Methylcobalamin (1500mcg) + Niacinamide (100mg) + Vitamin B6 (Pyridoxine) (100mg) (Medical Monograph)

Overview

A high-potency neurotropic B-complex combination used primarily for the management of neuropathies, nutritional deficiencies, and metabolic support. Methylcobalamin is the active, coenzyme form of Vitamin B12, essential for nerve myelination and hematopoiesis. Niacinamide (Vitamin B3) supports cellular energy metabolism and NAD+ synthesis. Pyridoxine (Vitamin B6) is a cofactor in neurotransmitter synthesis and amino acid metabolism. This combination is widely prescribed in India for diabetic neuropathy, peripheral neuritis, and B-vitamin deficiencies.

The combination acts synergistically to support nerve health, energy metabolism, and homocysteine regulation. Methylcobalamin acts as a cofactor for methionine synthase, converting homocysteine to methionine, crucial for myelin synthesis and neuronal repair. It also aids in methylmalonyl-CoA conversion, important for fatty acid metabolism in nerves. Niacinamide is a precursor for NAD+ and NADP+, coenzymes vital for cellular respiration, ATP production, and DNA repair. Pyridoxine, as PLP, is a cofactor for over 140 enzymes involved in neurotransmitter synthesis (GABA, serotonin, dopamine), heme synthesis, and homocysteine metabolism (via cystathionine beta-synthase).