Nefistar 10mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Seizures or convulsions
- Severe dizziness or fainting
- Rapid or irregular heartbeat
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe abdominal pain or vomiting blood
- Blood in stool or black, tarry stools
- Yellowing of the skin or eyes
- Decreased urine output or inability to urinate
- Confusion, hallucinations, or unusual behavior
If experiencing severe symptoms, call emergency services immediately.
What is nefistar 10mg tablet used for?
This medicine is a centrally acting analgesic used for short-term relief of moderate to severe acute pain. It works by inhibiting the reuptake of serotonin, norepinephrine, and dopamine in the brain and spinal cord. It is available as a 10 mg oral tablet and is typically taken every 4 to 6 hours as needed, with a maximum daily dose of 120 mg. It is not recommended for children under 12 years and should be used with caution in the elderly and those with liver or kidney disease.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nefistar 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मध्यम से गंभीर तीव्र दर्द के अल्पकालिक उपचार के लिए उपयोग की जाती है। यह मुख्य रूप से सर्जरी के बाद के दर्द, दांतों के दर्द, चोट के दर्द और मांसपेशियों के दर्द में राहत देती है। यह मस्तिष्क और रीढ़ की हड्डी में सेरोटोनिन, नॉरएपिनेफ्रिन और डोपामाइन के पुनः अवशोषण को रोककर काम करती है, जिससे दर्द का अनुभव कम होता है। यह दवा 10 मिलीग्राम की गोली के रूप में उपलब्ध है और आमतौर पर हर 4 से 6 घंटे में आवश्यकतानुसार ली जाती है। यह 12 वर्ष से कम उम्र के बच्चों के लिए नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, बेचैनी, चक्कर आना, नींद आना, मुंह सूखना और पसीना आना शामिल हैं। ये आमतौर पर हल्के होते हैं और दवा जारी रखने पर कम हो जाते हैं। गंभीर दुष्प्रभावों में दौरे, मतिभ्रम, भ्रम, धड़कन तेज होना, पेशाब रुकना और गंभीर एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। खुराक बढ़ाएं नहीं और न ही निर्धारित समय से अधिक बार लें। इस दवा के साथ शराब न लें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं या मशीनरी न चलाएं। यदि आपको दौरे, जिगर या गुर्दे की समस्या, हृदय रोग, ग्लूकोमा या पेशाब में कठिनाई है तो अपने डॉक्टर को बताएं। लंबे समय तक उपयोग के बाद अचानक दवा बंद न करें।
💊 nefistar 10mg tablet Uses & Benefits
[{"condition":"Acute postoperative pain","description":"This medicine is used to relieve moderate to severe pain following surgical procedures, often as part of a multimodal analgesia approach.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"It helps reduce pain associated with muscle strains, sprains, and other soft tissue injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"This medicine can be prescribed for short-term relief of pain after dental extractions or other oral procedures.","evidence":"Well-established"},{"condition":"Trauma-related pain","description":"It is used for pain management in patients with fractures, contusions, or other traumatic injuries.","evidence":"Well-established"},{"condition":"Cancer pain","description":"In some settings, this medicine is used as an adjunct for cancer-related pain, though it is not a first-line opioid alternative.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, but evidence is limited and it is not a standard treatment.","evidence":"Limited"},{"condition":"Neuropathic pain","description":"Occasionally used for neuropathic pain conditions, but robust clinical trials are lacking.","evidence":"Limited"}]
Primary treatment for: Acute pain
Also treats: Postoperative pain, Musculoskeletal pain, Dental pain, Trauma-related pain
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nefistar 10mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Calcium channel blockers- Dihydropyridines (DHP) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | Typically 2 to 3 years from the date of manufacture, but refer to the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a centrally acting analgesic that is chemically distinct from opioids and nonsteroidal anti-inflammatory drugs. Its exact mechanism is not fully understood, but it is believed to inhibit the reuptake of serotonin, norepinephrine, and dopamine in the central nervous system, thereby enhancing descending pain-inhibitory pathways. It also has anticholinergic and sympathomimetic effects that may contribute to its analgesic properties.
