Nebilock Am 5mg/5mg Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Chest pain or tightness
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Irregular or very slow heartbeat
- Sudden weight gain or swelling in legs
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is nebilock am 5mg/5mg tablet used for?
This medicine is a combination of nebivolol and amlodipine used to treat high blood pressure. It works by relaxing blood vessels and slowing the heart rate to lower blood pressure. It is taken once daily by mouth, usually with or without food. Do not stop taking it suddenly without consulting your doctor.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nebilock am 5mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए इस्तेमाल की जाती है। इसमें नेबिवोलोल और एम्लोडिपिन दो दवाएं शामिल हैं जो मिलकर रक्त वाहिकाओं को आराम देती हैं और हृदय की गति को धीमा करती हैं, जिससे रक्तचाप कम होता है। यह दवा आमतौर पर दिन में एक बार मुंह से ली जाती है। यह उन रोगियों के लिए है जिनका रक्तचाप अकेले एक दवा से नियंत्रित नहीं हो पाता। इसे डॉक्टर की सलाह के बिना बंद न करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में सिरदर्द, चक्कर आना, थकान, और पैरों में सूजन शामिल हैं। कुछ लोगों को धड़कन धीमी होना, ठंड लगना, या नींद में गड़बड़ी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें बहुत कम रक्तचाप, धड़कन रुकना, सांस लेने में कठिनाई, या चेहरे पर सूजन शामिल हो सकते हैं। अगर आपको कोई भी असामान्य लक्षण महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, खासकर अगर आपको हृदय रोग है, क्योंकि इससे सीने में दर्द या दिल का दौरा पड़ सकता है। अगर आपको अस्थमा, मधुमेह, गुर्दे या यकृत की समस्या है तो अपने डॉक्टर को बताएं। शराब न पिएं क्योंकि इससे चक्कर और कम रक्तचाप हो सकता है। गाड़ी चलाते समय सावधानी बरतें जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है। नियमित रूप से रक्तचाप और हृदय गति की जांच कराएं।
💊 nebilock am 5mg/5mg tablet Uses & Benefits
- [{"condition":"Essential hypertension","description":"This medicine is used to lower high blood pressure in adults when a single agent does not provide adequate control.
- The combination of nebivolol and amlodipine reduces both cardiac output and peripheral vascular resistance, leading to effective blood pressure reduction.","evidence":"Well-established"},{"condition":"Hypertension with angina","description":"In patients with both high blood pressure and stable angina, this medicine can help reduce blood pressure and decrease the frequency of angina episodes by lowering cardiac workload and improving coronary blood flow.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Hypertension in patients with metabolic syndrome","description":"Nebivolol's nitric oxide-enhancing properties may offer advantages in patients with metabolic syndrome, but this combination is not specifically approved for this population.","evidence":"Limited"}]
Primary treatment for: Essential hypertension
Also treats: Angina pectoris, Heart failure (stable, with caution)
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nebilock am 5mg/5mg tablet |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specifically instructed. Keep in the original container with the lid tightly closed. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. Do not use after the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. The World Health Organization does not provide specific recommendations for this fixed-dose combination. Management of hypertension should follow current national and international guidelines. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research has published guidelines for the management of hypertension, but specific recommendations for this combination are not available. Consult a qualified clinician for individualized treatment. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Nebivolol is a highly selective beta-1 adrenergic receptor blocker that reduces heart rate, myocardial contractility, and cardiac output. It also stimulates beta-3 adrenergic receptors, leading to increased nitric oxide release and vasodilation. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle cells. This inhibition causes relaxation of peripheral arterioles, reducing systemic vascular resistance. The combined effect is a more pronounced reduction in blood pressure than either agent alone, with potentially fewer reflex tachycardia effects due to nebivolol's rate-limiting action.
Mechanism Steps
💡 How to Take nebilock am 5mg/5mg tablet
Strength: Each immediate-release tablet contains nebivolol 5 mg and amlodipine 5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, with or without food. The dose may be adjusted by your doctor based on your blood pressure response and tolerability. Some patients may require a lower starting dose, especially if elderly or if you have liver or kidney problems. Do not exceed the dose prescribed by your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concurrent medications. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, particularly dizziness, bradycardia, and hypotension. Start with a lower dose and titrate slowly under medical supervision. Regular monitoring of blood pressure, heart rate, and renal function is recommended. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually necessary. In severe renal impairment (creatinine clearance less than 30 mL/min), nebivolol clearance may be reduced, and dose adjustment may be required. Amlodipine is not significantly affected by renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, this medicine should be used with caution, and a lower starting dose may be considered. In severe hepatic impairment, this medicine is contraindicated. Both nebivolol and amlodipine are metabolized in the liver, and their clearance may be prolonged. Regular monitoring of liver function is advised. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is one tablet (nebivolol 5 mg and amlodipine 5 mg) once daily. Do not exceed this dose unless specifically instructed by your doctor. Higher doses may increase the risk of side effects without providing additional benefit. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nebilock am 5mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluoxetine | Major | |
| Ketoconazole | Major | |
| Rifampin | Major | |
| Digoxin | Moderate | |
| Clonidine | Moderate | |
| NSAIDs | Moderate | |
| Simvastatin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's wort)
- Other beta-blockers or calcium channel blockers
⚡ Moderate Interactions
- Digoxin
- Clonidine
- NSAIDs
- Simvastatin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can intensify the blood pressure-lowering effects, leading to dizziness, lightheadedness, and increased risk of fainting. Alcohol may also worsen the sedative effects of nebivolol and increase the risk of liver problems. If you choose to drink, discuss safe limits with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia (heart rate less than 50 beats per minute)","Second- or third-degree heart block without a pacemaker","Cardiogenic shock","Severe liver impairment (Child-Pugh C)","Known hypersensitivity to nebivolol, amlodipine, or any component of the formulation","Acute decompensated heart failure","Severe aortic stenosis"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly, as it can worsen angina or cause a heart attack.","Use with caution in patients with asthma or COPD due to risk of bronchospasm.","May mask symptoms of hypoglycemia in diabetic patients.","Can cause dizziness; avoid driving or operating machinery until you know how it affects you.","Use with caution in patients with peripheral vascular disease.","May worsen symptoms of Raynaud's phenomenon.","Avoid alcohol consumption while taking this medicine.","Inform your doctor if you have kidney or liver problems.","Use with caution in elderly patients, who may be more sensitive to side effects.","Do not use during pregnancy unless clearly needed and advised by a doctor."]
