nefropres c 150mcg tablet - Clonidine (150mcg) medicine

Nefropres C 150mcg Tablet: Complete Medicine Guide

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Clonidine (150mcg)
🏭 Renauxe Pharma India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 31, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for hypertension; moderate for menopausal hot flashes; limited for off-label uses.
Reviewed by
SaathiMed Expert Panel | Oct 31, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Severe dizziness or fainting
  • Very slow heartbeat (less than 50 beats per minute)
  • Chest pain or difficulty breathing
  • Sudden severe headache or blurred vision
  • Swelling of the face, lips, or throat
  • Unusual bruising or bleeding
  • Confusion or hallucinations

If experiencing severe symptoms, call emergency services immediately.

What is nefropres c 150mcg tablet used for?

This medicine contains clonidine 150 micrograms, an alpha-2 adrenergic agonist used to treat high blood pressure. It works by reducing sympathetic nervous system activity, which lowers heart rate and relaxes blood vessels. It is taken orally, usually twice daily, and should not be stopped suddenly.

  • Generic Name: Clonidine (150mcg)
  • Manufacturer: Renauxe Pharma India Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nefropres c 150mcg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा क्लोनिडीन 150 माइक्रोग्राम युक्त एक प्रिस्क्रिप्शन टैबलेट है, जिसका उपयोग मुख्य रूप से उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए किया जाता है। यह मस्तिष्क में अल्फा-2 रिसेप्टर्स को उत्तेजित करके सहानुभूति तंत्रिका तंत्र की गतिविधि को कम करती है, जिससे हृदय गति धीमी होती है और रक्त वाहिकाएं फैलती हैं, जिससे रक्तचाप कम होता है। यह दवा मेनोपॉज़ के दौरान होने वाली गर्म लहरों, ध्यान आभाव विकार (ADHD), और कुछ दर्द सिंड्रोम में भी प्रभावी हो सकती है, लेकिन इनका उपयोग डॉक्टर की सलाह से ही करें। इस दवा को अचानक बंद न करें, क्योंकि इससे रक्तचाप खतरनाक रूप से बढ़ सकता है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, कब्ज, और थकान शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ हफ्तों में सुधर जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें गंभीर निम्न रक्तचाप, धीमी हृदय गति, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको सीने में दर्द, सांस लेने में कठिनाई, या बहुत धीमी धड़कन महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे रक्तचाप खतरनाक रूप से बढ़ सकता है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें। बैठने या लेटने से उठते समय धीरे-धीरे उठें। इस दवा के साथ शराब न लें। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं। नियमित रूप से रक्तचाप की जांच कराएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 nefropres c 150mcg tablet Uses & Benefits

[{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure by reducing sympathetic outflow from the brain, leading to decreased heart rate and vasodilation.","evidence":"Well-established"},{"condition":"Hypertensive urgency","description":"In some settings, this medicine may be used orally for rapid blood pressure reduction in hypertensive urgency, but this is typically done under close medical supervision.","evidence":"Moderate"},{"condition":"Menopausal hot flashes","description":"This medicine can reduce the frequency and severity of hot flashes in some women, though it is not a first-line treatment.","evidence":"Moderate"},{"condition":"Attention deficit hyperactivity disorder (ADHD)","description":"Sometimes prescribed as an adjunct for ADHD, particularly when stimulants are ineffective or not tolerated, but this is an off-label use.","evidence":"Limited"}]

Off-label uses: [{"condition":"Tourette syndrome","description":"May help reduce tics in some patients, but evidence is limited and it is not a standard treatment.","evidence":"Limited"},{"condition":"Opioid withdrawal","description":"Sometimes used to manage autonomic symptoms during opioid withdrawal, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Neuropathic pain","description":"Occasionally used for certain types of neuropathic pain, but evidence is not robust.","evidence":"Limited"}]

Primary treatment for: Hypertension

Also treats: Menopausal hot flashes, ADHD (off-label), Tourette syndrome (off-label)

