Eclo N Cream: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of face, lips, or throat, or difficulty breathing.
- Signs of adrenal suppression such as extreme fatigue, weakness, dizziness, or weight loss.
- Severe skin irritation, blistering, or peeling at the application site.
- Worsening of the infection with increased redness, swelling, or pus.
- Vision changes or eye pain if cream accidentally gets into the eyes.
- Symptoms of high blood sugar such as increased thirst and urination.
If experiencing severe symptoms, call emergency services immediately.
What is ncp cream used for?
This medicine is a topical cream containing nadifloxacin (an antibiotic) and clobetasol (a very potent steroid). It is used to treat skin conditions where bacterial infection and inflammation occur together, such as infected eczema or dermatitis. Apply a thin layer to the affected area as directed by your doctor.
- Generic Name: Nadifloxacin (1% w/w) + Clobetasol (0.05% w/w)
- Manufacturer: Yaher Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ncp cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें नाडिफ्लोक्सासिन (एंटीबायोटिक) और क्लोबेटासोल (बहुत शक्तिशाली स्टेरॉयड) होते हैं। इसका उपयोग उन त्वचा रोगों के इलाज के लिए किया जाता है जिनमें बैक्टीरियल संक्रमण और सूजन दोनों होते हैं, जैसे संक्रमित एक्जिमा या डर्मेटाइटिस। यह खुजली, लालिमा और सूजन को कम करने में मदद करती है। इसे डॉक्टर के निर्देशानुसार प्रभावित त्वचा पर पतली परत में लगाएं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली, लालिमा या सूखापन शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। लंबे समय तक उपयोग करने पर त्वचा पतली हो सकती है, खिंचाव के निशान पड़ सकते हैं, या बाल बढ़ सकते हैं। कभी-कभी गंभीर एलर्जी प्रतिक्रिया हो सकती है। अगर आपको गंभीर जलन, छाले, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग डॉक्टर के बताए अनुसार ही करें। प्रभावित त्वचा पर पतली परत लगाएं और हल्के से मलें। आंखों, होंठों और मुंह के अंदर लगाने से बचें। उपयोग के बाद हाथ धो लें। चेहरे, जांघों के बीच या बगल में बिना डॉक्टर की सलाह के न लगाएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 ncp cream Uses & Benefits
[{"condition":"Infected eczema","description":"Used to treat eczema that has become infected with bacteria, reducing both inflammation and bacterial growth.","evidence":"Well-established"},{"condition":"Infected dermatitis","description":"Helps control inflammation and bacterial infection in various types of dermatitis.","evidence":"Well-established"},{"condition":"Infected psoriasis","description":"May be used for short-term treatment of psoriasis plaques that have become infected.","evidence":"Moderate"},{"condition":"Bacterial skin infections with inflammation","description":"Treats conditions where both a bacterial infection and an inflammatory component are present.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Infected insect bites","description":"Sometimes used to reduce inflammation and prevent infection from scratching insect bites.","evidence":"Limited"},{"condition":"Infected minor cuts or abrasions","description":"May be prescribed to prevent infection and reduce inflammation in minor wounds.","evidence":"Limited"}]
Primary treatment for: Infected inflammatory skin conditions
Also treats: Eczema with secondary bacterial infection, Dermatitis with secondary bacterial infection, Psoriasis with secondary bacterial infection
📋 Drug Information
| Generic Name(s) | Nadifloxacin (1% w/w) + Clobetasol (0.05% w/w) |
| Brand Name | ncp cream |
| Manufacturer | Yaher Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | |
| Route of Administration | Topical |
| Storage | Store below 30°C in a cool, dry place. Protect from direct sunlight. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Nadifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and repair. This action stops bacteria from multiplying and leads to bacterial cell death. Clobetasol is a very potent synthetic corticosteroid that binds to glucocorticoid receptors inside cells. This binding leads to suppression of inflammatory pathways, reduction of immune cell activity, and decreased production of inflammatory chemicals like cytokines and prostaglandins. The result is a rapid reduction in redness, swelling, itching, and pain. Together, the antibiotic controls bacterial infection while the steroid calms inflammation.
Mechanism Steps
💡 How to Take ncp cream
Strength: Cream containing nadifloxacin 1% w/w and clobetasol 0.05% w/w.
Dosage Information
| Adult Dosage | Apply a thin layer of this medicine to the affected area of skin once or twice daily, or as directed by your doctor. The exact frequency and duration depend on the condition being treated and your response to therapy. Do not use for longer than prescribed. Dose must be individualized by a qualified clinician based on indication, age, and skin condition. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects of topical corticosteroids. Use the lowest effective amount for the shortest duration. Consult a doctor for appropriate dosing. |
| Renal Impairment | No specific dose adjustment is established for topical use in renal impairment. Use with caution. |
| Hepatic Impairment | No specific dose adjustment is established for topical use in hepatic impairment. Use with caution. |
| Maximum Daily Dose | Not established from the available information. Use only as prescribed by a doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ncp cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other topical corticosteroids | Major | |
| Oral corticosteroids | Major | |
| CYP3A4 inhibitors | Moderate | |
| Warfarin | Moderate | |
| Diuretics | Minor |
🚨 Major Interactions
- Other topical corticosteroids
- Oral or injectable corticosteroids
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- Anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
No specific interaction between this topical cream and alcohol is established. However, alcohol may worsen certain skin conditions and should be consumed in moderation.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nadifloxacin, clobetasol, or any component of the cream","Untreated bacterial, viral, or fungal skin infections without appropriate therapy","Acne vulgaris, rosacea, and perioral dermatitis","Application on the face, groin, or underarms unless specifically directed by a doctor","Use in children under 12 years unless prescribed by a doctor"]
⚠️ Warnings & Precautions
["For external use only. Do not swallow.","Avoid contact with eyes, lips, and mucous membranes.","Do not use on large areas or for prolonged periods without medical supervision.","Do not cover with airtight dressings unless instructed.","Use with caution in children and elderly.","Consult a doctor if you are pregnant or breastfeeding.","Do not use for conditions other than those prescribed.","Stop use and consult a doctor if irritation or allergic reaction occurs."]
