Neoxone 500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or stopped breathing
- Severe chest pain or irregular heartbeat
- Sudden swelling of the face, lips, or throat
- Severe vomiting or diarrhoea with abdominal cramps
- Yellowing of the skin or eyes
- Unusual bruising or bleeding
- Confusion or extreme drowsiness that does not improve
- Seizures or loss of consciousness
If experiencing severe symptoms, call emergency services immediately.
What is neoxone 500mg injection used for?
This medicine is a naltrexone injection used to rapidly reverse opioid overdose and to help prevent relapse in opioid use disorder under medical supervision. It works by blocking opioid receptors in the brain.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 neoxone 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा नाल्ट्रेक्सोन हाइड्रोक्लोराइड का इंजेक्शन है, जिसका उपयोग ओपिओइड की अधिक मात्रा (ओवरडोज़) से होने वाले खतरनाक प्रभावों को तुरंत उलटने के लिए किया जाता है। यह सांस रुकने, नींद आने और बेहोशी जैसी समस्याओं को ठीक करने में मदद करती है। इसके अलावा, यह ओपिओइड की लत के इलाज के कार्यक्रम में भी इस्तेमाल की जाती है ताकि मरीज दोबारा नशे की ओर न लौटे। यह दवा सिर्फ अस्पताल या डॉक्टर की देखरेख में ही दी जाती है, घर पर खुद से नहीं लगाई जाती।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, सिरदर्द, चक्कर आना, नींद आना, थकान और इंजेक्शन लगाने की जगह पर दर्द या लालिमा शामिल हैं। कुछ लोगों को बेचैनी या घबराहट भी हो सकती है। गंभीर दुष्प्रभाव कम होते हैं, लेकिन अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, तेज़ धड़कन, सीने में दर्द या बहुत ज़्यादा उल्टी-दस्त हो तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा सिर्फ डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर को ज़रूर बताएं। अपनी सभी दवाओं की जानकारी डॉक्टर को दें, खासकर दर्द निवारक ओपिओइड दवाएं। इंजेक्शन के बाद तब तक वाहन न चलाएं जब तक आप पूरी तरह सतर्क न हो जाएं। शराब का सेवन न करें। लीवर या किडनी की बीमारी हो तो डॉक्टर को बताएं।
💊 neoxone 500mg injection Uses & Benefits
[{"condition":"Opioid overdose","description":"This medicine is used to rapidly reverse respiratory depression, sedation, and coma caused by opioid overdose.","evidence":"Well-established"},{"condition":"Opioid use disorder (relapse prevention)","description":"In some supervised treatment programmes, this medicine is used to help prevent relapse by blocking the rewarding effects of opioids.","evidence":"Well-established"},{"condition":"Opioid-induced respiratory depression in hospital settings","description":"It may be used in hospitals to reverse breathing problems caused by opioid medicines given for pain relief.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Alcohol use disorder","description":"Naltrexone is sometimes used off-label to reduce alcohol craving and heavy drinking, but this is not the primary approved use of the injectable form.","evidence":"Limited"},{"condition":"Impulse control disorders","description":"There is limited evidence for use in some impulse control disorders, but this is not a standard approved indication.","evidence":"Limited"}]
Primary treatment for: Opioid overdose
Also treats: Opioid use disorder, Opioid-induced respiratory depression
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | neoxone 500mg injection |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 3 generation |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep the container in the outer carton to protect from light. Once dispensed, follow the storage instructions provided by the pharmacy or healthcare provider. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture, but the exact expiry date is printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking opioid receptors in the central nervous system. The active ingredient, naltrexone, is a competitive antagonist at mu, kappa, and delta opioid receptors. When it occupies these receptors, opioid medicines and endogenous opioids cannot bind and produce their effects. This helps to reverse opioid overdose and reduces the rewarding effects of opioids in people with opioid use disorder.
Mechanism Steps
💡 How to Take neoxone 500mg injection
Strength: Injection, 500 mg
Dosage Information
| Adult Dosage | The dose of this medicine is determined by a qualified clinician based on the indication, the patient's age, weight, kidney and liver function, and the severity of the condition. For opioid overdose, a typical initial dose may be given intravenously or intramuscularly, and repeated doses may be needed if symptoms return. For relapse prevention in opioid use disorder, the dose and frequency are individualized and must be supervised by a specialist. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. The dose should be selected with caution, usually starting at the lower end of the range, and kidney and liver function should be checked before use. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose adjustment may be needed based on kidney function. Consult a qualified clinician for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose adjustment may be needed, and liver function should be monitored. Consult a qualified clinician for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the indication and the patient's condition. It must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of neoxone 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Morphine | Major | |
| Fentanyl | Major | |
| Oxycodone | Major | |
| Buprenorphine | Major | |
| Methadone | Major | |
| Thioridazine | Moderate | |
| Carbamazepine | Moderate | |
| Rifampicin | Moderate | |
| Loperamide | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Opioid analgesics (e.g., morphine, fentanyl, oxycodone)
- Buprenorphine
- Methadone
⚡ Moderate Interactions
- Thioridazine
- Liver enzyme inducers (e.g., carbamazepine, rifampicin)
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol can increase the risk of drowsiness, dizziness, and liver problems. It may also worsen the underlying condition being treated.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to naltrexone or any ingredient in the injection","Current opioid dependence without medical supervision","Acute opioid withdrawal","Severe liver disease","Pregnancy (unless clearly needed and advised by a specialist)","Breastfeeding (unless advised by a doctor)"]
⚠️ Warnings & Precautions
["This medicine must only be given by a healthcare professional in a setting with emergency facilities.","It can precipitate severe withdrawal in opioid-dependent patients; ensure the patient is opioid-free before administration.","Use with caution in patients with liver disease; monitor liver function.","Use with caution in patients with kidney disease; dose adjustment may be needed.","Avoid alcohol while receiving this medicine.","Do not drive or operate machinery until fully alert.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Tell your doctor about all other medicines you are taking, especially opioids."]
