Amlodipine + Metoprolol Succinate 5mg/50mg Extended-release Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fainting or severe dizziness
- Difficulty breathing or wheezing
- Chest pain that worsens or does not respond to rest
- Severe bradycardia (heart rate below 50 bpm) with symptoms
- Sudden weight gain or swelling in legs and feet
- Signs of allergic reaction: rash, itching, swelling of face, lips, or throat
- Yellowing of skin or eyes, dark urine
If experiencing severe symptoms, call emergency services immediately.
What is metpil a 50 tablet sr used for?
This medicine is a combination of Amlodipine (5mg) and Metoprolol Succinate (47.5mg) used to treat high blood pressure and chronic stable angina. It works by relaxing blood vessels and slowing the heart rate, reducing the heart's workload. It is taken once daily as an extended-release tablet.
- Generic Name: Amlodipine (5mg) + Metoprolol Succinate (47.5mg)
- Manufacturer: Alteus Biogenics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 metpil a 50 tablet sr के बारे में (Hindi Summary)
उपयोग: यह दवा एम्लोडिपिन (5mg) और मेटोप्रोलोल सक्सिनेट (47.5mg) का संयोजन है, जिसका उपयोग उच्च रक्तचाप (हाइपरटेंशन) और स्थिर एनजाइना (दिल से जुड़ी छाती में दर्द) के इलाज के लिए किया जाता है। यह रक्त वाहिकाओं को आराम देकर और हृदय की गति को धीमा करके रक्तचाप को कम करती है और हृदय पर दबाव कम करती है। यह दवा आमतौर पर दिन में एक बार ली जाती है और इसे चिकित्सक के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, चक्कर आना, सिरदर्द, टखनों या पैरों में सूजन, धीमी हृदय गति और हाथ-पैर ठंडे होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको बेहोशी, गंभीर चक्कर, सांस लेने में कठिनाई, छाती में दर्द, या एलर्जी के लक्षण जैसे दाने, खुजली, या चेहरे, होंठ, या गले में सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को चिकित्सक के निर्देशानुसार ही लें, आमतौर पर दिन में एक बार। गोली को चबाएं या तोड़ें नहीं, पूरा निगल लें। अचानक दवा बंद न करें, क्योंकि इससे एनजाइना या दिल का दौरा पड़ सकता है। यदि आपको अस्थमा, सीओपीडी, मधुमेह, थायरॉइड विकार, जिगर या गुर्दे की बीमारी, या हृदय विफलता है, तो अपने डॉक्टर को बताएं। शराब से बचें, क्योंकि इससे चक्कर और निम्न रक्तचाप बढ़ सकता है। नियमित रूप से अपने रक्तचाप और हृदय गति की निगरानी करें।
💊 metpil a 50 tablet sr Uses & Benefits
[{"condition":"Hypertension","description":"Effectively lowers blood pressure by reducing peripheral vascular resistance and cardiac output, thereby decreasing the risk of stroke, heart attack, and kidney damage.","evidence":"Well-established"},{"condition":"Chronic Stable Angina","description":"Reduces the frequency and severity of angina attacks by decreasing heart rate, contractility, and myocardial oxygen demand, while amlodipine improves coronary blood flow.","evidence":"Well-established"},{"condition":"Hypertension with Angina","description":"Provides dual benefit for patients who have both high blood pressure and angina, simplifying treatment regimen.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Rate control in atrial fibrillation","description":"Metoprolol component may help control heart rate in atrial fibrillation, but this combination is not first-line for this indication.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Beta-blockers like metoprolol are sometimes used off-label to prevent migraines, but the combination with amlodipine is not standard.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Chronic stable angina, Hypertension with angina
📋 Drug Information
| Generic Name(s) | Amlodipine (5mg) + Metoprolol Succinate (47.5mg) |
| Brand Name | metpil a 50 tablet sr |
| Manufacturer | Alteus Biogenics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Amlodipine inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle cells, causing relaxation of peripheral arterioles and reducing peripheral vascular resistance. Metoprolol succinate selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, myocardial contractility, and cardiac output. Together, they lower blood pressure and decrease myocardial oxygen demand, improving angina symptoms.
Mechanism Steps
💡 How to Take metpil a 50 tablet sr
Strength: Extended-release tablet containing Amlodipine 5mg and Metoprolol Succinate 47.5mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of Amlodipine 5mg and Metoprolol Succinate 47.5mg extended-release once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and hypotension. Start with a lower dose and titrate slowly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is typically required for mild to moderate renal impairment. In severe renal impairment, metoprolol clearance may be reduced; use with caution and individualize dose by a qualified clinician. |
| Hepatic Impairment | In hepatic impairment, amlodipine clearance is reduced, and metoprolol metabolism may be affected. Start with a lower dose and titrate slowly. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is Amlodipine 10mg and Metoprolol Succinate 95mg (equivalent to 100mg metoprolol tartrate). Do not exceed this dose unless directed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of metpil a 50 tablet sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| CYP3A4 inhibitors | Major | |
| CYP2D6 inhibitors | Major | |
| Verapamil/diltiazem | Major | |
| Clonidine | Major | |
| NSAIDs | Moderate | |
| Alpha-blockers | Moderate | |
| Insulin/oral hypoglycemics | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- Verapamil or diltiazem
- Clonidine
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Alpha-blockers (e.g., prazosin)
- Insulin and oral hypoglycemics
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering and sedative effects of this medicine, increasing the risk of dizziness, fainting, and falls. It is advisable to avoid alcohol or limit intake while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second- or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Severe peripheral arterial disease","Known hypersensitivity to amlodipine, metoprolol, or any component","Sick sinus syndrome without pacemaker"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly; taper gradually to avoid rebound angina or hypertension.","Use with caution in patients with asthma or COPD; metoprolol may cause bronchospasm.","May mask symptoms of hypoglycemia in diabetic patients.","May worsen symptoms of peripheral arterial disease.","Use with caution in patients with liver or kidney impairment; dose adjustment may be needed.","Avoid alcohol; may increase dizziness and hypotension.","May cause dizziness; avoid driving or operating machinery until you know how it affects you."]