📋 Drug Information

Generic Name(s)Clonidine (150mcg)
Brand Namenefropres c 150mcg tablet
ManufacturerRenauxe Pharma India Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassAlpha 2-adrenoceptors agonist (Central sympatholytics)
Route of AdministrationOral
StorageStore this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep out of reach of children.
Shelf LifeThe shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always taper the dose gradually when discontinuing this medicine to prevent rebound hypertension.
2
Monitor blood pressure and heart rate regularly, especially after dose adjustments.
3
Advise patients to avoid alcohol and other CNS depressants while taking this medicine.
4
Use caution in elderly patients and those with renal or hepatic impairment; start with a low dose.
5
Instruct patients to rise slowly from sitting or lying positions to minimize dizziness.
6
Consider alternative antihypertensives in patients with severe bradycardia or heart block.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
High blood pressure
This medicine is commonly prescribed for this.
Likely Use
✅
Hot flashes
This medicine may be prescribed off-label for menopausal hot flashes.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Cough
This medicine is not used for cough.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is well absorbed after oral administration, with peak plasma concentrations typically reached within 1 to 3 hours. The bioavailability is approximately 70-80% due to some first-pass metabolism.
DistributionThis medicine is highly lipophilic and distributes widely into body tissues, including the brain. It crosses the blood-brain barrier and the placenta, and it is excreted in breast milk.
Protein BindingApproximately 20-40% bound to plasma proteins.
MetabolismThis medicine is metabolized in the liver, primarily by cytochrome P450 enzymes, to inactive metabolites. About 50% of the dose is metabolized, and the rest is excreted unchanged by the kidneys.
Half-LifeThe elimination half-life of this medicine is approximately 6 to 24 hours, with an average of about 12 hours. It may be prolonged in patients with renal impairment.
ExcretionThis medicine and its metabolites are primarily excreted in the urine (about 40-60% as unchanged drug) and to a lesser extent in feces.
BioavailabilityThe oral bioavailability of this medicine is approximately 70-80%.
Onset of ActionThe blood pressure lowering effect of this medicine begins within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations are reached within 1 to 3 hours after oral administration.
Duration of ActionThe antihypertensive effect of this medicine lasts approximately 6 to 12 hours after a single oral dose, but with regular dosing, the effect is sustained.

How It Works

This medicine works by stimulating alpha-2 adrenergic receptors in the brainstem, particularly in the nucleus tractus solitarii. This stimulation reduces sympathetic nervous system outflow from the central nervous system to the periphery. As a result, heart rate decreases, blood vessels relax, and blood pressure falls. It also reduces the release of norepinephrine from sympathetic nerve endings. The overall effect is a reduction in both systolic and diastolic blood pressure, with a slowing of the heart rate.

Mechanism Steps

1
Central alpha-2 receptor stimulation: This medicine crosses the blood-brain barrier and binds to alpha-2 adrenergic receptors in the brainstem.
2
Reduced sympathetic outflow: Activation of these receptors decreases the release of norepinephrine and reduces sympathetic nerve signals to the heart and blood vessels.
3
Decreased heart rate and vasodilation: The reduced sympathetic activity leads to a slower heart rate and relaxation of blood vessels, which lowers blood pressure.
4
Lowered blood pressure: The combined effects on the heart and blood vessels result in a sustained reduction in both systolic and diastolic blood pressure.

💡 How to Take nefropres c 150mcg tablet

Strength: This medicine is available as an immediate-release oral tablet containing 150 micrograms of clonidine.

1Take this medicine orally with a glass of water.
2Take it at the same times each day to maintain consistent blood levels.
3You may take it with or without food, but taking it with food may reduce stomach upset.
4Do not crush, chew, or break the tablet unless your doctor advises otherwise.
5If you miss a dose, follow the missed dose instructions.
6Do not stop taking this medicine suddenly without consulting your doctor.

Dosage Information

Adult DosageThe usual starting dose of this medicine for hypertension is 100 to 300 micrograms taken orally twice daily. The dose may be increased gradually based on blood pressure response, usually by 100 to 200 micrograms per day, up to a maximum of 2.4 mg per day. For other indications, the dose may vary. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not adjust the dose without consulting your doctor.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially drowsiness, dizziness, and hypotension. Start with a low dose and titrate slowly. Monitor blood pressure and heart rate closely.
Renal ImpairmentIn patients with renal impairment, the elimination half-life of this medicine is prolonged. Dose reduction may be necessary. Start with a low dose and titrate based on response. Monitor renal function regularly.
Hepatic ImpairmentIn patients with hepatic impairment, this medicine should be used with caution. Dose reduction may be necessary. Monitor liver function tests periodically.
Maximum Daily DoseThe maximum recommended daily dose of this medicine for hypertension is 2.4 mg per day, but doses above 1.2 mg per day are rarely used. The dose should be individualized by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
May reduce stomach upset and improve tolerability.
Grapefruit juice
Avoid
May increase drug levels and side effects.
High-fat meals
Take with caution
May increase absorption and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up. If you miss multiple doses, contact your doctor.