🤱 Lactation Safety
Not established from the available information. Both nebivolol and amlodipine may pass into breast milk. The decision to breastfeed while taking this medicine should be made in consultation with a qualified clinician, considering the potential benefits of breastfeeding and the potential risks to the infant.
💊 Overdose Management
Overdose of this medicine can cause severe hypotension, bradycardia, heart failure, and bronchospasm. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids, atropine for bradycardia, vasopressors for hypotension, and glucagon. Hemodialysis is not effective for removing nebivolol or amlodipine from the body. Do not attempt to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than 12 hours have passed since the scheduled time. If more than 12 hours have passed, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not crush, chew, or split the tablet unless your doctor or pharmacist has advised you it is safe to do so. Do not stop this medicine suddenly, especially if you have heart disease, because abrupt withdrawal of the nebivolol component can cause chest pain, worsening angina, or even a heart attack. Inform your doctor if you have asthma, chronic obstructive pulmonary disease, diabetes, thyroid disorders, kidney or liver problems, or a history of heart failure. This medicine can mask symptoms of low blood sugar (hypoglycemia) in people with diabetes, so monitor your blood glucose more carefully. Avoid alcohol, as it can increase dizziness and low blood pressure. Use caution when driving or operating machinery until you know how this medicine affects you. Tell all your healthcare providers, including your dentist, that you take this medicine. Keep all follow-up appointments to monitor your blood pressure, heart rate, and laboratory tests. Store this medicine at room temperature, away from moisture and direct sunlight, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, particularly dizziness, bradycardia, and hypotension. Start with a lower dose and titrate slowly. Regular monitoring of blood pressure, heart rate, and renal function is recommended. Falls are a risk due to dizziness, so take precautions.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conceiving. This medicine may not be safe during pregnancy, and your doctor may switch you to a safer alternative. Effective contraception should be discussed if you are of childbearing age and taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Beta-blockers may interact with anesthetic agents and can affect heart rate and blood pressure during surgery. Your doctor may advise you to continue or temporarily stop the medicine based on the type of surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth or affect blood pressure during dental work. Your dentist may take precautions to monitor your blood pressure and heart rate. Continue taking your medicine as usual unless advised otherwise.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial while taking this medicine. However, avoid sudden strenuous activities, especially in hot weather, as this can cause dizziness or fainting due to low blood pressure. Stay well hydrated. If you experience chest pain, severe shortness of breath, or dizziness during exercise, stop and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work and daily activities with appropriate precautions. If your job involves shift work, consult your doctor about the best time to take your dose.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your blood pressure is well controlled for a long period, your doctor may consider reducing or stopping the medicine gradually. Abrupt discontinuation can lead to rebound hypertension, angina, or heart attack. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. Regular check-ups should include blood pressure, heart rate, kidney function, and electrolyte levels. Prolonged use of beta-blockers may increase the risk of developing diabetes or worsen glucose tolerance. Amlodipine can cause persistent ankle swelling. Do not stop the medicine without medical advice, as uncontrolled hypertension can lead to heart attack, stroke, and kidney damage.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Weight loss, exercise, and dietary changes can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors or ARBs combined with calcium channel blockers or diuretics may be alternatives if this medicine is not tolerated.
Evidence: Well-establishedAn interventional procedure for resistant hypertension, but not widely available.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider that you are taking this medicine. Continue taking your medicine as prescribed unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and avoid leaving it in a hot car or checked luggage. Check local customs regulations for carrying prescription medicines, and carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1 to 2 hours, but the full effect may take 1 to 2 weeks. Your doctor will monitor your blood pressure and adjust the dose if needed.
A: Yes, you can take this medicine with or without food. Taking it with food may help reduce stomach upset. Avoid grapefruit and grapefruit juice as they can increase drug levels.
A: If you miss a dose, take it as soon as you remember if less than 12 hours have passed. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop this medicine suddenly without consulting your doctor. Abrupt withdrawal can cause serious heart problems, including worsening angina or heart attack.
A: The safety of this medicine during pregnancy is not well established. Consult your doctor if you are pregnant or planning to become pregnant. Your doctor will weigh the benefits and risks.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls blood pressure but does not cure the underlying condition. Lifestyle changes and long-term medication are often needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: Blood pressure returns to high levels if you stop taking the medicine. Always consult your doctor before making any changes. - Myth: This medicine causes kidney damage.
Fact: When used as prescribed, this medicine is generally safe for the kidneys. However, regular monitoring is advised, especially in patients with kidney disease.
🔄 Alternative Options
Generic Alternatives
- Nebivolol 5 mg + Amlodipine 5 mg tablet (generic)
Brand Alternatives
- Nebilock AM 5mg/5mg Tablet