Axecor 1000mg Tablet (ranolazine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain that is severe, prolonged, or not relieved by rest or nitrates
- Fainting or loss of consciousness
- Irregular or rapid heartbeat
- Severe dizziness or lightheadedness
- Swelling of face, lips, tongue, or throat
- Difficulty breathing
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is nefazor 1000mg tablet er used for?
This medicine is a prescription oral tablet containing ranolazine 1000 mg. It is used to treat chronic stable angina by reducing the frequency of chest pain episodes. It works by inhibiting the late sodium current in heart muscle cells, which reduces calcium overload and decreases the heart's workload. It is not for acute angina attacks.
- Generic Name: Ranolazine (1000mg)
- Manufacturer: Taj Pharma India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nefazor 1000mg tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा रैनोलाज़िन 1000 मिलीग्राम की एक प्रिस्क्रिप्शन टैबलेट है। इसका उपयोग पुरानी स्थिर एंजाइना (सीने में दर्द) के इलाज के लिए किया जाता है। यह दवा दिल की मांसपेशियों में सोडियम के प्रवाह को कम करके काम करती है, जिससे दिल पर दबाव कम होता है और दर्द के दौरे कम आते हैं। यह दवा तीव्र एंजाइना के दौरे के लिए नहीं है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, कब्ज, मतली और कमजोरी शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में दिल की धड़कन में गड़बड़ी, एलर्जी, गुर्दे की समस्या और खून के थक्के बनने में कमी शामिल हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल योग्य डॉक्टर की सलाह पर ही लें। डॉक्टर से पूछे बिना दवा शुरू, बंद या उसकी मात्रा न बदलें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। इस दवा के साथ अंगूर का जूस न पिएं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। यदि आप गर्भवती हैं या गर्भवती होने की योजना बना रही हैं, तो अपने डॉक्टर से सलाह लें।
💊 nefazor 1000mg tablet er Uses & Benefits
[{"condition":"Chronic stable angina","description":"This medicine is used to reduce the frequency of angina episodes in patients who continue to have symptoms despite treatment with other anti-anginal medicines.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Diabetic peripheral neuropathy","description":"Some studies suggest this medicine may help relieve nerve pain in people with diabetes, but this is not an approved use.","evidence":"Limited"}]
Primary treatment for: Chronic stable angina
Also treats: Coronary artery disease, Myocardial ischemia
📋 Drug Information
| Generic Name(s) | Ranolazine (1000mg) |
| Brand Name | nefazor 1000mg tablet er |
| Manufacturer | Taj Pharma India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Late Sodium channel blocker- angina |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. |
| Shelf Life | The shelf life of this medicine is not established from the available information. Check the expiry date on the package. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the late sodium current in heart muscle cells. During a heart attack or when the heart is under stress, there is an abnormal increase in late sodium current, which leads to calcium overload inside the cells. This calcium overload impairs the heart's ability to relax and increases oxygen demand. By blocking the late sodium current, this medicine reduces calcium overload, improves the heart's ability to relax, and decreases the workload on the heart. This helps to relieve angina symptoms and improve exercise tolerance.
