Nafodil 25 Tablet (naftopidil 25mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Prolonged and painful erection lasting more than 4 hours
- Severe dizziness or fainting
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing
- Chest pain or irregular heartbeat
- Sudden severe headache or vision changes
- Signs of an allergic reaction such as rash, itching, or hives
If experiencing severe symptoms, call emergency services immediately.
What is nafodil 25 tablet used for?
This medicine contains Naftopidil 25 mg, an alpha-blocker used to treat urinary symptoms of an enlarged prostate (BPH) in men. It works by relaxing prostate and bladder neck muscles to improve urine flow. It is taken orally once daily, usually at bedtime, and is not for use in women or children.
- Generic Name: Naftopidil (25mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nafodil 25 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नैफ्टोपिडिल 25 मिलीग्राम युक्त एक टैबलेट है, जिसका उपयोग पुरुषों में बढ़े हुए प्रोस्टेट ग्रंथि (बिनाइन प्रोस्टेटिक हाइपरप्लासिया) के कारण होने वाले मूत्र संबंधी लक्षणों के इलाज के लिए किया जाता है। यह दवा प्रोस्टेट और मूत्राशय की गर्दन की मांसपेशियों को शिथिल करके पेशाब की धारा को बेहतर बनाती है और बार-बार पेशाब आने, रात में पेशाब आने, और पेशाब शुरू करने में कठिनाई जैसे लक्षणों को कम करती है। यह दवा केवल पुरुषों के लिए है और इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में चक्कर आना, सिरदर्द, खड़े होने पर चक्कर आना, और नाक बहना शामिल हैं। कुछ लोगों को थकान, धड़कन तेज होना, या पैरों में सूजन भी हो सकती है। ये दुष्प्रभाव आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। यदि कोई गंभीर दुष्प्रभाव जैसे लंबे समय तक इरेक्शन बना रहना, गंभीर चक्कर आना, या बेहोशी हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। यह दवा चक्कर और निम्न रक्तचाप का कारण बन सकती है, इसलिए बैठने या लेटने की स्थिति से धीरे-धीरे उठें। शराब का सेवन न करें क्योंकि इससे चक्कर और बढ़ सकते हैं। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आपको कैसे प्रभावित करती है। यदि आपको मोतियाबिंद की सर्जरी करानी है, तो अपने नेत्र सर्जन को इस दवा के बारे में बताएं। दवा को बच्चों की पहुंच से दूर रखें और निर्देशानुसार ही सेवन करें।
💊 nafodil 25 tablet Uses & Benefits
[{"condition":"Benign prostatic hyperplasia (BPH)","description":"This medicine is used to relieve urinary symptoms associated with an enlarged prostate, such as weak urine flow, hesitancy, frequent urination, and nocturia.","evidence":"Well-established"},{"condition":"Lower urinary tract symptoms (LUTS) due to BPH","description":"It helps to improve the maximum urinary flow rate and reduces the overall symptom score in men with LUTS caused by benign prostatic enlargement.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Ureteral stone expulsion","description":"Sometimes used off-label to help facilitate the passage of distal ureteral stones by relaxing the smooth muscle of the ureter.","evidence":"Limited"},{"condition":"Neurogenic bladder dysfunction","description":"Occasionally prescribed off-label to reduce bladder outlet resistance in certain neurogenic bladder conditions.","evidence":"Limited"}]
Primary treatment for: Benign prostatic hyperplasia (BPH)
Also treats: Lower urinary tract symptoms (LUTS), Nocturia, Urinary hesitancy, Weak urinary stream
📋 Drug Information
| Generic Name(s) | Naftopidil (25mg) |
| Brand Name | nafodil 25 tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Uroselective adrenergic receptor(α1a) antagonist |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | Not established from the available information. Refer to the packaging for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively blocking alpha-1 adrenergic receptors, with a preference for the alpha-1A and alpha-1D subtypes that are predominantly found in the prostate gland, bladder neck, and urethra. By blocking these receptors, it prevents the binding of norepinephrine and other catecholamines that would otherwise cause contraction of the smooth muscle in these tissues. This leads to relaxation of the smooth muscle, which reduces the dynamic obstruction of the bladder outlet and improves urine flow. Unlike non-selective alpha-blockers, this medicine has a relatively greater effect on the prostate and bladder neck than on blood vessels, although some blood pressure lowering can still occur. The relaxation of prostatic smooth muscle helps to alleviate the symptoms of benign prostatic hyperplasia without reducing the size of the prostate gland itself.