⚠️ Side Effects of nefropres c 150mcg tablet

✅ Common Side Effects

Dry mouth (Very common (>10%))
Sip water frequently, chew sugar-free gum, or use saliva substitutes. Consult your doctor if it becomes bothersome.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you. Usually improves with continued use.
Dizziness (Common (5-10%))
Stand up slowly from sitting or lying positions. If dizziness persists, contact your doctor.
Constipation (Common (5-10%))
Increase dietary fiber and fluid intake. Consult your doctor if constipation persists.
Fatigue (Common (5-10%))
Ensure adequate rest. If fatigue interferes with daily activities, consult your doctor.

🚨 Serious Side Effects

Severe hypotension (Rare (<0.1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or blurred vision.
Symptomatic bradycardia (Rare (<0.1%))
Contact your doctor if you have a very slow heartbeat, weakness, or confusion.
Rebound hypertension (Uncommon (0.1-1%))
Do not stop this medicine abruptly. If you experience a sudden increase in blood pressure after missing doses, seek medical help immediately.
Allergic reactions (Rare (<0.1%))
Seek emergency care if you develop rash, itching, swelling of the face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Hallucinations
Contact your doctor immediately if you experience hallucinations or confusion.
Thrombocytopenia
Report any unusual bruising or bleeding to your doctor.
Gynecomastia
Consult your doctor if you notice breast enlargement or tenderness.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Beta-blockers Major
Tricyclic antidepressants Major
MAOIs Major
Sedatives Moderate
Alcohol Moderate
NSAIDs Moderate
Antacids Minor
Digoxin Minor

🚨 Major Interactions

  • Beta-blockers
  • Tricyclic antidepressants
  • Monoamine oxidase inhibitors (MAOIs)

⚡ Moderate Interactions

  • Sedatives and hypnotics
  • Alcohol
  • NSAIDs

🍷 Alcohol Interaction

Alcohol can increase the sedative and blood pressure-lowering effects of this medicine. It is advisable to avoid alcohol while taking this medicine to prevent excessive drowsiness, dizziness, and low blood pressure.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to clonidine or any component of the formulation","Severe bradycardia","Second- or third-degree heart block","Severe hypotension","Cardiogenic shock"]

⚠️ Warnings & Precautions

["Do not discontinue this medicine abruptly, as it can cause rebound hypertension. Taper the dose gradually under medical supervision.","Use with caution in patients with severe coronary insufficiency, recent myocardial infarction, or cerebrovascular disease.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how this medicine affects you.","Use with caution in patients with renal impairment; dose adjustment may be required.","Use with caution in patients with hepatic impairment; dose adjustment may be required.","May cause dry mouth; good oral hygiene and hydration can help.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]

🤱 Lactation Safety

This medicine is excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.

💊 Overdose Management

Overdose of this medicine can cause severe hypotension, bradycardia, respiratory depression, and coma. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids, vasopressors, and atropine for bradycardia. Gastric lavage may be considered if ingestion occurred recently. Naloxone may be used to reverse respiratory depression, but it is not a specific antidote for clonidine.

⏰ Missed Dose

If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your doctor before restarting, as abrupt discontinuation can cause rebound hypertension.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not stop taking this medicine suddenly without medical advice, as this can cause a dangerous increase in blood pressure. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness or dizziness. Stand up slowly from a sitting or lying position to prevent dizziness. Avoid alcohol while taking this medicine because it can increase drowsiness and low blood pressure. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep all follow-up appointments and monitor your blood pressure regularly. Store this medicine at room temperature away from moisture and heat. Do not share this medicine with others, even if they have similar symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the sedative and blood pressure-lowering effects of this medicine. Start with a low dose and titrate slowly. Monitor for dizziness, falls, and cognitive changes.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It may not be the preferred antihypertensive during pregnancy. Your doctor may switch you to a safer alternative.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rate during surgery. Do not stop the medicine without medical advice.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It can cause dry mouth, which may increase the risk of dental problems. Maintain good oral hygiene and stay hydrated.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight through balanced diet and regular exercise.
🥗
Reduce salt intake to help control blood pressure.
😴
Limit alcohol and avoid smoking.
💧
Practice stress-reducing techniques such as yoga or meditation.
🧘
Monitor your blood pressure at home regularly.
🌞
Get adequate sleep and stay hydrated.