Mechanism Steps
💡 How to Take nefistar 10mg tablet
Strength: This medicine is available as an immediate-release oral tablet containing 10 mg of nefopam hydrochloride.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mg to 20 mg taken orally every 4 to 6 hours as needed for pain. The maximum recommended daily dose is 120 mg. However, the dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the prescribed dose. This medicine is intended for short-term use only. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially anticholinergic effects, drowsiness, and dizziness. Start with a lower dose and titrate slowly. The dose must be individualized by a qualified clinician based on renal and hepatic function and overall health status. |
| Renal Impairment | This medicine should be used with caution in patients with renal impairment. Dose adjustment may be necessary. The exact dosing recommendations are not established from the available information. Consult a qualified clinician. |
| Hepatic Impairment | This medicine is extensively metabolized in the liver. It should be used with caution in patients with hepatic impairment. Dose adjustment may be necessary. The exact dosing recommendations are not established from the available information. Consult a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 120 mg, but this may vary based on individual patient factors. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nefistar 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Tramadol | Major | |
| SSRIs | Major | |
| Anticholinergics | Major | |
| CNS depressants | Moderate | |
| Sympathomimetics | Moderate | |
| Antihypertensives | Moderate | |
| Warfarin | Minor | |
| Diuretics | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Tramadol
- Selective serotonin reuptake inhibitors (SSRIs)
- Anticholinergic drugs
⚡ Moderate Interactions
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Sympathomimetics (e.g., pseudoephedrine)
- Antihypertensives
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol can increase the sedative and central nervous system depressant effects of this medicine, leading to excessive drowsiness, dizziness, and impaired coordination. It may also increase the risk of respiratory depression and other serious side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nefopam or any component of the formulation","Children under 12 years of age","Patients with a history of convulsions or epilepsy","Patients taking monoamine oxidase inhibitors (MAOIs)","Patients with severe hepatic impairment","Patients with severe renal impairment","Patients with glaucoma (due to anticholinergic effects)","Patients with urinary retention or prostatic hyperplasia"]
⚠️ Warnings & Precautions
["This medicine can cause seizures, especially in patients with a history of epilepsy or those taking other drugs that lower the seizure threshold.","It can cause dependence and withdrawal symptoms with prolonged use. Use for the shortest duration possible.","Avoid abrupt discontinuation after prolonged use to prevent withdrawal symptoms.","This medicine can cause drowsiness and dizziness. Do not drive or operate machinery until you know how it affects you.","Avoid alcohol and other CNS depressants while taking this medicine.","Use with caution in elderly patients due to increased risk of anticholinergic effects and falls.","Use with caution in patients with cardiovascular disease, as it can cause tachycardia and hypertension.","Use with caution in patients with hepatic or renal impairment; dose adjustment may be needed.","This medicine may interact with many other drugs. Inform your doctor about all medications you are taking."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a breastfeeding woman. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe symptoms such as seizures, hallucinations, tachycardia, hypertension, and respiratory depression. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the overdose is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it more frequently than directed. Avoid alcohol and other central nervous system depressants while taking this medicine, as they can increase drowsiness and dizziness. Do not drive or operate machinery until you know how this medicine affects you. Inform your doctor if you have a history of seizures, liver or kidney problems, heart disease, glaucoma, or difficulty urinating. Do not stop taking this medicine suddenly after prolonged use without consulting your doctor. Keep this medicine out of reach of children. Store it at room temperature away from moisture and heat. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially anticholinergic effects (dry mouth, urinary retention, constipation), drowsiness, and dizziness. They are also at higher risk of falls and fractures. Start with a lower dose and titrate slowly. Regular monitoring of renal and hepatic function is recommended. Avoid concomitant use with other anticholinergic drugs.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Discuss alternative pain management options with your doctor.
🏥 Post-Surgery Considerations
This medicine is often used for postoperative pain management. It can be used as part of a multimodal analgesia regimen. However, it should be used with caution in patients recovering from surgery, especially if they have underlying liver or kidney disease. Monitor for side effects such as drowsiness, dizziness, and respiratory depression, especially if combined with other sedatives.
🦷 Dental Procedures
This medicine can be used for pain relief after dental procedures such as tooth extraction. Inform your dentist that you are taking this medicine before any dental work. It may interact with local anesthetics or other medications used during dental procedures. Avoid alcohol and driving after dental work if you have taken this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness and drowsiness. Avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how the medicine affects you. If you exercise, do so with caution and avoid strenuous activities that could lead to injury. Listen to your body and stop if you feel dizzy or unwell.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, which may affect your ability to work or perform daily activities. Avoid driving, operating machinery, or engaging in activities that require mental alertness until you know how the medicine affects you. Inform your employer if your job involves such tasks. Take breaks and rest if you feel drowsy.
🛑 When to Stop This Medicine
You should stop taking this medicine when your pain is adequately controlled or as directed by your doctor. Do not stop suddenly after prolonged use; consult your doctor for a gradual tapering schedule to prevent withdrawal symptoms. If you experience serious side effects, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of dependence, withdrawal symptoms, and potential for serious side effects such as seizures and liver toxicity. If prolonged use is necessary, regular monitoring of liver and kidney function, as well as assessment for signs of dependence, is advised. The medicine should be tapered gradually under medical supervision to avoid withdrawal.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help reduce pain in some individuals, but evidence is mixed.
Evidence: LimitedHelps manage chronic pain by changing thought patterns and behaviors.
Evidence: Well-establishedMay provide mild pain relief for some types of pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor that you are taking this medicine. It is generally safe to receive vaccines while on this medicine, but consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a letter from your doctor explaining the medical need for the medication. If crossing time zones, adjust your dosing schedule gradually to avoid missed doses. Store the medicine in a cool, dry place away from direct sunlight. Check the customs regulations of your destination country regarding controlled substances, as some countries may have restrictions. Always keep the medicine in your carry-on luggage to avoid loss or temperature extremes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 15 to 30 minutes after oral administration, with peak effects in about 1 to 2 hours.
A: The analgesic effect typically lasts for 4 to 6 hours, so it is usually taken every 4 to 6 hours as needed.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The safety of this medicine during pregnancy is not well established. It should be used only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
A: Do not stop taking this medicine suddenly after prolonged use, as it can cause withdrawal symptoms. Consult your doctor for a tapering schedule.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is an opioid.
Fact: This medicine is not an opioid. It is a centrally acting non-opioid analgesic with a different mechanism of action. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol should be avoided while taking this medicine as it can increase drowsiness, dizziness, and the risk of respiratory depression. - Myth: This medicine can be used for long-term pain management.
Fact: This medicine is intended for short-term use only. Prolonged use can lead to dependence and withdrawal symptoms. - Myth: This medicine is safe for children.
Fact: This medicine is not recommended for children under 12 years of age due to safety concerns.
🔄 Alternative Options
Generic Alternatives
- Nefopam hydrochloride 10 mg tablet
Brand Alternatives
- Nefistar 10mg Tablet