Nefazor 750mg Tablet Er (ranolazine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular or rapid heartbeat
- Fainting or loss of consciousness
- Severe dizziness or lightheadedness
- Chest pain that is worsening or not responding to usual treatment
- Shortness of breath or difficulty breathing
- Swelling of face, lips, tongue, or throat
- Decreased urine output or swelling in legs
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is nefazor 750mg tablet er used for?
This medicine is an extended-release tablet containing ranolazine, used to treat chronic stable angina by reducing the frequency of chest pain attacks. It works by inhibiting the late sodium current in heart cells, improving blood flow without significantly lowering heart rate or blood pressure.
- Generic Name: Ranolazine (750mg)
- Manufacturer: Taj Pharma India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nefazor 750mg tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा रैनोलाज़िन नामक सक्रिय तत्व से बनी है और मुख्य रूप से पुरानी स्थिर एंजाइना (सीने में दर्द) के इलाज के लिए उपयोग की जाती है। यह दवा दिल की मांसपेशियों में सोडियम चैनल को ब्लॉक करके काम करती है, जिससे दिल को खून की आपूर्ति बेहतर होती है और दर्द के दौरे कम होते हैं। यह दवा तुरंत दर्द के लिए नहीं है, बल्कि नियमित रूप से लेने पर दर्द की आवृत्ति कम करती है। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, कब्ज, जी मिचलाना और कमजोरी शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन दिल की धड़कन अनियमित होना, बेहोशी, या सांस लेने में कठिनाई हो सकती है। अगर ऐसा हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे भोजन के साथ या बिना भोजन के ले सकते हैं, लेकिन भोजन के साथ लेने से पेट की परेशानी कम होती है। अंगूर का रस न पिएं क्योंकि इससे दवा का स्तर बढ़ सकता है। कोई भी अन्य दवा शुरू करने से पहले डॉक्टर से सलाह लें। गाड़ी चलाते समय सावधानी बरतें।
💊 nefazor 750mg tablet er Uses & Benefits
[{"condition":"Chronic stable angina","description":"This medicine is used to reduce the frequency of angina attacks in patients with chronic stable angina who have not responded adequately to other anti-anginal medicines.","evidence":"Well-established"},{"condition":"Microvascular angina","description":"Sometimes used in patients with chest pain due to small vessel disease of the heart, though evidence is more limited.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Atrial fibrillation","description":"Ranolazine has been studied for reducing atrial fibrillation burden, but it is not approved for this use.","evidence":"Limited"},{"condition":"Diabetic neuropathy","description":"Some studies suggest benefit in painful diabetic neuropathy, but this is not an approved indication.","evidence":"Limited"}]
Primary treatment for: Chronic stable angina
Also treats: Microvascular angina, Coronary artery disease
📋 Drug Information
| Generic Name(s) | Ranolazine (750mg) |
| Brand Name | nefazor 750mg tablet er |
| Manufacturer | Taj Pharma India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Late Sodium channel blocker- angina |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and heat. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the late inward sodium current in cardiac muscle cells. By blocking this current, it reduces the accumulation of intracellular sodium, which in turn decreases calcium overload through the sodium-calcium exchanger. This leads to reduced diastolic wall tension and improved coronary blood flow, relieving angina without significantly affecting heart rate or blood pressure.