Mechanism Steps
💡 How to Take nefazor 1000mg tablet er
Strength: This medicine is available as an immediate-release tablet containing 1000 mg of ranolazine.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 500 mg to 1000 mg taken twice daily by mouth. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. The maximum recommended dose is 1000 mg twice daily. This medicine should be taken with or without food, but consistency is important. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and low blood pressure. Dose adjustment may be necessary based on kidney and liver function. Consult your doctor for individualized dosing. |
| Renal Impairment | For patients with mild to moderate kidney impairment, no dose adjustment is typically needed. For patients with severe kidney impairment or those on dialysis, this medicine is not recommended. Consult your doctor for individualized advice. |
| Hepatic Impairment | For patients with mild liver impairment, no dose adjustment is typically needed. For patients with moderate to severe liver impairment, this medicine is contraindicated. Consult your doctor for individualized advice. |
| Maximum Daily Dose | The maximum recommended daily dose is 2000 mg (1000 mg twice daily). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nefazor 1000mg tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Ritonavir | Major | |
| Rifampin | Major | |
| Carbamazepine | Major | |
| St. John's wort | Major | |
| Amiodarone | Major | |
| Sotalol | Major | |
| Diltiazem | Moderate | |
| Simvastatin | Moderate |
🚨 Major Interactions
- Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Strong CYP3A inducers (e.g., rifampin, carbamazepine, St. John's wort)
- QT prolonging drugs (e.g., amiodarone, sotalol, moxifloxacin)
⚡ Moderate Interactions
- Moderate CYP3A inhibitors (e.g., diltiazem, verapamil, erythromycin)
- Simvastatin
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness and low blood pressure when taken with this medicine. It is advisable to limit or avoid alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe liver disease","Concomitant use with strong CYP3A inhibitors","Concomitant use with strong CYP3A inducers","Known hypersensitivity to ranolazine","QT prolongation or a history of ventricular arrhythmias"]
⚠️ Warnings & Precautions
["This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid grapefruit juice while taking this medicine.","Inform your doctor if you have kidney or liver problems.","This medicine is not for acute angina attacks; keep fast-acting nitrates available.","Do not stop taking this medicine without consulting your doctor.","This medicine may interact with many other medicines; always inform your doctor about all medicines you are taking."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Symptoms of overdose may include severe dizziness, fainting, irregular heartbeat, and difficulty breathing. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
This medicine should only be taken under the supervision of a qualified clinician. Do not start, stop, or change the dose without consulting your doctor. Inform your doctor about all other medicines you are taking, especially those for infections, heart conditions, or depression, as many can interact with this medicine. Avoid drinking grapefruit juice while taking this medicine, as it can increase the levels of the medicine in your body and raise the risk of side effects. Use caution when driving or operating machinery until you know how this medicine affects you, as it can cause dizziness. If you have liver or kidney problems, your doctor may need to adjust your dose or monitor you more closely. Do not use this medicine to treat an acute angina attack; keep your fast-acting nitrate medicine available for that purpose. If you become pregnant or plan to become pregnant, talk to your doctor about the risks and benefits.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and low blood pressure. Dose adjustment may be necessary based on kidney and liver function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The risks and benefits should be discussed, and alternative treatments may be considered.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be stopped temporarily, as advised by your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain medicines used in dentistry, and your dentist may need to take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Before starting any exercise program, consult your doctor. This medicine may cause dizziness, so avoid strenuous activities until you know how it affects you. Stop exercising and seek medical help if you experience chest pain, shortness of breath, or severe dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue your usual work activities, but take precautions if your job involves heavy machinery or driving.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or your condition changes, your doctor may adjust or stop the medicine. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of liver and kidney function, as well as heart rhythm. Some patients may experience persistent side effects such as dizziness or constipation. It is important to attend all follow-up appointments and report any new or worsening symptoms to your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress management can complement medicine for angina.
Evidence: Well-establishedAngioplasty or bypass surgery may be considered for certain patients.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known with this medicine. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about how to adjust your dosing schedule. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take several weeks to show its full effect. Continue taking it as prescribed and consult your doctor if you do not notice improvement.
A: Yes, you can take this medicine with or without food. However, avoid grapefruit juice as it can increase the levels of the medicine in your body.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor for individualized advice.
🤔 Common Patient Concerns
🔄 Substitutes for nefazor 1000mg tablet er
View AllAlternative brands with exact same active ingredient:
-
revulant 1000mg tabletSun Pharmaceutical Industries Ltd ₹87.00 43.1% CHEAPER
-
randear 1000mg tablet erAlkem Laboratories Ltd ₹112.50 26.5% CHEAPER
-
Ranomeg 1000mg TabletRidhima Biocare ₹135.94 11.2% CHEAPER
-
axecor 1000mg tabletRangsubbs ₹158.00 3.3% COSTLIER
-
ranozex 1000mg tablet erSun Pharmaceutical Industries Ltd ₹170.00 11.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used to treat acute angina attacks.
Fact: This medicine is not for acute angina attacks. It is a maintenance therapy to reduce the frequency of episodes. For acute attacks, use fast-acting nitrates as prescribed. - Myth: This medicine can be taken with grapefruit juice.
Fact: Grapefruit juice can increase the levels of this medicine in the body and should be avoided. - Myth: This medicine is safe for everyone with angina.
Fact: This medicine is not safe for people with severe liver disease or certain heart rhythm problems. Consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Ranolazine
Brand Alternatives
- Axecor 1000mg Tablet