A high-potency neurotropic B-complex combination used primarily for the management of neuropathies, nutritional deficiencies, and metabolic support. Methylcobalamin is the active, coenzyme form of Vitamin B12, essential for nerve myelination and hematopoiesis. Niacinamide (Vitamin B3) supports cellular energy metabolism and NAD+ synthesis. Pyridoxine (Vitamin B6) is a cofactor in neurotransmitter synthesis and amino acid metabolism. This combination is widely prescribed in India for diabetic neuropathy, peripheral neuritis, and B-vitamin deficiencies.
Adult: One tablet/capsule once daily, or as directed by the physician. Often prescribed for 4-12 weeks initially, then as maintenance.
Note: Administer orally after a meal to minimize potential gastric irritation. Tablet/Capsule should be swallowed whole with a glass of water. Do not crush or chew. Timing is not critical but consistency is recommended.
The combination acts synergistically to support nerve health, energy metabolism, and homocysteine regulation. Methylcobalamin acts as a cofactor for methionine synthase, converting homocysteine to methionine, crucial for myelin synthesis and neuronal repair. It also aids in methylmalonyl-CoA conversion, important for fatty acid metabolism in nerves. Niacinamide is a precursor for NAD+ and NADP+, coenzymes vital for cellular respiration, ATP production, and DNA repair. Pyridoxine, as PLP, is a cofactor for over 140 enzymes involved in neurotransmitter synthesis (GABA, serotonin, dopamine), heme synthesis, and homocysteine metabolism (via cystathionine beta-synthase).
Pregnancy: Category A (Indian/CDC classification). Water-soluble vitamins cross the placenta. This high-dose combination should be used only if clearly needed and under medical supervision. Recommended Dietary Allowance (RDA) levels are preferred for routine supplementation in pregnancy.
Driving: No known effects on driving ability. However, dizziness, a rare side effect, should be considered.
| Levodopa | Pyridoxine (>10mg/day) accelerates peripheral decarboxylation of Levodopa, reducing its central efficacy for Parkinson's disease. | Major |
| Chloramphenicol | May antagonize the hematological response to Methylcobalamin. | Moderate |
| Isoniazid, Cycloserine, Penicillamine | These drugs are Pyridoxine antagonists and can increase requirement/deficiency. | Moderate |
| Phenobarbital, Phenytoin | Pyridoxine may decrease serum levels of these anticonvulsants. | Moderate |
| Folic Acid (high dose) | May mask hematological signs of B12 deficiency, allowing neurological damage to progress. | Major |
| Proton Pump Inhibitors (PPIs), Metformin | Long-term use can reduce absorption of dietary B12, increasing therapeutic need for Methylcobalamin. | Moderate |
Same composition (Methylcobalamin (1500mcg) + Niacinamide (100mg) + Vitamin B6 (Pyridoxine) (100mg)), different brands: