeba histolytica infections in the intestine and liver.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Treats diarrheal illness caused by Giardia lamblia.","evidence":"Well-established"},{"condition":"Mixed aerobic-anaerobic infections","description":"Used for intra-abdominal infections, pelvic inflammatory disease, and other mixed infections where both cefixime and ornidazole are indicated.","evidence":"Moderate"},{"condition":"Bacterial gastroenteritis","description":"May be used for severe or persistent bacterial diarrhea caused by susceptible organisms.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Dental infections","description":"Sometimes prescribed for dental abscesses or periodontitis when anaerobic coverage is needed.","evidence":"Limited"},{"condition":"Prophylaxis in colorectal surgery","description":"Occasionally used off-label for surgical prophylaxis in combination with other agents.","evidence":"Limited"}]
Primary treatment for: Bacterial and protozoal infections
Also treats: Typhoid fever, Amoebic dysentery, Giardiasis, Intra-abdominal infections, Pelvic inflammatory disease
📋 Drug Information
| Generic Name(s) | Cefixime (NA) + Ornidazole (NA) |
| Brand Name | nicef oz tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specified by the manufacturer. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Cefixime, a third-generation cephalosporin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to weakened cell walls and bacterial lysis. Ornidazole, a nitroimidazole derivative, enters susceptible anaerobic bacteria and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA, causing strand breakage and cell death. Together, they provide broad-spectrum coverage against many gram-negative and gram-positive aerobes as well as anaerobes and protozoa.
Mechanism Steps
💡 How to Take nicef oz tablet
Strength: This medicine is available as an immediate-release tablet for oral administration. The specific strength is not provided in the available information. Commonly available strengths include cefixime 200 mg and ornidazole 500 mg per tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, or as prescribed by your doctor. The exact dose and duration depend on the type and severity of the infection, your age, weight, kidney and liver function, and other medications you are taking. For typhoid fever, a common regimen is one tablet twice daily for 10-14 days. For amoebic dysentery, the duration may be 5-10 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function and are more susceptible to side effects. Dose adjustment may be necessary based on renal function. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, dose adjustment of cefixime is required. For creatinine clearance (CrCl) 20-60 mL/min, a reduced dose or increased dosing interval may be needed. For CrCl <20 mL/min, further reduction is advised. Ornidazole generally does not require dose adjustment in renal impairment, but caution is advised. Consult your doctor for personalized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, ornidazole should be used with caution as it is metabolized in the liver. Dose reduction may be considered in severe hepatic impairment. Cefixime does not require significant dose adjustment in hepatic impairment. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is two tablets (each containing cefixime 200 mg and ornidazole 500 mg) per day, unless otherwise prescribed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nicef oz tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Carbamazepine | Moderate | |
| Phenytoin | Moderate | |
| Lithium | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Anticoagulants (e.g., heparin, clopidogrel)
⚡ Moderate Interactions
- Carbamazepine
- Phenytoin
- Lithium
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Ornidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime, other cephalosporins, or ornidazole","Known allergy to nitroimidazole derivatives (e.g., metronidazole)","Severe renal impairment without dose adjustment","Severe hepatic impairment","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding","Alcohol consumption during treatment and for 48 hours after"]
⚠️ Warnings & Precautions
["Take with food to reduce gastrointestinal upset.","Avoid alcohol completely during treatment and for 48 hours after the last dose.","Do not use this medicine for viral infections like the common cold or flu.","Complete the full course as prescribed, even if symptoms improve.","Inform your doctor if you have kidney or liver disease.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Prolonged use may lead to superinfection with resistant organisms.","Discontinue and seek medical help if signs of allergic reaction occur."]
🤱 Lactation Safety
Both cefixime and ornidazole are excreted in breast milk. Ornidazole may cause adverse effects in the nursing infant. Therefore, this medicine is not recommended during breastfeeding. If treatment is essential, breastfeeding should be discontinued during the course and for at least 48 hours after the last dose. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, diarrhea, and neurological symptoms such as dizziness, headache, and seizures. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis may be considered for cefixime overdose in severe cases, but ornidazole is not effectively removed by dialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you feel better, as this can lead to treatment failure and antibiotic resistance. Take each dose with a full glass of water, preferably with food to reduce stomach upset. Avoid alcohol completely while taking this medicine and for at least 48 hours after the last dose, because ornidazole can cause a disulfiram-like reaction with symptoms like severe nausea, vomiting, flushing, and rapid heartbeat. Inform your doctor if you have kidney or liver problems, as dose adjustments may be needed. Do not share this medicine with others. Keep it out of reach of children. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Store this medicine at room temperature, away from moisture and direct sunlight. If you experience any signs of an allergic reaction, such as rash, itching, or swelling, stop the medicine and seek immediate medical help.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and are more prone to side effects. Dose adjustment may be necessary. Monitor renal function and watch for signs of superinfection.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed. Use effective contraception during treatment.
🏥 Post-Surgery Considerations
This medicine may be used for surgical prophylaxis or to treat postoperative infections. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or fatigue, avoid strenuous exercise until you feel better. Light activity is fine if tolerated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor, even if you feel better. Stopping early can lead to relapse and antibiotic resistance. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rare blood or liver abnormalities. It is generally prescribed for short durations. Prolonged use should be avoided unless specifically directed by a doctor, with regular monitoring of blood counts and liver function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent antibiotic-associated diarrhea.
Evidence: ModerateEssential for managing diarrhea and dehydration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If crossing time zones, adjust dosing times gradually under medical advice. Check customs regulations for carrying prescription medicines. Always carry enough supply for your trip and a few extra doses in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset.
A: Take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol must be strictly avoided during treatment and for 48 hours after the last dose due to the risk of a disulfiram-like reaction.
🤔 Common Patient Concerns
🔄 Substitutes for nicef oz tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine is only effective against specific bacterial and protozoal infections. It is not effective for viral diarrhea or other causes. - Myth: I can stop taking this medicine once I feel better.
Fact: You must complete the full course as prescribed to prevent relapse and antibiotic resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a dangerous reaction with ornidazole. Avoid alcohol completely during treatment and for 48 hours after.
🔄 Alternative Options
Generic Alternatives
- Cefixime + Ornidazole tablets from other manufacturers
Brand Alternatives
- Nicef OZ Tablet