Neft 100mg Tablet: Comprehensive Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe or persistent diarrhoea
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- Sudden swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is neft 100mg tablet used for?
This medicine is a 100 mg immediate-release tablet of nintedanib, used to treat idiopathic pulmonary fibrosis and other progressive fibrosing interstitial lung diseases. It works by inhibiting multiple tyrosine kinases to slow lung fibrosis. It is taken twice daily with food.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 neft 100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निन्टेडैनिब का 100 मिलीग्राम टैबलेट है, जिसका उपयोग इडियोपैथिक पल्मोनरी फाइब्रोसिस (आईपीएफ) और अन्य फेफड़ों के फाइब्रोसिस वाले रोगों के इलाज के लिए किया जाता है। यह फेफड़ों में फाइब्रोसिस की प्रगति को धीमा करती है। इसे भोजन के साथ दिन में दो बार लिया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, मतली, उल्टी, पेट दर्द, भूख में कमी और वजन कम होना शामिल हैं। दस्त सबसे आम है। गंभीर दुष्प्रभावों में आंतों में छेद, रक्तस्राव, दिल का दौरा और लीवर की क्षति शामिल हो सकते हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार भोजन के साथ दिन में दो बार लें। टैबलेट को चबाएं या तोड़ें नहीं। ग्रेपफ्रूट और उसके जूस से बचें। लीवर की जांच नियमित रूप से कराते रहें। गर्भवती महिलाएं इस दवा का सेवन न करें। दवा शुरू करने या बंद करने से पहले डॉक्टर से सलाह लें।
💊 neft 100mg tablet Uses & Benefits
[{"condition":"Idiopathic pulmonary fibrosis (IPF)","description":"This medicine slows the decline in lung function in adults with IPF by reducing fibrosis progression.","evidence":"Well-established"},{"condition":"Systemic sclerosis-associated interstitial lung disease (SSc-ILD)","description":"It reduces the rate of decline in forced vital capacity in patients with SSc-ILD.","evidence":"Well-established"},{"condition":"Progressive fibrosing interstitial lung diseases (PF-ILD)","description":"This medicine is used to slow disease progression in patients with PF-ILD other than IPF.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Other fibrotic disorders (e.g., liver fibrosis, kidney fibrosis)","description":"Some studies have explored the use of this medicine in other fibrotic conditions, but evidence is limited and it is not approved for these uses.","evidence":"Limited"}]
Primary treatment for: Idiopathic pulmonary fibrosis
Also treats: Systemic sclerosis-associated interstitial lung disease, Progressive fibrosing interstitial lung diseases
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | neft 100mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | Urinary Antiseptic-Nitrofurantoin |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container to protect from moisture and light. Do not refrigerate or freeze. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the package before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a small-molecule tyrosine kinase inhibitor that targets multiple receptor kinases involved in the pathogenesis of pulmonary fibrosis. It competitively binds to the ATP-binding site of platelet-derived growth factor receptors (PDGFR) alpha and beta, fibroblast growth factor receptors (FGFR) 1-3, and vascular endothelial growth factor receptors (VEGFR) 1-3, as well as Src family kinases and colony-stimulating factor 1 receptor (CSF1R). By inhibiting these kinases, it blocks signalling pathways that drive fibroblast proliferation, migration, and transformation into myofibroblasts, and reduces the secretion of extracellular matrix proteins. This results in slowed progression of fibrosis in the lungs.