🤱 Lactation Safety
Naltrexone is present in breast milk. Breastfeeding is not recommended while receiving this medicine unless advised by a doctor after weighing the benefits and risks.
💊 Overdose Management
Overdose with this medicine is unlikely in a clinical setting because it is given by healthcare professionals. If an excessive dose is given, the patient should be monitored closely for signs of opioid withdrawal, liver injury, and cardiac effects. Treatment is supportive and symptomatic. There is no specific antidote for naltrexone overdose. In case of accidental overdose, seek immediate medical attention.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are managed by the clinical team. If you miss an appointment for your injection, contact your clinic as soon as possible to reschedule. Do not attempt to self-administer this medicine.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a setting where emergency equipment and medicines are available. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, because the decision to use this medicine will depend on your individual situation. Inform your medical team about all other medicines you take, especially opioid painkillers, because this medicine can block their effects and may cause withdrawal. Do not drive or operate heavy machinery until you are fully alert and your doctor says it is safe. Avoid alcohol while receiving this medicine, as it can increase drowsiness and dizziness. If you have liver or kidney problems, your doctor may need to adjust your care or monitor you more closely. Keep all follow-up appointments so your doctor can check how you are responding and whether any dose changes are needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Kidney and liver function should be checked before use, and the dose should be selected with caution. Monitoring for side effects is important.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss this with your doctor before receiving this medicine. The safety of this medicine in pregnancy is not fully established, and the decision to use it should be based on a careful assessment of benefits and risks.
🏥 Post-Surgery Considerations
If you have recently had surgery and are receiving opioid pain relief, this medicine may block the effects of those opioids and cause withdrawal. Inform your surgical team if you are receiving this medicine.
🦷 Dental Procedures
If you are scheduled for a dental procedure and may need opioid pain relief, inform your dentist that you are receiving this medicine. It may block the effects of opioid painkillers, and alternative pain management may be needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after receiving this medicine, as you may feel dizzy or drowsy. Wait until you are fully alert and your doctor says it is safe to resume normal activities.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting, so it may require time off work for the appointment and monitoring. After the injection, you may feel drowsy or dizzy, so you should not drive or operate machinery until you are fully alert. Discuss your work schedule with your doctor and plan your return to work accordingly.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The decision to stop should be based on your clinical progress and the advice of your healthcare team. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with liver injury, especially at higher doses. Regular monitoring of liver function is recommended. Some patients may experience ongoing nausea, headache, or sleep problems. Long-term use should be reviewed regularly by a specialist to ensure the benefits continue to outweigh the risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for opioid use disorder.
Evidence: Well-establishedPeer support can help maintain recovery.
Evidence: Well-establishedAn alternative form of naltrexone for relapse prevention.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in the original carton to protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
This medicine is given by a healthcare professional, so travel advice mainly applies to patients who are receiving it as part of a treatment programme. If you need to travel, carry a copy of your prescription and a letter from your doctor explaining the treatment. Keep the medicine in its original packaging and store it as advised, usually in a refrigerator. Check the customs regulations of your destination country for injectable medicines. Plan your travel around your injection schedule and inform your clinic in advance.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: When given intravenously, this medicine starts to work within 1 to 2 minutes. When given intramuscularly, it usually starts to work within 5 to 10 minutes.
A: The effects can last for 24 to 72 hours, depending on the dose and route of administration.
A: No, this medicine must only be given by a healthcare professional in a monitored setting.
A: The safety of this medicine in pregnancy is not fully established. It should only be used if clearly needed and advised by a specialist.
A: Contact your clinic as soon as possible to reschedule. Do not attempt to self-administer this medicine.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Naltrexone injection can be used to treat any type of pain.
Fact: This medicine is not a painkiller. It blocks opioid painkillers and is used for opioid overdose and opioid use disorder. - Myth: Naltrexone injection is safe to use without medical supervision.
Fact: This medicine must only be given by a healthcare professional in a monitored setting because it can cause serious withdrawal and other complications. - Myth: Naltrexone injection can be taken with opioid painkillers for better pain relief.
Fact: This medicine blocks the effects of opioid painkillers and can cause withdrawal. They should not be used together unless under specialist supervision.
🔄 Alternative Options
Generic Alternatives
- Naltrexone hydrochloride injection
Brand Alternatives
- neoxone 500mg injection