Mechanism Steps
💡 How to Take nafodil 25 tablet
Strength: Naftopidil 25 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 25 mg taken orally once daily, preferably at bedtime. However, the dose may be increased to 50 mg or 75 mg once daily based on your response and tolerability, as determined by your doctor. The dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and other medications you are taking. Do not change the dose without consulting your doctor. Take the tablet with or without food, but it is best to take it at the same time each day to maintain consistent blood levels. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not indicated for use in children. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, particularly dizziness and orthostatic hypotension. The starting dose should be low, and dose increases should be made cautiously. Regular monitoring of blood pressure and renal function is advised. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually necessary. In severe renal impairment, this medicine should be used with caution, and the dose may need to be reduced. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is usually necessary. In severe hepatic impairment, this medicine is contraindicated or should be used with extreme caution. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 75 mg, but this must be determined by a qualified clinician based on individual patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nafodil 25 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other alpha-blockers | Major | |
| PDE5 inhibitors | Major | |
| Antihypertensives | Major | |
| CYP3A4 inhibitors | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| Diuretics | Moderate | |
| NSAIDs | Minor | |
| Antacids | Minor | |
| Alcohol | Moderate | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Other alpha-blockers (e.g., prazosin, terazosin, doxazosin)
- Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)
- Antihypertensive agents (e.g., amlodipine, lisinopril, hydrochlorothiazide)
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Diuretics
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering effect of this medicine and increase the risk of dizziness, drowsiness, and fainting. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Naftopidil or any component of the tablet","History of orthostatic hypotension","Severe hepatic impairment","Severe renal impairment","Women and children","Concurrent use with other alpha-blockers or PDE5 inhibitors (relative contraindication)"]
⚠️ Warnings & Precautions
["This medicine can cause dizziness and orthostatic hypotension, especially at the start of treatment. Rise slowly from sitting or lying positions.","Avoid driving or operating heavy machinery until you know how this medicine affects you.","Inform your eye surgeon about this medicine before cataract surgery, as it can cause intraoperative floppy iris syndrome.","Avoid alcohol while taking this medicine, as it can increase dizziness and low blood pressure.","Use with caution in patients with liver or kidney disease. Dose adjustment may be needed.","Do not stop taking this medicine abruptly without consulting your doctor.","This medicine does not cure prostate enlargement and does not reduce the risk of prostate cancer. Regular check-ups are important."]
🤱 Lactation Safety
This medicine is not intended for use in women. It is not known whether this medicine is excreted in human breast milk. Consult your doctor if you are breastfeeding.
💊 Overdose Management
If you suspect an overdose of this medicine, seek immediate medical attention. Symptoms of overdose may include severe dizziness, fainting, and a rapid heartbeat. Treatment is supportive and symptomatic, as there is no specific antidote. Contact your doctor or a poison control center for guidance.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before you start taking this medicine, tell your doctor if you have ever had low blood pressure, fainting spells, liver disease, kidney disease, or a condition called cataract surgery planned in the near future. This medicine can cause dizziness and a drop in blood pressure when you stand up, especially during the first few days of treatment, so it is advisable to get up slowly from a sitting or lying position. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not take this medicine with alcohol, as alcohol can increase the blood pressure-lowering effect and make you feel more dizzy or faint. If you are scheduled for eye surgery for cataracts, inform your eye surgeon that you are taking this medicine, because it can increase the risk of complications during the procedure. Do not share this medicine with anyone else, even if they have similar symptoms. Keep this medicine out of the reach of children. Store it at room temperature, away from direct sunlight and moisture. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you experience any serious side effects such as a prolonged erection, severe dizziness, or fainting, seek medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the blood pressure-lowering effects of this medicine and may experience more dizziness or falls. The starting dose should be low, and dose increases should be gradual. Regular monitoring of blood pressure and renal function is advised. Fall prevention measures should be taken.
