Naltrexone 1000mg Injection: Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain
- Dark urine or pale stools
- Signs of severe allergic reaction (rash, swelling, difficulty breathing)
- Severe injection site pain, swelling, or abscess
- Confusion, hallucinations, or suicidal thoughts
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is nacxone 1000mg injection used for?
This medicine is an injectable opioid antagonist used to treat opioid and alcohol dependence. It works by blocking opioid receptors in the brain, reducing cravings and preventing the euphoric effects of opioids. It is administered by a healthcare professional, usually once monthly.
- Generic Name: Information coming soon
- Manufacturer: Multiple manufacturers
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nacxone 1000mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा ओपिओइड और शराब की लत के इलाज में उपयोग की जाती है। यह मस्तिष्क में ओपिओइड रिसेप्टर्स को ब्लॉक करती है, जिससे ओपिओइड के प्रभाव और शराब की लालसा कम होती है। यह एक इंजेक्शन है जो स्वास्थ्य पेशेवर द्वारा दिया जाता है, आमतौर पर महीने में एक बार।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, सिरदर्द, थकान, चक्कर आना और इंजेक्शन स्थल पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभावों में लीवर की क्षति, एलर्जी प्रतिक्रियाएं और ओपिओइड वापसी के लक्षण शामिल हो सकते हैं। किसी भी असामान्य लक्षण की तुरंत डॉक्टर को सूचना दें।
सुरक्षा सलाह: यह दवा केवल स्वास्थ्य पेशेवर द्वारा क्लिनिक में दी जानी चाहिए। इसे स्वयं न लगाएं। इस दवा को लेने से पहले अपने डॉक्टर को सभी दवाओं के बारे में बताएं, खासकर ओपिओइड। शराब से बचें क्योंकि इससे लीवर की समस्या बढ़ सकती है। नियमित लीवर फंक्शन टेस्ट कराएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 nacxone 1000mg injection Uses & Benefits
[{"condition":"Opioid dependence","description":"Used as part of a comprehensive treatment program to help patients remain opioid-free by blocking the effects of opioids.","evidence":"Well-established"},{"condition":"Alcohol dependence","description":"Helps reduce alcohol craving and prevents relapse in patients with alcohol use disorder.","evidence":"Well-established"},{"condition":"Opioid overdose reversal","description":"May be used in emergency settings to reverse opioid overdose, though the 1000 mg strength is typically for extended-release maintenance.","evidence":"Established for immediate-release formulations; limited for this specific strength"}]
Off-label uses: [{"condition":"Impulse control disorders","description":"Sometimes prescribed off-label for pathological gambling or kleptomania.","evidence":"Limited"},{"condition":"Weight loss maintenance","description":"Investigated for weight loss in combination with bupropion, but not standard for this formulation.","evidence":"Investigational"}]
Primary treatment for: Opioid dependence
Also treats: Alcohol dependence
📋 Drug Information
| Generic Name(s) | Information coming soon |
| Brand Name | nacxone 1000mg injection |
| Manufacturer | Multiple manufacturers |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 3 generation |
| Route of Administration | Parenteral (intramuscular injection) |
| Storage | Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Keep in the original carton until use. |
| Shelf Life | Refer to the product packaging for the expiration date. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by competitively antagonizing opioid receptors in the central nervous system. Naltrexone binds with high affinity to mu, kappa, and delta opioid receptors, thereby blocking the effects of exogenous opioids and endogenous endorphins. This blockade prevents the euphoric and reinforcing effects of opioids, reducing the desire to use them. In alcohol dependence, the exact mechanism is not fully understood, but it is thought to involve modulation of the endogenous opioid system, which plays a role in alcohol reward pathways.