Mechanism Steps
💡 How to Take neft 100mg tablet
Strength: 100 mg immediate-release tablet
Dosage Information
| Adult Dosage | The recommended dose of this medicine is 150 mg twice daily for idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial lung disease. For progressive fibrosing interstitial lung diseases, the dose is also 150 mg twice daily. However, the dose may be reduced to 100 mg twice daily if adverse effects occur. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and tolerability. This medicine should be taken with food to improve absorption and reduce gastrointestinal side effects. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more susceptible to adverse effects such as diarrhoea and liver enzyme elevations. Monitor closely and adjust dose as needed. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. This medicine has not been studied in patients with severe renal impairment (creatinine clearance <30 mL/min), and its use is not recommended in this population. |
| Hepatic Impairment | No dose adjustment is required for patients with mild hepatic impairment (Child-Pugh A). This medicine is contraindicated in patients with moderate or severe hepatic impairment (Child-Pugh B or C). |
| Maximum Daily Dose | The maximum recommended daily dose is 300 mg (150 mg twice daily). In case of adverse effects, the dose may be reduced to 200 mg daily (100 mg twice daily). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of neft 100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Major | |
| Clopidogrel | Major | |
| Verapamil | Moderate | |
| St. John's wort | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- Anticoagulants (e.g., warfarin, heparin)
- Antiplatelet agents (e.g., clopidogrel, aspirin)
⚡ Moderate Interactions
- P-glycoprotein inhibitors (e.g., verapamil, quinidine)
- P-glycoprotein inducers (e.g., St. John's wort)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and gastrointestinal side effects. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","Moderate or severe hepatic impairment (Child-Pugh B or C)","Known hypersensitivity to nintedanib or any component of the formulation","Concomitant use with strong CYP3A4 inducers"]
⚠️ Warnings & Precautions
["Diarrhoea: May be severe; monitor and treat promptly. Dose reduction or interruption may be needed.","Liver enzymes: Elevations can occur; monitor regularly. Discontinue if severe.","Bleeding: Increased risk; monitor for signs of bleeding.","Gastrointestinal perforation: Rare but serious; seek immediate care for severe abdominal pain.","Arterial thromboembolic events: Increased risk; monitor cardiovascular symptoms.","Pregnancy: Contraindicated; use effective contraception.","Lactation: Discontinue breastfeeding during treatment.","Renal impairment: Use with caution in severe renal impairment."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, breastfeeding should be discontinued during treatment and for at least 3 months after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, treatment should be symptomatic and supportive. Monitor vital signs and liver function. Contact a poison control centre or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if there is more than 6 hours until your next scheduled dose. If it is less than 6 hours until your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually twice daily with food to reduce stomach upset. Do not crush, chew, or split the tablet; swallow it whole with water. Avoid grapefruit and grapefruit juice during treatment as it may increase the levels of this medicine in your body. Inform your doctor if you have a history of liver problems, bleeding disorders, or recent surgery. Do not start any new medicine, including over-the-counter products and herbal supplements, without consulting your doctor. Use effective contraception during treatment and for at least three months after the last dose if you are a woman of childbearing potential. Men should also use contraception during treatment and for three months after stopping. Regular blood tests to check liver function are necessary. If you experience severe diarrhoea, nausea, or vomiting, contact your doctor; you may need to pause treatment or adjust the dose. Do not stop taking this medicine without medical advice.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more prone to side effects such as diarrhoea and liver enzyme elevations. Close monitoring is recommended. No dose adjustment is required based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy. Women of childbearing potential should use effective contraception during treatment and for at least 3 months after the last dose. If you are planning pregnancy, consult your doctor to discuss alternative treatments.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and impaired wound healing. Inform your surgeon that you are taking this medicine. It may need to be temporarily stopped before surgery. Consult your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine as it may increase bleeding risk. Your dentist may recommend precautions. Do not stop the medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities if you experience breathlessness or fatigue. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, diarrhoea, or nausea, which can affect your ability to work or drive. Avoid driving or operating machinery if you feel unwell. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, your doctor may adjust the dose or discontinue treatment. Stopping abruptly may lead to worsening of your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with persistent gastrointestinal side effects, liver enzyme elevations, and increased risk of bleeding. Regular monitoring of liver function and clinical status is required. The benefits of slowing lung function decline generally outweigh the risks in appropriately selected patients.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antifibrotic medication approved for IPF.
Evidence: Well-establishedFor eligible patients with advanced disease.
Evidence: Well-establishedExercise and education program to improve quality of life.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Ensure you are up to date with influenza and pneumococcal vaccinations as respiratory infections can worsen lung disease. Live vaccines should be avoided if you are on immunosuppressive therapy, but this medicine is not typically immunosuppressive. Consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture and light. If crossing time zones, adjust dosing times gradually, but maintain approximately 12-hour intervals. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working gradually. Clinical trials have shown benefits over 52 weeks, but you may not notice immediate effects. It slows the decline in lung function over time.
A: Some medicines can interact with this medicine. Always inform your doctor about all prescription, over-the-counter, and herbal products you are taking.
A: Mild diarrhoea is common. Stay hydrated and take the medicine with food. If diarrhoea is severe or persistent, contact your doctor; dose reduction may be needed.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure pulmonary fibrosis.
Fact: This medicine slows the progression of fibrosis but does not cure the disease. - Myth: This medicine can be taken without food.
Fact: This medicine should be taken with food to improve absorption and reduce stomach upset. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is contraindicated in pregnancy as it may harm the fetus.
🔄 Alternative Options
Brand Alternatives
- Nintedanib 100 mg tablet
- Nintedanib 150 mg tablet