🤰 Pregnancy Planning (TTC)
This medicine is not intended for use in women. If you are a woman planning pregnancy, this medicine is not applicable. Men taking this medicine who are planning to father a child should consult their doctor, as the effects on fertility are not fully established.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before certain surgeries, especially cataract surgery, to reduce the risk of complications. Follow your doctor's instructions regarding when to resume the medicine after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There are no specific contraindications, but it is important for your dentist to know your complete medication history. If you experience dizziness during dental treatment, inform your dentist immediately.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness and low blood pressure, especially when standing up quickly. Avoid strenuous exercises that involve sudden changes in position until you know how the medicine affects you. Stay well hydrated during exercise. If you feel dizzy or faint during exercise, stop immediately and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people, especially during the first few days of treatment. Avoid driving or operating heavy machinery until you know how it affects you. If your job involves operating machinery or working at heights, inform your employer and take necessary precautions. Most people can continue their normal daily activities with caution.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as priapism, severe dizziness, or allergic reactions, seek immediate medical attention and follow your doctor's advice regarding discontinuation. Your doctor may adjust the dose or switch to another medicine if needed.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated. However, regular monitoring of blood pressure, kidney function, and liver function may be advised by your doctor. Some patients may experience persistent dizziness or orthostatic hypotension. The medicine does not cure benign prostatic hyperplasia, so symptoms may return if the medicine is stopped. Long-term use does not appear to increase the risk of prostate cancer, but routine prostate health checks should continue.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Weight loss, dietary changes, and pelvic floor exercises can help manage BPH symptoms.
Evidence: Well-establishedMedicines like tamsulosin or alfuzosin may be alternatives if this medicine is not suitable.
Evidence: Well-establishedMedicines like finasteride can shrink the prostate over time but take longer to work.
Evidence: Well-establishedProcedures like TURP may be considered for severe symptoms not controlled by medicines.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. If you are crossing time zones, continue taking your dose at the same time each day as much as possible. Store the medicine at room temperature and away from direct sunlight. Check the customs regulations of your destination country regarding prescription medicines. Always carry enough supply for the duration of your trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Some improvement may be noticed within a few days, but it usually takes 2 to 4 weeks for the full benefits to become apparent.
A: Yes, you can take it with or without food, but it is best to take it at the same time each day.
A: If you remember within a few hours, take the missed dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is generally safe for long-term use under medical supervision. Regular follow-up with your doctor is recommended.
A: Do not stop taking this medicine without consulting your doctor. Symptoms may return if you stop abruptly.
🤔 Common Patient Concerns
🔄 Substitutes for nafodil 25 tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure an enlarged prostate.
Fact: This medicine helps manage symptoms but does not cure or shrink the prostate. It is a symptomatic treatment. - Myth: This medicine is safe for women and children.
Fact: This medicine is only for adult men with benign prostatic hyperplasia. It is not indicated for women or children. - Myth: You can stop taking this medicine once symptoms improve.
Fact: Symptoms may return if you stop the medicine. Always consult your doctor before stopping. - Myth: This medicine can be taken with any other medicine without risk.
Fact: This medicine can interact with other medicines, especially those for blood pressure or erectile dysfunction. Always inform your doctor about all medicines you take.
🔄 Alternative Options
Generic Alternatives
- Naftopidil 25 mg tablet
Brand Alternatives
- Nafodil 25 Tablet