🤱 Lactation Safety
It is not known whether nadifloxacin or clobetasol pass into breast milk in significant amounts after topical application. However, corticosteroids can pass into breast milk. Consult your doctor before using this medicine while breastfeeding. Avoid applying to the breast area to prevent infant exposure.
💊 Overdose Management
Overdose with this topical cream is unlikely. If accidental ingestion occurs, seek medical attention immediately. Prolonged excessive topical application may lead to systemic steroid effects; in such cases, stop use and consult a doctor.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for a missed dose.
Additional Safety Advice
Use this medicine exactly as prescribed by your doctor. Apply a thin layer to the affected skin and gently rub it in. Do not cover the area with airtight dressings unless your doctor tells you to, as this can increase absorption and side effects. Avoid contact with eyes, lips, and inside the nose or mouth. Wash your hands thoroughly after applying the cream, unless your hands are the treated area. Do not use this medicine on the face, groin, or underarms unless specifically directed by a doctor. Do not use it for longer than the recommended duration. If your skin condition does not improve within a few days or gets worse, consult your doctor. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of topical corticosteroids, including skin thinning and systemic effects. Use the lowest effective amount for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Topical corticosteroids should be used with caution during pregnancy. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine on surgical wounds. It may interfere with wound healing and increase the risk of infection if applied to open wounds.
🦷 Dental Procedures
This medicine is for topical skin use and is not expected to affect dental procedures. However, inform your dentist about all medicines you are using.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while using this medicine. However, avoid activities that cause excessive sweating or friction on the treated area, as this may irritate the skin. If you swim, apply the cream after swimming and pat the skin dry gently.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you experience any application site reactions, avoid tasks that require concentration until you feel comfortable.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if your condition worsens, if you experience severe irritation or allergic reactions, or if you have used it for the prescribed duration without improvement. Do not stop abruptly if you have been using it for a long time; consult your doctor for a tapering schedule.
📅 Long-Term Use Effects
Long-term use of this medicine, especially over large areas or with occlusive dressings, can lead to skin thinning, stretch marks, visible blood vessels, increased hair growth, and increased risk of secondary infections. Systemic absorption of clobetasol can cause adrenal suppression, Cushing's syndrome, and high blood sugar. Regular monitoring by a doctor is recommended if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For bacterial infections without significant inflammation.
Evidence: Well-establishedFor inflammatory skin conditions without infection.
Evidence: Well-establishedFor more extensive or severe bacterial skin infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interaction between this topical medicine and vaccines is established. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are using.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs. Store it in a cool, dry place away from direct sunlight. If traveling to a hot climate, keep it in a cool bag. Do not leave it in a car where temperatures can exceed 30°C. If you are crossing time zones, continue applying as per your usual schedule; no time zone adjustment is needed for topical application.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may notice improvement in itching and redness within a few days. Full effect may take up to a week or more depending on the condition.
A: Do not stop abruptly without consulting your doctor. Your doctor will advise you on how to taper or stop the medicine.
A: No, unless specifically instructed by your doctor. This medicine contains a very potent steroid and can cause skin thinning and other side effects on the face.
A: Consult your doctor before using this medicine during pregnancy. It should be used only if clearly needed.
🤔 Common Patient Concerns
🔄 Substitutes for ncp cream
View AllAlternative brands with exact same active ingredient:
-
nadimin plus creamLeeford Healthcare Ltd ₹105.00 37.5% CHEAPER
-
clotop nd creamAS Lifesciences ₹120.00 28.6% CHEAPER
-
naditop c creamGodetia Healthcare ₹135.00 19.6% CHEAPER
-
nadix c creamCanbro Healthcare ₹140.25 16.5% CHEAPER
-
eclo n creamEskon Pharma ₹168.70 0.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin rash.
Fact: This medicine is only for specific infected inflammatory skin conditions. Using it for other rashes can worsen them or cause side effects. - Myth: More cream means faster healing.
Fact: Applying more than prescribed increases the risk of side effects without improving results. Always use a thin layer as directed. - Myth: It is safe to use on the face.
Fact: This medicine contains a very potent steroid and should not be used on the face unless specifically instructed by a doctor.
🔄 Alternative Options
Generic Alternatives
- Nadifloxacin and clobetasol cream (generic versions may be available)
Brand Alternatives
- Eclo N Cream