Mechanism Steps
💡 How to Take nacxone 1000mg injection
Strength: Injection, 1000 mg (specific strength as provided)
Dosage Information
| Adult Dosage | The typical adult dose of this medicine is 380 mg of extended-release naltrexone administered intramuscularly every 4 weeks (once monthly). However, the 1000 mg strength mentioned may be a different formulation or concentration; dosing must be individualized by a qualified clinician based on the specific product, indication, and patient factors. It is essential to follow the prescribed dosing schedule and not to adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are recommended for elderly patients, but caution is advised due to potential age-related decreases in hepatic and renal function. Individualization by a clinician is necessary. |
| Renal Impairment | No dosage adjustment is typically required for mild to moderate renal impairment. Use with caution in severe renal impairment. |
| Hepatic Impairment | This medicine is contraindicated in patients with acute hepatitis or liver failure. In patients with mild to moderate hepatic impairment, no dosage adjustment is needed, but monitoring is recommended. |
| Maximum Daily Dose | The maximum recommended dose is determined by the prescribed regimen. For extended-release injectable naltrexone, the usual dose is 380 mg once monthly. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nacxone 1000mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioid analgesics | Major | |
| Thioridazine | Major | |
| Metoclopramide | Moderate | |
| Antidepressants | Moderate |
🚨 Major Interactions
- Opioid analgesics
- Thioridazine
⚡ Moderate Interactions
- Metoclopramide
- Antidepressants
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Although naltrexone is used to treat alcohol dependence, concurrent alcohol consumption may increase the risk of liver damage and reduce the effectiveness of treatment. Patients should discuss any alcohol use with their doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Patients currently receiving opioid analgesics","Patients with acute hepatitis or liver failure","Known hypersensitivity to naltrexone or any component of the formulation","Patients in acute opioid withdrawal"]
⚠️ Warnings & Precautions
["This medicine should only be administered by a healthcare professional.","Patients must be opioid-free for at least 7-10 days before initiating therapy to avoid precipitated withdrawal.","Regular monitoring of liver function is essential.","Caution in patients with renal impairment.","Patients should be advised to carry identification indicating they are receiving naltrexone, as it may affect emergency treatment with opioids."]
🤱 Lactation Safety
Naltrexone is excreted in breast milk. Caution should be exercised when administered to a nursing woman. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
There is limited experience with overdose of this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Naltrexone is not expected to cause serious toxicity in overdose due to its antagonistic properties, but the injection vehicle may cause local reactions.
⏰ Missed Dose
If you miss a scheduled dose of this medicine, contact your healthcare provider as soon as possible to reschedule. Do not attempt to self-administer. The dosing schedule is typically every 4 weeks or as determined by your doctor.
Additional Safety Advice
This medicine must only be administered by a healthcare professional in a clinical setting. Do not attempt to self-administer. Before receiving this medicine, inform your doctor about all medications you are taking, especially opioids, as combining them can cause severe withdrawal. Avoid alcohol while on this medicine as it may increase liver toxicity. Regular liver function tests are recommended during treatment. Women who are pregnant or breastfeeding should consult their doctor before receiving this medicine. Do not drive or operate heavy machinery until you know how this medicine affects you.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced hepatic and renal function, which can affect drug metabolism and excretion. Close monitoring is advised. No specific dose adjustments are recommended, but individualization is necessary.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor. This medicine is Pregnancy Category C and should be used during pregnancy only if clearly needed. Effective contraception is recommended for women of childbearing potential.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are receiving this medicine, as it may interfere with opioid pain management. Alternative pain relief strategies may be needed.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine, as it may affect the choice of pain medications. Non-opioid pain relievers may be recommended.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are associated with this medicine. However, if you experience dizziness or fatigue, avoid strenuous activities until you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is important to inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Discontinuation should be planned with your healthcare provider, especially if you are at risk of relapse. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with liver enzyme elevations. Regular monitoring of liver function is recommended. Some patients may experience persistent injection site reactions. The medicine is generally well-tolerated for extended periods, but the need for continued treatment should be reassessed periodically.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Counseling and support groups can complement medication for addiction treatment.
Evidence: Well-establishedOther medications for opioid dependence that may be alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store in refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not use if expired
✅ DO
Keep out of reach of children
❌ DON'T
Do not store at room temperature for extended periods
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label. Keep a copy of your prescription and a letter from your doctor explaining the medical necessity. Store it in a cool, refrigerated environment if possible; use a cooler bag with ice packs during travel. Check airline and customs regulations for carrying injectable medications. Plan your doses around travel schedules; if crossing time zones, consult your doctor for timing adjustments.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The injection provides opioid blockade within hours, but full therapeutic effects develop over several days. It lasts for about 28-30 days.
A: Avoid opioids and alcohol. Also avoid driving or operating machinery until you know how the medicine affects you.
A: No, naltrexone is not addictive. It is an antagonist and does not produce euphoria.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Naltrexone injection is a substitute for opioids.
Fact: Naltrexone is an antagonist, not an agonist. It blocks opioids and does not produce euphoria. - Myth: You can start naltrexone immediately after opioid use.
Fact: You must be opioid-free for 7-10 days to avoid severe withdrawal.
🔄 Alternative Options
Generic Alternatives
- Naltrexone hydrochloride injection
Brand Alternatives
- Vivitrol