🏋️ Exercise Considerations

This medicine can cause dizziness and low blood pressure, especially when standing up quickly. Avoid strenuous exercise or sudden changes in posture until you know how the medicine affects you. Stay hydrated during exercise.

🥗 Diet Recommendations

Follow a low-sodium diet.
Include potassium-rich foods like bananas, oranges, and spinach.
Reduce intake of processed and high-fat foods.
Stay well hydrated.
Limit caffeine and alcohol.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, dizziness, and dry mouth, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause fatigue, so plan your work schedule accordingly.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your blood pressure is well-controlled, your doctor may gradually reduce the dose. Abrupt discontinuation can cause rebound hypertension.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to tolerance, requiring dose adjustments. It can cause dry mouth, constipation, and sexual dysfunction. Regular monitoring of blood pressure, heart rate, and renal function is recommended. Do not stop the medicine abruptly. Periodic evaluation by your doctor is necessary to assess the continued benefit and adjust the dose.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress reduction can help lower blood pressure and may reduce the need for medication.

Evidence: Well-established
Other antihypertensive classes

ACE inhibitors, ARBs, calcium channel blockers, and diuretics are alternative options for hypertension.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, inform your healthcare provider about all medicines you are taking before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the dosing schedule. Store at room temperature and protect from moisture. Check customs regulations for carrying prescription medicines to your destination.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with resistant hypertension
He was prescribed this medicine as an add-on to his existing blood pressure medications. After starting treatment, his blood pressure gradually came under control. He experienced dry mouth initially, which improved after a few weeks. He was advised not to stop the medicine suddenly and to monitor his blood pressure at home.
💡 Lesson: This medicine can be effective for resistant hypertension, but adherence and regular monitoring are key. Dry mouth is a common side effect that often improves with time.
👤 A 52-year-old woman with menopausal hot flashes
She was prescribed this medicine off-label for severe hot flashes that interfered with her sleep. She noticed a significant reduction in the frequency and intensity of hot flashes within two weeks. She was cautioned about drowsiness and advised to take the dose at bedtime.
💡 Lesson: This medicine can be helpful for menopausal hot flashes, but it is not a first-line treatment. Taking it at bedtime can minimize daytime drowsiness.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts lowering blood pressure within 30 to 60 minutes after a dose, but it may take several days to weeks to achieve full effect. Your doctor will adjust the dose based on your response.

Q: Can I stop taking this medicine if my blood pressure is normal?

A: No, do not stop this medicine without consulting your doctor. Stopping suddenly can cause a dangerous rise in blood pressure. Your doctor will guide you on how to taper the dose safely.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe during pregnancy?

A: This medicine crosses the placenta and should be used during pregnancy only if the potential benefit justifies the potential risk. Consult your doctor if you are pregnant or planning to become pregnant.

Q: Can I drink alcohol while taking this medicine?

A: It is best to avoid alcohol while taking this medicine, as it can increase drowsiness, dizziness, and low blood pressure.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • How do I stop this medicine safely?

🔄 Substitutes for nefropres c 150mcg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be stopped once blood pressure is normal.
    Fact: This medicine controls blood pressure but does not cure hypertension. Stopping it suddenly can cause a dangerous rise in blood pressure. Always consult your doctor before stopping.
  • Myth: This medicine is safe to take during pregnancy without any risk.
    Fact: This medicine crosses the placenta and should be used during pregnancy only if the potential benefit justifies the potential risk. Consult your doctor.
  • Myth: This medicine can be taken with alcohol without any problems.
    Fact: Alcohol can increase the sedative and blood pressure-lowering effects of this medicine. It is best to avoid alcohol.

🔄 Alternative Options

Generic Alternatives

  • Clonidine 150 mcg tablet

Brand Alternatives

  • Nefropres C 150mcg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Clonidine","class":"Alpha-2 agonist","primary_use":"Hypertension","common_side_effects":"Dry mouth, drowsiness, dizziness"},{"medicine":"Methyldopa","class":"Alpha-2 agonist","primary_use":"Hypertension in pregnancy","common_side_effects":"Sedation, dry mouth, orthostatic hypotension"},{"medicine":"Guanfacine","class":"Alpha-2A agonist","primary_use":"Hypertension, ADHD","common_side_effects":"Dry mouth, somnolence, fatigue"}]

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