Mechanism Steps
💡 How to Take nefazor 750mg tablet er
Strength: Extended-release tablet, 750 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 500 mg to 1000 mg taken twice daily, depending on the indication and patient response. The starting dose is often 500 mg twice daily and may be increased to 1000 mg twice daily if needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose selection should be cautious, usually starting at the lower end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function. |
| Renal Impairment | For patients with mild to moderate renal impairment (creatinine clearance 30-80 mL/min), no dose adjustment is required. This medicine is contraindicated in patients with severe renal impairment (creatinine clearance < 30 mL/min). |
| Hepatic Impairment | For patients with mild to moderate hepatic impairment, no dose adjustment is required. This medicine is contraindicated in patients with severe hepatic impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is 2000 mg (1000 mg twice daily). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nefazor 750mg tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Ritonavir | Major | |
| Rifampin | Major | |
| Carbamazepine | Major | |
| St. John's wort | Major | |
| Quinidine | Major | |
| Sotalol | Major | |
| Dofetilide | Major | |
| Diltiazem | Moderate |
🚨 Major Interactions
- Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- CYP3A inducers (e.g., rifampin, carbamazepine, St. John's wort)
- QT prolonging drugs (e.g., quinidine, sotalol, dofetilide)
⚡ Moderate Interactions
- Moderate CYP3A inhibitors (e.g., diltiazem, verapamil, erythromycin)
- P-glycoprotein inhibitors (e.g., cyclosporine)
- Simvastatin
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness and low blood pressure when taken with this medicine. It is advisable to limit or avoid alcohol consumption while on this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe hepatic impairment","Concomitant use with strong CYP3A inhibitors","Concomitant use with CYP3A inducers","Known hypersensitivity to ranolazine","History of QT prolongation or congenital long QT syndrome"]
⚠️ Warnings & Precautions
["This medicine may prolong the QT interval. Use with caution in patients with a history of QT prolongation, bradycardia, or electrolyte abnormalities.","Avoid use in patients with severe kidney impairment (creatinine clearance < 30 mL/min).","Do not use in patients with severe liver disease.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not crush, chew, or break the extended-release tablet."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Symptoms of overdose may include severe dizziness, fainting, irregular heartbeat, and nausea. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis is not expected to be effective in removing this medicine from the body.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the extended-release tablet; swallow it whole with water. You may take it with or without food, but taking it with food may reduce stomach upset. Avoid drinking grapefruit juice while taking this medicine, as it can increase the level of the medicine in your blood and raise the risk of side effects. Do not start or stop any other medicine without consulting your doctor, especially medicines for infections, depression, or heart rhythm problems. Inform your doctor if you have liver or kidney disease, or if you have a history of irregular heartbeat. Do not drive or operate heavy machinery until you know how this medicine affects you. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, particularly dizziness and QT prolongation. Dose selection should be cautious, and regular monitoring of heart rhythm and kidney function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. There are no adequate studies of this medicine in pregnant women. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
After surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with other medications used during surgery. Your doctor may advise temporary discontinuation or dose adjustment.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with certain local anesthetics or other medications used during dental procedures. Your dentist may consult with your doctor before proceeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is beneficial for heart health, but avoid strenuous activities that trigger angina. Consult your doctor before starting any new exercise program. If you experience chest pain during exercise, stop immediately and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is important to take the medicine at the same times each day, which may require adjusting your work schedule. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as irregular heartbeat, fainting, or severe allergic reactions, seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine if needed.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of heart rhythm, kidney function, and liver function. Some patients may develop tolerance, but this is not common. It is important to continue lifestyle modifications and follow-up with your doctor to ensure optimal management of angina.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, regular exercise, smoking cessation, and stress management can complement medical therapy.
Evidence: Well-establishedAngioplasty or bypass surgery may be considered for certain patients with coronary artery disease.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, patients with heart disease should discuss vaccination schedules with their doctor, especially for influenza and pneumococcal vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about adjusting the dosing schedule. Store at room temperature and avoid leaving it in a hot car. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take several days to weeks of regular use before you notice a reduction in angina attacks. It is not for immediate relief of an acute attack.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Avoid grapefruit and grapefruit juice, as they can increase the level of this medicine in your blood and increase the risk of side effects.
A: Do not stop taking this medicine without consulting your doctor. Stopping suddenly may worsen your angina.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken for immediate relief of an angina attack.
Fact: This medicine is not for immediate relief of acute angina. It is a preventive medicine that reduces the frequency of attacks over time. - Myth: This medicine can be crushed or chewed for faster action.
Fact: This medicine is an extended-release tablet and must be swallowed whole. Crushing or chewing can cause a rapid release of the drug and increase side effects. - Myth: This medicine is safe to take with any other medicine.
Fact: This medicine can interact with many drugs, especially those that affect liver enzymes or heart rhythm. Always consult your doctor before taking any other medicine.
🔄 Alternative Options
Generic Alternatives
- Ranolazine extended-release tablet
Brand Alternatives
- Nefazor 750mg Tablet ER