🤱 Lactation Safety
Amlodipine and metoprolol are excreted in breast milk in small amounts. The use of this medicine during breastfeeding should be discussed with a doctor, as potential effects on the infant are not fully established.
💊 Overdose Management
Overdose can cause severe hypotension, bradycardia, heart failure, and bronchospasm. Seek immediate medical attention. Treatment is supportive and may include intravenous fluids, atropine, glucagon, and vasopressors. Hemodialysis is not effective for removing amlodipine or metoprolol.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed, usually once daily, with or without food. Do not crush, chew, or break the extended-release tablet; swallow it whole. Do not stop this medicine abruptly, as sudden withdrawal can worsen angina or cause a heart attack. Inform your doctor if you have asthma, chronic obstructive pulmonary disease, diabetes, thyroid disorders, liver or kidney disease, or heart failure. Avoid alcohol, as it may increase dizziness and low blood pressure. Monitor your heart rate and blood pressure regularly. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for the next dose; never double the dose. Keep all medical appointments and lab tests as advised.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the blood pressure-lowering and heart rate-slowing effects of this medicine. Start with a lower dose and titrate slowly. Monitor for dizziness, falls, and cognitive changes. Regular monitoring of renal and hepatic function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conceiving. This medicine is generally not recommended during pregnancy. Your doctor may switch you to a safer alternative. Use effective contraception while taking this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rate during surgery. Your doctor may advise you to continue or temporarily stop the medicine before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may interact with local anesthetics containing epinephrine, potentially causing severe hypertension or arrhythmias. Your dentist may adjust the anesthetic used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial, but avoid sudden strenuous activities, especially in hot weather, as this medicine can cause dizziness and low blood pressure. Warm up and cool down gradually. If you experience chest pain, severe shortness of breath, or dizziness during exercise, stop and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. It is usually safe to continue most work activities, but inform your employer if your job involves operating machinery or working at heights.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your doctor decides to discontinue, the dose should be tapered gradually over 1 to 2 weeks to avoid rebound hypertension or angina. If you need to stop for surgery or other reasons, your doctor will provide specific instructions.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for managing hypertension and angina. Regular monitoring of blood pressure, heart rate, and renal function is recommended. Some patients may develop tolerance to metoprolol, but this is uncommon. Long-term use may be associated with an increased risk of new-onset diabetes, particularly with metoprolol. Periodic eye exams are advised for patients on long-term amlodipine due to rare reports of visual disturbances.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help control blood pressure and angina.
Evidence: Well-establishedACE inhibitors, ARBs, diuretics, or other calcium channel blockers may be alternatives if this combination is not suitable.
Evidence: Well-establishedFor severe angina not controlled by medication, invasive procedures may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medications you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Carry enough supply for the entire trip and a few extra days. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Amlodipine begins to lower blood pressure within 24 to 48 hours, with full effect after 1 to 2 weeks. Metoprolol starts reducing heart rate within 1 to 2 hours, but full therapeutic effect may take several days.
A: No, you should not stop this medicine without consulting your doctor. High blood pressure is a chronic condition, and stopping abruptly can cause rebound hypertension or angina.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine is generally not recommended during pregnancy, especially in the second and third trimesters. Consult your doctor for alternative treatments.
A: It is advisable to avoid alcohol as it may increase dizziness and low blood pressure.
🤔 Common Patient Concerns
🔄 Substitutes for metpil a 50 tablet sr
View AllAlternative brands with exact same active ingredient:
-
genericart amlodipine besylate+metoprolol succinate 5mg/50mg tablet erSwast Aushadhi Seva Generic Medicine Store ₹63.75 64.1% CHEAPER
-
bitoprol-a2 tablet erBi-Cure Remedies ₹70.00 60.6% CHEAPER
-
amlocaid-m tablet prMedicaid Labs LLP ₹79.00 55.6% CHEAPER
-
lorpotem am tabletVernoxy Pharma Pvt Ltd ₹88.67 50.1% CHEAPER
-
revelol-am 50/5 tablet prIpca Laboratories Ltd ₹253.22 42.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure is a chronic condition. Stopping this medicine abruptly can cause rebound hypertension or angina. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage.
Fact: This medicine is not directly nephrotoxic. It may actually protect the kidneys by controlling blood pressure. Regular monitoring is advised. - Myth: You can crush or chew the tablet for faster action.
Fact: This is an extended-release tablet. Crushing or chewing can cause a rapid release of the drug, leading to dangerous drops in blood pressure and heart rate.
🔄 Alternative Options
Generic Alternatives
- Amlodipine 5mg + Metoprolol Succinate 47.5mg extended-release tablet (various manufacturers)